• 구강회복응용과학지
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• 제28권3호
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• pp.253-268
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• 2012

수직적, 수평적 골흡수가 심한 환자에서 임플란트를 이용한 전악수복의 경우 경조직과 연조직 이식을 통해서 임플란트를 원하는 위치에 식립할 수도 있지만, 치은과 치아의 기능과 심미를 회복할 수 있는 fixed detachable prostheses를 대체 술식으로 사용할 수도 있다. 이러한 증례에서 다양한 재료가 수복물의 제작에 사용 가능하지만, metal/acrylic 보철물에서는 레진치아의 파절 및 탈락이 일어날 수 있고, metal/ceramic 혹은 zirconia/ceramic 보철물에서는 도재의 chipping이나 파절과 같은 문제가 발생할 수 있다. 이에 최근에 심미적이면서도 기능적인 보철수복을 위해 zirconia에 도재를 축성하지 않고 임상적으로 적용가능한 monolithic zirconia framework이 출시되어 사용되고 있다. 본 임상 증례는 심미적인 요구도가 높은 완전 무치악 환자에서 임플란트를 식립하고 chipping이나 파절의 위험을 감소시키기 위해 monolithic zirconia framework을 이용해 만들어진 complete fixed detachable 보철물을 이용한 수복에 대해 보고하고자 한다. 이번 증례에서 보철물은 심미적, 기능적으로 만족스러웠으며, 2년 간의 정기검사에서 임상적인 합병증은 보고되지 않았다.

• 대한골관절종양학회지
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• 제18권2호
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• pp.113-117
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• 2012

73세 남자환자가 내원 8개월 전 좌측 원위 대퇴부의 연부 조직 종괴로 타 병원에서 절제술을 시행받은 뒤, 재발하여 4개월 뒤 재수술을 받았으나, 수술 부위의 치유되지 않는 창상을 주소로 내원하였다. 타 병원에서 시행한 조직 검사 소견은 단순 낭종이었다. 수술 소견상 종괴는 외측 광근의 근막층을 침범하면서 경계가 불규칙하며 주변으로 유착되어 있어, 종괴로부터 5 cm 경계를 확보하여 단순 절제술을 시행하였다. 본원 조직검사 결과, 악성 섬유성 조직구종으로 진단되어 추가적인 방사선 치료를 시행하였다. 수술 후 1년째까지, 크기가 증가되거나 타 부위에 전이되는 소견은 관찰되지 않았다. 단순 낭종으로 생각하고 절제술을 시행하였으나, 악성 섬유성 조직구종으로 확진되었던 경우로, 종양 절제술은 수술 전 세밀한 검사 및 진단이 필요할 것으로 사료된다.

• 대한두개안면성형외과학회지
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• 제21권4호
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• pp.229-236
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• 2020

Background: Oncologic resection of the scalp confers several obstacles to the reconstructive surgeon dependent upon patient-specific and wound-specific factors. We aim to describe our experiences with various reconstructive methods, and delineate risk factors for coverage failure and complications in the setting of scalp reconstruction. Methods: A retrospective chart review was conducted, examining patients who underwent resection of fungating scalp tumors with subsequent soft-tissue reconstruction from 2003 to 2019. Patient demographics, wound and oncologic characteristics, treatment modalities, and outcomes were recorded and analyzed. Results: A total of 189 patients were appropriate for inclusion, undergoing a range of reconstructive methods from skin grafting to free flaps. Thirty-three patients (17.5%) underwent preoperative radiation. In all, 48 patients (25.4%) suffered wound site complications, 25 (13.2%) underwent reoperation, and 47 (24.9%) suffered from mortality. Preoperative radiation therapy was an independent risk factor for wound complications (odds ratio [OR], 2.85; 95% confidence interval [CI], 1.1-7.3; p=0.028) and reoperations (OR, 4.45; 95% CI, 1.5-13.2; p=0.007). Similarly, the presence of an underlying titanium mesh was an independent predictor of wound complications (OR, 2.49; 95% CI, 1.1-5.6; p=0.029) and reoperations (OR, 3.40; 95% CI, 1.2-9.7; p=0.020). Both immunosuppressed status (OR, 2.88; 95% CI, 1.2-7.1; p=0.021) and preoperative radiation therapy (OR, 3.34; 95% CI, 1.2-9.7; p=0.022) were risk factors for mortality. Conclusion: Both preoperative radiation and the presence of underlying titanium mesh are independent risk factors for wound site complications and increased reoperation rates following oncologic resection and reconstruction of the scalp. Additionally, preoperative radiation, along with an immunosuppressed state, may predict patient mortality following scalp resection and reconstruction.

• 한국식품영양과학회지
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• 제22권1호
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• pp.19-26
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• 1993

단식 또는 기초사료를 투여한 성장기 rat 에 우지 또는 들깨유를 매일 일정량 투여하여 2일 간격으로 체중변화와 장기중량, 혈액의 생화학적검사 간조직검사를하여 다음의 결론을 얻었다. 완전 단식rat군(F)과 단식중 우지 (FT)와 들깨유(FP)를 투여한 rat군은 1일 평균 -6.2~-4.0%인 체중감소를 보이고 기초식이군 (B) 또는 기초식이에 우지 (BT)나 들깨유(BP)를 투여한 rat군은 1일 2.3~4.0%의 체중증가를 보였다. F군은 4일만에 모두 아사하였고, FT와 FP군은 6~10일 사이에 모두 아사하였다. 단식에 의한 영향으로 아사직전 이들 rat는 간중량(3.6~4.0g) serum cholesterol(70~73.2mg/㎗), serum triglyceride (6.5~7..5mg/㎗) blood glucose (76-91mg/㎗)의 현저한 감소와 GPT (117.5-186.5u), blood urea nitrogen (38~65mg/㎗)을 대폭 증가하는 특징을 가졌다. 유지시료 불포화도에 따른 영향에서 FP군은 FT군에 비해 약 2일 정도 생존일수의 감축과 serum cholesterol, serum triglyceride, blood urea nitrogen 감소를 보이나 GPT, blood glucose를 약간 증가하였다. BP군은 BT군에 비해 serum cholesterol, triglyceride를 상당히 감소하고 blood urea nitrogen의 근소한 감소와 GPT는 대폭 증가하였다. Blood glucose는 거의 차이가 없었다. 간조직 검사 결과 F군은 아사직전 간실질내 염증 세포 침윤을 보이고 FT, FP군은 유지 시료의 불포화도 차이에 관계없이 아사직전 일부 rat가 염증세포 침윤, 간실질의 염증, 간세포의 손상된 모양이 관찰되었다. 따라서 어떤 목적으로 단식 또는 유지만을 공급하는 무단백질 제한식이를 할 때 극심한 체중감소를 보이고 혈중 cholesterol과 trig1yceride는 크게 낮아지며 간을 포함한 모든 조직의 붕괴의 조짐으로 blood urea nitrogen이 크게 증가되고 그에 따른 간기능저하로 GPT도 크게 상승하고 rat의 경우 4~6일만에 사망하였다. 단식중이거나 혹은 정상식이내 고도 불포화 유지 (들깨유)의 섭취는 포화지방 (우지)에비해 혈중 cholesterol 과 triglyceride를 감소시키는 효과는 있지만 GPT가 유의적으로 증가됨을 볼때 장기간 고도 불포화 유지를 다량 섭취함은 간기능을 저하 시킬 수 있음이 나타났다.

• 대한의료기공학회지
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• 제11권1호
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• pp.236-261
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• 2009

'Jeom-hyeol-gigong(點穴氣功)' gives a drill, Gi(氣) as a place to jam. This pathogen(邪氣) is removed. Given the low places and supplement it energy to flow up the well is the cure. This is an internal organ and muscular Gi allows a natural flow. Blood, one that moves and guides Gi is Gi I still feel that it makes any blood, making you feel good in life is flowing with vitality. Gi driving our whole body, while supplying vital energy and blood circulation, helping to defend the body is functioning. 'Jeom-hyeol-gigong' principle of Gi where the blockages to flow naturally energy is to let the flow. Aura of the voluntary and proactive action will be to have healthy bodies. Gi as a whole-body blood circulation leading to the cells in each tissue to supply energy and nutrients to every cell as the original principles of free activities that will maximize your life. Gi to prevent the three causes Internal causes: 5 greed and 7 emotions External causes: climate, food, pathogens, stress, etc. The internal nor the external causes: internal and external factors that cause the complex elements, incorrect position of the bone caused by an imbalance Heart disease will be police officers and raise their resistance to disease than the body, what jung-gi(正氣) have to develop. Beneficial to human body's resistance to raise the jung-gi people young-gi(營氣) and wi-gi(衛氣) should be enhanced. If the form is perfectly possible, Gi cycle itself should not have to breathe. Abdominal diagnosis 'bok-su-ap-an-beop(伏手壓按法)', 'sam-ji-tam-an-beop(三指探按法)' hands are like this, which outlined five viscera in order to understand the problem, the lower side of the clavicle (lung), the pit of stomach (Heart), both the lower ribs (liver), navel below (kidney) can be diagnosed at such areas. In each area of the skin, abdominal muscle tension, aching, or pressing a fuss about, beating the ruling of the state and the problem is a clue. And mo-hyeol(募穴) and certain Acupressure group, the chest, back, belly, so that scattered around each' book 'of the problem can be found. This is also the target of such a diagnosis, such as shape, color of skin, muscle Mostly the scope of the pitch in the cervical spine is broad across the hips. sugi(手氣) method that 'an method(按法) and 'ma method(摩法), bak method(拍法) is.

• Journal of Periodontal and Implant Science
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• 제24권3호
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• pp.597-606
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• 1994

Oxygen derived radicals($O_2\;^-$, $H_2O_2$, and $OH^-$) are thought to play a role in a lot of human diseases. And it has been believed that antioxidant enzymes such as superoxide dismutase(SOD) and catalase could protect the tissues from damage resulting from the oxygen derived free radicals. The purpose of this study was performed to investigate the activity of the SOD(CuZn- and Mn-SOD) and catalase in inflammatory gingival tissues and the correlation between boold glucose level and antioxidants and age in non-insulin dependent diabetes mellitus(NI- DDM) patients. For this study, the patients were classified into normal, inflammatory, and diabetic, and ten their papillary bleeding index(PBI) and gingival index were checked. Subjects consisted of 11 healthy patients with no inflammatroy gingiva, 20 adult periodontitis patients, and 8 diabetic patients, aged 33 to 66(average: 44.62). The blood glucose level of diabetic group was ranged from 120ml/dl to 160ml/dl(physical status 0 : averge : 135.67ml/dl). Gingival tissues were surgically obtained from the patients during periodontal surgery, extraction, and clinical corwn lenghening procedure. The activity of CuZn and Mn- SOD and catalase in the gingival tissues was measured by using UV-spectrophotometer by the same methods that Crapo et al. And Aebi did, respectively. The results were as follows : 1. The Mn-SOD activity was significantly lower in inflammatory group in comparison to normal group(P<0.05), and the activities of antioxidants in diabetic group were not significant in comparison to normal inflammatory group(P>0.05). 2. The activities of antioxidants showed little variation among individuals of different ages (P>0.05). 3. The higher blood glucose level was, the higher gingival index was(P<0.05). 4. There was no correlation between blood glucoe level and activity of antioxidant in inflammatory gingival tissues of NIDDM patients(P>0.05). In conclusion, these results, within the limits of the present experiment, suggest that the activity of Mn-SOD might reflect the inflammatory status of gingival tissue, and the activity of antioxidants was independent of blood glucose level of diabetic patients in physical status 0.

• Journal of Periodontal and Implant Science
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• 제34권1호
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• pp.71-81
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• 2004

Peri-implantitis could be the result of biomechanical and occlusal overload as well as microbiologic invasion. The dental implant may be more susceptible to dental plaque than the natural tooth, as the predictability of a stable soft tissue attachment complex has not yet been confirmed. With the development of peri-implantitis, the implant surface would be exposed to the oral environment and becomes coated with bacteria. The objective of therapy for this condition is to regain integration of the implant with bone. Since fibroblast adherence to surfaces is impeded by endotoxin, it would seem that decontamination would be desirable to obtain maximum osseointegration. The purpose of this study was to determine whether various chemotherapeutic and mechanical treatments(distilled water, air-powder abrasive, hypersaturated citric acid, tetracycline) can detoxify contaminated titanium implant surface by means of kinetic LAL test. Experimental rough surface titanium disks were fabricated. All of them were divided into two groups(A.a group and P.g group) and each contaminated by A. actinomycetemcomitans and P. gingivalis suspension. Contaminated disks were treated with distilled water, air-powder abrasive, citric acid and tetracycline, and then all disks were placed into LPS-free water for elution. The results were as follows : 1. In A.a group, LPS elute level of all test groups were significantly lower than control group(p<0.05). 2. In A.a group, LPS elute level of test 2, test 3 and test4 groups were significantly lower than that of control group(p<0.05). But, among the test 2, test 3, test4 groups, the significant differences were not detected. 3. In P.g group, LPS elute level of test 2, test 3 and test 4 groups were lower than that of control group(p<0.05). But, among the test groups, the significant differences were not detected. From the result of this study, it would be concluded that air-powder abrasive, hypersaturated citric acid and tetracycline treatments may be effective at reducing endotoxin level on rough titanium implant surfaces, and can be clinically used. But the treatments in peri-implantitis differentially impact osseointegration making one method clinically superior. To gain this knowledges, further molecular biologic and histopathologic studies should be developed.

• Journal of Periodontal and Implant Science
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• 제25권3호
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• pp.529-538
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• 1995

It has been believed that the increased release of free oxygen radicals ($O_2^-,H_2O_2$, and $OH^-$) might be a factor in the pathogenesis of periodontal diseases. Antioxidant enzymes such as glutathione peroxidase(GSH-PX) and catalase can protect the tissue damage from the $H_2O_2$. In order to investigate the GSH-PX and catalase activity in the blood plasma and red blood cells(RBCs) of the patients with periodontitis, 19 patients who had good general health, attachment loss more than 6 mm and bone loss were selected as periodontitis group, 7 patients who had severely inflamed gingiva were selected as gingivitis group, and 15 volunteers with good general and periodontal health were selected as normal group. 17 of 26 patients were performed scaling and root planing to reduce the gingival inflammation for gingivitis and periodontitis groups, and were selected as posttreatment group. After blood plasma and RBCs were collected and separated 1 ml of peripheral blood from each subject, GSH-PX activity in blood plasma and RBCs was measured by the same method that Stefan et al. did, and catalase activity in RBCs was measured by the same method that Beers et al. did. The difference of GSH-PX and catalase activity between normal, gingivitis, and periodontitis groups was statistically analyzed by ANOVA with SPSS/PC+ program, and the difference between pretreatment and posttreatment groups was analyzed by Student t-test. The results were as follows : 1. GSH-PX activity in blood plasma was significantly lower in the gingivitis group($0.8683{\pm}0.0658$), periodontitis group($0.7130{\pm}0.1333$) than in the normal group($1.0241{\pm}0.0801$)(p<0.05), and GSH-PX activity in RBCs was significantly lower in the gingivitis groupt. $0.8156{\pm}0.1167$), periodontitis group($0.7533{\pm}0.1185$) than in the normal group($l.1963{\pm}0.2044$)(P<0.05), but there was no statistical significance in the difference of GSH-PX activity in RBCs between the gingivitis group and periodontitis group(p>0.05). 2. Catalase activity in RBCs was siginficantly lower in the periodontitis group($117.34{\pm}35.01$) than in the normal group($l52.38{\pm}32.09$)(p<0.05). 3. GSH-PX activity in blood plasma was significantly increased in the posttreatment groupe $1.0376{\pm}0.2820$) compared to the pretreatment group(0.7608 0.1600) (p<0.05), and GSH-PX activity in RBC was significantly increased in the posttreatment group($1.0421{\pm}0.2330$) compared to the pretreatment group($0.7728{\pm}0.1210$)(p<0.05). 4. There was no statistical significance in the difference of catalase activity in RBCs between the pretreatment group($112.04{\pm}43.65$) and posttreatment group($l33.41{\pm}39.16$)(p>0.05).The results, within the limits of the present experiment, suggest that the lowered activity of GSH-PX and catalase in blood plasma and RBCs may be related with periodontopathogenesis.

• Advances in pediatric surgery
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• 제3권2호
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• pp.98-107
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• 1997

To determine whether bile juice exclusion can prevent the mucosal damage, and Insulin-like growth factor-I can promote mucosal regeneration in ischemia-reperfusion injury of the bowel, 39 weanling rats with 10 cm of Thiry-Vella loop were studied. Animal groups were; Control, BL(common bile duct ligation), IGF{insulin-like growth factor-I(IGF-I) infusion} and IGF-BL(combined treatment). IGF-I(1.5 mg/kg/day) was continuously delivered through a subcutaneously implanted miniosmotic pump. After 15 minutes of superior mesenteric artery clamping, a tissue specimen(P) was taken after 30 minutes of reperfusion. Intestinal continuity was restored to allow oral feeding. A specimen of main tract(M) and another of the Thiry-Vella loop(T) were collected for histomorphometry after 48 hours of reperfusion and free feeding. Villus size ratio(VSR), crypt depth(CD), crypt-depth/villus-height ratio(CVR) and injury score(IS) were measured in 15 consecutive villi. The postoperative mortalities of bile duct ligation groups(BL and IGF-BL) were higher than those of other groups. In control group, VSR of M was lower(P<0.05) than P or T, but not in the other groups. VSR of M in control was lower than those in other groups. CD of T in control, IGF and IGF-BL group were higher than those of M. CD of M and T showed gradual increments from control, IGF and IGF-BL group, respectively. CVR of M and T in IGF group were higher than those in control. CVR in IGF-BL group, T was higher than M, and M was higher than P. About IS, M of BL($20.1{\pm}2.5$) and IGF-BL($20.9{\pm}3.3$) groups were significantly lower than that of control($32.4{\pm}2.5$). These results suggest that the exclusion of bile juice reduces the severity of the reperfusion injury of the mucosa, by inability to activate pancreatic enzymes and IGF-I stimulates mucosal regeneration in injured bowel, and the effect is potentiated by bile juice exclusion.

• 대한한방내과학회지
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• 제25권3호
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• pp.461-472
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• 2004

Objectives : For the screening of neuroprotective effects of medicinal herbs, the complex system of animal models suffer some disadvantages in controlling critical parameters such as blood pressure and body temperature. Additionally, application of drugs to the appropriate brain area sometimes is difficult, due to poor permeability though the blood brain barrier, and so potential protective effects might be masked. Methods : Organotypic hippocampal slice culture (OHSC) method has the advantages of being relatively easy to prepare and of maintaining the general structure, including tissue integrity and the connections between cells. Drugs can easily be applied and neuronal damage can easily be quantified by using tissues and culture media. This study demonstrates neuroprotective effects of Puerariae radix (葛根, PR), Salviae miltiorrhizae radix (丹蔘, SR), Rhei rhizoma (大黃, RR), and Bupleuri radix (柴胡, BR). These were screenedand compared to MK-801, antagonist of NMDA receptors, by using OHSC of 1 week-old Sprague-Dawley rats. Oxygen/glucose deprivation (OGD) were conducted in an anaerobic chamber $(85%\;N_2,\;10%\;CO_2\;and\;5%\;H_2)$ in a deoxygenated glucose-free medium for 60 minutes. Water extracts of each herbs were treated to culture media with $5\;{\mu}g/ml$ for 48 hours. Results : Neuronal cell death in the cultures was monitored by densitometric measurements of the cellular uptake of propidium iodide (PI). PI fluorescence images were obtained at 48 hours after the OGD and medicinal herb treatment. Also TUNEL-positive cells in the CAI and DG regions and LDH concentrations in culture media were measured at 48 hours after the OGD. According to measured data, MK-801, PR, SR and BR demonstrated significant neuroprotective effect against excessive neuronal cell death and apoptosis induced by the OGD insult. Especially, PR revealed similar neuroprotective effect to MK-801 and RR demonstrated weak neuroprotective effect. Conclusions : These results suggest that OHSC can be a suitable method for screening of neuroprotective effects of medicinal herbs. (This work was supported by the research program of Dongguk University and Grant 01-PJ9-PG1-01CO03-0003 from Ministry of Health & Welfare.)