• Interdisciplinary Bio Central
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• 제3권1호
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• pp.3.1-3.16
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• 2011

Investigation of the genetic functions in complex biological systems is a challenging step in recent year. Hence, several valuable and interesting research projects have been developed with novel ideas to find out the unknown functions of genes or proteins. To validate the applicability of their novel ideas, various approaches are built up. To date, the most promising and commonly used approach for discovering the target proteins from biological system using small molecule is well known a forward chemical genetics which is considered to be more convenient than the classical genetics. Although, the forward chemical genetics consists of the three basic components, the target identification is the most challenging step to chemical biology researchers. Hence, the diverse target identification methods have been developed and adopted to disclose the small molecule bound protein. Herein, in this review, we briefly described the first two parts chemical toolbox and screening, and then the target identifications in forward chemical genetics are thoroughly described along with the illustrative real example case study. In the tabular form, the different biological active small molecules which are the successful examples of target identifications are accounted in this research review.

• 대한통합의학회지
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• 제9권3호
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• pp.135-144
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• 2021

Purpose : The purpose of this study was to investigate the effect of 2 weeks of backward walking exercise (BWE) on cervical angle and gait parameters in college students with forward head posture. Methods : Fifteen subjects participated in the experiment. All the participants had a craniovertebral angle (CVA) of 55 degrees or less. The purpose of the study was explained to all the subjects prior to participation, and volunteered to take part in the study. A camera capable of taking pictures of the lateral plane was installed at a distance of 1.5 meters from each subject. Images of forward head posture were obtained before and after performing the BWE, and the CVA and craniorotational angle (CRA) were compared pre- versus post exercise. Foot pressure and gait parameters (step length of left and right, stride length, stance of left and right, swing of left and right, step time of left and right, and stride time) were measured using a rehabilitation treadmill. The subjects performed the BWE for 2 weeks. The exercise program consisted of a 5-minute warm-up exercise, 20-minute main exercise, and 5-minute cool-down exercise. In the main exercise, the treadmill speed was set to 2.4 km/h in the first week and 3.4 km/h in the second week. A paired t test was used to compare the CVA and CRA and gait parameters before and after the exercise. Results : Comparison of the CVA and CRA before and after the BWE revealed a significant difference post exercise, with a marked improvement in forward head posture after the exercise (p<.05). Conclusion : Based on the results of this study, the BWE is considered to be an effective exercise for the forward head posture. Also, additional research is needed to shed light on the impact of the BWE on gait parameters.

• Investigative and Clinical Urology
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• 제59권6호
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• pp.355-356
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• 2018

• Journal of Gastric Cancer
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• 제23권1호
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• pp.1-2
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• 2023

• 정보보호학회논문지
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• 제11권5호
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• pp.43-52
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• 2001

Y. Zheng은 기존의 서명 후 암호화(signature-then-encryption)기법을 기반으로하여 디지털 서명 기법과 대칭키 암호 기법을 결합시킨 signcryption이라는 새로운 기법을 제안하였다. Signcryption은 기밀성과 인증성을 동시에 만족시키면서 계산량과 통신비용을 줄여 효율성을 높인 방법이다. 또한, C. Gamage등은 대리 서명 기법과 signcryption 기법을 효율적으로 결합시킨 proxy-signcryption 기법을 제안 하였다. 그러나 이 두 기법에서 송신자의 개인키가 드러날 경우 그 개인키를 알게되는 사람은 과거에 송신자가 생성한 signcrypt된 문서를 복호화 할 수 있게된다. 즉, 기존의 signcryption 기법은 송신자의 개인키에 대한 forward secrecy의 성질을 제공하지 못한다. 본 논문서는 Zheng의 기법을 변형하여 forward secrecy를 제공하는 signcryption기법과 proxy-signcryption을 제안한다.

• Journal of Mechanical Science and Technology
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• 제19권spc1호
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• pp.371-376
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• 2005

Relative contributions of lower extremity joints on the support moment were investigated in this study. Three-dimensional gait analyses were performed in normal walking and in unexpected step-down walking. For both gait studies, inverse dynamics were performed to obtain each joint moment of the lower extremity, which was applied to the forward dynamics simulation to determine the contributions on the support moment at different phases of walking. The forward dynamic simulation results showed that, in normal walking, the ankle plantar flexors contributed significantly during single-limb-support. However, the ankle plantar flexors, knee extensors and hip extensors worked together during double-limb-support. In unexpected step-down walking, the important contributors on the support of the body during single-limb-support were not only ankle plantar flexors but also knee extensors. This study, analyzing the relative contributions of the lower limb joint moments for the body support, would be helpful to understand different unexpected walking conditions and compensatory mechanisms for various pathological gaits.

• 한국운동역학회지
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• 제14권3호
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• pp.149-163
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• 2004

This study analyzed kinematic variables about the cross step, the delivery and the release for women's javelin athletics recorded over 50m in the 2004 Busan International Athletics Competition. It was used the Kwon3D Motion Analysis Package Ver. 3.1 Program(Kwon, 2000) for analysing the kinematic variables about the distance, the velocity, and the angle, then we had the results as follows; 1 In the Cross step phase, the COG velocity was low because their step length was short. To keep the CM velocity from the approach to the last cross over step contact, the athletes have to keep the longer step length within about 130% of the athletics' height. 2. In the Delivery phase, the athletics' COG height was gradually lower, and the deceleration of the COG was going up. As the same in the cross step, Therefore the athletes have to increase the step length within about 100% of their height, in order to increasing the COG velocity. And it was shown they have to make small angle of the elbow as possible from the right foot contact to the left foot contact in order to being the big acceleration of the upperarm at the release phase. 3. In the release phase, it was shown to being low position of the release point as the COG was low and then the release velocity of the upperarm was low. Specially when the shoulder lean lateral angle is big at the release phase, it was shown they have a excessive release angle. And, when it was shown the high rotation angle of the shoulder, the shoulder was opened forward bigger than the trunk was opened forward. So the transmission of velocity from the proximal segments was a fast change.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 1993년도 제1회 학술강연회논문집
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• pp.55-61
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• 1993

An experimental investigation was conducted in order to determine the flammability limit of the solid fuel ramjet using the backward facing step flow combustion of the plexiglass grain. In order to get the different step height ratio, the grain was drilled straight forward or stepwise. The Phoenics computer code was adopted in order to compare. the flow patterns of the some sample tests using a non-reacting cold turbulent flow model. The stepwise grain give some loading advantage; specially thin and long shape grain design.

• 한국통신학회논문지
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• 제26권11B호
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• pp.1522-1533
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• 2001

본 논문에서는 cdma2000 시스템에서 순방향 폐루프전력제어를 위해 수신 E$_{b}$/I$_{o}$ 를 추정하는 방법을 다루고 있다. 이동국 수신 b//I$_{o}$ 의 추정은 순방향 전력제어 부채널(forward power control subchannel) 전송 심벌을 이용하고 있다. 수신비트에너지와 잡음분산의 추정은 주파수 선택적 Rayleigh 페이딩 채널에서 해석되었다. 특히, 수신비트에너지의 추정은 SIR(signal-to-interference ratio)을 향상시키기 위해서 rake 핑거들과 1/Q 수신심벌들웨 대하여 코히런트 결합에 의해 수행되었다. 그리고 본 논문에서는 차량속도와 전력조정스텝크기에 따른 순방향 폐루프 전력제어의 성능을 비트오율과 전력제어에러 측면에서 평가하고 있다. 시뮬레이션 결과로는 차량속도에 따른 최적의 전력조정스텝크기를 제시하고 있다.

• 대한기계학회논문집
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• 제15권6호
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• pp.2083-2099
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• 1991

본 연구에서는 다른 실험 조건은 일정하게 유지하면서 아래 벽면의 표면조도 를 체계적으로 변화시켜 표면조도가 후향계단 뒤의 재부착 흐름 및 재발달경계층에 미 치는 영향을 조사하고자 하며 구체적인 내응은 다음과 같다. (1) 표면조도가 재부착 길이와 재발달경계층에 미치는 영향의 조사. (2) 표면조도가 평균속도와 난류량 분포 에 미치는 영향의 조사. (3) 여러 종류 표면조도 변화에 따른 재부착길이와 재발달 경 계층 회복에 미치는 영향과 결과의 상호 비교.