• Herbal Formula Science
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• v.30 no.2
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• pp.45-57
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• 2022

Objectives : Yukil-san (YIS, 六一散; Liu yi san) is composed of Talcum and Glycyrrhizae Radix, the name is said to be derived from the proportion of the two herbal components of the formula. The YIS originated from 'Formulas from the discussion illuminating the Yellow Emperor's Basic Question'(黃帝素問宣明論方; Huang di su wen xuan ming lun fang) written by Liu Wan-Su (劉完素). YIS could clear summerheat, resolve dampness, and augment the qi. This formula may be used to treat the common cold, influenza, acute gastroenteritis, cystitis, urethritis and bacillary dysentery. But, there is insufficient of study about the effects of YIS on the anti-inflammatory activities. The present study evaluated the anti-inflammatory effects of YIS on lipopolysaccharide (LPS)-activated RAW 264.7 cells. Methods : Cell viability was assessed by MTT assay and nitric oxide (NO) was evaluated by measuring the nitrite content in culture medium. Pro-inflammatory cytokines such as tumor necrosis factor-α, interleukin-1β and IL-6 were quantified by ELISA kit. The expression of proteins related with nuclear factor-κB (NF-κB) pathway and inducible NO synthase (iNOS) were assessed by western blot analysis. Results : YIS significantly inhibited the expression of iNOS increased by LPS, and thus significantly inhibited the production of NO. In addition, YIS significantly inhibited pro-inflammatory cytokines. In the regulation of inflammation, NF-κB pathway plays a crucial role. YIS inhibited the expression of p-IκBα and thus inhibited the translocation of NF-κB to the nucleus. Conclusions : These results suggest that YIS ameliorates inflammatory response in LPS-activated RAW 264.7 cells through the inhibition of inflammatory mediators, via suppression of the NF-κB pathway. Therefore, this study provides objective evidence for the anti-inflammatory effect of YIS including the underlying mechanisms.

• Journal of the Korean Institute of Gas
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• v.25 no.2
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• pp.64-71
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• 2021

Research on polymer matrix composites with excellent molding processability and mechanical properties in the automotive field including hydrogen fuel cell electric vehicles is expanding to Computer-Aided Engineering (CAE) to support the design of materials with specific mechanical properties. CAE automation requires the prediction of the mechanical properties and behavior of materials. Unlike single materials, the mechanical properties prediction of polymer matrix composites is difficult to explain with formulas because the mechanical behavior is complicated to be explained only by the relationship between the matrix and the filler. In this study, the stress-strain curve according to the composition of polymer matrix composites, which was difficult to predict due to its sensitivity to large plastic deformation and composition, was predicted based on machine learning of the test data. The developed model finds a complex correlation between matrix and filler types and compositions, and predicts the total stress-strain curve meaningfully even in the absence of learned test data. It is expected that the material design AI system can be completed in the future based on the developed model that predicts the mechanical properties of polymer matrix composites even for the combination and composition that have not been learned.

• Journal of the Korean Institute of Gas
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• v.26 no.6
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• pp.9-15
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• 2022

In order to verify the durability of the high-pressure hydrogen tank in the operating pressure range, a hydraulic rupture test should be performed. However, if the bubbles generated by the initial injection process of water are attached to the inner wall of the tank and remain, a sudden pressure change of the bubbles during the rupture of the pressurized tank may cause shock and noise. Therefore, in this study, the flow velocity required to remove the bubbles remaining on the inner wall of the tank was predicted through simplified formulas, and the shape of the injection nozzle to maintain the flow velocity was determined based on the shape of the hydrogen tank for the hydrogen bus. In addition, a numerical model was developed to predict the change in flow velocity according to the inlet pressure, and an experiment was performed through a model tank to prove the validity of the prediction result. As a result of the experiment, the flow velocity near the tank wall was similar to the predicted value of the analysis model, and when the inlet pressure was 1.5 to 5.5 bar, the minimum size of the removable bubble was predicted to be about 2.2 to 4.6 mm.

• Journal of Korean Society of Forest Science
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• v.111 no.4
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• pp.630-643
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• 2022

This study was conducted to derive the fresh weight and dry weight estimation formulas of Pinus densiflora and prepare a weight table using them. Aone-variable formula using only the diameter at breast height (DBH) and a two-variable formula using DBH and height were used to calculate the fresh and dry weight. Each equation was verified using statistics, such as fit index, standard error, and residuals. Theoptimal equation was evaluated for applicability by calculating the weight as a coefficient derived from a statistical verification. W = bD+cD² was selected for the one-variable equation, while W = aD^bH^c was selected for the two-variable equation. The fit index of the former was 0.87-0.92, while that of the latter was 0.94-0.98, both of which showed a good fit. A new weight table was prepared using the optimal estimation formula, and it was compared and analyzed with a previous weight table. Analysis results showed that Gangwon pine had higher values in the previous weight table, while pines in the central region had higher values in the newly created weight table.

• Journal of radiological science and technology
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• v.45 no.3
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• pp.241-248
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• 2022

In this study, a recovery coefficient (RC) calculation was conducted that can correct the underestimation of the standardized uptake value (SUV) due to the partial volume effect (PVE) through phantom measurements and formulas. The experiment was conducted using a dynamic phantom capable of implement cranio-caudal movement at a respiratory rate of 15 times per minute along with the measured phantom experiment of the stopped state, and the RC of the moving state is calculated and compared. Ingenuity TF (Philips Healthcare, Netherland) was used as a positron emission tomography/computed tomography (PET/CT) device. PET-CT Phantom (Biodex Medical System, USA) was used as a phantom for measurement. A phantom image in a stationary state was acquired, and a moving phantom image was acquired using the AZ-733V Respiratory Phantom (Anzai Medical Co, Japan) capable of breathing movement in the cranio-caudal direction under the same acquisition parameters. For RC calculation, the sphere maximum radioactivity concentration and the background mean radioactivity concentration of the acquired images were measured, and the initially determined sphere and background radioactivity concentrations were calculated. The calculated RC was 0.08 to 0.72. The size of sphere smaller, it was confirmed that the RC reduced. And the RC in the moving state reduced than in the stationary state. As a result of this study, the change of the RC was confirmed according to the size of spheres and the phantom moving. Using the RC derived by implement movement of breathing with the respiratory phantom, it is possible to considering correction of underestimated SUV by the partial volume effect of PET images and the patient movements.

• Tunnel and Underground Space
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• v.32 no.5
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• pp.312-326
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• 2022

The generalized Hoek-Brown (GHB) criterion, which is recognized as one of the standard failure conditions for rock mass, is specialized for rock engineering applications and covers a wide range of rock mass conditions. Accordingly, many research efforts have been devoted to the incorporation of this criterion into the stability analysis of rock structures. In this study, the slip-line analysis method, which is a kind of elastoplastic analysis method, is combined with the GHB failure criterion to derive analytical equations that can easily calculate the plastic radius and stress distribution in the vicinity of the circular tunnel. In the process of derivation of related formulas, it is assumed that the behavior of rock mass after failure is perfectly plastic and the in-situ stress condition is hydrostatic. In the formulation, it is revealed that the plastic radius can be calculated analytically using the two respective tangential friction angles corresponding to the stress conditions at tunnel wall and elastic-plastic boundary. It is also shown that the plastic radius and stress distribution calculated using the derived analytical equations coincide with the results of Lee & Pietruszczak's numerical method published in 2008. In the latter part of this paper, the influence of the quality of the rock mass on the size of the plastic zone, the stress distribution, and the change of the tangential friction angle was investigated using the derived analytical equations.

• Composites Research
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• v.36 no.1
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• pp.16-24
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• 2023

This paper presents a multi-scale progressive fatigue damage model incorporating the model for interfacial debonding between fibers and matrix. The micromechanics model for the progressive interface debonding was adopted, which defined the four different interface phases: (1) perfectly bonded fibers; (2) mild imperfect interface; (3) severe imperfect interface; and (4) completely debonded fibers. As the number of cycles increases, the progressive transition from the perfectly bonded state to the completely debonded fiber state occurs. Eshelby's tensor for each imperfect state is calculated by the linear spring model for a damaged interface, and effective elastic properties are obtained using the multi-phase homogenization method. The fatigue damage evolution formulas for fiber, matrix and interface were proposed to demonstrate the fatigue behavior of CFRP laminates under cyclic loading. The material parameters for the fiber/matrix fatigue damage were characterized using the chaotic firefly algorithm. The model was implemented into the UMAT subroutine of ABAQUS, and successfully validated with flat-bar UD laminate specimens ([0]₈,[90]₈, [30]₁₆) of AS4/3501-6 graphite/epoxy composite.

• Korean Journal of Construction Engineering and Management
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• v.24 no.5
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• pp.52-62
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• 2023

The objective of this study is to propose an automated algorithm for precise cutting length of slab rebar complying with regulations such as anchorage length, standard hooks, and lapping length. This algorithm aims to improve the traditional manual quantity take-off process typically outsourced by external contractors. By providing accurate rebar quantity data at BBS(Bar Bending Schedule) level from the bidding phase, uncertainty in quantity take-off can be eliminated and reliance on out-sourcing reduced. In addition, the algorithm allows for early determination of precise quantities, enabling construction firms to preapre competitive and optimized bids, leading to increased profit margins during contract negotiations. The proposed algorithm not only streamlines redundant tasks across various processes, including estimating, budgeting, and BBS generation but also offers flexibility in handling post-contract structural drawing changes. In particular, the proposed algorithm, when combined with BIM, can solve the technical problems of using BIM in the early phases of construction, and the algorithm's formulas and shape codes that built as REVIT-based family files, can help saving time and manpower.

• Journal of Science Education
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• v.47 no.2
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• pp.211-224
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• 2023

The purpose of this study is to suggest how to investigate the reliability of the assessment, which consists of items generated by automatic item generation using empirical example data. To achieve this, we analyzed the illustrative assessment data by applying the multivariate generalizability theory, which can reflect the design of responding to different items for each student and multiple error sources in the assessment score. The result of the G-study showed that, in most designs, the student effect corresponding to the true score of the classical test theory was relatively large after residual effects. In addition, in the design where the content domain was fixed, the ranking of students did not change depending on the item types or items. Similarly, in the design where the item format was fixed, the difficulty showed little variation depending on the content domains. The result of the D-study indicated that the original assessment data achieved a sufficient level of reliability. It was also found that higher reliability than the original assessment data could be obtained by reducing the number of items in the content domains of operation, geometry, and probability and statistics, or by assigning higher weights to the domains of letters and formulas, and function. The efficient measurement conditions presented in this study are limited to the illustrative assessment data. However, the method applied in this study can be utilized to determine the reliability and to find efficient measurement conditions for the various assessment situations using automatic item generation based on measurement traits.

• Journal of Korea Entertainment Industry Association
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• v.13 no.4
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• pp.39-51
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• 2019

This study was tested on Ratafia Champagne Trouillard 1947 of old fortified wine and analyzed differences from existing wines. Old fortified wine in Champagne, France and blanding is Pinot Noir, Chardonnay and Pinot Meunier. Alcohol level is 18% and test date is Feb. 15-21, 2019(six days of decanting period/15 p.m. on the last tasting day). Tester is composed of one FICB grand commander one KOV Finland commander. The wine opening was tested for two blades after wire removal and the decanting time was applied to the calculation formula of 2019(this year)-1947(vintage year)/12=6 days set in this study. Aroma smelled like cherries, fruits, soy sauce and licorice and bouquet was identified in five stages. The first stage was presented with the smell of pot, the second stage was light coffee, the third stage smell of fruit and flowers, the fourth stage smell of wild honey and the fifth stage smell of refined brandy. Then, the test was analyzed in seven stages. This study has the following implications: First, the new concept of old wine was applied to fortified wine. Specific computational formulas for the decanting period were derived. The decanting presented five steps of aromas and bouquet. Wine testing has been expanded from the previous five to seven levels. A new taste of Champagne old fortified wine was analyzed.