• The Korean Journal of Emergency Medical Services
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• v.27 no.2
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• pp.31-40
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• 2023

Purpose: The study aims to provide basic data for understanding the department of paramedicines' bachelor's degree courses to enable curriculum development and reorganization. Methods: The 2023 academic curricula for all eleven universities with active departments of paramedicine offering bachelor's degrees were investigated from April 25 to May 10, 2023. Results: The average courseload was 22.0 units. There were 7.73 major subjects, with 19.45 units on average. The culture subject was available in 7 colleges and was 2.55 units on the average 1.18 subject. Grouping the major subjects showed that 15.3% of subjects were related to advanced paramedicine (the most common course), followed by 11.8% related to research methodology and seminar, and 10.8% related to radiology and simulations. Related subjects in statistics, disaster, and forensic science were also offered. Conclusion: This study found that the curricula of the departments of paramedicine differed from that of the general bachelor's degree. Going forward, university leaders should organize the paramedicine curriculum considering the environmental changes in emergency medicine and the scalability of EMT-Paramedic jobs.

• Proceedings of the Korea Information Processing Society Conference
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• 2021.05a
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• pp.521-524
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• 2021

HEIF (High Efficiency File Format)는 MPEG에서 개발된 이미지 포맷으로써, 비디오 코덱인 H.265를 활용하여 정지된 화면을 하나의 이미지 형태로 저장할 수 있도록 개발된 컨테이너이다. 아이폰은 2017년부터 HEIF를 사용하고 있으며, 2019년부터는 갤럭시 S10과 같은 안드로이드 기기도 해당 포맷을 지원하고 있다. 이 포맷은 우수한 압축률을 가지도록 이미지를 제공할 수 있으나, 복잡한 내부 구조를 가지고 있으며 기기나 소프트웨어 간 호환성이 현저하게 부족하여 일반적으로 사용되는 JPEG(또는 JPG) 파일을 대체하기에는 아직 대중적이지 못한 상황이다. 하지만 이미 많은 기기에서 HEIF를 사용하고 있음에도 불구하고 디지털 포렌식 연구는 부족한 상황이다. 이는 디지털 포렌식 조사 과정에서 파일 내부에 포함된 정보의 파악이 미흡하여 잠재적인 증거를 놓칠 수 있는 위험에 노출될 수 있다. 따라서 본 논문에서는 아이폰에서 촬영된 HEIF 형식의 사진 파일과 갤럭시에서 촬영된 모션 포토 파일을 분석하여 파일 내부에 포함된 정보와 특징들을 알아본다. 또한 이미지 뷰어기능을 지원하는 소프트웨어를 대상으로 HEIF에 대한 지원 여부를 조사하고 HEIF 뷰어를 분석하는 포렌식 도구의 요구사항을 제시한다.

• Journal of Korean Clinical Nursing Research
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• v.29 no.3
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• pp.261-270
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• 2023

Purpose: This study aimed to identify the influence of knowledge of personal information protection law and nursing patient advocacy on practice of personal information protection among nurses. Methods: The subjects were 130 nurses who have worked for six months or more in the ward of the tertiary or general hospitals. Data were collected from February 20 to March 3, 2023. Results: Factors influencing practice of personal information protection were acting as an advocate (β=.32, p=.004), environmental and educational influences (β=.21, p=.040), knowledge of personal information protection law (β=.19, p=.013) and clinical experience for five years or more but less than ten years (β=.17, p=.036). The regression model showed an explanatory power of 34.0%. Conclusion: Acting as an advocate has the most effect on practice of personal information protection. To promote practice of personal information protection for nurses, it is necessary to provide education related to privacy protection and encourage nursing patient advocacy.

• Analytical Science and Technology
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• v.24 no.2
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• pp.69-77
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• 2011

Ethylene glycol (EG) is produced commercially in large amounts and is widely used as antifreeze or deicing solution for cars, boats, and aircraft. EG poisoning occurs in suicide attempts and infrequently, either intentionally through misuse or accidental as EG has a sweet taste. EG has in itself a low toxicity, but is in vivo broken down to higher toxic organic acids which are responsible for extensive cellular damage in various tissues caused principally by the metabolites glycolic acid and oxalic acid. The most conclusive analytical method of diagnosing EG poisoning is determination of EG concentration. However, victims are sometimes admitted at a late stage to hospitals or died during emergency treatment like a gastric lavage or found rotten dead, when blood EG concentrations are low or not detected. Therefore, in this study, the identification of EG was not only performed by gas chromatograpyc-mass spectrometry (GC-MS) following derivatization but also further toxicological analyses of metabolites, glycolic acid (GA) and oxalic acid (OA), were performed by ion chromatography in various biological specimens. A ranges of blood concentrations (3 cases) was $10\sim2,400\;{\mu}g/mL$ for EG, $224\sim1,164\;{\mu}g/mL$ for GA and ND $\sim40\;{\mu}g/mL$ for OA, respectively, In other biological specimens (liver, kidney, bile and pleural fluid), a range of concentrations (3 cases) was ND $\sim55,000\;{\mu}g/mL$ for EG, ND $\sim1,124\;{\mu}g/mL$ for GA and ND $\sim60\;{\mu}g/mL$ for OA, respectively. Liver and kidney tissues were recommended specimens including blood because OA, a final metabolite of EG, was identified large amounts in these despite no detectable EG caused by some therapy.

• Fire Science and Engineering
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• v.33 no.6
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• pp.72-79
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• 2019

Through this study, we developed a model for predicting chemical accidents lead to casualties. The model was derived from the logistic regression analysis model and applied to the variables affecting the accident. The accident data used in the model was analyzed by studying the statistics of past chemical accidents, and applying independent variables that were statistically significant through data analysis, such as the type of accident, cause, place of occurrence, status of casualties, and type of chemical accident that caused the casualties. A significance of p < 0.05 was applied. The model developed in this study is meaningful for the prevention of casualties caused by chemical accidents and the establishment of safety systems in the workplace. The analysis using the model found that the most influential factor in the occurrence of casualty in accidents was chemical explosions. Therefore, there is an urgent need to prepare countermeasures to prevent chemical accidents, specifically explosions, from occurring in the workplace.

• Analytical Science and Technology
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• v.12 no.6
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• pp.565-570
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• 1999

The alcohol dehydrogenase (ADH) gene from Bacillus stearothermopilus was amplified by the polymerase chain reaction. The amplified DNA was inserted into the expression vector pGEX-KG, and expressed it as a fusion protein with glutathione S-transferase (GST) in E. coli. The recombinant ADH was produced by induction with 1 mM isopropyl-${\beta}$-D-thiogalactopyranoside at $37^{\circ}C$ and purified by glutathione affinity chromatography. The recombinant ADH exhibited high substrate specificity for ethanol. The activity of the recombinant ADH proceeded optimally at pH 9.0 and $70^{\circ}C$. The recombinant ADH was highly stable against high temperature. This thermostable alcohol dehydrogenase can be used for the enzymatic determination of alcohol and for the industrial production of alcohol.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.219-223
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• 2016

Background: Promoter hypermethylation is a frequent epigenetic mechanism for gene transcription repression in cancer and is one of the hallmarks of the disease. Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) contributes to cell contact-mediated communication. Dysregulation of promoter methylation has been reported in various cancers. Objectives: The objectives of this study were to investigate the CELSR3 hypermethylation level in oral squamous cell carcinomas (OSCCs) using methylation-sensitive high-resolution melting analysis (MS-HRM) and to correlate CELSR3 methylation with patient demographic and clinicopathological parameters. Materials and Methods: Frozen tissue samples of healthy subjects' normal mucosa and OSCCs were examined with regard to their methylation levels of the CELSR3 gene using MS-HRM. Results: MS-HRM analysis revealed a high methylation level of CELSR3 in 86% of OSCC cases. Significant correlations were found between CELSR3 quantitative methylation levels with patient ethnicity (P=0.005), age (P=0.024) and pathological stages (P=0.004). A moderate positive correlation between CELSR3 and patient age was also evident (R=0.444, P=0.001). Conclusions: CELSR3 promoter hypermethylation may be an important mechanism involved in oral carcinogenesis. It may thus be used as a biomarker in OSCC prognostication.

• The korean journal of orthodontics
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• v.46 no.3
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• pp.171-179
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• 2016

Objective: The primary aim of the study was to generate new prediction equations for the estimation of maxillary and mandibular canine and premolar widths based on mandibular incisors and first permanent molar widths. Methods: A total of 2,340 calculations (768 based on the sum of mandibular incisor and first permanent molar widths, and 1,572 based on the maxillary and mandibular canine and premolar widths) were performed, and a digital stereomicroscope was used to derive the the digital models and measurements. Mesiodistal widths of maxillary and mandibular teeth were measured via scanned digital models. Results: There was a strong positive correlation between the estimation of maxillary (r = 0.85994, $r^2=0.7395$) and mandibular (r = 0.8708, $r^2=0.7582$) canine and premolar widths. The intraclass correlation coefficients were statistically significant, and the coefficients were in the strong correlation range, with an average of 0.9. Linear regression analysis was used to establish prediction equations. Prediction equations were developed to estimate maxillary arches based on $Y=15.746+0.602{\times}sum$ of mandibular incisors and mandibular first permanent molar widths (sum of mandibular incisors [SMI] + molars), $Y=18.224+0.540{\times}(SMI+molars)$, and $Y=16.186+0.586{\times}(SMI+molars)$ for both genders, and to estimate mandibular arches the parameters used were $Y=16.391+0.564{\times}(SMI+molars)$, $Y=14.444+0.609{\times}(SMI+molars)$, and $Y=19.915+0.481{\times}(SMI+molars)$. Conclusions: These formulas will be helpful for orthodontic diagnosis and clinical treatment planning during the mixed dentition stage.

• International Journal of Oral Biology
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• v.39 no.2
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• pp.57-63
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• 2014

The purpose of this study is to evaluate salivary flow rate, salivary pH, and cariogenic activity using unstimulated saliva of the head and neck cancer patients. Twenty three cancer patients (19 males, 4 females) who had undergone chemotherapy and radiation therapy and twenty four healthy volunteers (14 males, 10 females) as a control were included. Salivary flow rate, salivary pH, and cariogenic activity using unstimulated saliva were examined. Compared to saliva of the control group, salivary flow rate (p<0.001) and salivary pH (p<0.001) were significantly lower in head and neck cancer patients. The colony counts of Lactobacilli was higher in head and neck cancer patients (p<0.05) than in control group. These salivary factors and cariogenic activity can increase the prevalence of dental caries in head and neck cancer patients.

• BMB Reports
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• v.54 no.10
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• pp.528-533
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• 2021

Osteoarthritis (OA) is a degenerative disorder that can result in the loss of articular cartilage. No effective treatment against OA is currently available. Thus, interest in natural health products to relieve OA symptoms is increasing. However, their qualities such as efficacy, toxicity, and mechanism are poorly understood. In this study, we determined the efficacy of avenanthramide (Avn)-C extracted from oats as a promising candidate to prevent OA progression and its mechanism of action to prevent the expression of matrix-metalloproteinases (MMPs) in OA pathogenesis. Interleukin-1 beta (IL-1β), a proinflammatory cytokine as a main causing factor of cartilage destruction, was used to induce OA-like condition of chondrocytes in vitro. Avn-C restrained IL-1β-mediated expression and activity of MMPs, such as MMP-3, -12, and -13 in mouse articular chondrocytes. Moreover, Avn-C alleviated cartilage destruction in experimental OA mouse model induced by destabilization of the medial meniscus (DMM) surgery. However, Avn-C did not affect the expression of inflammatory mediators (Ptgs2 and Nos) or anabolic factors (Col2a1, Aggrecan, and Sox9), although expression levels of these genes were upregulated or downregulated by IL-1β, respectively. The inhibition of MMP expression by Avn-C in articular chondrocytes was mediated by p38 kinase and c-Jun N-terminal kinase (JNK) signaling, but not by ERK or NF-κB. Interestingly, Avn-C added with SB203580 and SP600125 as specific inhibitors of p38 kinase and JNK, respectively, enhanced its inhibitory effect on the expression of MMPs in IL-1β treated chondrocytes. Taken together, these results suggest that Avn-C is an effective candidate to prevent OA progression and a natural health product to relieve OA pathogenesis.