• Archives of Pharmacal Research
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• v.27 no.6
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• pp.646-652
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• 2004

The objective of this study was to determine the acute effect of trimetazidine (TMZ) on the pre-fatigue, fatigue and post-fatigue contractile characteristics and tension-frequency relationships of isolated rat diaphragm muscle. Muscle strips were taken from the ventral-costal aspects of the diaphragm muscle of rats killed by decapitation. The muscle strips were suspended in organ baths containing Krebs solution, with a gas mixture of 95% $O_2$ and 5% $CO_2$ at $37^{\circ}C$ and pH 7.35-7.45. After determining the thermoregulation and optimum muscle length the muscles were subjected to direct supramaximal stimulation with 0.05 Hz frequency square pulses for periods of 0.5 msec to obtain control values. After adding $5{\times}10^{-6}{\;}and{\;}5{\times}10^{-5}$ M trimetazidine solution to the respective bath media, the contractile parameters of the muscles were recorded. The contractile parameters were also recorded for both the trimetazidine and tri-metazidine-free media after application of the high frequency fatigue protocols. Later, the tension-frequency relationship was determined by applying stimulating pulses of 10, 20, 50 and 100 Hz to the muscle strips. Whilst the twitch tension obtained from the $5{\times}10^{-6}{\;}and{\;}5{\times}10^{-5}$ M trimetazidine media showed numerical increases compared to that of the controls, these were not statistically significant (p>0.05). The contraction time exhibited a dose dependent increase (p<0.001), whilst the contraction and relaxation rates did not differ significantly. The isometric contraction forces obtained with the different stimulating frequencies showed a significant increase in the tetanic contraction only at 100 Hz (p<0.05). A comparison of the pre- and post-fatigue twitch tensions in the trimetazidine media showed the post- fatigue twitch tensions to be significantly higher than those of the pre-fatigue contraction forces (p<0.05). In the $5{\times}10^{-6}{\;}and{\;}5{\times}10^{-5}$ M trimetazidine media the increases in the post-fatigue contraction force were 22 and 30%, respectively. These results demonstrated that in isolated rat diaphragm muscle, TMZ significantly limited the mechanical performance decrease during fatigue. It is our opinion that trimetazidine contributed to the observed fatigue tolerance by eliminating the factors of fatigue, due to preservation of intracellular calcium homeostasis, provision of the ATP energy levels needed by ATPase dependent pumps and especially by keeping the intracellular pH within cer-tain limits.

• Journal of the Korean Society of School Health
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• v.23 no.1
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• pp.63-70
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• 2010

Purpose: To identify the need to reform in the crisis response of Health Teacher, School Nurse, in elementary school during epidemic outbreak of influenza H1N1. Methods: 139 elementary health teachers, school nurse, in seoul elementary school responded in the questionnaire, and we analysed by using frequency and percent, t-test, and paired t-test. Results: The Job status became 121% more 'during influenza H1N1 (flu) outbreak' than Job status of 'before outbreak'. The proportion of the flu-related duty among their daily workload was up to 77.5%. The administration-related workload of the flu-related duty was 30.8%. and students' health assessment including temperature measurement 18.7%. Furthermore, an impediment of usual daily work due to an increaed flu-related workload was 95.7%, and no alternative plan such as disposition of assistant labor force was 86.1%. Especially, an impediment of health education was 61.0%, so the major concern was the loss of health education. We compared average scores (a five-point Likert scale) of health teachers' work motivation, exhaustion, work relationship and Job management of 'during' with 'before' flu-outbreak. The difference range of 'during' minus 'before' work motivation score was from -0.4 points to -0.9; work exhaustion range from 1.8 to 1.9; the difficulty of relationship between students, school personnel, parents of students, and health teachers from 1.4 points to 1.3 points; and the consideration of changing Job, taking time off from the Job and retirement from 1.4 to 1.6 points. Conclusion: The health teachers had a heavy workload due to flu-outbreak. They also experienced the impediment of usual work implementation. However, there was a shortage of alternative plan such as disposition of an assistant labor force. Under their Job status like this, the health teachers' motivation score was decreased and work exhaustion was increased. Furthermore, they had a lot of relation difficulty with students and school personnel. Therefore, we suggested that in contrast to the usual Job status, there is a need to have a prepared response during school crisis like flu-outbreak such as improved response system in seoul metropolitan education office, simplification or dispersion of administrative work, and temporary call-center for simple inquiries or advices.

• Journal of the Korean Geotechnical Society
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• v.38 no.6
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• pp.17-28
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• 2022

The effect of the soil-structure interaction (SSI) on has been recently evaluated in shaking table tests. However, most of these tests were conducted on single-degree-of-freedom (SDOF) superstructures and a single-pile. This study investigates the inertial interaction effect of a multi-degree-of-freedom (MDOF) superstructure system with a group piles on a large-scale shaking table test. Whereas the SDOF superstructure system shows a single-frequency amplification tendency, the MDOF superstructure system exhibited amplification tendencies of the acceleration phase and frequency responses for multiple frequencies. In addition, the amplification phenomenon between the footing and the column-type superstructure exceeded that between the footing and the wall-type superstructure, indicating a greater inertial interaction effect of the column-type superstructure. The relationship between shear force and inertial force, the relative vertical and horizontal displacements on the footing was figured out. Also, the ananlysis of dynamic p-y curve at each depth was conducted. In summary, the MDOF and SDOP superstructure systems exhibited different behaviors and the column-type superstructure exerted a higher interaction effect than the wall-type superstructure.

• Journal of the Korean Society of Hazard Mitigation
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• v.11 no.3
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• pp.209-218
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• 2011

The present study proposes a new estimation relationship for the transmission rate of the steel breakwater which is expected to make up for the weakness points in existing hard solution for shore protection. The steel breakwater consists of the wave dissipator of the dual horizontal plates, the supporting columns and their foundations, and thus its respective designs should also be conducted one by one. Furthermore, the breakwater has to ensure both functions of shore protection and structure stabilization. The study produced experimental data for the stability and safety investigation of the steel breakwater. The forces acting on the steel breakwater were classified into two categories, one is vertical up and down loads for the pile resistance and the other was maximum difference of the vertical load acting on horizontally different position for the torsion. The study applied the stability force produced by the summation of maximum pressure at each point and the safety force acting on each point simultaneously. The regular wave corresponding to the significant wave was utilized for measuring wave pressure and force. The study showed the method for the proper position of submerged upper plate by considering occurrence frequency of tide level. The design process finally determined by trial and error is proposed in the present study.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.14 no.4
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• pp.265-273
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• 2002

In this paper, wave absorbing characteristics of a horizontal submerged punching plate are investigated throughout the calculation and the experiment. The punching plate with the array of circular holes can force the flow to separate and to form eddies of high vorticity and cause significant energy loss. As an analytic tool, the linear water wave theory and the eigenfunction expansion method is applied. Darcy's law that the normal velocity of the fluid passing through the punching plate is linearly proportional to the pressure difference between two sides of the punching plate is assumed. The proportional constant called the porous coefficient is deeply dependent to the porosity. To obtain the relationship between the porosity and the porous coefficient the systematic model test for the punching plates with 6 different porosities is conducted at 2-dimensional wave tank. It is found that the porous coefficient is linearly proportional to the porosity(b=57.63P-0.9717). It is also noted that the optimal porosity value is near P=0.1 and the optimal range of submergence depth is $d/h\\leq0.2$ within entire frequency range.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2001.06a
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• pp.14-14
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• 2001

Nitride films such as TiN, CrN etc. deposited on glass by PVD processes have been developed for many industrial applications. These nitride films deposited on glass were widely used for not only decorative and optical coatings but also wear and corrosion resistance coatings employed as dies and molds made of glass for the example of lens forming molds. However, the major problem of nitride coatings on glass by PVD process is non-uniform film owing to pin-hole and micro crack. It is estimated that nonuniform coating is influenced by a different surface energy between metal nitrides and glass due to binding states. In this work, therefore, for the evaluation of nucleation and growth mechanism of nitride films on glass TiN and CrN film were synthesized on glass with various nitrogen partial pressure by unbalanced magnetron sputtering. Prior to deposition, for the examination of relationship between surface energy and film microstructure plasma pre-treatment process was carried out with various argon to hydrogen flow rate and substrate bias voltage, duty cycle and frequency by using pulsed DC power supply. Surface energy owing to the different plasma pre-treatment was calculated by the measurement of wetting angle and surface conditions of glass were investigated by X-ray Photoelectron Spectroscopy(XPS) and Atomic Force Microscope(AFM). The microstructure change of nitride films on glass with increase of film thickness were analyzed by X-Ray Diffraction(XRD) and Scanning Electron Microscopy(SEM).

• Journal of the Korean earth science society
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• v.34 no.2
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• pp.136-147
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• 2013

This study examined the effect of the Antarctic Oscillation (AAO) in June on the June rainfall in Korea by using a correlational statistical analysis. Results showed that there is a highly positive correlation between the two variables. In other words, the June rainfall in Korea is influenced by the Mascarene High and Australian High that are strengthened in the Southern Hemisphere, which is a typical positive AAO pattern. When these two anomalous pressure systems strengthen, the cold cross-equatorial flows in the direction from the region around Australia to the equator are intensified, which in turn, force a western North Pacific subtropical high (WNPSH) to develop northward. This pressure development eventually drives the rain belt to head north. As a result, the Changma begins early in the positive AAO phase and the June rainfall increases in Korea. In addition, a WNPSH that develops more northward increases the landfall (or affecting) frequency of tropical cyclones in Korea, which plays an important role in increasing the June rainfall.

• Journal of Preventive Medicine and Public Health
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• v.41 no.1
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• pp.45-50
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• 2008

Objectives : To determine the relationship between exercise and the incidence of type 2 diabetes in an impaired fasting glucose group. Methods : This prospective cohort study was conducted in 19,440 men and 4,297 women, aged 30-69 years, with impaired fasting glucose at baseline who had undergone biennial medical evaluation through the National Health Insurance Corporation from 2000 to 2004. Impaired fasting glucose was defined as fasting glucose of 100 to 125 mg/dl and the subjects were divided into 3 groups depending on weekly exercise frequency. Multivariate logistic regression analysis was used to evaluate the association between the baseline exercise status and incidence of type 2 diabetes. Results : During the 4-year follow-up, a total of 3,239 men and 283 women developed type 2 diabetes, a cumulative incidence of 16.6% for men, and 6.5% for women. Also, 1,688 men (21.2%) and 127 women (15.2%) developed type 2 diabetes in the obese group. The adjusted relative risk (RR) of developing type 2 diabetes in non-exercising men was significantly higher than exercising men regularly (RR= 1.375, 95% CI=1.236-1.529)(p<0.0001), and the RR for non-exercising women was higher than exercising women regularly (RR=1.124, 95% CI=0.711-1.778). The RR for non-exercise men/women in the obese group was 1.571 (95% CI=1.351-1.827)(p<0.0001)/1.869 (95% CI=0.846-4.130). Conclusions : Regular exercise is effective in preventing type 2 diabetes in people with impaired fasting glucose, and particularly in obese people. People with risk factors for diabetes should participate in a regular exercise program.

• Smart Structures and Systems
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• v.21 no.3
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• pp.257-262
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• 2018

Vibrational problems in the domestic Small Horizontal Axis Wind Turbines (SHAWT) are due to flap wise vibrations caused by varying wind velocities acting perpendicular to its blade surface. It has been reported that monitoring the structural health of the turbine blades requires special attention as they are key elements of a wind power generation, and account for 15-20% of the total turbine cost. If this vibration problem is taken care, the SHAWT can be made as commercial success. In this work, Shape Memory Alloy (SMA) wires made of Nitinol (Ni-Ti) alloys are embedded into the Glass Fibre Reinforced Polymer (GFRP) wind turbine blade in order to reduce the flapwise vibrations. Experimental study of Nitinol (Ni-Ti) wire characteristics has been done and relationship between different parameters like current, displacement, time and temperature has been established. When the wind turbine blades are subjected to varying wind velocity, flapwise vibration occurs which has to be controlled continuously, otherwise the blade will be damaged due to the resonance. Therefore, in order to control these flapwise vibrations actively, a non-linear current controller unit was developed and fabricated, which provides actuation force required for active vibration control in smart blade. Experimental analysis was performed on conventional GFRP and smart blade, depicted a 20% increase in natural frequency and 20% reduction in amplitude of vibration. With addition of active vibration control unit, the smart blade showed 61% reduction in amplitude of vibration.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2004.07a
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• pp.74-77
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• 2004

[ $HfO_2$ ] dielectric layers were grown on the p-type Si(100) substrate by metalorganic molecular beam epitaxy(MOMBE). Hafnium $t-butoxide[Hf(O{\cdot}t-C_4H_9)_4]$ was used as a Hf precursor and Argon gas was used as a carrier gas. The thickness of the layers was measured by scanning electron microscopy (SEM) and high-resolution transmission electron measurement(HR-TEM). The properties of the $HfO_2$ layers were evaluated by X-ray diffraction(XRD), high frequency capacitance-voltage measurement(HF C-V), current-voltage measurement(I-V), and atomic force measurement(AFM). HF C-V measurements have shown that $HfO_2$ layer grown by MOMBE has a high dielectric constant(k=19-21). The properties of $HfO_2$ films are affected by various process variables such as substrate temperature, bubbler temperature, Ar, and $O_2$ gas flows. In this paper, we examined the relationship between the $O_2/Ar$ gas ratio and the electrical properties of $HfO_2$.