• 제목/요약/키워드: Focused Sampling

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Estimation Methods for Population Pharmacokinetic Models using Stochastic Sampling Approach (확률적 표본추출 방법을 이용한 집단 약동학 모형의 추정과 검증에 관한 고찰)

  • Kim, Kwang-Hee;Yoon, Jeong-Hwa;Lee, Eun-Kyung
    • The Korean Journal of Applied Statistics
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    • v.28 no.2
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    • pp.175-188
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    • 2015
  • This study is about estimation methods for the population pharmacokinetic and pharmacodymic model. This is a nonlinear mixed effect model, and it is difficult to find estimates of parameters because of nonlinearity. In this study, we examined theoretical background of various estimation methods provided by NONMEM, which is the most widely used software in the pharmacometrics area. We focused on estimation methods using a stochastic sampling approach - IMP, IMPMAP, SAEM and BAYES. The SAEM method showed the best performance among methods, and IMPMAP and BAYES methods showed slightly less performance than SAEM. The major obstacle to a stochastic sampling approach is the running time to find solution. We propose new approach to find more precise initial values using an ITS method to shorten the running time.

Improved Focused Sampling for Class Imbalance Problem (클래스 불균형 문제를 해결하기 위한 개선된 집중 샘플링)

  • Kim, Man-Sun;Yang, Hyung-Jeong;Kim, Soo-Hyung;Cheah, Wooi Ping
    • The KIPS Transactions:PartB
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    • v.14B no.4
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    • pp.287-294
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    • 2007
  • Many classification algorithms for real world data suffer from a data class imbalance problem. To solve this problem, various methods have been proposed such as altering the training balance and designing better sampling strategies. The previous methods are not satisfy in the distribution of the input data and the constraint. In this paper, we propose a focused sampling method which is more superior than previous methods. To solve the problem, we must select some useful data set from all training sets. To get useful data set, the proposed method devide the region according to scores which are computed based on the distribution of SOM over the input data. The scores are sorted in ascending order. They represent the distribution or the input data, which may in turn represent the characteristics or the whole data. A new training dataset is obtained by eliminating unuseful data which are located in the region between an upper bound and a lower bound. The proposed method gives a better or at least similar performance compare to classification accuracy of previous approaches. Besides, it also gives several benefits : ratio reduction of class imbalance; size reduction of training sets; prevention of over-fitting. The proposed method has been tested with kNN classifier. An experimental result in ecoli data set shows that this method achieves the precision up to 2.27 times than the other methods.

Transmission Electron Microscope Sampling Method for Three-Dimensional Structure Analysis of Two-Dimensional Soft Materials

  • Lee, Sang-Gil;Lee, Ji-Hyun;Yoo, Seung Jo;Datta, Suvo Jit;Hwang, In-Chul;Yoon, Kyung-Byung;Kim, Jin-Gyu
    • Applied Microscopy
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    • v.45 no.4
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    • pp.203-207
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    • 2015
  • Sample preparation is very important for crystal structure analysis of novel nanostructured materials in electron microscopy. Generally, a grid dispersion method has been used as transmission electron microscope (TEM) sampling method of nano-powder samples. However, it is difficult to obtain the cross-sectional information for the tabular-structured materials. In order to solve this problem, we have attempted a new sample preparation method using focused ion beam. Base on this approach, it was possible to successfully obtain the electron diffraction patterns and high-resolution TEM images of the cross-section of tabular structure. Finally, we were able to obtain three-dimensional crystallographic information of novel zeolite nano-crystal of the tabular morphology by applying the new sample preparation technique.

Impact of Marketer Capabilities and Marketer Persistence on Marketer Performance and Distribution of Agricultural Product Equipment: Evidence from East Java, Indonesia

  • Herry KRISTANTO;Margono SETIAWAN;Sunaryo;Dodi Wirawan IRAWANTO
    • Journal of Distribution Science
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    • v.21 no.9
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    • pp.35-42
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    • 2023
  • Purpose: The research aims at examining the impact of marketer capabilities and persistence on marketer performance and distribution of agricultural product facilities. Research design, data, and methodology: The research employs quantitative methods using a cross-sectional design survey by analyzing the marketer of agricultural production facilities. Sampling was done using the purposive sampling technique and data were taken from 235 respondents. The data were then processed using SEM-PLS. Results: The findings reveal that both marketer capabilities and marketer persistence significantly impact the performance of agricultural product facility marketers. Notably, marketer persistence exerts a more dominant influence on marketer performance than marketer capabilities. Effective communication and coordination between the sales team and the distribution center emerge as crucial factors determining the success of distributing agricultural equipment to reach farmers' land at the optimal time. Conclusions: The findings offer valuable managerial insights for agricultural product facility companies seeking to enhance marketer performance. To achieve this, companies should focus on increasing marketer persistence, with an emphasis on nurture-focused persistence rather than closure-focused persistence. Additionally, improving marketer capabilities is crucial, starting with relationship development, followed by trust building, customer retention, responsiveness, and acquisition. These strategies can collectively contribute to boosting marketer performance within the organization.

Estimation of the Number of Sampling Points Required for the Determination of Soil CO2 Efflux in Two Types of Plantation in a Temperate Region

  • Lee, Na-Yeon(Mi-Sun);Koizumi, Hiroshi
    • Journal of Ecology and Environment
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    • v.32 no.2
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    • pp.67-73
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    • 2009
  • Soil $CO_2$ efflux can vary markedly in magnitude over both time and space, and understanding this variation is crucial for the correct measurement of $CO_2$ efflux in ecological studies. Although considerable research has quantified temporal variability in this flux, comparatively little effort has focused on its spatial variability. To account for spatial heterogeneity, we must be able to determine the number of sampling points required to adequately estimate soil $CO_2$ efflux in a target ecosystem. In this paper, we report the results of a study of the number of sampling points required for estimating soil $CO_2$ efflux using a closed-dynamic chamber in young and old Japanese cedar plantations in central Japan. The spatial heterogeneity in soil $CO_2$ efflux was significantly higher in the mature plantation than in the young stand. In the young plantation, 95% of samples of 9 randomly-chosen flux measurements from a population of 16 measurements made using 72-$cm^2$ chambers produced flux estimates within 20% of the full-population mean. In the mature plantation, 20 sampling points are required to achieve means within $\pm$ 20% of the full-population mean (15 measurements) for 95% of the sample dates. Variation in soil temperature and moisture could not explain the observed spatial variation in soil $CO_2$ efflux, even though both parameters are a good predictor of temporal variation in $CO_2$ efflux. Our results and those of previous studies suggest that, on average, approximately 46 sampling points are required to estimate the mean and variance of soil $CO_2$ flux in temperate and boreal forests to a precision of $\pm$ 10% at the 95% confidence level, and 12 points are required to achieve a precision of $\pm$ 20%.

Physical modeling synthesizing of 25 strings Gayageum using white noise as exciter (화이트 노이즈를 익사이터로 이용하는 25현 가야금의 피지컬 모델링 신디사이징)

  • Bae, June;Kim, Jangyoung;Yang, Yoongi
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.22 no.5
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    • pp.740-746
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    • 2018
  • Up until now, attempts to produce computer instruments have been largely focused on two types of sampling methods and physical modeling. Since the sampling method removes much of the harmonics in the sampling process, the effect of exciter that emphasizing the harmonic of the strings are mini. However, the physical modeling method can produce a lot of harmonics, and by emphasizing the harmonics of a particular frequency band among these harmonics, it is possible to produce a sound more like a lively sound. In this paper, we propose a method of using white noise in realizing exciter emphasizing harmonics of pre - specified frequency band in prefectural physical modeling. And comparing the envelope and spectrum of the Gayageum sound, we confirmed that the physical modeling method with the exciter is more suitable for the actual Gayageum sound than the sampling method and the conventional physical modeling method.

Up-Sampling Method of Depth Map Using Weighted Joint Bilateral Filter (가중치 결합 양방향 필터를 이용한 깊이 지도의 업샘플링 방법)

  • Oh, Dong-ryul;Oh, Byung Tae;Shin, Jitae
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.40 no.6
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    • pp.1175-1184
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    • 2015
  • A depth map is an image which contains 3D distance information. Generally, it is difficult to acquire a high resolution (HD), noise-removed, good quality depth map directly from the camera. Therefore, many researches have been focused on acquisition of the high resolution and the good quality depth map by up-sampling and pre/post image processing of the low resolution depth map. However, many researches are lack of effective up-sampling for the edge region which has huge impact on image perceptual-quality. In this paper, we propose an up-sampling method, based on joint bilateral filter, which improves up-sampling of the edge region and visual quality of synthetic images by adopting different weights for the edge parts that is sensitive to human perception characteristics. The proposed method has gains in terms of PSNR and subjective video quality compared to previous researches.

A Study on Workers' Exposure to Organic Solvents in Petroleum Refinery (원유정제업 작업자들의 유기용제에 대한 노출 평가)

  • Choi, Sang Jun;Paik, Nam Won;Kim, Jin Kyoung;Choi, Yeon Ki;Jung, Hyun Hee;Heo, Sung-Min
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.15 no.1
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    • pp.27-35
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    • 2005
  • This study was carried out to evaluate the characteristics of petroleum refinery workers' exposure to organic solvents. Exposure assessment was conducted by full shift-based long term personal sampling(TWA-P) and task-based short term personal sampling(STEL-P) strategy. Major organic solvents that workers can be exposed are various, varying from C3~C12, and this study focused on 11 kinds including benzene, considering toxicity and concentration level. In comparison with two sampling results, STEL-P shows a significant(p<0.001) excess of exposure level rather than TWA-P. As the potential risk index for benzene is calculated as 16, benzene should be set the highest priority for control in petroleum refinery industry. The tasks with the highest benzene exposure level were de-watering(AM;99.8 ppm), draining(AM;19.6ppm), sampling(AM;16.2ppm), and manual gauging(AM;15.02ppm). Petroleum refinery workers' exposure pattern to organic solvents differs by tasks performed, and some task has a high risk of temporary extreme exposure. Therefore, traditional 8-hour TWA sampling strategy have possibility of underestimation of exposure level of workers in petroleum refinery.

Improving prediction performance of network traffic using dense sampling technique (밀집 샘플링 기법을 이용한 네트워크 트래픽 예측 성능 향상)

  • Jin-Seon Lee;Il-Seok Oh
    • Smart Media Journal
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    • v.13 no.6
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    • pp.24-34
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    • 2024
  • If the future can be predicted from network traffic data, which is a time series, it can achieve effects such as efficient resource allocation, prevention of malicious attacks, and energy saving. Many models based on statistical and deep learning techniques have been proposed, and most of these studies have focused on improving model structures and learning algorithms. Another approach to improving the prediction performance of the model is to obtain a good-quality data. With the aim of obtaining a good-quality data, this paper applies a dense sampling technique that augments time series data to the application of network traffic prediction and analyzes the performance improvement. As a dataset, UNSW-NB15, which is widely used for network traffic analysis, is used. Performance is analyzed using RMSE, MAE, and MAPE. To increase the objectivity of performance measurement, experiment is performed independently 10 times and the performance of existing sparse sampling and dense sampling is compared as a box plot. As a result of comparing the performance by changing the window size and the horizon factor, dense sampling consistently showed a better performance.

Stress and Coping Strategies of Breast Cancer Patients and their Spouses (유방암 환자와 배우자의 스트레스와 대처방식)

  • Cha, Kyeong-Sook;Yoo, Yang-Sook;Cho, Ok-Hee
    • Asian Oncology Nursing
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    • v.12 no.1
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    • pp.20-26
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    • 2012
  • Purpose: The purpose of this study was to identify the stress and the coping strategies in breast cancer patients and their spouses. Methods: The stress level was measured by the Stress Questionnaire of Andersson & Albertsson (2000). The coping strategies were measured by the modified Lazarus & Folkman's Ways of Coping Questionnaire. The data were collected by a survey sampling 49 couples from one hospital in Seoul. The data were analyzed by t-test, ANOVA and paired t-test. Results: There was no significant differences between the stress level of breast cancer patients and their spouses. The problem-focused coping of breast cancer patients was significant higher than their spouses. The cancer patients and their spouses used problem-focused coping mode more than emotion-focused coping mode. In the problem-focused coping mode, breast cancer patients used two coping strategies - 'seeking information' and 'cognitive reconstruction' - significantly more than their spouses. In emotion-focused coping mode, the breast cancer patients used one coping strategy, 'emotional expression', significantly more than the their spouses. Conclusion: Further study needs to attempt to develop nursing interventions that could improve positive coping strategies.