• International Journal of Oral Biology
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• v.44 no.4
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• pp.160-164
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• 2019

Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythia (Tf), Prevotella intermedia (Pi), and Fusobacterium nucleatum (Fn) are major periodontal pathogens. Lipopolysaccharides (LPSs) from periodontal bacteria play an important role in periodontal pathogenesis by stimulating host cells to produce inflammatory cytokines. In this study, highly pure LPSs from the five major periodontopathogens were prepared, and their monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α)-inducing activities were compared in human umbilical vein endothelial cells (HUVECs) and THP-1 macrophagic cells, respectively. In HUVECs, LPSs from Aa and Fn were potent stimulators for MCP-1 induction; however, LPSs from Pg, Pi, and Tf were much weaker MCP-1 inducers. In THP-1 cells, LPSs from Pg, Aa, and Fn were relatively strong inducers of TNF-α, whereas LPSs from Pi and Tf produced little activity. The Toll-like receptor (TLR)2/TLR4 dependency of various LPSs was also determined by measuring NF-κB reporter activity in TLR2- or TLR4-expressing 293 cells. LPSs from Aa, Fn, and Tf stimulated only TLR4; however, LPSs from Pg and Pi stimulated both TLR2 and TLR4. These results suggest that LPSs from major periodontal bacteria differ considerably in their cell-stimulating activity.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.14
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• pp.5691-5695
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• 2015

Background: Continuous surveillance of pattern of blood stream infection is necessary in febrile neutropenia (FN)especially with the recent escalating trend in the management of pediatric cancer patients towards intensified regimens and with the increase in infections caused by resistant organisms limiting the choice of antibiotics. Aim: To monitor change in pattern of blood stream infections (BSI) in FN pediatric cancer patients. Materials and Methods: Surveillance of FN episodes with positive BSI was prospectively monitored and compared to a previous surveillance in the same pediatric oncology unit. Results: A total of 232 BSI positive episodes were documented in 192 patients during a 6 months period. The results of recent surveillance analysis showed an increase in intensified regimens of chemotherapy, antimicrobial resistance, fungal infections, and prolonged duration of episodes when compared to previous surveillance, with p value sof <0.001, 0.005, 0.021, and <0.001, respectively. There was an apparent decrease in the crude mortality but this was not statistically significant, to 6% in 2011 from 10 % in 2006. Conclusions: The pattern of BSI at our institution is still inclining towards gram positive organisms but is showing a shift towards more antibiotic resistance and fungal infections.

• Korean Journal of Ichthyology
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• v.19 no.3
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• pp.253-256
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• 2007

The chromosome numbers of two species (Culter brevicauda and Erythroculter erythropterus) of Korean Cultrinae are investigated. In two species, the mitotic chromosomes from 24 groups with two chromosomes each indicated that it is a diploid. Their karyotypes and total length of chromosomes were slightly different from each other. The karyotype of C. brevicauda and E. erthropterus is 2n=48 (7M+10SM+7ST), FN=96 and 2n=48 (6M+10SM+8ST), FN=96. Observed chromosomes of C. brevicauda and E. erythropterus ranged from 5.4 to $2.2{\mu}m$ and 6.1 to $2.3{\mu}m$ in length, respectively.

• Journal of Nutrition and Health
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• v.38 no.3
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• pp.242-250
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• 2005

This study was conducted to assess the bone mineral density (BMD) and the anthropometric measurements, life style, and other environmental factors affecting BMD in Korean adolescents. Subjects were 167 high school students (83 male students, 84 female students) in Seoul. BMD was measured in the lumbar spine (LS), femoral neck (FN), femoral trochanter (FT), and Ward's triangle (WT) by dual energy x-ray absorptiometry (DEXA). The questionnaire was used to assess the anthropometric measurements, life style, and other environmental factors. Bone mineral density of LS, FN, FT and WT were 0.967, 0.960, 0.795, $0.761 g/{\cal}cm^2$. The BMD of LS was not different by sex but the male students's BMD of FN, FT and WT were higher significantly than the female students (LS: 0.976 vs. 0.958, FN: 1.040 vs. 0.880, FT: 0.842 vs. 0.749, WT: 0.827 vs. $0.695 g/{\cal}cm^2$) Female students's BMD of LS, FN, WT, and FT was positively correlated with weight but male students's BMD of WT was not correlated with weight. The factors such as the life style, activity and exercise have significant influence on BMD. This study confirms that the major factor affecting BMD was body weight and the factors such as the life style, activity and exercise is related to accumulation of BMD. The classification of sexual characteristics is needed for further studies on BMD of adolescents.

• Korean Journal of Community Nutrition
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• v.9 no.1
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• pp.73-80
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• 2004

Bone mineral density (BMD) focus one's attention on prevention effects of osteoporosis. This study was conducted to investigate BMD (lumbar spin : L2- L4, femur neck : m, femur trochanter TR, femur ward's triangle : WT, wrist) and look into the factors that affect BMD by menopause in 89 nonsmoking healthy Korean women (40-60 yr). Anthropometric index and body composition, nutrient intakes, osteocalcin and total protein, albumin, total cholesterol, triacylglycerol and calcium in serum were determined. Body fat mass, diastolic blood pressure and serum cholesterol concentration of postmenopausal women were significantly higher than those of premenopausal women. FN, TR, WT, wrist BMD of postmenopausal women were not different from those of premenopausal women. However L2- L4 BMD of postmenopausal women was lower than that of premenopausal women. Significant positive correlations were found between L2-L4, FN, TR, WT and weight (r = 0.44, r = 0.64, r = 0.58, r = 0.57) and significant positive correlations were found between FN, TR, WT and BMI (r =: 0.54, r = 0.41, r = 0.54) of premenopausal women. Whereas significant positive correlation was only found between TR BMD and weight. BMI (r = 0.38, r = 0.29) of postmenopausal women. FN BMD and WC (waist circumstance) of premenopausal women were found significant positive correlation (r = 0.35) whereas L2-L4 BMD and WC of postmenopausal women was found significant negative correlation (r = -0.31) . In premenopausal women. differences of bone BMD were not shown by exercise and alcohol drinking, but in postmenopausal women, significant difference of FN BMD was shown by exercise and alcohol drinking. These results suggested that by menopause, effects of weight, BMI, WC, exercise and alcohol drinking on bone BMD were different. Therefore, by menopause, we should consider the different ways to increase the bone BMD according to different factors.

• Journal of Veterinary Science
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• v.25 no.3
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• pp.37.1-37.10
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• 2024

Importance: The portal vein to aorta (PV/Ao) ratio is used to assess the clinical significance of extrahepatic portosystemic shunt (EHPSS). Previous studies using computed tomography (CT) were conducted in dogs but not in cats. Objective: This study aimed to establish normal reference values for PV indices (PV/Ao ratio and PV diameter) in cats and determine the usefulness of these for predicting symptomatic EHPSS. Methods: This study included 95 dogs and 114 cats that underwent abdominal CT. The canine normal (CN) group included dogs without EHPSS. The cats were classified into feline normal (FN, 88/114), feline asymptomatic (FA, 16/114), and feline symptomatic (FS, 10/114) groups. The PV and Ao diameters were measured in axial cross-sections. Results: The group FN had a higher PV/Ao ratio than the group CN (p < 0.001). Within the feline groups, the PV indices were in the order FN > FA > FS (both p < 0.001). The mean PV diameter and PV/Ao ratio for group FN were 5.23±0.77 mm and 1.46±0.19, respectively. The cutoff values between groups FN and FS were 4.115 mm for PV diameter (sensitivity, 100%; specificity, 97.7%) and 1.170 for PV/Ao ratio (90%, 92.1%). The cutoff values between group FA and FS were 3.835 mm (90%, 93.8%) and 1.010 (70%, 100%), respectively. Conclusions and Relevance: The results demonstrated significant differences in PV indices between dogs and cats. In cats, the PV/Ao ratio demonstrated high diagnostic performance for symptomatic EHPSS. The PV diameter also performed well, in contrast to dogs.

• Fisheries and Aquatic Sciences
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• v.10 no.1
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• pp.24-29
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• 2007

Our objective was to clarify the cytogenetic characteristics, including karyotypes, cellular DNA content, and nuclear size of erythrocytes, of black plaice Pleuronectes obscurus, dotted gizzard shad Konosirus punctatus, and perch sculpin Pseudoblennius percoides, collected from the coastal areas of Jo Island, Busan, Korea. Karyotypes of P. obscurus and K. punctatus both had a diploid number of 48 and a fundamental number (FN) of 48, with a chromosome formula of 48T. The karyotype of p. percoides had a diploid number of 46 and FN of 56, with a chromosome formula of 10SM +36T. No sex-associated heteromorphic pairs were detected for any species. The variation in DNA values (P. obscurus=1.15 pg/nucleus, K. punctatus=1.56pg/nucleus, P. percoides=1.11 pg/nucleus) was positively related to variation in chromosome FN.

• Journal of Pharmaceutical Investigation
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• v.19 no.2
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• pp.109-116
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• 1989

Solid dispersion of fenticonazole nitrate (FN) with poloxamer 407, polyethylene glycol 6000, povidone (K-90) were prepared by the solvent method. To characterize the state of the drug in solid dispersions, the x-ray diffractometry and differential scanning calorimetry were carried out. The identification of these systems suggested that FN in the poloxamer 407 system remained in crystalline state, and the drug in the PVP system was amorphous. A marked increase in the dissolution rate of FN was attained by dispersing the drug in the hydrophilic polymers used, and the dispersion with poloxamer 407 was superior to the other two carriers in releasing the drug into solution.

• Journal of the Korean Society of Tobacco Science
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• v.1 no.2
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• pp.93-102
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• 1979

Chemical compositions of Flue - cured and Burley tobacco leaf and smoke were analyzed to find out simple correlation between compositions. Based on the simple correlation ( $r$ ) data, four regression equations were obtained for dry condensate and nicotine in smoke as follows, $Y_{FT}=\;0.816+4.638X_1+0.346X_2$......................................(1) $Y_{BT}=\;0.235+0.884X_3-0.088X_4$......................................(2) $Y_{FN}=\;0.015+0.090X_5+0.476X_1$......................................(3) $Y_{BN}=-0.026+0.101X_3-0.006X_4$.........................................(4) where, $Y_{FT}$ : dry condensate (mg/cig.) in cigarette smoke of Flue-cured $Y_{BT}$ : dry condensate (mg /cig. ) in cigarette smoke of Burley $Y_{FN}$ : nicotine contents (mg/cig.)in cigarette smoke of Flue-cured $Y_{BN}$ : nicotine contorts (mg/cig. ) in cigarette smoke of Burley $X_1$ : total alkaloid contents (%) of Flue-cured $X_2$ : curde ash contents (%)of Flue -cured $X_3$ : alcohol -benzene extract contents (%) of Burley $X_4$ : curde ash contents (%) of Burley $X_5$ : hexane extract content (%) of Flue -cured Standard deviation for regressions equations were obtained respectively. equation(1),$\pm$3.16 : equation (2),$\pm$1.94 : equation (3),$\pm$0.35 , equation (4) $\pm$ 0.33. Regression equations between dry condensate and nicotine contorts in cigarette smoke were also obtained in the forms of equation(5) and(6) $Y_{FN}$= 0.274 $Y_{FT}$- 3.259............................(5) $Y_{BN}$= 0.249 $Y_{BT}$ - 2.093.............................(6) Standard deviations, $\pm$ 0.061 and $\pm$ 0.152, were obtained for regression equation(5) and (6) respectively.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.33 no.4
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• pp.245-249
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• 2007

The alternation of extracellular matrix (ECM) protein in aging process is associated with symptoms such as wrinkling and loss of elasticity in skin. Now, the major target proteins for anti-aging have been metalloproteases and the structural proteins such as collagen and elastin. Recently, the interaction of cell and ECM proteins (collagen, fibrillin, and fibronectin) is reported to have an important role in survival, proliferation and tissue reconstruction. Fibronectin is a matrix adhesion protein which binds to collagen and integrin and degraded by serine proteases. It has been reported that fragments of fibronectin (Fn-fr's) were involved in matrix metalloproteases (MMPs) expression in osteoblast. But, the role of Fn-fr's in human skin and in skin cells has not been reported yet. Therefore, we investigated the differences of fibronectin fragmentation pattern between young and aged human skin, and demonstrated that the fragmentation of fibronectins is significantly increased in aged human skin. Also, treatment of Fn-fr's (70, 45 kDa) increased MMP-1 expression and MMP-2 activity in human dermal fibroblasts. Our results suggest that Fn-fr's as a potential new factor to accelerate skin aging.