• Bulletin of the Korean Chemical Society
• /
• v.28 no.10
• /
• pp.1834-1836
• /
• 2007

• Bulletin of the Korean Chemical Society
• /
• v.30 no.12
• /
• pp.2989-2992
• /
• 2009

An efficient synthetic route of novel 2′(${\alpha}$)-C-fluoro-2′(${\beta}$)-C-methyl carbocyclic nucleoside analogues is described. The key fluorinated intermediate 7 was prepared from the epoxide intermediate 5 via selective ring-opening of epoxide. Coupling of 7 with nucleosidic bases under the Mitsunobu reactions followed by deprotection afforded the target carbocyclic nucleoside analogues. The synthesized compounds were evaluated as inhibitors of the hepatitis C virus (HCV) in Huh-7 cell line in vitro.