• 대한공간정보학회지
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• 제24권2호
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• pp.55-62
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• 2016

Economic and social damages are expected due to yellow dust, occurring every year in Korea and risk of citizens is getting higher accordingly. This study acquired tweet data for yellow dust, which had been the greatest since 2009 for 11 days before and after February 23, 2015. After that, it conducted an analysis on the issue words and association rule. Regarding acquired tweet data, the results of analyzing issue words by using open source R, statistics language shows that 'Mask' was ranked to be the highest, followed by health-related issue words. This indicates that people put the priority in the use of mask for keeping their health, as a result of the occurrence of yellow dust, and subsequently, they showed an interest in diseases, caused by yellow dust. In addition, yellow dust-related diseases, 'cold', 'rhinitis', 'flu', 'asthma', 'bronchitis' were found as issue words, revealing that people had a high concern on the disease occurrence of the respiratory system. The analytical results are judged to reflect the citizen's thought effectively in the process of establishing measures for the prevention of yellow dust.

• Journal of Information Science Theory and Practice
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• 제1권1호
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• pp.42-53
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• 2013

Timely access to quality healthcare information during an outbreak plays an important role in curtailing its spread. The aim of this study was to investigate the information needs and seeking behavior of the general public in Singapore during the H1N1 pandemic. A pre-tested questionnaire was used for data collection. The convenience snowball sampling method was used and 260 working adults and tertiary-level students participated in this study. The most crucial information needs of a majority of the participants were: symptoms of H1N1, causes of the infection, preventive measures, and possible treatments. Data analysis also revealed that mass media such as television, newspapers, and radio were most frequently used for seeking the needed information. The use of human information sources was also quite high while only a small number of the respondents accessed online news and healthcare websites. About three-quarters of the participants indicated that the gathered information helped them to stay vigilant and take necessary precautionary measures. A major problem identified by the participants in using H1N1 information was the lack of understanding of certain terms used in public communications. This paper suggests certain measures for strengthening health information communication during future outbreaks.

• 약학회지
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• 제51권3호
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• pp.174-178
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• 2007

A reverse-phase high performance liquid chromatography method with electrospray ionization and detection by mass spectrometry is described for the simultaneous determination of doxifluridine and its active metabolite 5-flu-orouracil (5-FU) in monkey serum. The method has greater sensitivity and simpler process than previous published methods with good accuracy and precision. A proper liquid/liquid extraction was used to extract simultaneously doxifluridine and 5-FU which has considerable difference in the polarity. Extracts were analyzed using LC/MS/MS providing a short analysis time within 5 min. The lower limit of quantification was validated at 10.0 ng/ml of serum for both doxifluridine and 5-FU. Accuracy and precision of quality control (QC) samples for both analytes met FDA Guidance criteria of ±15% for average QC accuracy with coefficients of variation less than 15%. The method will be applicable for preclinical studies and bioequivalence studies.

• 지역사회간호학회지
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• 제26권1호
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• pp.11-17
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• 2015

Purpose: This study was to ascertain whether there are differences in health care utilization and expenditure for Type I Medical Aid Beneficiaries before and after applying Copayment. Methods: This study was one-group pretest posttest design study using secondary data analysis. Data for pretest group were collected from claims data of the Korea National Health Insurance Corporation and data for posttest group were collected through door to-door interviews using a structured questionnaire. A total of 1,364 subjects were sampled systematically from medical aid beneficiaries who had applied for copayment during the period from December 12, 2007 to September 25, 2008. Results: There was no negative effect of copayment on accessibility to medical services, medication adherence (p=.94), and quality of life (p=.25). Some of the subjects' health behaviors even increased preferably after applying for copayment including flu prevention (p<.001), health care examination (p=.035), and cancer screening (p=.002). However, significant suppressive effects of copayment were found on outpatient hospital visiting days (p<.001) and outpatient medical expenditure (p<.001). Conclusion: Copayment does not seem to be a great influencing factor on beneficiaries' accessibility to medical services and their health behavior even though it has suppressive effects on outpatients' use of health care.

• Bulletin of the Korean Chemical Society
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• 제30권7호
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• pp.1611-1615
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• 2009

We designed new anthracene-based host material to increase color purity as well as device efficiency. The new blue host, 9,10-bis(2,4-dimethylphenyl)anthracene (BDA), has highly twisted structure and wide band gap due to ortho interaction between anthracene and introduced 2,4-dimethylphenyl substituents. BDA exhibited deep blue fluorescence in solution (${\lambda}_{max}$ = 410 nm) and in solid state (${\lambda}_{max}$ = 429 nm), respectively, with the wide optical band gap (E = 3.12 eV). Blue-light-emitting OLEDs using obtained host and 2% Flu-DPAN as emitter showed 8 cd/A of high efficiency as well as high color purity [CIE coordinates = (0.15, 015)].

• Journal of Ginseng Research
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• 제44권2호
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• pp.194-204
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• 2020

The detrimental impact of air pollution as a result of frequent exposure to fine particles posed a global public health risk mainly to the pulmonary disorders in pediatric and geriatric population. Here, we reviewed the current literature regarding the role of ginseng and/or its components as antimicrobials, especially against pathogens that cause respiratory infections in animal and in vitro models. Some of the possible mechanisms for ginseng-mediated viral inhibition suggested are improvements in systemic and mucosa-specific antibody responses, serum hemagglutinin inhibition, lymphocyte proliferation, cell survival rate, and viral clearance in the lungs. In addition, ginseng reduces the expression levels of proinflammatory cytokines (IFN-γ, TNF-α, IL-2, IL-4, IL-5, IL-6, IL-8) and chemokines produced by airway epithelial cells and macrophages, thus preventing weight loss. In case of bacterial infections, ginseng acts by alleviating inflammatory cytokine production, increasing survival rates, and activating phagocytes and natural killer cells. In addition, ginseng inhibits biofilm formation and induces the dispersion and dissolution of mature biofilms. Most clinical trials revealed that ginseng, at various dosages, is a safe and effective method of seasonal prophylaxis, relieving the symptoms and reducing the risk and duration of colds and flu. Taken together, these findings support the efficacy of ginseng as a therapeutic and prophylactic agent for respiratory infections.

• Archives of Pharmacal Research
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• 제19권2호
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• pp.143-147
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• 1996

LB20304 is a novel fluoroquinolone that exhibits a potent broad spectrum antibacterial activity against both gram-positve and gram-negative bacteria. The MICs (Minimal Inhibitory Concentration) of LB20304 were determined against both gram-positve and gram-negative bacteria under various conditions including several media, pHs, and inoculum concentrations. The in vitro activity of LB20304 was not significantly affected by the changes in testing conditions such as components of media and inoculum concentrations, but it was slightly reduced by acid condition. The MICs and MBCs (Minimal Bactericidal Concentration) of LB20304 against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were hardly affected by the presence of 50 % human serum, mouse serum, guinea pig serum or horse serum, and the MBCs were equal to or at most four-times higher than the MiCs. The activities of LB20304 were decreased by the presence of high concentraion of $Mg^{++}$ or human urine (pH, 5.5) in the test media. The frequencies of mutants resistant to LB20304 were similar to or lower than those found in ciprofloxacin and sparfloxacin.

• Environmental Analysis Health and Toxicology
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• 제26권
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• pp.4.1-4.6
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• 2011

Objectives: This study was carried out to determine whether or not pine needles can be used as passive samplers of atmospheric polycyclic aromatic hydrocarbons (PAHs) using the correlation between accumulated PAH concentrations in air (Ca, ng/$m^3$) and those deposited on pine needles (Cp, ng/g dry). Methods: PAHs in ambient air was collected using low volume PUF sampler and pine needles was gathered at same place for 7 months. Results: A good correlation ($R^2$=0.8582, p<0.05) was found between Ca and Cp for PAHs with a higher gaseous state in air (AcPy, Acp, Flu, Phen, Ant, Flt, Pyr, BaA and Chry), but there was a poorer correlation ($R^2$=0.1491, p=0.5123) for the PAHs with a lower gaseous state (BbF, BkF, BaP, DahA, BghiP and Ind123). A positive correlation ($R^2$=0.8542) was revealed between the logarithm of the octanol-air partitioning coefficient ($logK_{oa}$) and Cp/Ca for the PAHs with a higher gaseous state in air, but there was a negative correlation ($R^2$=0.8131) for the PAHs with a lower gaseous state. The Ca-Cp model could not be used to estimate PAHs concentrations in air using deposited PAHs concentrations on pine needles, but the logKoa-Cp/Ca model could be used. Conclusions: It was found that pine needles can be used as passive samplers of atmospheric PAHs.

• 동의생리병리학회지
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• 제20권4호
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• pp.1032-1035
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• 2006

Angelicas Tenuissimae Radix (ATR) has traditionally been used for flu-like symptoms, limb-ache and disability, and even for toothache. In the present study, the effect of ATR on carrageenan-induced edema, acetic acid-induced abdominal pain, and heat-induced hyperalgesia were investigated using rats and mice. In the present results, ATR reduced carrageenan-induced edema in rats and inhibited acetic acid-induced abdominal pain in mice. Here in this study, we have shown that ATR possesses anti-inflammatory and analgesic effects.

• 한국의사학회지
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• 제26권1호
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• pp.19-26
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• 2013

1. $38^{\circ}C{\sim}40^{\circ}C$의 고열을 동반한 상기도감염증은 편도선염이 주원인이며 계절마다 반복되는 특징이 있는데 도한(盜汗), 탁성(濁聲), 기침, 식욕부진의 증상을 동시에 호소하는 경우 대청룡탕(大靑龍湯)을 투여하였더니 반복적으로 발생하는 고열의 치료 및 상당기간 재발 방지에 효과가 있었다. 2. 소아가 평소 도한증(盜汗證)을 호소할 경우 만성적인 상기도감염증이 있는지 우선 확인할 필요도 있을 것이다. 3. 고열을 동반한 상기도감염증을 반복해서 앓는 소아의 경우 우선 대청룡탕(大靑龍湯)으로 고열을 안정시킨 후 나머지 여증(餘症)을 상한치법(傷寒治法)에 따라 변증(辨證)하여 치료하면 좋을 것이다.