• Journal of Energy Engineering
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• v.2 no.1
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• pp.95-103
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• 1993

A conceptual thermoelectric heat pump(cooling mode) of small capacity is designed. Its performance is investigated through parametric analysis. COP and cooling capacity decease as the ambient temperature increases with ${\mu}$, J, T$\sub$wi/, fixed. To design a system of fixed capacity comes to calculate ${\mu}$ and J when T$\sub$wi/, and T$\sub$a/ are given. As v is fixed by semi-conductor manufacturers, optimum combination of n and I should be searched for ν. Optimum current could be calculated using ${\mu}$-J curve and optimum value of ${\mu}$. COR$\sub$R/ increases as water flow rate increases and T$\sub$a/ decreases. The effect of heat transfer coefficient at hot(heat releasing) side is more significant than that at cold(heat absorbing) side.

• YAKHAK HOEJI
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• v.60 no.2
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• pp.64-72
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• 2016

Jakyakgamcho-tang is a well-known traditional herbal medicine and has been used for the treatment of mainly pains in oriental medicine. In this study, analytical method for the quantitative determination of the eleven marker components, gallic acid (1), oxypaeoniflorin (2), paeoniflorin (3), albiflorin (4), liquiritin (5), isoliquiritin (6), ononin (7), liquiritigenin (8), benzoylpaeoniflorin (9), paeonol (10), and glycyrrhizin (11) in Jakyakgamcho-tang decoction was performed using an ultra-performance liquid chromatography-electrospray ionization-mass spectrometer. The analytical column for separation of the compounds 1~11 was used an UPLC BEH $C_{18}$ ($100{\times}2.1mm$, $1.7{\mu}m$) column and column oven temperature was maintained at $45^{\circ}C$. The mobile phase consisted of 0.1% (v/v) aqueous formic acid (A) and acetonitrile (B) by gradient elution. The flow rate was 0.3 ml/min and injection volume was $2.0{\mu}l$. Correlation coefficient in the calibration curves of the compounds 1~11 were showed a good linearity with more than 0.99. The limit of detection and limit of quantification values of the compounds 1~13 were detected in the ranges 0.06~18.43 ng/ml and 0.18~58.29 ng/ml, respectively. Among the compounds 1~11, the compounds 10 were not detected in this sample, while the ten compounds, 1~9 and 11, were detected $44.05{\sim}19,289.05{\mu}g/g$ in Jakyakgamcho-tang extract.

• YAKHAK HOEJI
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• v.52 no.2
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• pp.93-100
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• 2008

A liquid chromatographic method with tandom spectrometric detection (LC/MS/MS) for the simultaneous determination of doxifluridine and its active metabolite, 5-fluorouracil (5-FU) was developed over the concentration range of $5{\sim}2000$ ng/ml, respectively. Doxifluridine, 5-FU and internal standard, 5-chlorouracil (5-CU), were extracted from liver and intestine tissue via protein precipitation. Acetonitrile was used as the extraction solvent and the supernatant was evaporated and reconstructed in mobile phase. Optimum chromatographic separation was achieved on a Agilent Zorbax $C_{18}$ ($100\;mm{\times}2.1\;mm$, $3.5\;{\mu}m$) column with mobile phase run in isocratic with methanol : water (20 : 80, v/v). The flow rate was 0.2 ml/min with total cycle time of 5 min. The lower limit of quantification was validated at 5.0 ng/ml of liver and intestine tissue, for both doxifluridine and 5-FU, respectively. The intra-day and inter-day precision and accuracy of quality control (QC) samples were <11% coefficient of variation and <7% relative error from theoretical concentration for both analytes. In addition, the special designed stability study was performed, because the metabolism of doxifluridine occurs spontaneously even in ice bath for monkey liver. The stability of doxifluridine in liver and intestine of monkey and beagle dog was compared. It was found that bioanalytical validation could not be performed for the monkey liver; however, beagle dog's liver has relatively low speed of metabolism compared to monkey liver and instead of monkey liver, beagle dog's liver could be used for the validation. Bioanalytical validation could be performed in monkey intestine. Eventually, this developed method for liver and intestine will be useful in support of the toxicokinetic and pharmacokinetic studies of doxifluridine and 5-FU.

• KIEAE Journal
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• v.16 no.4
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• pp.71-77
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• 2016

Purpose : The energy saving in a residential building (apartment) sector is known as one of the effective solution of energy reduction. In South Korea, the government has recently reinforced regulations associated with the energy performance of buildings. However, there is a lack of research on the methods for the energy performance diagnosis that is used to analyze the wall thermal performance of the existing apartments. Because a reliable diagnosis is necessary to save the building energy, this study analyzed wall thermal performance of an existing apartment in Seoul. Method : This paper applied two methods for analysis of the thermal insulation performance; HFM(Heat Flow Meter) method and ASTR(Air-Surface Temperature Ratio) method. The HFM method is suggested by ISO9869-1 code to measure the thermal performance. The ASTR method is proposed by this study for the simplified In-situ measurement and it uses three temperature data (interior wall surface, interior and exterior air) and the overall heat transfer coefficient. This study conducted the experiment of an existing apartment in Seoul using these methods and analyzed the results. Furthermore, the energy simulation tool of the building was used to suggest retrofit of the building based on the results of measurements. Result : The error rate of HFM method and ASTR method was analyzed in about 17 to 20%. As the results of comparison between the initial design values of the wall and the measured values, the 26% degradation of insulation thermal performance was measured. Lastly, the energy simulation tool of the building shows 10.8% energy savings in accordance with the construction of suggested retrofit.

• Journal of Environmental Health Sciences
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• v.36 no.5
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• pp.383-390
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• 2010

Exposure to fugitive dust can contribute to several respiratory health problems, and proper sampling of fugitive dust is necessary to assess exposure. However, field sampling of soil dust encounters problems from spatial and temporal differences in soil properties, field operations, and meteorological conditions. To minimize these problems, we designed a dust generator that simulates dust generation from soil. The dust generator consisted of a rotating chamber where soil samples were loaded and tumbled, and a settling chamber, where airborne soil dust samples were collected. As standard operating conditions, we decided on 2 g soil mass, 10 min sampling time, and 20 rpm rotating speed, with a flow rate of 30 l/min, based on three common soil textures of loam, sandy loam and silt loam. To evaluate optimal operating conditions, we used mixtures of Joomoonjin silica sand and clay. Although the average $PM_{10}$ concentration of Joomoonjin silica sand was low, dust concentrations were increased by an increased content of clay. The dust concentrations were consistent across repeated experiments, and showed similar concentration profiles during the sampling time with mixtures of clay and sand (coefficient of variation was $13.6{\pm}w;7.1%$). The results demonstrated that these standard operating conditions were suitable for the dust generator, which can be used to investigate variations in soil properties that affect dust production and potential potency of fugitive dust exposure.

• Journal of Korea Foundry Society
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• v.27 no.1
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• pp.31-35
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• 2007

In order to develop the semi-solid forming technology for magnesium alloy the rheological and thixotropic behavior of Mg alloy slurry with varying shear rates and cooling rates was investigated and simulated with considering the viscosity based on microstructures and processing variables. The viscosity of slurry of Mg alloy (AZ91D) in semi-solid region was exponentially increased with a solid fraction, and was decreased with increasing a shear rate. In order to analyze precisely the rheological behavior, the ANYCAST program modified with the Carreau model and the different heat transfer coefficient between the cast and mold was used to simulate the flow behavior of Mg semi-solid slurry during the injection into a casting mold in a high pressure diecasting machine. The simulated rheological behavior of Mg alloy slurry was matched well with the experimental results.

• Natural Product Sciences
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• v.22 no.2
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• pp.93-101
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• 2016

For efficient quality control of the Samryeongbaekchul-san decoction, a powerful and accurate an ultra-performance liquid chromatography (UPLC) coupled with electrospray ionization (ESI) tandem mass spectrometry (MS) method was developed for quantitative analysis of the thirteen constituents: allantoin (1), spinosin (2), liquiritin (3), ginsenoside Rg1 (4), liquiritigenin (5), platycodin D2 (6), platycodin D (7), ginsenoside Rb1 (8), glycyrrhizin (9), 6-gingerol (10), atractylenolide III (11), atractylenolide II (12), and atractylenolide I (13). Separation of the compounds 1 - 13 was performed on a UPLC BEH $C_{18}$ column ($2.1{\times}100mm$, $1.7{\mu}m$) at a column temperature of $40^{\circ}C$ with a gradient solvent system of 0.1% (v/v) formic acid aqueous-acetonitrile. The flow rate and injection volume were 0.3 mL/min and $2.0{\mu}L$. Calibration curves of all compounds were showed good linearity with values of the correlation coefficient ${\geq}0.9920$ within the test ranges. The values of limits of detection and quantification for all analytes were 0.04 - 4.53 ng/mL and 0.13 - 13.60 ng/mL. The result of an experiment, compounds 2, 6, 12, and 13 were not detected while compounds 1, 3 - 5, and 7 - 11 were detected with 1,570.42, 5,239.85, 299.35, 318.88, 562.27, 340.87, 12,253.69, 73.80, and $115.01{\mu}g/g$, respectively.

• Journal of the Korean Solar Energy Society
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• v.38 no.5
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• pp.49-62
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• 2018

This study aims to analyze the performance of solar thermal system with heat pump for domestic hot water and heat supply. There are four types of system. Systems are categorized based on the existence of a heat pump and the ways of controlling the working fluid circulating from the collector. Working fluid is controlled by either temperature level (categorized as system 1 and 2) or sequential flow (system 3 and 4). Heat balance of the system, the solar fraction, hot water and heating supply rates, and performance of heat pump are analyzed using TRNSYS and TESS component programs. Technical specifications of the main facilities are as follow; the area of the collector to $25m^2$, the volumes of the main tank and the buffer tank to $0.5m^3$ and $0.8m^3$, respectively. Heating capacity of the heat pump in the heating mode is set to 30,000 kJ / hr. Hot water supply set 65 liters per person each day, total heat transfer coefficient of the building to 1,500 kJ / kg.K. Indoor temperature is kept steadily around $22^{\circ}C$. The results are as follows; 6 months average solar fraction of system 1 turns out to be 39%, which is 6.7% higher than system 2 without the heat pump, indicating a 25% increase of solar fraction compared to that of system 2. In addition, the solar fraction of system 1 is 2% higher than that of system 3. Hot water and heating supply rate of system 1 are 93% and 35%, respectively. Considering the heat balance of the system, higher heat efficiency, and solar fraction, as whole, it can be concluded that system 1 is the most suitable system for hot water and heat supply.

• Analytical Science and Technology
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• v.34 no.5
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• pp.212-224
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• 2021

The intent of the present work was to develop a simple, sensitive, accurate, precise, rapid and economical UV- spectrophotometric and reverse phase high pressure liquid chromatographic method for the simultaneous estimation of Spironolactone and Furosemide in bulk and combined tablet dosage forms. UV-Spectrophotometry was carried out by simultaneous equation method using 0.02 M potassium dihydrogen phosphate buffer pH 3.5: Acetonitrile (50:50) v/v as a solvent. The linearity range was 2-14 ㎍ mL^-1 for Spironolactone and Furosemide with a correlation coefficient > 0.99. The chromatographic separation was achieved on 250 mm × 4.6 mm, hypersil BDS C18 column with particle size 5 ㎛, by using an isocratic mixture of 0.02 M potassium dihydrogen phosphate buffer pH 3.5: Acetonitrile: tert butyl methyl ether (49:50:1) v/v/v as a solvent at a flow rate of 1 mL min^-1 and UV detection was carried out at 254 nm. The retention time were observed to be 3.666 and 6.661 minutes for Furosemide and Spironolactone respectively. The two developed methods were validated according to the ICH guidelines for accuracy, precision, linearity, LOD, LOQ and were found to be within the limits. It can be concluded that these two methods could be successfully used for the simultaneous estimation of Spironolactone and Furosemide in bulk and combined tablet dosage forms.

• Nuclear Engineering and Technology
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• v.52 no.12
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• pp.2699-2708
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• 2020

Helical-coil steam generator (HCSG) technology is a major design candidate for small modular reactors due to its compactness and capability to produce superheated steam with high generation efficiency. In this paper, we investigate the feasibility of the passively autonomous power maneuvering by coupling the 3-D transient multi-physics of a soluble-boron-free (SBF) core with a time-dependent HCSG model. The predictor corrector quasi-static method was used to reduce the cost of the transient 3-D neutronic solution. In the numerical system simulations, the feedwater flow rate to the secondary of the HCSGs is adjusted to extract the demanded power from the primary loop. This varies the coolant temperature at the inlet of the SBF core, which governs the passively autonomous power maneuvering due to the strongly negative coolant reactivity feedback. Here, we simulate a 100-50-100 load-follow operation with a 5%/minute power ramping speed to investigate the feasibility of the passively autonomous load-follow in a 450 MW_th SBF PWR. In addition, the passively autonomous frequency control operation is investigated. The various system models are coupled, and they are solved by an in-house Fortran-95 code. The results of this work demonstrate constant steam temperature in the secondary side and limited variation of the primary coolant temperature. Meanwhile, the variations of the core axial shape index and the core power peaking are sufficiently small.