• 약학회지
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• 제34권3호
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• pp.161-165
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• 1990

An automated, simple, and reliable method was developed for determining in vitro drug release rate from transdermal delivery dosage forms. The patch is held in position in the heating block by sandwiching it between the middle plate and the bottom plate of diffusion cell. The dissolution profile of the commercially available transdermal scopolamine patch was determined over a 72-h period, and the results were compared with those obtained with other methods; paddle-over-disk method, reciprocating method, and diffusion cell method. It was demonstrated that the flow-through method is equivalent in terms of release rate profile and accumulated released drug amount over the lifetime of the dosage form tested. Also this method is simple, reliable and reproducible. Therefore, this technique can be used in a quality control for assuring product uniformity.

• Journal of Plant Biology
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• 제38권4호
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• pp.329-336
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• 1995

Raphanus sativus L. var. hortensis f. raphanistroides (wild radish: Brassicaceae), a herbaceous perennial, occurs only on beaches in East Asia. Genetic diversity and population structure of seven Korean populations were investigated using starch gel electrophoresis. Although the Korean populatins are small, isolated with patchy distribution, the population maintain a moderate level of genetic diversity; the mean percentage fo polymorphic loci was 51.4%, mean number of alleles per locus was 1.84, and mean expected heterozygosity was 0.116. A combination of animal-outcrossing breeding system, wide geographical distribution, restricted ecological distribution, and a propensity for high fecundity may in part be explanatory factors contributing the moderate level of genetic diversity within populations. An overall excess of homozygotes relative to Hardy-Weinberg expetations (mean FISa=0.116) indicates that consanguineous mating occur within wild radish populations, leading to a family structure within a circumscribed area. Although population of wild radish experience a limited gene flow, only 5% of the total genetic variation found in Korean wild radish populations examined is due to differences among populations (mean GST=0.052). This value is considerably lower than the mean values of species with similar life history and ecological characteristics. However, significant differences were found in allele frequencies between populations for all polymorphic loci (P<0.01). It is supposed that directional selection toward genetic uniformity (similar gene frequencies) in a relatively homogenous habitat is thought to be operated among Korean wild radish populations.

• 대한기계학회논문집B
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• 제29권3호
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• pp.330-339
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• 2005

An experimental study on the behavior of droplets impinging on a solid flat surface was carried out in the present study. Breakup of a liquid droplet impinging on a solid surface has been investigated experimentally for various liquids with different properties. The liquid droplet temperature and incident angle were chosen as major parameters. Liquid droplet temperature and incident angle varied in the range from $-20{\circ}C\;to\;30{\circ}C\;and\;from\;30{\circ}\;to\;60{\circ},$ respectively. It was found that the variation of droplet temperature influences upon the mean diameter and uniformity of droplets which were bounced out from the solid surface. With increase of incident angle the dispersion mass fraction increases, causing the decrease of liquid film flow rate. As the liquid temperature increases, dispersion mass fraction increases since the surface tension decreases.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2004년도 제22회 춘계학술대회논문집
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• pp.34-40
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• 2004

Two different type scramjet models with side-wall compression and top-wall compression inlets have been tested in HPTF (Hypersonic Propulsion Test Facility) under the experimental conditions of Mach number 5.8, total temperature 1700K, total pressure 4.5㎫ and mass flow rate 3.5kg/s. The liquid kerosene was used as main fuel for the scramjets. In order to get fast ignition in the combustor, a small amount of hydrogen was used as a pilot. A strut with alternative tail was employed for increasing the compression ratio and for mixing enhancement in the side-wall compression case. Recessed cavities were used as a flameholder for combustion stability. The combustion efficiency was estimated by one dimensional theory. The uniformity of the facility nozzle flow was verified by a scanning pitot rake. The experimental results showed that the kerosene fuel was successfully ignited and stable combustion was achieved for both scramjet models. However the thrusts were still less than the model drags due to the low combustion efficiencies.

• 설비공학논문집
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• 제19권1호
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• pp.86-93
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• 2007

The PEM (polymer electrolyte membrane) fuel cell is one of the promising fuel cell systems as a new small power generating device for automobiles and buildings. The optimal design of cooling plates installed between MEA (membrane electrode assembly) is very important to achieve high performance and reliability of the PEMFC because it is very sensitive to temperature variations. In this study, six types of cooling plate models for the PEMFC including basic serpentine and parallel shapes were designed and their cooling performances were analyzed by using three-dimensional fluid dynamics with commercial software. The model 3 designed by revising the basic serpentine model represented the best cooling performance among them in the aspect of uniformity of temperature distribution and thermal reliability, The serpentine models showed higher pressure drop than the parallel models due to a higher flow rate.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2005년도 춘계학술대회 논문집
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• pp.113-116
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• 2005

In this paper, a computational and experimental analysis about the flow behavior of thin polymer film in the spin coating process for stable cover layer coating of a blu-ray disc is described. The blu-ray disc, a next-generation optical disc format over 25GB, consists of a 1.1mm thick substrate and a 0.1mm tick cover layer. Generally, cover layer on the blu-ray disc is made by the polymer spin coating process. However, it is hard to secure sufficient coating uniformity around the rim on the cover layer. In order to get the uniform thickness deviation and to minimize the bead around the rim, the edge of the disc substrate can be modified into various shapes around the rim on the disc and analyzed with various parameters, such as surface tension, viscosity, and rotation speed, etc. The optimal shape of the rim was tried to get by 3 dimensional computer simulation of the polymer expulsion process.

• 한국진공학회지
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• 제9권1호
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• pp.7-15
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• 2000

An ECR-PECVD system with the characteristics of high ionization rat다 ability of plasma processing in a wide pressure range and deposition at low temperature was manufactured and characterized for the deposition of thin films. The system consists of a vacuum chamber, sample stage, vacuum gauge, vacuum pump, gas injection part, vacuum sealing valve, ECR source and a control part. The control of system is carried out by the microprocessor and the ROM program. We have investigated the vacuum characteristics of ECR-PECVD system, and also have diagnosed the characteristics of ECR microwave plasma by using the Langmuir probe. From the data of system and plasma characterization, we could confirmed the stability of pressure in the vacuum chamber according to the variation of gas flow rate and the effect of ion bombardment by the negative DC self bias voltage. The plasma density was increased with the increase of gas flow rate and ECR power. On the other hand, it was decreased with the increase of horizontal radius and distance between ECR source and probe. The calculated plasma densities were in the range of 49.7\times10^{11}\sim3.7\times10^{12}\textrm{cm}^{-3}$. It is also expected that we can estimate the thickness uniformity of film fabricated by the ECR-PECVD system from the distribution of the plasma density.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년 영문 학술대회
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• pp.456-459
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• 2008

The purpose of this paper is to examine the aerodynamic characteristics of three hypersonic configurations including pure liftbody configuration, pure waverider configuration and liftbody integrated with waverider configuration. Hypersonic forbodies were designed based on these configurations. For the purpose to integrate with ramjet or scramjet, all the forebodies were designed integrated with hypersonic inlet. To better understand the forebody performance, three dimensional flow field calculation of these hypersonic forebodies integrated with hypersonic inlet were conducted in the design and off design conditions. The computational results show that waverider offer an aerodynamic performance advantage in the terms of higher lift-drag ratios over the other two configurations. Liftbody offer good aerodynamic performance in subsonic region. The aerodynamic performance of the liftbody integrated with waverider configuration is not comparable to that of pure waverider in the terms of lift-drag ratios and is not comparable to that of pure liftbody in subsonic. But the liftbody integrated with waverider configuration exhibit good lateral-directional and longitudinal-directional stability characteristics. Both pure waverider and liftbody integrated with waverider configuration can provide relatively uniform flow for the inlet and offer good aerodynamic characteristics in the terms of recovery coefficient of total pressure and uniformity coefficient.

• 설비공학논문집
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• 제20권1호
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• pp.17-25
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• 2008

To achieve the unidirectional airflow in a cleanroom, we need to predict accurately the static pressure losses at the lower plenum and to control properly the opening pressure ratio of access floor panels based on these pressure losses. At first, the present study proposed a correlation to predict the velocity distribution at the lower plenum, because the accuracy to predict pressure losses at the lower plenum depends on how to calculate the velocity correctly against the inner structures at the lower plenum. In the second place, this study proposed correlations which considered the effect of inner structures such as columns, ducts and equipments at the lower plenum on pressure losses. In order to test the accuracy of these correlations, we compared air flow patterns before regulating the opening ratio of access floor with those after regulating. Results after regulating the opening ratio of access floor show good unidirectional uniform airflow pattern. So the present method can be used as an important tool to control the air flow in a cleanroom.

• 한국환경과학회지
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• 제30권12호
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• pp.983-991
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• 2021

The role of the distribution basin role is to apportion incoming raw water to the primary sedimentation basin as part of the water treatment process. The purpose of this study was to calculate the amount of water in the distribution basin using computational fluid dynamics (CFD) analysis and to find a way to improve any non-uniformity. We used the Taguchi method and the minitab tool as optimization methods. The results of the CFD calculation showed that the distribution flow had a deviation of 5% at the minimum inflow, 10% at the average inflow, and 22% at the maximum inflow. At maximum flow, the appropriate heights of the 7 weirs(C, D, A, B, E, F, G) were 40 mm, 20 mm, 20 mm, 0, 0, 0, and 20 mm, respectively, according to the Taguchi optimization tool. Here, the maximum deviation of the distribution amount was 9% and the standard deviation was 23.7. The appropriate heights of the 7 weirs, according to the Minitab tool, were 40 mm, 20 mm, 20 mm, 0, 0, 0, and 20 mm, respectively, for weirs C, D, A, B, E, F, and G. Therefore, the maximum deviation of the distribution amount was 8% and the standard deviation was 17.1, which was slightly improved compared to the Taguchi method.