• Journal of the Korea Society for Simulation
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• v.8 no.3
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• pp.49-66
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• 1999

Semiconductor wafer fabrication is known to be one of the most complex manufacturing processes due to process intricacy, random yields, product diversity, and rapid changing technologies. In this study we are concerned with the impact of lot release and dispatching policies on the performance of semiconductor wafer fabrication facilities. We consider several semiconductor wafer fabrication environments according to the machine failure types such as no failure, normal MTBF, bottleneck with low MTBF, high randomness, and high MTBF cases. Lot release rules to be considered are Deterministic, Poisson process, WR(Workload Regulation), SA(Starvation Avoidance), and Multi-SA. These rules are combined with several dispatching rules such as FIFO (First In First Out), SRPT (Shortest Remaining Processing Time), and NING/M(smallest Number In Next Queue per Machine). We applied the combined policies to each of semiconductor wafer fabrication environments. These policies are assessed in terms of throughput and flow time. Basically Weins fabrication setup was used to make the simulation models. The simulation parameters were obtained through the preliminary simulation experiments. The key results throughout the simulation experiments is that Multi-SA and SA are the most robust rules, which give mostly good performance for any wafer fabrication environments when used with any dispatching rules. The more important result is that for each of wafer fabrication environments there exist the best and worst choices of lot release and dispatching policies. For example, the Poisson release rule results in the least throughput and largest flow time without regard to failure types and dispatching rules.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1099-1104
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• 2014

Aims and Background: Ginsenoside Rh2, which exerts the potent anticancer action both in vitro and in vivo, is one of the most well characterized ginsenosides extracted from ginseng. Although its effects on cancer are significant, the underlying mechanisms remain unknown. In this study, we sought to elucidate possible links between ginsenoside Rh2 and phosphoglucose isomerase/autocrine motility factor (PGI/AMF). Methods: $KG1{\alpha}$, a leukemia cell line highly expressing PGI/AMF was assessed by western blot analysis and reverse transcription- PCR (RT-PCR) assay after transfection of a small interfering (si)-RNA to silence PGI/AMF. The effect of PGI/AMF on proliferation was measured by typan blue assay and antibody array. A cell counting kit (CCK)-8 and flow cytometry (FCM) were adopted to investigate the effects of Rh2 on PGI/AMF. The relationships between PGI/AMF and Rh2 associated with Akt, mTOR, Raptor, Rag were detected by western blot analysis. Results: KG1${\alpha}$ cells expressed PGI/AMF and its down-regulation significantly inhibited proliferation. The antibody array indicated that the probable mechanism was reduced expression of PARP, State1, SAPK/JNK and Erk1/2, while those of PRAS40 and p38 were up-regulated. Silencing of PGI/AMF enhanced the sensibility of $KG1{\alpha}$ to Rh2 by suppressing the expression of mTOR, Raptor and Akt. Conclusion: These results suggested that ginsenoside Rh2 suppressed the proliferation of $KG1{\alpha}$, the same as down-regulation of PGI/AMF. Down-regulation of PGI/AMF enhanced the pharmacological effects of ginsenoside Rh2 on KG1${\alpha}$ by reducing Akt/mTOR signaling.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.685-689
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• 2013

Objective: To study the effects of down-regulation of HDAC6 expression on proliferation, cell cycling and migration of esophageal squamous cell carcinoma (ESCC) cells and related molecular mechanisms. Methods: ESCC cell line EC9706 cells were randomly divided into untreated (with no transfection), control siRNA (transfected with control siRNA) and HDAC6 siRNA (transfected with HDAC6 small interfering RNA) groups. Effects of HDAC6 siRNA interference on expression of HDAC6 mRNA and protein in EC9706 cells were investigated by semi-quantitative RT-PCR, Western blotting and immunocytochemistry methods. Effects of down-regulation of HDAC6 expression on cell proliferation, cell cycle, and cell migration were studied using a CCK-8 kit, flow cytometry and Boyden chambers, respectively. Changes of mRNA and protein expression levels of cell cycle related factor (p21) and cell migration related factor (E-cadherin) were investigated by semi-quantitative RT-PCR and Western blotting methods. Results: After transfection of HDAC6 siRNA, the expression of HDAC6 mRNA and protein in EC9706 cells was significantly downregulated. In the HDAC6 siRNA group, cell proliferation was markedly inhibited, the percentage of cells in G0/G1 phase evidently increased and the percentage of cells in S phase decreased, and the number of migrating cells significantly and obviously decreased. The mRNA and protein expression levels of p21 and E-cadherin in the HDAC6 siRNA group were significantly higher than those in the untreated group and the control siRNA group, respectively. Conclusions: HDAC6 siRNA can effectively downregulate the expression of HDAC6 mRNA and protein in EC9706 cells. Down-regulation of HDAC6 expression can obviously inhibit cell proliferation, arrest cell cycling in the G0/G1 phase and reduce cell migration. The latter two functions may be closely related with the elevation of mRNA and protein expression of p21 and E-cadherin.

• Journal of Korea Water Resources Association
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• v.44 no.4
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• pp.285-293
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• 2011

This study presents effects of downstream control point by coupled operation of dams and multi function weirs in the Geum River. Geum river basin that study area did authoritativeness high quality data to acquisition possibility. We applied the flow duration curve, flow regime coefficient, impounded flow index analysis to investigate the quantitative changes in natural flow regimes. In sphere that water supply is possible, this study applied believability that satisfy 95% at estimation year. Impounded flow index was calculated 0.292 by dam coupled operation and 0.297 by dam-weir coupled operation. The results indicate that the storage amount is increased by 29.7% as being added. Duration flow of downstream control point was improved because became coupled operation by regulation of dam and weir in the geum river.

• Journal of Korean Society of Environmental Engineers
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• v.39 no.4
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• pp.180-185
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• 2017

For the management of mercury-containing products, the products were selected to do material flow analysis in preference of not having selected in previous studies. Domestically mercury have been added to pigment for prevention of bacterial growth. So, in this study paint containing pigment was selected as a target. 71 samples of paint products collected in 2014 and data of 38 samples of wastes (dust, sludge, paint) analyzed in 2010 were used in material flow analysis. The result shows that mercury was 0~0.25 mg/kg in products and 0.23~0.69 mg/kg in the wastes. In the material flow analysis, the amount of flow in the process of distribution was 10.06 kg/year, but the amount of flow in disposal like a landfill, incineration and recycling was much than distribution as 25.27 kg/year. It was caused by different sampling period between collecting products and data of wastes. Therefore, It could be possible to be affected from regulation by RoHS like decreasing usage of mercury in paint products or eradicated in the industry. Mercury contents in current paint products are very low to affect discharging to the environment.

• Journal of Korean Society of Transportation
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• v.11 no.1
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• pp.87-103
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• 1993

The subject this paper is the signal control strategy under oversaturated conditions. The nature of traffic control for oversaturation is essentially different from the standard control modes. While under non-saturated situation traffic control is needed for the sake of safety and efficiency, the throughput is essential under oversaturated conditions. Therefore berth objective and strategies differ. For an oversaturated stream the cycle time and the signal offset are thought to be of rather secondary importance. For this case the green split may well be the most important control variable to serve the excessive demand. Up to now, however, most efforts have concentrated on the strategy with the concept which lies just on the extension of Webster's. "Green-split Coordination Strategy for Over-Saturated Networks", presents newly contrived three types of strategies named Forward-coordination, Backward-coordination and Network-coordination respectively and describes the algorithms with the evaluations. The forward coordination strategy treats the forward wave of flow between two signals. The aim is to prevent the outbreak of queue due to the accumulation of temporary excess of demand in near-saturation or saturation flow. The backward coordination strategy treats the backward rave of flow between two signals. The goal is to prevent the waste of green time caused by the exit block at the upstream signal. for this purpose a feedback regulation is provided of the upstream green-split so that the inflow-outflow balance is kept zero. The resultant surplus of green time is alloted to other signal stages. Also here the examination is made of the appropriate value of the feedback control parameter. The network coordination strategy is operated to maximize the network throughput in a specific direction applying a bang-bang control at the bottleneck intersection. This is a type of intervenient control for policy reasons. For this strategy the green-split coordinations, particuarly the backward coordination, are essential as the tactical elements. In order to evaluate the preposed strategies those are compared with the latest existing strategy called saturation-degree-ratio control by the simulation experiments in an assumed 4$\times$4 grid network. The results are satisfactory showing a 10-15% reduction in delays and a 15% increase in network capacity.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.39 no.1
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• pp.84-89
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• 2011

A Xenon Feed System (XFS) has been developed for hall-effect thruster to small satellite space-propulsion system applications. The XFS delivers low pressure gas to the Anode and Cathode of thruster head unit from a xenon storage tank. Accurate throttling of the propellant mass flow rate is independently required for each channel of the thruster head unit. The mass flow rate to each channel is controlled using the accumulator tank pressure regulation through a micron orifice and isolation valve. This paper discusses the Xenon Feed System design including the component selections, performance estimation and functional test.

• The Journal of Internal Korean Medicine
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• v.21 no.3
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• pp.417-424
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• 2000

Objective : The purpose of this study was to investigate the effects of Sasim-tang water extract on the cardiovascular systems including changes of blood pressure and regional cerebral blood flow volume (rCBF) in male Sprague-Dawely rats. Methods : The changes of blood pressure were recorded by data acquisition system composed of MacLab and Macintosh computer. The changes of rCBF were observed by Laser-Doppler flowmetry through a opened cranial window. Results : 1. The changes of blood pressure was not affected by Sasim-tang extract intravenous injection in rats. 2. After pretreatment with propranolol(3mg/kg), L-NNA(10mg/kg) and 000(10mg/kg), the changes of blood pressure was not affected by Sasim tang extract intravenous injection in rats. 3. The changes of rCBF was increased in dose-dependent manner by Sasim-tang extract intravenous injection in rats. 4, After pretreatment with propranolol(3mg/kg), ODQ(10mg/kg) and L-NNA(10mg/kg), rCBF was significantly decreased in dose- dependent manner by Sasim-tang extract intravenous injection in rats. Conclusions : These results suggest that Sasim-tang was related to the regulation of the sympathetic nerve system, nitric oxide synthesis and synthesis of cyclic GMP.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.6
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• pp.886-890
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• 1999

From previous studies, there is a strong possibility in buffaloes that the marked increase in blood volume (BV) under hot conditions contributes to heat transportation from the rectum to the skin. The present study was done to clarify changes with environmental temperature on water-shift between blood and extracellular fluid (ECF), heat distribution between the rectum and the skin, and blood flow rates (BFR) at the hind legs (reflecting the skin surface). Four buffaloes and four Friesian cows were successively exposed to three different temperatures of $20^{\circ}C$, $30^{\circ}C$ and $35^{\circ}C$. BV and ECF volume were measured with Evans' blue and sodium-thiocyanate dilution methods, respectively. Rectal and subcutaneous (as the skin) temperatures were measured by copper-constantan thermocouples. BFR were measured by a supersonic blood flow meter. With an increase in environmental temperature, skin temperature in buffaloes increased significantly than cows, but rectal temperature was not significantly different between two species. BV, especially plasma compartment, increased significantly in only buffaloes, while ECF volume did not change in both species. BFR increased significantly in buffaloes, but not in cows. From these results, the increased of BV may be caused by water flowing from ECF compartment. The water-shift may induce the increase of BFR and skin temperature. It is suggested in the present study that internal changes of blood compartment in buffaloes contribute to transfer of heat to the skin surface.

• Journal of Korean Society for Atmospheric Environment
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• v.26 no.6
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• pp.690-696
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• 2010

Abatement of perfluorocompounds (PFCs) used in semiconductor and display industries has received an attention due to the increasingly stricter regulation on their emission. In order to meet this circumstance, we have developed a radio frequency (RF) driven plasma reactor with multiple annular shaped electrodes, characterized by an easy installment between a processing chamber and a vacuum pump. Abatement experiment has been performed with respect to $CF_4$, a representative PFCs widely used in the plasma etching process, by varying the power, $CF_4$ and $O_2$ flow rates, $CF_4$ concentration, and pressure. The influence of these variables on the $CF_4$ abatement was analyzed and discussed in terms of the destruction & removal efficiency (DRE), measured with a Fourier transform infrared (FTIR) spectrometer. The results revealed that DRE was enhanced with the increase in the discharge power and pressure, but dropped with the $CF_4$ flow rate and concentration. The addition of small quantity of $O_2$ lead to the improvement of DRE, which, however, leveled off and then decreased with $O_2$ flow rate.