• CELLMED
• /
• v.2 no.1
• /
• pp.10.1-10.6
• /
• 2012

Acupuncture works by stimulating peripheral sensory nerves and their endings causing an increase in cutaneous blood flow and microcirculation, as well as release of neurotransmitters, neuropeptides, and hormones. SP6 Patch is a nanoscale nontransdermal device that mildly stimulates Stomach 36 (zusanli) and other acupuncture points. As stimulation of these points has been indicated to have an effect on hypothalamic function, it is of great research interest to investigate the effect of SP6 Patch on the physiology of organs that are affected by hypothalamic regulation. Bioelectrical tissue impedance data indicative of cellular physiologic organ function, using an Electro Interstitial Scan (EIS) system, were acquired from hypothalamus, pancreas, liver, intestines, kidneys, thyroid and adrenal glands in 10 (1 male, 9 females) volunteers while wearing the SP6 Patch daily for 1 week. EIS testing was performed at baseline with no patch, 30 min after wearing the patch, and after wearing the patch 12 h/day for 1 week. Subjects were instructed to keep well hydrated during the study period. All subjects served as their own control. The hypothesis was: The SP6 Patch worn 12 h/day on the Stomach 36 acupuncture point for 1 week, may significantly improve cellular physiologic functional status of different organs measured by EIS. All tested organs achieved significant improvement in their functional physiologic status after wearing the SP6 Pach 12 h/day for 1 week compared to baseline with an overall average statistical power > 89%. Based upon these results the hypothesis was accepted as true.

• BMB Reports
• /
• v.41 no.10
• /
• pp.716-721
• /
• 2008

To explore the effects of deregulated expression of the EBNA1 binding protein 2 (EBP2) on cell growth, we generated human HEK293 stable clones constitutively expressing an EBP2-EGFP fusion protein. We found both RNA and protein levels of cyclin E1, a dominant oncoprotein, were elevated in the EBP2- EGFP stable clones. These findings were confirmed by flow cytometry bivariate analysis of cyclin expression versus DNA content. Moreover, the increase in p21 expression and the specific phosphorylation at Ser1981 of ATM and Ser15 of p53 were also observed in these stable clones, and these observations may explain the failure to observe an increase in Cdk2 kinase activity. In addition, after one year of passage culture, the EBP2-EGFP stable clones tended to lose 4 to 5 chromosomes per cell when compared to that of control cells. All of these findings provide a possible link between deregulated expression of EBP2 and tumor development.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.44 no.3
• /
• pp.247-255
• /
• 2016

The purpose of this study is to investigate unsteady-state characteristics of a pintle thruster with various pintle speed. Based on steady state experimental results, non-linear pintle stroke equation is obtained and applied to the unsteady state experimental system. For the unsteady state experiments, three different pintle speeds are used: 3.10 mm/s, 5.65 mm/s, 10.83 mm/s, respectively. Results show that backward pintle stroke results in faster convergence time because of high chamber pressure during backward pintle stroke sequence. During the forward and backward process, thrust curve shows singular points. These phenomenons is caused by variation of mass flow rate, which is mainly due to changes of both chamber pressures and nozzle throat area. This behavior becomes distinctive for a faster pintle speed case.

• Journal of the Korean Society for Precision Engineering
• /
• v.28 no.10
• /
• pp.1146-1152
• /
• 2011

Ink transfer process is very important to determine quality of printed pattern, therefore its mechanism should be understood to control printing quality. Although there have been many attempts to understand ink transfer mechanism by numerical simulation and experimental studies, their model was too much simple to model realistic printing process and our understanding is not enough yet. In this paper we designed ink transfer visualization system to present flow visualization of ink transfer process for gravure offset printing. We considered rotational effect of blanket roll which is related with printing speed and used non-Newtonian fluid as working fluid such as Ag paste. For printing unit, cantilever-type blanket roll is used for convenient visualization of ink transfer. Serial images were captured continuously by using high-speed CMOS camera and long range microscope. We investigated the effects of various design parameters such as printing speed and pattern angle on the ink transfer process. We found more stretched ink filament for non-Newtonian fluid than Newtonian fluid. As increasing printing speed, length of stretched ink filament and height of break-up point are also increased. We also compared ink transfer process between CD and MD pattern and its relationship with ink transfer mechanism.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.34 no.5
• /
• pp.499-504
• /
• 2010

It is important to determine the exact soot mass in a DPF system in order to control the timing of PM regeneration. The soot mass accumulated in a filter can be estimated from the pressure drop in the filter and the exhaust gas flow rates. In this study, the soot index is defined as the pressure drop in the DPF divided by the pressure drop in a DOC. An effective signal processing method for determining the soot index is proposed; the results yielded by this method indicate good correlation between the soot index and the amount of soot loaded into the filter for both steady-state and transient-state operating conditions in a 3L diesel engine for passenger vehicles.

• Journal of Korean Society on Water Environment
• /
• v.23 no.6
• /
• pp.934-944
• /
• 2007

Fine suspended solids (SS) induced into a reservoir after flood events play important ecological and water quality roles by presenting persistent turbidity and attenuating light. Thus the origin and physical features must be characterized to understand their transport processes and associated impacts, and for the establishment of watershed based prevention strategies. This study was aimed to characterize the physical properties of the SS sampled from Daecheong Reservoir and its upstream rivers during flood events. Extensive field and laboratory experiments were carried out to identify the turbidity-SS relationships, particle size distributions, settling velocity, and mineral compositions of the SS. Results showed that the turbidity-SS relationships are site-specific depending on the locations and flood events in the system. The turbidity measured within the reservoir was much greater than that measured in the upstream rivers for the same SS value. The effective diameters ($D_{50}$) in the rivers were in the range of $13.3{\sim}54.3{\mu}m$, while those in the reservoir were reduced to $2.5{\sim}14.0{\mu}m$ due to a fast settling of large particles in the rivers. The major minerals consisting of the SS were found to be Illite, Muscovite, Albite, and Quartz both in the rivers and reservoir. Their apparent settling velocities at various locations in the reservoir were in the range of 0.06~0.13 m/day. The research outcome provides a fundamental information for the fine suspended particles that cause persistent turbidity in the reservoir, and can be used as basic parameters for modeling study to search watershed based optimal control measures.

• Journal of Korean Society on Water Environment
• /
• v.36 no.5
• /
• pp.364-372
• /
• 2020

The "Master Plan for the Revitalization of Water in the Nakdong River" is designed for the fundamental improvement of water quality in the Nakdong River. The water quality and flow of the Nakdong River system tributaries was monitored in this study. Among the living environmental standard parameters of 195 rivers, BOD (Biochemical oxygen demand), T-P (Total phosphorus) and TOC (Total organic carbon) were assessed to analyze the water quality from 2012 to 2019. We examined the role of TOC. It was found that 12 rivers exceeded the water quality of the second grade (3.0 mg/L BOD standard, 0.1 mg/L T-P standard, 4.0 mg/L TOC standard) based on BOD and T-P concentrations: the Gumi stream, Gisegok stream, Yongha stream, Yongho stream, Changnyeong stream, Gajwa stream, Gwangok stream, Yeongsan stream, Toerae stream, Hwapo stream, Sangnam stream and Hogye stream. These rivers require strategies to improve the quality of the Nakdong River. Based on the ongoing project, it is possible to supplement the "Master Plan for the Revitalization of Water in the Nakdong River" and manage it after verifying it as a component of people's life and therefore used to establish water quality control measures.

• Fire Science and Engineering
• /
• v.19 no.1 s.57
• /
• pp.70-89
• /
• 2005

Fire scenarios in a space $20.0m\;\times\;4.0m$ floor and 3.0m high were simulated by using computational fluid dynamics program (FDS 4.0.3) to investigate the effect of the combined operation of both sprinkler and vent systems, which are installed for cooling and blocking smoke which propagates beneath the ceiling of a horizontal corridor, on the temperature and smoke density of it. It was shown that the combined operation both sprinkler and vent systems was more effective than each operation for cooling and blocking smoke, the number of operating sprinklers was two because of corner effect of wall, and over-installed sprinklers deteriorated the effect of cooling and blocking smoke. This study showed that the case of two sprinklers and vent flow rate $3.0m^3/s$ in fire scenario was the most effective for cooling and blocking smoke. It was confirmed that the smoke downdrag occurs in operating sprinkler system, and the more smoke droplets produced by increasing fire size, the greater smoke downdrag occurred.

• Journal of Korean Society of Water and Wastewater
• /
• v.25 no.4
• /
• pp.581-589
• /
• 2011

Generally, treated water or raw water is transported into storage reservoirs which are receiving facilities of local governments from multi-regional water supply systems. A water supply control and operation center is operated not only to manage the water facilities more economically and efficiently but also to mitigate the shortage of water resources due to the increase in water consumption. To achieve the goal, important information such as the flow-rate in the systems, water levels of storage reservoirs or tanks, and pump-operation schedule should be considered based on the resonable water demand forecasting. However, it is difficult to acquire the pattern of water demand used in local government, since the operating information is not shared between multi-regional and local water systems. The pattern of water demand is irregular and unpredictable. Also, additional changes such as an abrupt accident and frequent changes of electric power rates could occur. Consequently, it is not easy to forecast accurate water demands. Therefore, it is necessary to introduce a short-term water demands forecasting and to develop an application of the forecasting models. In this study, the forecasting simulator for water demand is developed based on mathematical and neural network methods as linear and non-linear models to implement the optimal water demands forecasting. It is shown that MLP(Multi-Layered Perceptron) and ANFIS(Adaptive Neuro-Fuzzy Inference System) can be applied to obtain better forecasting results in multi-regional water supply systems with a large scale and local water supply systems with small or medium scale than conventional methods, respectively.

• Proceedings of the Korean Society of Agricultural Engineers Conference
• /
• 2005.10a
• /
• pp.580-585
• /
• 2005

Natural environment of Weolgok-ri watershed has been well preserved as a traditional agricultural watershed. A year record of streamflow, $NO_3-N$, T-N and T-P concentrations data(Apr, 2004-Mar. 2005) was examined to estimate annual and seasonal patterns of pollutnat loads in streamflow and baseflow from the agriculture watershed. To estimate pollutant loads from baseflow, baseflow component from total stream flow was seperated using digital filter method in the Web-based Hydrograph Analysis Tool system. Loads of $NO_3-N$, T-N and T-P from streamflow and baseflow were evaluated to investigate pollutant loads contribution by baseflow. The $NO_3-N$, T-N, and T-P loads from streamflow were 13.85 kg/ha, 45.92 kg/ha and 1.887 kg/ha, respectively. $NO_3-N$, T-N and T-P loads from baseflow were 7.43 kg/ha, 24.70 kg/ha, 0.582 kg/ha, respectively. It was found that $NO_3-N$ and T-N loads were contributed by the baseflow(53% and 53% of Total-loads) than the direct runoff(47% and 47% of Total loads). However, only 30% of total T-P was contributed by the baseflow. It is recommended that one needs to assess pollutant load contribution by the baseflow to identify appropriate control strategies for effective watershed management.