• Biomolecules & Therapeutics
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• v.26 no.2
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• pp.182-190
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• 2018

The objective of this work is to evaluate the effect of polyamidoamine (PAMAM) dendrimers on electroosmotic flow (EOF) through skin. The effect of size and concentration of dendrimer was studied, using generation 1, 4 and 7 dendrimer (G1, G4 and G7, respectively). As a marker molecule for the direction and magnitude of EOF, a neutral molecule, acetoaminophen (AAP) was used. The visualization of dendrimer permeation into the current conducting pore (CCP) of skin was made using G4-fluorescein isothiocyanate (FITC) conjugate and confocal microscopy. Without dendrimer, anodal flux of AAP was much higher than cathodal or passive flux. When G1 dendrimer was added, anodal flux decreased, presumably due to the decrease in EOF by the association of G1 dendrimer with net negative charge in CCP. As the generation increased, larger decrease in anodal flux was observed, and the direction of EOF was reversed. Small amount of methanol used for the preparation of dendrimer solution also contributed to the decrease in anodal flux of AAP. Cross-sectional view perpendicular to the skin surface by confocal laser scanning microscope (CLSM) study showed that G4 dendrimer-FITC conjugate (G4-FITC) can penetrate into the viable epidermis and dermis under anodal current. The permeation route seemed to be localized on hair follicle region. These results suggest that PAMAM dendrimers can permeate into CCP and change the magnitude and direction of EOF. Overall, we obtained a better understanding on the mechanistic insights into the electroosmosis phenomena and its role on flux during iontophoresis.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.6 no.4
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• pp.325-336
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• 1994

A numerical simulation of velocity and temperature fields and Nusselt number distributions is performed by using the algebraic stress model (ASM) for the velocity profiles and low Reynolds number ${\kappa}-{\varepsilon}$ model and the algebraic heat flux model(AHFM) for turbulent heat transfer in a $180^{\circ}$ bend with a constant wall heat flux. In the low Reynolds number ${\kappa}-{\varepsilon}$ model, turbulent Prandtl number is modified by considering the streamline curvature effect and the non-equilibrium effect between turbulent kinetic energy production and dissipation rate. Every heat flux term presented in the transport equation of turbulent heat flux is reduced to algebraic expressions in a way similar to algebraic stress model. Also. in the wall region, low Reynods number algebraic heat flux model(AHFM) is applied.

• Nuclear Engineering and Technology
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• v.37 no.5
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• pp.457-468
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• 2005

An experimental study on post-CHF heat transfer has been performed with a $3\times3$ rod bundle using a vertical steam-water two-phase flow at low flow conditions. The effects of various parameters on the post-CHF heat transfer are investigated and the reasons for the parametric effects are discussed. As the heat transfer regime changes from CHF to post-CHF, the radial wall temperature distribution is changed depending on the pressure and the mass flux conditions. The superheat of the fluid increases considerably with an increase of the wall temperature (or heat flux) and with a decrease of the mass flux. This implies, indirectly, a strong thermal non-equilibrium at high wall temperature and low mass flux conditions. In order to improve the prediction accuracy of the existing post-CHF correlations, it is necessary to perform more experiments, particularly direct measurement of the vapor superheat, and to modify the correlation by considering a strong thermal non-equilibrium at low flow and low pressure conditions.

• Journal of the Korean Society of Marine Environment & Safety
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• v.17 no.1
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• pp.23-28
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• 2011

This paper outlines extraction potential of tidal stream resources from the simplified channel in which flow is driven by a head difference between inlet and outlet. Energy extraction alters the flow within a simple channel, and extraction of 10% energy flux in a natural channel would give rise to a flow speed reduction of about 5.7%. If 20% of the undisturbed energy flux is extracted, the flow speed is reduced by 11.3%. The simple channel also suggests that extractable energy might be higher if flow speed reductions are considered acceptable.

• Membrane Journal
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• v.8 no.2
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• pp.102-108
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• 1998

Permeation behavior of the semiconductor rinsing wastewater containing Si particles was examined by ultrafiltration using the polysulfone plate membrane. The permeation flux was gradually decreased with time. It was due to the growth of cake deposited on the membrane surface and the pore plugging by Si particles. Permeation flux of cross flow type was 1.4 times higher than that of the dead end flow type. Nitrogen back flushing which is the removing method of membrane fouling was superior to the water sweeping. With nitrogen back flushing, the decrease of permeation flux due to the fouling was recovered about 85 % to the initial flux in the flat plate membrane system. The rejection rate of Si particles was about 90 % and the size of Si particle in the permeate was about 70 nm.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.11
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• pp.1432-1439
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• 2004

By using unique experimental techniques and careful construction of the experimental apparatus, the characteristics of the local heat transfer were investigated using the condensing R134a two-phase flow, in horizontal single mini-channels. The circular channels (D$_{h}$=0.493, 0.691, and 1.067 mm) and rectangular channels (Aspect Ratio=1.0, D$_{h}$=0.494, 0.658, and 0.972 mm) were tested and compared. Tests were performed for a mass flux of 100, 200, 400, and 600 kg/$m^2$s, a heat flux of 5 to 20 ㎾/$m^2$, and a saturation temperature of 4$0^{\circ}C$. In this study, effect of heat flux, mass flux, vapor qualities, hydraulic diameter, and channel geometry on flow condensation are investigated and the experimental local condensation heat transfer coefficients are shown. The experimental data of condensation Nusselt number are compared with existing correlations.ons.

• Nuclear Engineering and Technology
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• v.51 no.8
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• pp.1897-1904
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• 2019

Three-layer back propagation network (BPN) and genetic neural network (GNN) were developed in this study to predict the flow boiling heat transfer coefficient (HTC) in conventional and small-diameter channels. The GNN has higher precision than BPN (with root mean square errors of 17.16% and 20.50%, respectively) and other correlations. The inputs include vapor quality x, mass flux G, heat flux q, diameter D and physical parameter φ, and the predicted flow boiling HTC is set as the outputs. Influences of input parameters on the flow boiling HTC are discussed based on the trained GNN: nucleate boiling promoted by a larger saturated pressure, a larger heat flux and a smaller diameter is dominant in small channels; convective boiling improved by a larger mass flux and a larger vapor quality is more significant in conventional channels. The HTC increases with pressure both in conventional and small channels. The HTC in conventional channels rises when mass flux increases but remains almost unaffected in small channels. A larger heat flux leads to the HTC growth in small channels and an increase of HTC was observed in conventional channels at a higher vapor quality. HTC increases inversely with diameter before dry out.

• 한국연소학회:학술대회논문집
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• 2014.11a
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• pp.21-24
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• 2014

In the entrained-flow coal gasifier, coal ash turns into a molten slag most of which deposits onto the wall to form liquid and solid layers. Critical viscosity refers to the viscosity at the interface of the two layers. The slag layers play an important role in protecting the wall from physical/chemical attack from the hot syngas and in continuously discharging the ash to the slag tap at the bottom of the gasifier. For coal with high ash melting point and slag viscosity, CaO-based flux is added to coal to lower the viscosity. This study evaulates the effect of critical viscosity temperature and ash/flux ratio on the slag behavior using numerical modelling in a commercial gasifier. The changes in the slag layer thickness, heat transfer rate, surface temperature and velocity profiles were analyzed to understand the underlying mechanism of slag flow and heat transfer.

• Journal of Fisheries and Marine Sciences Education
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• v.27 no.5
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• pp.1310-1317
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• 2015

Two-phase flow boiling heat transfer in micro-channels was experimently investigated. The test section consisted of 15 rectangular micro-channels with a depth of 0.45mm, width of 0.20mm. The experiments were performed for heat fluxes ranging from 5.6 to 46.1kW/m2 and mass fluxes from 150 to 450kg/m2s using FC-72 as the working fluid. According to the results, at the low heat flux region, heat transfer coefficient strongly depends on the heat flux, while heat transfer coefficient at the high heat flux region was independent on the heat flux. Four correlations were used to predict the heat transfer coefficient. The measured heat transfer coefficient was compared with four correlations. It was found that Kaew-On and Wongwises's correlation well predicted the measured data, within the MAE of 40.3%.

• Journal of Fisheries and Marine Sciences Education
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• v.28 no.5
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• pp.1388-1394
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• 2016

This paper presents a experimental study of two-phase flow boiling of FC-72 in multi channels. Flow boiling heat transfer coefficients are obtained with mass flux ranging from 152.9 to $353.9kg/m^2s$ and heat flux from 5.6 to $46.1kW/m^2$. The experimental results show that the heat transfer is governed by nucleate boiling mechanism in the low heat flux region. However, it is found that the effects of nucleate boiling and forced convection boiling are combined as the heat flux increases. A new correlation to predict the heat transfer coefficient is developed by using the dimensionless number such as Reynolds number, Weber number, boiling number. This correlation shows good predictive accuracy against the measured data.