• Korean Journal of Clinical Pharmacy
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• v.2 no.1
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• pp.1-9
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• 1992

Protective effect of urokinase on reperfusion were studied followed by global ischemia in the isolated perfused rat heart. Separately, anti-platelet aggregation effect of urokinase also investigated. Urokinase exhibited positive effect for the protection of rat heart function by increasing the LV dp/dt, coronary flow(CF) and the Tate pressure product(RPP), and by decreasing the LVEDP on reperfusion. Urokinase also decreased arrhythmia by $74.7\%(P<0.05) induced by global ischemia in the rat heart. In the platelet aggregation study, urokinase did not show the inhibitory effect of ADP or collagen induced platelet aggregation inviuo and exvivo.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.6
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• pp.365-372
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• 2016

Using the computational fluid dynamics (CFD) technique, we simulated the fluid flow in a Taylor reactor considering the aggregation and breakage of particles. We calculated the population balance equation (PBE) to determine the particle-size distribution by implementing the quadrature method-of-moment (QMOM). It was used that six moments for an initial moments, the sum of Brownian kernel and turbulent kernel for aggregation kernel, and power-law kernel for breakage kernel. We predicted the final mean particle size when the particle had various initial volume fraction values. The result showed that the mean particle size and initial growth rate increased as the initial volume fraction of the particle increased.

• Journal of Environmental Science International
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• v.28 no.2
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• pp.259-266
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• 2019

Two main sources of data, meteorological data and land surface characteristics, are essential to effectively run a distributed rainfall-runoff model. The specification and averaging of the land surface characteristics in a suitable way is crucial to obtaining accurate runoff output. Recent advances in remote sensing techniques are often being used to derive better representations of these land surface characteristics. Due to the mismatch in scale between digital land cover maps and numerical grid sizes, issues related to upscaling or downscaling occur regularly. A specific method is typically selected to average and represent the land surface characteristics. This paper examines the amount of flooding by applying the FLO-2D routing model, where vegetation heterogeneity is manipulated using the Manning's roughness coefficient. Three different upscaling methods, arithmetic, dominant, and aggregation, were tested. To investigate further, the rainfall-runoff model with FLO-2D was facilitated in Yongdam catchment and heavy rainfall events during wet season were selected. The results show aggregation method provides better results, in terms of the amount of peak flow and the relative time taken to achieve it. These rwsults suggest that the aggregation method, which is a reasonably realistic description of area-averaged vegetation nature and characteristics, is more likely to occur in reality.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2879-2884
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• 2007

Dynamic responses of electrorheological (ER) fluids in steady pressure flow to stepwise electric field excitations are investigated experimentally. The transient periods under various applied electric fields and flow velocities were determined from the pressure behavior of the ER fluid in the flow channel with two parallel-plate electrodes. The pressure response times were exponentially decreased with the increase of the flow velocity, but increased with the increase of the applied electric field strength. In order to investigate the cluster structure formation of the ER particles, it was verified using the flow visualization technique that the transient response of ER fluids in the flow mode is assigned to the densification process in the competition of the electric field-induced particle attractive interaction forces and the hydrodynamic forces, unlike that in the shear mode determined by the aggregation process.

• The KIPS Transactions:PartD
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• v.14D no.6
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• pp.597-604
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• 2007

Stream data is a continuous flow of information that mostly arrives as the form of an infinite rapid stream. Recently researchers show a great deal of interests in analyzing such data to obtain value added information. Here, we propose an efficient cube computation algorithm for multidimensional analysis of stream data. The fact that stream data arrives in an unsorted fashion and aggregation results can only be obtained after the last data item has been read. cube computation requires a tremendous amount of memory. In order to resolve such difficulties, we compute user selected aggregation fables only, and use a combination of an way and AVL trees as a temporary storage for aggregation tables. The proposed cube computation algorithm works even when main memory is not large enough to store all the aggregation tables during the computation. We showed that the proposed algorithm is practically fast enough by theoretical analysis and performance evaluation.

• Journal of Ginseng Research
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• v.47 no.6
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• pp.706-713
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• 2023

Background and objective: The ability to inhibit aggregation has been demonstrated with synthetically derived ginsenoside compounds G-Rp (1, 3, and 4) and ginsenosides naturally found in Panax ginseng 20(S)-Rg3, Rg6, F4, and Ro. Among these compounds, Rk3 (G-Rk3) from Panax ginseng needs to be further explored in order to reveal the mechanisms of action during inhibition. Methodology: Our study focused to investigate the action of G-Rk3 on agonist-stimulated human platelet aggregation, inhibition of platelet signaling molecules such as fibrinogen binding with integrin α_IIbβ₃ using flow cytometry, intracellular calcium mobilization, dense granule secretion, and thromboxane B₂ secretion. In addition, we checked the regulation of phosphorylation on PI3K/MAPK pathway, and thrombin-induced clot retraction was also observed in platelets rich plasma. Key Results: G-Rk3 significantly increased amounts of cyclic adenosine monophosphate (cAMP) and led to significant phosphorylation of cAMP-dependent kinase substrates vasodilator-stimulated phosphoprotein (VASP) and inositol 1,4,5-trisphosphate receptor (IP₃R). In the presence of G-Rk3, dense tubular system Ca²⁺ was inhibited, and platelet activity was lowered by inactivating the integrin αIIb/β₃ and reducing the binding of fibrinogen. Furthermore, the effect of G-Rk3 extended to the inhibition of MAPK and PI3K/Akt phosphorylation resulting in the reduced secretion of intracellular granules and reduced production of TXA₂. Lastly, G-Rk3 inhibited platelet aggregation and thrombus formation via fibrin clot. Conclusions and implications: These results suggest that when dealing with cardiovascular diseases brought upon by faulty aggregation among platelets or through the formation of a thrombus, the G-Rk3 compound can play a role as an effective prophylactic or therapeutic agent.

• Korean Journal of Veterinary Research
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• v.36 no.4
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• pp.873-886
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• 1996

For better understanding the interrelationship of hemorrhage and aggregation mechanism, cyclopiazonic acid(CPA) known as promoting the aggregation of platelet, aflatoxin $B_1(AFB_1)$ inhibiting platelet aggregation were used as toxic mycotoxins in these studies. In order to investigate the potential role of prostaglandin metabolism on the platelet aggregation, a variety of prostaglandin metabolites such as $PGF_{2{\alpha}}$, $PGE_2$ and $TXB_2$ were measured in homogenized rabbit platelets by TLC and LSC. And the role of $Ca^{{+}{+}}$ on the platelet aggregation was investigated by flow cytometer. Finally, the morphological effects of mycotoxins on platelet were determined by transmission electron microscope. The results and conclusions obtained from these studies are: 1) CPA induced no changes but $AFB_1$ increased $PGE_2$ and $TXB_2$. 2) CPA promoted ADP, collagen, thrombin, A.A., and PAF-induced $Ca^{{+}{+}}$ release. $AFB_1$, however, decreased $Ca^{{+}{+}}$ level except collagen-induced $Ca^{{+}{+}}$ release. When the calcium blocker, verapamil, was used, CPA decreased thrombin-induced $Ca^{{+}{+}}$ release and increased collagen, ADP, PAF and A.A.-induced $Ca^{{+}{+}}$ release. $AFB_1$ in contrast decreased the all factors induced $Ca^{{+}{+}}$ release. 3) $AFB_1$ did not induce any ultrastructural changes except large vacuole formation in a few platelets. And CPA also did not induce any changes except moderate shape change, indicator of platelet activation. In conclusion, CPA promoted platelet aggregation by the increases of $Ca^{{+}{+}}$ release but had no changes in A.A. metabolites. Antiaggregating effects of $AFB_1$ may be due to decreases of $Ca^{{+}{+}}$ release and increases of $PGE_2$ and $PGF_{2{\alpha}}$ formation. These data provide the basis for the future study of mobilization and function of $Ca^{{+}{+}}$ in platelet aggregation.

• Laboraroty Animal Research
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• v.33 no.2
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• pp.105-113
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• 2017

insenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, blood flow-improving effects of the dried powder and extract of ARMG were investigated. Rats were orally administered with dried powder (PARMG) or ethanol extract (EARMG) of ARMG (125, 250 or 500 mg/kg) or aspirin (30 mg/kg, a reference control) for 3 weeks. Forty min after the final administration, carotid arterial thrombosis was induced by applying a 70% $FeCl_3$-soaked filter paper outside the arterial wall for 5 min, and the blood flow was monitored with a laser Doppler probe. Both PARMG and EARMG delayed the $FeCl_3$-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at high doses. In mechanism studies, a high concentration of EARMG inhibited platelet aggregation induced by collagen in vitro. In addition, EARMG improved the blood lipid profiles, decreasing triglyceride and cholesterol levels. Although additional action mechanisms remain to be clarified, it is suggested that ARMG containing high amount of ginsenosides such as $Rg_3$ improves blood flow not only by inhibiting oxidative thrombosis, but also by modifying blood lipid profiles.

• Magazine of the Korea Concrete Institute
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• v.4 no.2
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• pp.119-126
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• 1992

고강도 시멘트 복합체의 유동성 손실을 감소시키기 위한 연구의 일환으로 시멘트계 입자에 대한 고성능감수제의 흡착특성, 현탄액 속에서의 응집특성을 관찰하여 시멘트풀과 모르터의 유동성과 관련시켜 고찰하였다. 본 연구결과 알루미네이트계 화합물이 많이 함유된 보통포틀랜드 시멘트의 흡착률이 가장 크며, 시멘트풀 및 모르처의 유동성 손실이 작았으며 나프탈린계 고성능 감수제가 유동성 손실면에서 얼마간 유리하였다.

• The Korean Journal of Blood Transfusion
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• v.29 no.3
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• pp.229-239
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• 2018

The circulatory system is closely related to the inter-relationship between the anatomy of the heart and blood vessels, and the fluid dynamic properties of blood. The physical properties of blood, which affect blood flow, are called hemorheologic factors. Hemorheologic factors, such as blood viscosity and erythrocyte aggregation, are influenced mainly by hematocrit. A higher hematocrit level results in an increase in blood viscosity, erythrocyte aggregation, which impedes the circulation itself, and tissue oxygenation. An excess of serum ferritin causes injury to vascular endothelial cells and erythrocytes via oxygen free radicals. In addition, an excess of blood can aggravatee the adverse effects of the hemorheologic parameters and induce atherogenesis, microcirculatory disturbances, and major cardiovascular events. A preventive and therapeutic approach with a phlebotomy or blood donation has been stimulated by the knowledge that blood loss, such as regular donations, is associated with significant decreases in key hemorheologic variables, including blood viscosity, erythrocyte aggregation, hematocrit, and fibrinogen. Major cardiovascular events have been improved in regular blood donors by improving blood flow and microcirculation by decreasing the level of oxidative stress, improving the hemorheologic parameters, and reducing the serum ferritin level. Confirmation of the positive preventive and therapeutic effects of blood donations on cardiovascular disease by a well-designed and well-controlled Cohort study may be good news to patients with cardiovascular disease or at risk of these diseases, as well as patients who require a transfusion.