• Journal of Microbiology and Biotechnology
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• 제24권1호
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• pp.119-126
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• 2014

Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disorder that primarily affects the flexible joints and may also affect a number of tissues and organs. The progression of RA involves an inflammatory response of the capsule around the joint, swelling of synovial cells with excess synovial fluid (SF), and the development of fibrous tissue in the synovium. Since the progressive pathology of the disease often leads to the irreversible destruction of articular cartilage and ankylosis of the joint, early diagnosis of RA is essential. Thus, we undertook a comparative proteomic approach to investigate novel biomarkers for early diagnosis using SFs and serums from RA patients. As a result, we identified 32 differentially expressed spots in SFs and 34 spots in serums. The differential expression of the STEAP4 and ZNF 658 proteins were validated using immunoblotting of the SFs and serums, respectively. These data suggest that differentially expressed proteins in SFs and serums could be used as RA-specific biomarkers for the diagnosis and monitoring of RA. Furthermore, these findings advance our understanding of the molecular etiopathogenesis of RA.

• 마이크로전자및패키징학회지
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• 제14권4호
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• pp.79-85
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• 2007

본 연구의 목적은 OSP, 전해 Au과 무전해 Ni/Au로써 표면처리를 달리한 연성회로기판 상에 Au 스터드 플립칩 범프의 초음파 접합 가능성을 연구하는 것이었다. Au 스터드 범프는 표면처리 방법에 상관없이 성공적으로 연성회로기판의 패드 상에 초음파 접합되었다 접합 강도는 접합 시간에 민감하게 영향을 받았다. 접합 시간이 길어짐에 따라 접합 강도는 증가하였으나, 2초 이상의 접합 시간에서는 이웃 범프끼리 단락되는 bridge 현상이 발생하였다. 최적 접합조건은 OSP 처리된 가판상에 0.5초간 초음파 접합하는 것이었다.

• 한국구조물진단유지관리공학회 논문집
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• 제28권3호
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• pp.91-99
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• 2024

배관시스템은 다양한 산업 분야에서 이용되는 중요한 설비이며 생활 및 안전과 관련된 영역에서 사용되고 있다. 배관시스템은 건축물 및 시설의 주요 구조부에 고정되어 있으나 외부 하중을 지지하지 않으며 주어진 고유기능을 수행하는 비구조요소이다. 지진하중으로 인한 배관시스템은 두 지지점 사이의 서로 다른 거동으로 발생하는 위상차로 인한 상대 변위의 영향을 받으며 변위 지배적인 반복거동 때문에 손상이 발생할 가능성이 있다. 배관시스템에서 피팅과 조인트는 지진하중에 취약한 대표적인 요소이다. 배관시스템의 피팅과 조인트에 대한 내진성능과 한계상태를 평가하고자 한다면 상대변위를 모사하기 위한 높은 스트로크를 가지는 엑츄에이터가 필요하나 실험을 수행할 수 있는 설비가 많지 않아 어려움이 있다. 따라서 피팅과 조인트로 연결된 배관시스템의 내진성능과 한계상태를 평가하기 위해서는 요소 단위의 실험이 필요하다. 이 연구에서는 수직배관시스템에서 지진하중에 취약한 요소인 피팅과 조인트를 포함하는 엘보 시험체에 대하여 내진성능을 평가하는 방법을 제시하였다. 엘보 시험체는 90° 배관 엘보의 양단에 직관부를 유동식 그루브 조인트를 이용하여 연결하였다. 엘보 시험체에 대하여 변형각에 기반을 둔 주기하중 프로토콜을 이용하여 내진성능을 평가하였다. 평가된 내진성능에 대한 여유도를 확인하기 위하여 일정한 진폭에 대한 주기하중을 적용하여 한계상태를 평가하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제7권5호
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• pp.1058-1076
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• 2013

The WBAN(Wireless Body Area Network) supplies mobile convenience to our medical services. But if we have few effective control variables across this service deployment, the hidden distortions or defects of the system might threaten the lives and rights of the stakeholders. Therefore we need to increase the service credibility, to get WBAN effective. This study proposes a governance mechanism using feasible variables that are currently in use in practices in WBAN environments against medical incidents. Control variables were tested in Seoul National University hospital and related medical industries of South Korea. We assume that WBAN systems would be open based on integrating patients, medical employees and law enforcements to get smart theater operations against medical incidents by implementing proposed MJA(Multilateral Joint Analysis) model. MJA model also contributes to the convergence of computer systems and medical services by demonstrating flexible SOA(Service Oriented Architecture) dashboard of healthcare services with credibility factors in medicine. The important components in MJA model across WBAN, were found to be "Safety, Accuracy and Reliability" in priority order. Factor analysis, correlations and ANOVA were used to evaluate this model and an IT dashboard with a realization of mobile application, was used to support participants' decision-making.

• 대한기계학회논문집A
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• 제25권12호
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• pp.2030-2039
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• 2001

Recently, various inpipe inspection robots are developed and its effective values are increased in industrial use. However, it is so difficult to make a inpipe inspection robot system which has flexible mobility and accuracy of inspection in pipelines. Especially, it is very important to know the exact crack position. In this paper, we are to present a lately developed inpipe inspection robot system which can resolve the above Problems. The robot is configured as an articulated structure like a snake. Two active driving vehicles are located in front and rear of the inspection robot respectively and passive modules such as a nondestructive testing module and a control module are chained between the active vehicles. Special feature of the robot system is a ground interface, which is able to show informations of robot and pipelines. By using this, so called virtual map in this paper, user is able to know the pipelines'feature and crack position.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2008년도 한국우주과학회보 제17권2호
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• pp.37.1-37.1
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• 2008

Space Science and Technology Laboratory at Kyung Hee University developed an 80cm Nasmyth telescope with the joint work of Space & Astronomy, Inc. It was set up at Muju county public astronomical observatory in Jeonlabuk-Do. Nasmyth focus system was selected for the telescope to use two focal points by a rotatable tertiary mirror. Focal ratios of the telescope are f10, f5 respectively. Support of the main mirror is made with Lasalle-system. This system uses 24-points in the back side of the mirror that are all resting on small counter-weights and side support is 10-points Boll link Flexible type with 2 Lasalle type. The mount is wheel & disk type Alt-Azimuth design using DC-servo motors. External high accuracy encoder has 47,600 sine-waves/rot. These encoders are used to make real-time corrections on all gearing errors.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 A
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• pp.420-421
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• 2006

The cost-effective reduction of greenhouse gas(GHG) emission to avert the most severe impacts of climate change remains one of the widely accepted priorities for global action. In order to facilitate cost-effective abatement strategies, the Kyoto Protocol introduced three mechanisms, or flexible instruments, the Emissions Trading(ET), the Joint Implementation(JI) and the Clean Development Mechanism(CDM). The CDM enables Annex I countries to the Kyoto Protocol to partially meet cost-effectively their emission reduction commitments by undertaking GHG mitigation Projects in developing countries, which do not have any GHG abatement obligations and where the emission reductions are cheaper. One of the major barriers hampering the wide spread implementation of CDM is the high transaction costs associated with the initial identification of promising CDM projects. This paper presents development of a pre-validation program of CDM. The developed program may provide a useful aid to potential investors and project developers as a supportive pre-evaluation tool, and may become an effective tool for the promotion of renewable energy and fuel switching projects.

• 한국지능시스템학회논문지
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• 제15권2호
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• pp.185-190
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• 2005

본 논문은 파리미터의 불확실성을 포함하는 Takagi-Sugeno(T-S) 퍼지 시스템을 위한 체계적인 출력 추종 제어기 설계기법을 제안한다. 불확실 T-S 퍼지 시스템은 효과적인 설계를 위하여 퍼지 입력 공간의 발화도의 우세성에 따르는 몇 개의 불확실 선형 시스템으로 표현된다. 출력 추종 제어 오차는 일반화된 리아푸노프 함수에 의하여 해석된다. 이에 따라 출력 추종 제어기 설계 문제는 몇 개의 불확실 선형 시스템의 안정화 문제로 변환된다. 강인 추종 제어기 설계 조건은 선형행렬 부등식의 형태로 유도된다. 마지막으로 파라미터 불확실성을 포함하는 혼돈 로렌Cm 카오스 시스템의 출력 추종 문제를 고려하여 본 논문에서 제안한 기법의 효용성을 입증한다.

• Wind and Structures
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• 제27권3호
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• pp.175-186
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• 2018

With the continuous increase of span lengths, modern bridges are becoming much more flexible and more prone to flutter under wind excitations. A reasonable probabilistic flutter analysis of long-span bridges involving random and uncertain variables may have to be taken into consideration. This paper presents a method for estimating the reliability index and failure probability due to flutter, which considers the very important variables including the extreme wind velocity at bridge site, damping ratio, mathematical modeling, and flutter derivatives. The Aizhai Bridge in China is selected as an example to demonstrate the numerical procedure for the flutter reliability analysis. In the presented method, the joint probability density function of wind speed and wind direction at the deck level of the bridge is first established. Then, based on the fundamental theories of structural reliability, the reliability index and failure probability due to flutter of the Aizhai Bridge is investigated by applying the Monte Carlo method and the first order reliability method (FORM). The probabilistic flutter analysis can provide a guideline in the design of long-span bridges and the results show that the structural damping and flutter derivatives have significant effects on the flutter reliability, more accurate and reliable data of which is needed.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1996년도 추계학술대회 논문집
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• pp.759-763
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• 1996

This paper presents a new approach to the design of neural control system using digital signal processors in order to improve the precision and robustness. Robotic manipulators have become increasingly important in the field of flexible automation. High speed and high-precision trajectory tracking are indispensable capabilities for their versatile application. The need to meet demanding control requirement in increasingly complex dynamical control systems under significant uncertainties, leads toward design of intelligent manipulation robots. The TMS320C31 is used in implementing real time neural control to provide an enhanced motion control for robotic manipulators. In this control scheme, the networks introduced are neural nets with dynamic neurons, whose dynamics are distributed over all the network nodes. The nets are trained by the distributed dynamic back propagation algorithm. The proposed neural network control scheme is simple in structure, fast in computation, and suitable for implementation of real-time control. Performance of the neural controller is illustrated by simulation and experimental results for a SCARA robot.