• Journal of Microbiology and Biotechnology
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• v.24 no.1
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• pp.119-126
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• 2014

Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disorder that primarily affects the flexible joints and may also affect a number of tissues and organs. The progression of RA involves an inflammatory response of the capsule around the joint, swelling of synovial cells with excess synovial fluid (SF), and the development of fibrous tissue in the synovium. Since the progressive pathology of the disease often leads to the irreversible destruction of articular cartilage and ankylosis of the joint, early diagnosis of RA is essential. Thus, we undertook a comparative proteomic approach to investigate novel biomarkers for early diagnosis using SFs and serums from RA patients. As a result, we identified 32 differentially expressed spots in SFs and 34 spots in serums. The differential expression of the STEAP4 and ZNF 658 proteins were validated using immunoblotting of the SFs and serums, respectively. These data suggest that differentially expressed proteins in SFs and serums could be used as RA-specific biomarkers for the diagnosis and monitoring of RA. Furthermore, these findings advance our understanding of the molecular etiopathogenesis of RA.

• Journal of the Microelectronics and Packaging Society
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• v.14 no.4
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• pp.79-85
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• 2007

This study was focused on the feasibility of ultrasonic bonding of Au stud flip chip bumps on the flexible printed circuit board (FPCB) with three different surface finishes: organic solderability preservative (OSP), electroplated Au and electroless Ni/immersion Au (ENIG). The Au stud flip chip bumps were successfully bonded to the bonding pads of the FPCBs, irrespective of surface finish. The bonding time strongly affected the joint integrity. The shear force increased with increasing bonding time, but the 'bridge' problem between bumps occurred at a bonding time over 2 s. The optimum condition was the ultrasonic bonding on the OSP-finished FPCB for 0.5 s.

• Journal of the Korea institute for structural maintenance and inspection
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• v.28 no.3
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• pp.91-99
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• 2024

Piping systems are crucial facilities used in various industries, particularly in areas related to daily life and safety. Piping systems are fixed to the main structures of buildings and facilities but do not support external loads and serve as non-structural elements performing specific functions. Piping systems are affected by relative displacements owing to phase differences arising from different behaviors between two support points under seismic loads; this can cause damage owing to the displacement-dominant cyclic behavior. Fittings and joints in piping systems are representative elements that are vulnerable to seismic loads. To evaluate the seismic performance and limit states of fittings and joints in piping systems, a high-stroke actuator is required to simulate relative displacements. However, this is challenging because only few facilities can conduct these experiments. Therefore, element-level experiments are required to evaluate the seismic performance and limit states of piping systems connected by fittings and joints. This study proposed a method to evaluate the seismic performance of an elbow specimen that includes fittings and joints that are vulnerable to seismic loads in vertical piping systems. The elbow specimen was created by connecting straight pipes to both ends of a 90° pipe elbow using flexible groove joints. The seismic performance of the elbow specimen was evaluated using a cyclic loading protocol based on deformation angles. To determine the margin of the evaluated seismic performance, the limit states were assessed by applying cyclic loading with a constant amplitude.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.5
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• pp.1058-1076
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• 2013

The WBAN(Wireless Body Area Network) supplies mobile convenience to our medical services. But if we have few effective control variables across this service deployment, the hidden distortions or defects of the system might threaten the lives and rights of the stakeholders. Therefore we need to increase the service credibility, to get WBAN effective. This study proposes a governance mechanism using feasible variables that are currently in use in practices in WBAN environments against medical incidents. Control variables were tested in Seoul National University hospital and related medical industries of South Korea. We assume that WBAN systems would be open based on integrating patients, medical employees and law enforcements to get smart theater operations against medical incidents by implementing proposed MJA(Multilateral Joint Analysis) model. MJA model also contributes to the convergence of computer systems and medical services by demonstrating flexible SOA(Service Oriented Architecture) dashboard of healthcare services with credibility factors in medicine. The important components in MJA model across WBAN, were found to be "Safety, Accuracy and Reliability" in priority order. Factor analysis, correlations and ANOVA were used to evaluate this model and an IT dashboard with a realization of mobile application, was used to support participants' decision-making.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.12
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• pp.2030-2039
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• 2001

Recently, various inpipe inspection robots are developed and its effective values are increased in industrial use. However, it is so difficult to make a inpipe inspection robot system which has flexible mobility and accuracy of inspection in pipelines. Especially, it is very important to know the exact crack position. In this paper, we are to present a lately developed inpipe inspection robot system which can resolve the above Problems. The robot is configured as an articulated structure like a snake. Two active driving vehicles are located in front and rear of the inspection robot respectively and passive modules such as a nondestructive testing module and a control module are chained between the active vehicles. Special feature of the robot system is a ground interface, which is able to show informations of robot and pipelines. By using this, so called virtual map in this paper, user is able to know the pipelines'feature and crack position.

• Bulletin of the Korean Space Science Society
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• 2008.10a
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• pp.37.1-37.1
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• 2008

Space Science and Technology Laboratory at Kyung Hee University developed an 80cm Nasmyth telescope with the joint work of Space & Astronomy, Inc. It was set up at Muju county public astronomical observatory in Jeonlabuk-Do. Nasmyth focus system was selected for the telescope to use two focal points by a rotatable tertiary mirror. Focal ratios of the telescope are f10, f5 respectively. Support of the main mirror is made with Lasalle-system. This system uses 24-points in the back side of the mirror that are all resting on small counter-weights and side support is 10-points Boll link Flexible type with 2 Lasalle type. The mount is wheel & disk type Alt-Azimuth design using DC-servo motors. External high accuracy encoder has 47,600 sine-waves/rot. These encoders are used to make real-time corrections on all gearing errors.

• Proceedings of the KIEE Conference
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• 2006.07a
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• pp.420-421
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• 2006

The cost-effective reduction of greenhouse gas(GHG) emission to avert the most severe impacts of climate change remains one of the widely accepted priorities for global action. In order to facilitate cost-effective abatement strategies, the Kyoto Protocol introduced three mechanisms, or flexible instruments, the Emissions Trading(ET), the Joint Implementation(JI) and the Clean Development Mechanism(CDM). The CDM enables Annex I countries to the Kyoto Protocol to partially meet cost-effectively their emission reduction commitments by undertaking GHG mitigation Projects in developing countries, which do not have any GHG abatement obligations and where the emission reductions are cheaper. One of the major barriers hampering the wide spread implementation of CDM is the high transaction costs associated with the initial identification of promising CDM projects. This paper presents development of a pre-validation program of CDM. The developed program may provide a useful aid to potential investors and project developers as a supportive pre-evaluation tool, and may become an effective tool for the promotion of renewable energy and fuel switching projects.

• Journal of the Korean Institute of Intelligent Systems
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• v.15 no.2
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• pp.185-190
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• 2005

A systematic output tracking control design technique for robust control of Takagi-Sugeno (T-S) fuzzy systems with norm bounded uncertainties is developed. The uncertain T-S fuzzy system is first represented as a set of uncertain local linear systems. The tracking problem is then converted into the stabilization problem for a set of uncertain local linear systems thereby leading to a more feasible controller design procedure. A sufficient condition for robust asymptotic output tracking is derived in terms of a set of linear matrix inequalities. A stability condition on the traversing time instances is also established. The output tracking control simulation for a flexible-joint robot-arm model is demonstrated, to convincingly show the effectiveness of the proposed system modeling and controller design.

• Wind and Structures
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• v.27 no.3
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• pp.175-186
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• 2018

With the continuous increase of span lengths, modern bridges are becoming much more flexible and more prone to flutter under wind excitations. A reasonable probabilistic flutter analysis of long-span bridges involving random and uncertain variables may have to be taken into consideration. This paper presents a method for estimating the reliability index and failure probability due to flutter, which considers the very important variables including the extreme wind velocity at bridge site, damping ratio, mathematical modeling, and flutter derivatives. The Aizhai Bridge in China is selected as an example to demonstrate the numerical procedure for the flutter reliability analysis. In the presented method, the joint probability density function of wind speed and wind direction at the deck level of the bridge is first established. Then, based on the fundamental theories of structural reliability, the reliability index and failure probability due to flutter of the Aizhai Bridge is investigated by applying the Monte Carlo method and the first order reliability method (FORM). The probabilistic flutter analysis can provide a guideline in the design of long-span bridges and the results show that the structural damping and flutter derivatives have significant effects on the flutter reliability, more accurate and reliable data of which is needed.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1996.11a
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• pp.759-763
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• 1996

This paper presents a new approach to the design of neural control system using digital signal processors in order to improve the precision and robustness. Robotic manipulators have become increasingly important in the field of flexible automation. High speed and high-precision trajectory tracking are indispensable capabilities for their versatile application. The need to meet demanding control requirement in increasingly complex dynamical control systems under significant uncertainties, leads toward design of intelligent manipulation robots. The TMS320C31 is used in implementing real time neural control to provide an enhanced motion control for robotic manipulators. In this control scheme, the networks introduced are neural nets with dynamic neurons, whose dynamics are distributed over all the network nodes. The nets are trained by the distributed dynamic back propagation algorithm. The proposed neural network control scheme is simple in structure, fast in computation, and suitable for implementation of real-time control. Performance of the neural controller is illustrated by simulation and experimental results for a SCARA robot.