• 대한피부과학회지
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• 제56권9호
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• pp.548-551
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• 2018

Biologics are the most advanced treatment for psoriasis. Ustekinumab, one of the biologics for psoriasis, is a human monoclonal antibody that binds to the p40 subunit of interleukin-12 and interleukin-23. A 41-year-old woman with a 17-year history of plaque psoriasis and psoriatic arthritis presented with worsening lesions. The patient had previously been treated with a number of topical and systemic medications and narrow band ultraviolet B. However, none of the treatments consistently controlled her disease. Thus, treatment with ustekinumab 45 mg via subcutaneous injection was initiated. Approximately 7 days after the first treatment, she experienced a flare with generalized pustules in her whole body. The condition was controlled with systemic steroid treatment. The patient was subsequently treated with adalimumab, and improvement in her plaque and pustular lesions was noted. Herein, we report a case of psoriasis that flared up after ustekinumab therapy, which was accompanied by a morphological change from plaque to pustular lesions.

• 대한조선학회지
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• 제27권3호
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• pp.56-72
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• 1990

본 논문에서는 유체동력학적면에서 선수 플레어 충격에 대하여 고찰하고, 특히 전형적인 플레어 충격하중 계산에서 사용된 가정에 대하여 검토한다. 압력이 작용하지 않는 자유표면 경계조건에 의한 계산결과들이 제시된다. 이 단순화된 경계조건을 사용하면 물이 제트처럼 올라오는 현상이나 평균자유표면 위의 젖은 부분과 같은 중요한 인자를 무시하게 되지만, 계산할 때는 아주 단순하다는 장점을 갖는다. 3차원 계산결과와 2차원 계산 결과를 실험과 비교하였으며, 근사 자유 표면 조건으로부터 발생하는 오차를 검토 하였다. 또, 2차원 및 3차원 해석에서 연직 굽힘 모멘트와 연직 전단력도 포함되었다.

• Journal of Medicine and Life Science
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• 제20권2호
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• pp.89-93
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• 2023

We present three cases of patients with breast cancer and psoriasis who received radiotherapy following breast-conserving surgery. One patient developed an extensive flare-up of psoriasis during chemotherapy. After discontinuing chemotherapy, she received conventional radiotherapy to the ipsilateral whole breast, axillary, and supraclavicular lymph nodes with 50.4 Gy in 28 fractions and boosted with 10 Gy in five fractions to the tumor bed. Two patients received hypofractionated whole-breast radiotherapy at a total dose of 40.05-42.4 Gy in 15-16 fractions. In all three cases, there was no flare-up of psoriatic events at least 6 months after the completion of radiotherapy. We hypothesized that there is a close relationship between psoriatic events and the extent of trauma rather than the daily dose of the fraction. Therefore, we confirmed that the effect of radiotherapy on psoriatic events is minimal if the radiation field size does not exceed that of the whole breast.

• Clinical and Experimental Reproductive Medicine
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• 제32권3호
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• pp.261-268
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• 2005

Objective: To compare the clinical results and pregnancy outcomes of in vitro fertilization (IVF) between GnRH antagonist cycles and GnRH agonist (GnRH-a) cycles including flare-up and long protocol in women with advanced age. Materials and Methods: Retrospective clinical study. From January 2001 to September 2003, IVF cycles of female patient 37 years over were included in this study. GnRH-a long protocol (62 cycles, 61 patients) and GnRH antagonist multi-dose flexible protocol (66 cycles, 51 patients) were compared with the control group of GnRH-a flare-up protocol (151 cycles, 138 patients). IVF cycles for non-obstructive azoospermia (NOA), endometriosis III, IV and polycystic ovarian syndrome (PCOS) were excluded in this study. Clinical results such as total gonadotropin dose, serum E2 on hCG administration, the number of retrieved oocytes and the pregnancy outcomes - clinical pregnancy rate (CPR), implantation rate (IR) and live birth rate (LBR) per embryo transfer - were compared. Results: There were significant differences in the total dose of gonadotropin (GnRH-a flare-up vs. GnRH-a long vs. GnRH-antagonist; 41.8 vs. 54.7 vs. 24.8), serum E2 on hCG administration (1787.2 vs. 1881.6 vs. 788.0), the numbers of retrieved oocytes (8.1 vs. 11.1 vs. 4.5) and endometrial thickness (9.1 vs. 10.4 vs. 8.0) which were significantly lower in GnRH-antagonist cycles. But pregnancy outcomes shows no significant differenced in CPR (25.0% vs. 35.8% vs. 24.5%), IR (11.7% vs. 12.3% vs. 10.1%) and LBR (15.8% vs. 28.3% vs. 15.1%) Conclusion: In women with advanced age, GnRH-antagonist cycles can result in comparable pregnancy outcomes to GnRH-a cycles including flare-up and long protocol. GnRH-a long protocol show higher CPR, IR and LBR than GnRH antagonist multi-dose flexible protocol and flare-up protocol without significant differences.

• 천문학회지
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• 제48권5호
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• pp.257-265
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• 2015

We present results of long-term multi-wavelength polarization observations of the powerful blazar 3C 279 after its γ-ray flare on 2013 December 20. We followed up this flare with single-dish polarization observations using two 21-m telescopes of the Korean VLBI Network. Observations carried out weekly from 2013 December 25 to 2015 January 11, at 22 GHz, 43 GHz, 86 GHz simultaneously, as part of the Monitoring Of GAmma-ray Bright AGN (MOGABA) program. We measured 3C 279 total flux densities of 22–34 Jy at 22 GHz, 15–28 Jy (43 GHz), and 10–21 Jy (86 GHz), showing mild variability of ≤ 50 % over the period of our observations. The spectral index between 22 GHz and 86 GHz ranged from −0.13 to −0.36. Linear polarization angles were 27°–38°, 30°–42°, and 33°–50° at 22 GHz, 43 GHz, and 86 GHz, respectively. The degree of linear polarization was in the range of 6–12 %, and slightly decreased with time at all frequencies. We investigated Faraday rotation and depolarization of the polarized emission at 22–86 GHz, and found Faraday rotation measures (RM) of −300 to −1200 rad m⁻² between 22 GHz and 43 GHz, and −800 to −5100 rad m⁻² between 43 GHz and 86 GHz. The RM values follow a power law with a mean power law index a of 2.2, implying that the polarized emission at these frequencies travels through a Faraday screen in or near the jet. We conclude that the regions emitting polarized radio emission may be different from the region responsible for the 2013 December γ-ray flare and are maintained by the dominant magnetic field perpendicular to the direction of the radio jet at milliarcsecond scales.

• 천문학회보
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• 제41권1호
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• pp.65.1-65.1
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• 2016

We present results of long-term multi-wavelength polarization observations of the powerful blazar 3C 279 after its ${\gamma}$-ray flare on 2013 December 20. We followed up this flare by means of single-dish polarization observations with two 21-m telescopes of the Korean VLBI Network, carried out weekly from 2013 December 25 to January 11, and at 22, 43, and 86 GHz, simultaneously. These observations were part of the Monitoring Of GAmma-ray Bright AGNs (MOGABA) program. We Measured 3C 279 total flux densities at 22, 43, and 86 GHz, showing a mild variability of a factor of ${\leq}50%$ over the period of our observations. The spectral index ranged from -0.13 to -0.36 at between 22 and 86 GHz. The degree of linear polarization was in the range of 6 ~ 12 %, and slightly decreased with time at all frequencies. We found Faraday rotation measures (RM) of -300 to $-1200rad\;m^{-2}$ between 22 and 43 GHz, and -800 to $-5100rad\;m^{-2}$ between 43 and 86 GHz. The RM values follow a power law ${\mid}RM{\mid}{\propto}{\nu}^{\alpha}$, with a mean ${\alpha}$ of 2.2, implying that the polarized emission at these frequencies travels through a Faraday screen in or near the jet. We conclude that the regions emitting polarized radio emission may be different from the region responsible for the 2013 December ${\gamma}$-ray flare, and that these regions are maintained by the dominant magnetic field perpendicular to the direction of the radio jet at milliarcsecond scales.

• 한국에너지공학회:학술대회논문집
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• 한국에너지공학회 1996년도 춘계학술발표회 초록집
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• pp.65-70
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• 1996

본 연구는 상용공정해석용 프로그램으로서 고체 반응물을 포함하고 있는 공정을 해석할 수 있는 ASPEN(Advanced System for Process Engineering) 코드를 이용하여 IGCC BSU 실험플랜트를 모사하고 실제 실험 결과와 비교하였으며, IGCC BSU 시스템을 수정보완하여 가스정화공정을 도입하고 석탄가스화기에서 생성된 생성가스에 대해 발전 연료로서의 타당성 및 적합성 여부를 살펴보고 이 자료를 토대로 향후 IGCC 플랜트의 scale-up 및 실용플랜트에 대한 이해를 도모코자 한다. 또한 환경적인 측면에서 IGCC BSU에서 방출되는 슬랙, 비산재 및 flare stack을 통한 SOx 및 NOx 등의 방출량을 살펴보았다.

• 천문학논총
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• 제11권1호
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• pp.243-250
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• 1996

Data acquisition system mounted on the Solar Flare Telescope at Bohyunsan Optical Astronomy Observatory is briefly described. The system is made up with CCD cameras, an image processor, a PCI-type PC and a SUN workstation. The image processor, MVC 150/40 comprises a variable scan acquisition module, an image manager and a binary correlator computational module. A typical polarization image of a sunspot is presented to demonstrate performance of the system.

• 수산해양기술연구
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• 제19권2호
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• pp.117-124
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• 1983

정면규칙파중에서 Bow-flare부 충격은 선저충격에 비해서 작용 시간이 길고, 선체 수직운동진폭이 큰 상태이거나, 파고가 큰 입사파가 적용되는 경우에 선체에 작용하는 충격력은 상당히 크며, 파고가 높아지면, 발생하는 모우멘트도 증가한다. 2. Bow-flare부가 큰 선형의 경우에는 선저노출이 일어나지 않더라도 부가질량의 급격한 증가에 따라 상당히 큰 충격력이 작용한다. 3. Deckwetness, 불규칙파중에서의 응답해석, 상대변위를 구할 때 Dynamic Swell-up의 양을 고려한 계산 등의 검토가 요망된다.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2010년도 춘계학술대회 초록집
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• pp.112.1-112.1
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• 2010

To develop domestic IGCC gasification technology, a gasification test bed with a capacity of 20 tons/day has been designed. The main components of the test bed designed are a coal pulverizing and feeding facility, a gasifier, a syngas cooler, a gas treatment unit, oxygen and nitrogen tanks, and flare stack. For wide applications to the development of advanced coal gasification technology, many special functions have been given to it such as syngas recirculation, char recirculation, and multiple stage gasification. The test bed will be used for testing the characteristics of various types of coals, deriving optimum conditions for efficient gasifier operation and trouble shooting for the Korea IGCC demonstration plant. It will also be applied as a useful tool to develop scale-up design technology of IGCC and proceed to commercialization.