• Title/Summary/Keyword: Five-Factor Model

검색결과 558건 처리시간 0.032초

소아 및 청소년 비만증에서 인슐린 저항성에 미치는 요인 (Affecting Factors of Insulin Resistance in Obese Children and Adolescents)

  • 김덕희;은호선;최인경;김호성;차봉수;김동기
    • Clinical and Experimental Pediatrics
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    • 제48권10호
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    • pp.1076-1081
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    • 2005
  • 목 적 : 인슐린 저항성은 소아 및 청소년 비만증에서 내당능 장애, 당뇨병증, 심혈관계질환을 일으키는 중요한 위험요인 중 하나로 알려져 있다. 따라서 이 연구의 목적은 비만증 청소년이 소아에 비해 인슐린저항성이 증가하는가 그리고 성별에 따른 차이점을 규명하며 인슐린저항성에 영향을 미치는 요인들을 분석하고자 한다. 방 법 : 5-16세의 학생 9,837명을 신체검사하여 92명의 비만증 소아와 187명의 비만증 청소년을 선별하였고, 이들을 대상으로 당부하검사, 공복상태의 혈당, 인슐린농도, 총콜레스테롤, LDL-콜레스테롤, HDL-콜레스테롤, 중성지방의 농도, leptin, hs-CRP 및 adiponectin 농도를 측정하였다. 결 과 : 당부하검사를 통한 비만증 소아 및 청소년에서 성별에 따른 인슐린의 농도는 여자에서 인슐린의 농도가 높았다(P<0.05). 비만증 소아에서 4명(4.3%), 비만증 청소년에서 25명(13.3%)에서 내당능 장애로 나타났으며, 당뇨병으로 진단된 경우는 1례도 없었다. 인슐린 저항성은 여자, leptin, adiponectin, 중성지방의 농도와 밀접한 상관관계가 있었다(P<0.05). 결 론 : 비만증에서 인슐린 저항성은 소아보다 청소년에서 컸으며, 남자보다 여자에서 컸다. 또한 leptin 및 중성지방의 농도가 높을수록, adiponectin의 농도가 낮을수록 인슐린 저항성이 컸다. 소아 및 청소년 비만증에서 인슐린 저항성에 미치는 요인들에 관하여 좀 더 많은 연구가 필요하다.

Assessment of Relationship between Fyn-related Kinase Gene Polymorphisms and Overweight/Obesity in Korean Population

  • Jung, Mi-Young;Kim, Bum-Shik;Kim, Youn-Jung;Koh, In-Song;Chung, Joo-Ho
    • The Korean Journal of Physiology and Pharmacology
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    • 제12권2호
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    • pp.83-87
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    • 2008
  • The fyn-related kinase (FRK) belongs to the tyrosine kinase family of protein kinases. Recent studies have shown that Frk affects pancreatic beta cell number during embryogenesis and promotes beta cell cytotoxic signals in response to streptozotocin. To investigate the genetic association between FRK polymorphisms and the risk of obesity in Korean population, single nucleotide polymorphisms (SNPs) in the FRK gene region were selected and analyzed. The body mass index (BMI) was calculated, and biochemical data (systolic blood pressure, diastolic blood pressure, hemoglobin A1C, triglyceride, total cholesterol, high density lipoprotein, and low density lipoprotein) of blood sample from each subject were also measured. One hundred fifty five healthy control and 204 overweight/obesity subjects were recruited. Genotype frequencies of six SNPs [rs6568920 (+8391G>A), rs3756772 (+56780A>G), rs3798234 (+75687C>T), rs9384970 (+68506G>A), rs1933739 (+72978G>A), and rs9400883 (+75809A>G)] in the FRK gene were determined by Affymetrix Targeted Genotyping Chip data. According to the classification of Korean Society for the Study of Obesity, control (BMI 18 to < 23) and overweight/obesity (BMI$\geq$23) subjects were recruited. For the analysis of genetic data, EM algorithm, SNPStats, Haploview, HapAnalyzer, SNPAnalyzer, and Helixtree programs were used. Multiple logistic regression analysis (codominant, dominant, and recessive models) was performed. Age and gender as covariates were adjusted. For biochemical data, Student's t test was used. The mean value of BMI in the control and overweigh/obesity groups was 21.1${\pm}$1.2 (mean${\pm}$SD) and 25.6${\pm}$2.0, respectively. All biochemical data of the overweight/obesity group were statistically significance, compared with the control group. Among six SNPs, two linkage disequilibrium (LD) blocks were discovered. One block consisted of rs1933739 and rs9400883, and the other comprised rs3756772 and rs3798234. One SNP (rs9384970, +68506G>A) showed an association with overweight/obesity in the codominant model (p=0.03). Interestingly, the AA genotype distribution in the overweight/obesity group (n=7, 3.5%) was higher than those in the control group (n=1, 0.6%), which is not found in either Japanese or Chinese subjects. Therefore, the AA genotype of rs9384970 may be a risk factor for development of obesity in Korean population. The results suggest that FRK may be associated with overweight/obesity in Korean population.

Korean Customer Attitudes Towards SNS Shopping

  • Cho, Young-Sang;Heo, Jeong-Yoon;Youn, Myoung-Kil
    • 유통과학연구
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    • 제10권8호
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    • pp.7-14
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    • 2012
  • As a new format of retailing, social shopping on SNS has rapidly grown in recent. Although there is much literature associated with customer behaviours in the academic world, little attention has been paid to identifying the shopping patterns of SNS shoppers. This paper will, thus, identify how perceived value has an impact on the buying intention of SNS shoppers, after illustrating what kind of factor influences the formation process of perceived value in the Korean marketplace. Given that SNS shoppers are for the most part 20s as well as 30s, the authors handed out questionnaires to them. Furthermore, based on literature review results, the conceptualised research model was developed. Despite lack of literature, the authors developed five constructs like price reduction, quantity- and time-limited message, product ranges, information-sharing, and required number of shoppers. The researchers made a considerable effort to identify the relationship between research concepts and each variable, based on a few research analysis methods such as frequency analysis, the Varimax rotation technique used orthogonal rotation, Cronbach's Alpha, PCA (Principle Component Analysis), and the like. Amongst the 5 variables used to measure the degree of influences on the perceived value as a social shopping characteristic, it has been evident that price cut, required minimum shoppers, product variety, and information-sharing have a positive impact on the perceived value formation processes of SNS customers. Also, this research implies that SNS retailers can differentiate themselves from other retailers by differently using the above factors. From a practitioner's point of view, these factors should be strategically used to increase the social shopping opportunities of SNS users. It is, furthermore, evident that the perceived value formed by the above 4 factors have played an important role in the buying decision process of SNS customers. In a sense, whether customers are aware of higher price cut rates, information-sharing, required minimum shoppers, and product variety has a positive impact on making buying decisions. From a retailer's point of view, online shopping mall operators are able to use blog as well as twitter to improve the buying intention as a marketing tool of social network, because the business activities provided by social shopping retailers, like the rapid, accurate responses to customer requirements, the provision of a variety of information, and the communications between customers are closely related to buying intentions. There are a few research limitations to conduct this empirical research. It was not easy to review prior papers, due to its lack. In spite of the increasing number of SNS shoppers in Korea, little research attention has been paid to this kind of research topic by academicians, because buying products or services through SNS is in its infancy. With regard to research populations, it would be difficult to generalise the research findings in Korea, owing to unbalanced respondent distribution. Considering the above research limitations as well as the growth of social shopping, many authors should pay considerable attention to SNS-related issues in the future, and develop the more sophisticated criteria to measure the characteristics of SNS shoppers.

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Reduction of Intestinal Polyp Formation in Min Mice Fed a High-Fat Diet with Aloe Vera Gel Extract

  • Chihara, Takeshi;Shimpo, Kan;Beppu, Hidehiko;Tomatsu, Akiko;Kaneko, Takaaki;Tanaka, Miyuki;Yamada, Muneo;Abe, Fumiaki;Sonoda, Shigeru
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권7호
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    • pp.4435-4440
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    • 2013
  • Aloe vera gel supercritical $CO_2$ extract (AVGE) has been shown to contain five phytosterols, reduce visceral fat accumulation, and influence the metabolism of glucose and lipids in animal model experiments. Recent epidemiologic studies have shown that obesity is an established risk factor for several cancers including colorectal cancer. Therefore, we examined the effects of AVGE on intestinal polyp formation in Apc-deficient Min mice fed a high-fat diet. Male Min mice were divided into normal diet (ND), high fat diet (HFD), low dose AVGE (HFD+LAVGE) and high dose AVGE (HFD+HAVGE) groups. The ND group received AIN-93G diet and the latter 3 groups were given modified high-fat AIN-93G diet (HFD) for 7 weeks. AVGE was suspended in 0.5% carboxymethyl cellulose (CMC) and administered orally to mice in HFD+LAVGE and HFD+HAVGE groups every day (except on Sunday) for 7 weeks at a dose of 3.75 and 12.5 mg/kg body weight, respectively. ND and HFD groups received 0.5% CMC alone. Between weeks 4 and 7, body weights in the HFD and HFD+LAVGE groups were reduced more than those in the ND group. However, body weights were not reduced in the HFD+HAVGE group. Mice were sacrificed at the end of the experiment and their intestines were scored for polyps. No significant differences were observed in either the incidence and multiplicity of intestinal polyps (${\geq}0.5$ mm in a diameter) among the three groups fed HFD. However, when intestinal polyps were categorized by their size into 0.5-1.4, 1.5-2.4, or ${\geq}2.5$ mm, the incidence and multiplicity of large polyps (${\geq}2.5$ mm) in the intestine in the HFD+HAVGE group were significantly lower than those in the HFD group. We measured plasma lipid (triglycerides and total cholesterol) and adipocytokine [interleukin-6 and high molecular weight (HMW) adiponectin] levels as possible indicators of mechanisms of inhibition. The results showed that HMW adiponectin levels in the HFD group were significantly lower than those in the ND group. However, the levels in the HFD+HAVGE group were significantly higher than those in the HFD group. These results indicate that HAVGE reduced large-sized intestinal polyps and ameliorated reduction in plasma HMW adiponectin levels in Min mice fed HFD.

다랑어 연승어업에서 눈다랑어 어획률에 미치는 낚시 및 미끼의 효과 (Effects of Hook and Bait Types on Bigeye Tuna Catch Rates in the Tuna Longline Fishery)

  • 김순송;문대연;안두해;황선재;김영승
    • 한국어류학회지
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    • 제20권2호
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    • pp.105-111
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    • 2008
  • 다랑어낚시 및 사용미끼에 따른 어획률을 비교하기 위해, 2006년 9~10월간 태평양 중동부 해역에서 다랑어연승 시험조사가 수행되었다. 일반선형모형(GLM)을 이용하여 재래식 다랑어낚시 1종(J4)와 환형낚시 3종(C15, C16, C18), 미끼 5종(고등어(CM), 전갱이(JM), 밀크피쉬(MF), 정어리(SD), 오징어(SQ)) 및 낚시심도를 나타내는 낚시 순번들이 눈다랑어 어획률(1,000낚시당 마리수)에 미치는 효과를 평가하였다. 총 28회 조업에서 낚시순번 간 눈다랑어 어획률에는 유의한 차이가 인정되었다. GLM분석에서 낚시순번에 의한 눈다랑어 어획률 편차는 33%로 나타났다. 미끼 종류 간 어획률 차이는 그 편차가 2.7%로 적게 나타났고, 낚시형 4종 간 그 차이는 매우 적어 유의하지 않게 나타났다. 따라서, 낚시형 및 미끼 종류의 선택은 다랑어 연승어업에서 눈다랑어 어획률 차이에 영향을 주지 않는 것으로 평가되었으나, 어획수심을 나타내는 낚시순번은 눈다랑어 어획률에 영향을 주는 요인으로 판단되었다.

3기 위암환자에서 시행한 술 후 보조항암화학요법들의 생존율 비교 (The Comparison of Survival Rates of Postoperative Adjuvant Chemotherapies in The Stage III Gastric Cancer Patients)

  • 김은미;김세원;김상운;송선교
    • Journal of Yeungnam Medical Science
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    • 제23권2호
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    • pp.193-204
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    • 2006
  • Purpose: Various postoperative adjuvant chemotherapy regimens have been proposed for the patients with advanced gastric cancer. The majority of clinical trials have shown no significant difference in the survival benefit. The aim of this study was to compare the survival rates of postoperative adjuvant chemotherapies used in stage III gastric cancer patients who received curative gastrectomy. Materials and Methods: Between 1990 and 1999, a survival analysis was performed in 260 patients who received curative gastric resection and postoperative adjuvant chemotherapy. The patients were divided into four groups according to the chemotherapeutic regimens received. The groups were: the F group: furtulon alone, FM group: furtulon and mitomycin, FAM group: 5-FU, adriamycin and mitomycin, FLEP group: 5-FU, leucovorin, etoposide and cisplatin. The survival rates were analyzed using the Kaplan-Meier method and the Cox proportional hazards model. Results: There were no differences among the groups of patients with regard to tumor characteristics except for lymph node metastasis and the ratio of metastasis to lymph nodes. In the FLEP group, the ratio of metastasis to lymph nodes was higher than in the other groups. The five and ten year survival rates of F, FM, FAM and FLEP were 51.9%, 28.9%, 59.5%, 49.8%, 66.1%, 57.4% and 30.0%, 27.5%, respectively. The univariate analysis showed that age, Borrmann type, lymph node metastasis, ratio of metastasis to lymph nodes, postoperative adjuvant chemotherapy and recurrence were significant factors for survival. For the multivariate analysis, recurrence, age, Borrmann type, ratio of lymph node metastasis and lymph node dissection were independent prognostic factors; however, the postoperative adjuvant chemotherapy was not an independent prognostic factor. Conclusion: The FAM regimen was the most beneficial postoperative adjuvant chemotherapy for improved survival rates; the FM regimen was the second and the FLEP regimen was the last. In order to determine the effectiveness of postoperative adjuvant chemotherapy in stage III gastric cancer, well designed prospective studies including a surgery only group will be needed.

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안전신고 제도(안전신문고) 도입에 따른 효과 분석 (Analysis of Effects on Adoption of a Safety e-Reporting System)

  • 이준;조상명;박은미;이상화
    • 한국방재안전학회논문집
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    • 제12권4호
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    • pp.27-41
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    • 2019
  • 본 연구는 안전 신문고 제도의 효과를 분석하기 위해 2014년 9월 ~ 2019년 7월까지 접수된 안전신고 데이터 분석을 수행하고 해당 데이터를 통해 안전신고 성과를 측정할 수 있는 항목을 선정하여 4대 불법 주정차 주민신고제 도입에 대한 효과, 도로교통사고 기반의 원단위법을 이용한 효과 분석을 수행하였다. 2019년 10월까지 49개 기초자치단체의 4대 불법 주정차 주민 신고제 도입 후 약 60% 정도 단속 단가가 감소되었으며, 단속인력에 대한 신고 1건의 가치는 21만 3천원/건으로 도출되었다. 과태료 부과 등을 통한 세수 확보를 건당 편익으로 산정하면 약 6만 2천원/건 정도 추정되었다. 이 둘을 합하면 4대 불법 주정차 주민신고 가치는 총 27만 5천원/건으로 도출되었다. 안전신문고의 신고 유형은 대부분 교통 및 시설로 이를 대표적인 신고가치로 정의하고 연도별 총 편익을 산정한 결과, 2014년부터 2019년까지 안전신문고로 접수된 신고건수는 1,164,439건, 2019년 4월 이후 7월까지 신고 된 4대 불법 주정차 신고건수는 502,721건으로 지난 5년간 총 편익을 산정하면 약 2,734억여 원이다.

방사성폐기물드럼 종류별 감쇠보정방법의 결정 (Determination of Attenuation Collection Methods According to the Type of Radioactive Waste Drums)

  • 곽상수;최병일;윤석중;이익환;강덕원;성기방
    • Journal of Radiation Protection and Research
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    • 제22권4호
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    • pp.309-317
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    • 1997
  • 비파괴적인 방법으로 방사성폐기물드럼에 대한 핵종분석을 수행할 때 드럼내 매질에 의한 방사선의 감쇠에 의해 핵종분석장치로 측정한 계수값은 실제 드럼내 방사능에 의한 계수값보다 작게 나타나 결과적으로 방사능의 측정결과가 과소평가된다. 그러므로 드럼내 매질에 의한 감쇠를 보정해 주어야 하는데 감쇠 보정방법은 드럼내 매질의 분포나 매질의 밀도에 따라 달리 적용해야 한다. 본 연구에서는 원자력발전소에서 발생하는 드럼 종류별로 모델드럼을 제작한 후 모델드럼에 표준감마선원을 넣고 핵종분석장치를 이용해 측정을 하여 드럼내 매질의 밀도를 구하였고, 이 값을 실제 매질의 밀도와 비교해 드럼종류에 따라 매질에 의한 최적의 감쇠 보정방법을 결정하였다. 그 결과 잡고체드럼의 경우에는 전송선원 보정방법과 평균밀도 보정방법, 차폐잡고체드럼의 경우 전송선원 보정방법과 두 감마선피크비교 보정방법이 최적의 감쇠 보정방법임을 알 수 있었고, 고밀도드럼인 폐수지, 농축폐액 및 폐필터드럼의 경우에는 평균밀도 보정방법과 두 감마선피크비교 보정방법을 사용해 드럼내 매질의 감쇠를 보정할 수 있다.

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대학생의 건강행위 평가 연구 (The Study of Evaluation of University Students' Health Behaviors)

  • 이창금;박연숙
    • 디지털융복합연구
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    • 제15권12호
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    • pp.517-529
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    • 2017
  • 본 연구는 한국 대학생의 건강행위를 측정할 수 있는 도구를 개발하고 평가하는 데 목적을 두고 있으며, 보호동기이론(Rogers, 1975)과 예방채택과정 모형(Weinstein, 1988)을 개념적 기틀로 사용하였다. 예비문항은 개별면담과 문헌고찰을 통해 추출하였으며, 내용타당도 검정과 문항 이해도 평가를 거친 후 CVI가 .8이상인 행위문항 55개, 인식문항 24개를 선정하고, 60명의 남녀 대학생들에게 사전조사를 실시하였다. 사전조사 후 타당도와 신뢰도 검정을 통해 행위문항 33개와 인식문항 24개로 본조사를 위한 문항을 확정하였다. 본조사 설문지는 3개 대학에 재학 중인 남녀 대학생 400명에게 배포되었고, 최종 373부를 자료로 수집하였다. 자료의 통계처리 결과로는 구성타당도를 위한 문항간의 상관관계와 요인간 상관관계는 적합한 것으로 나타났다. 탐색적 요인 분석에서는 약물복용관리, 위해행동줄이기, 스트레스대처, 몸을 잘 보살피기, 영양관리의 다섯 요인으로 구분된 설명변량이 54.498%였다. 집단 간 비교를 보면 건강행위의 의도를 가진 집단과 그렇지 않은 집단 간의 행위 점수가 유의한 차이를 보이는 것으로 확인되었다. 내적 일관성 신뢰도는 Cronbach's ${\alpha}$ 값이 .708-.810, 반분신뢰도는 Cronbach's ${\alpha}$ 값이 .702~.789로 적합하였다. 본조사 때 수집된 설문지 문항들의 신뢰도와 타당도를 검정하여 결과적으로 최종도구의 문항은 27문항으로 확정되었다.

Dislodgement resistance of modified resin-bonded fixed partial dentures utilizing tooth undercuts: an in vitro study

  • Doh, Re-Mee;Lee, Keun-Woo
    • The Journal of Advanced Prosthodontics
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    • 제1권2호
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    • pp.85-90
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    • 2009
  • STATEMENT OF PROBLEM. Over the years, resin-bonded fixed partial dentures (RBFPDs) have gone through substantial development and refinement. Several studies examined the biomechanics of tooth preparation and framework design in relation to the success rate of RBFPDs and considered retention and resistance form essential for increase of clinical retention. However, these criteria required preparations to be more invasive, which violates not only the original intentions of the RBFPD, but may also have an adverse effect on retention due to loss of enamel, an important factor in bonding. PURPOSE. The object of this in vitro study was to compare the dislodgement resistance of the new types of RBFPDs, the conventional three-unit fixed partial denture, and conventional design of RBFPD (Maryland bridge). MATERIAL AND METHODS. Fifty resin mandibular left second premolars and second molars were prepared on dentiforms, according to the RBFPD design. After model fabrication (five group, n = 10), prostheses were fabricated and cemented with zinc phosphate cement. After cementation, the specimens were subjected to tensile loading at a cross head speed of 4 mm/min in a universal testing machine. The separation load was recorded and analyzed statistically using one-way analysis of variance followed by Duncan's multiple range test. RESULTS. Group V, the pin-retained RBFPDs, had the highest mean dislodgement resistance, whereas specimens of group II, the conventional RBFPDs, exhibited a significantly lower mean dislodgement resistance compared to the other 4 groups (P <.05). There were no significant differences between group I, III, and IV in terms of dislodgement resistance (P>.05). Group V had the highest mean MPa (N/$mm^2$) (P <.05). There was no significant difference between groups I, II, III and IV (P > .05). CONCLUSION. Within the limits of the design of this in vitro study, it was concluded that: 1. The modified RBFPDs which utilizes the original tooth undercuts and requires no tooth preparation, compared with the conventional design of RBFPDs, has significantly high dislodgement resistance (P < .05). 2. The modified RBFPDs which utilizes the original tooth undercuts and requires minimal tooth preparation, compared with the conventional FPDs, has significantly no difference in retention and dislodgement resistance)(P>.05). 3. The pin-retained FPDs showed a high dislodgement resistance compared to the conventional three-unit FPDs (P<.05).