• 대한유전성대사질환학회지
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• 제18권3호
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• pp.69-77
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• 2018

Pregnancy and delivery pose a high risk of developing metabolic decompensation in women with defects of ketone body metabolism. In this review, the available reported cases in pregnancy are summarized. It is very important to properly manage women with defects of ketone body metabolism during pregnancy, especially nausea and vomiting in the first trimester of pregnancy, and during labor and delivery. Pregnant women with deficiencies of HMG-CoA lyase or succinyl-CoA:3-ketoacid CoA transferase (SCOT) often experience metabolic decompensations with nausea and vomiting of pregnancy, often requiring hospitalization. For successful delivery and to reduce stresses, vaginal delivery with epidural anesthesia or elective cesarean delivery with epidural or spinal anesthesia are recommended for women with HMG-CoA lyase and SCOT deficiency. In beta-ketothiolase deficiency, four pregnancies in three patients had favorable outcomes without severe metabolic problems.

• 대한한방부인과학회지
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• 제20권4호
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• pp.160-174
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• 2007

Purpose: The purpose of this study was to investigate about missed abortion pathophysiology, diagnosis, medical treatment and to research the trend of the study related to missed abortion. Methods: We referred a PubMed site by using search word of "missed abortion"(Limits: 3 Year, only items with abstracts, Human). Results: 37 journals with 49 papers were searched. Conclusion: 1. The study of missed abortion pathophysiology was the following. The first was that important pathologies such as molar pregnancy and placental trophoblastic disease can be diagnosed by routine histopathologic analysis of product of conception following first-trimester spontaneous miscarriages. The second was that coelomic fluid leptin concentration in missed abortion is higher than in normal. The third was that adenosine deaminae activity in serum and placenta of patients with anembryonic pregnancies and missed abortions was low. The forth was that Leptotrichia amnionii sp. nov. was the etiopathogenetic factor in missed abortion. 2. Transvaginal ultrasound assessment of irregular vaginal bleeding is effective in diagonosis of missed abortion. 3. There were medical therapy with misoprostol, mifepristone or anti progesterone for missed abortion. Misoprostol was administrated oral(sublingual) and vaginal.

• Journal of Genetic Medicine
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• 제2권1호
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• pp.7-10
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• 1998

The present report describes a case that showed a normal fetal karyotype in an antenatal genetic study but an abnormal placental karyotype of 46,XX,r (15) on postnatal examination. The pregnancy was complicated by fetal nuchal translucency in the first trimester and intrauterine growth restriction in the second and third trimesters. A 1780 gm female baby was born after 40 weeks of gestation, but died of respiratory distress and sepsis on the 10th day of life. Our case was unique in that the placental chromosomal aberration was a structural abnormality instead of a numerical aberration that is seen in most reported cases of confined placental mosaicism.

• Journal of Nutrition and Health
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• 제34권8호
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• pp.929-935
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• 2001

The purpose of this study was to investigate the effects of regular maternal exercise on maternal nutrients intake and pregnancy outcome. The number of subjects were 567 pregnant women at local general hospital in Daegu. General characteristics data and 24- hour food recalls were collected by trained interviewer. Structured interview and medical record review were carried out at first prenatal and delivery visit(included age, delivery history, height, pre-pregnancy weight, and pregnancy outcome etc). Regular exercise performance was surveyed at third trimester and 31.4% of subjects exercised regularly Overall weight gains during pregnancy were 13.9 $\pm$ 3.8kg and 14.7 $\pm$ 4.7kg in the exercise and sedentary group, respectively. The type of exercise was mainly strolling and light aerobic exercise. Usually firstpara subjects exercised more regularly than multipara subjects. There is no significant difference between regular exercise and severity of morning sickness. Weight gain during pregnancy was not relate to regular exercise. Though there is not statistically significant, the nutrients intakes were higher in regular exercise group than in sedentary group. We concluded regular exercise during pregnancy neither influenced pregnancy weight gain, severity of morning sickness nor baby birth weight but it could affect the nutritional and health statues of mother.

• Anatomy and Cell Biology
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• 제56권4호
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• pp.421-427
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• 2023

Bladder exstrophy is a rare congenital condition of the pelvis, bladder, and lower abdomen that opens the bladder against the abdominal wall, produces aberrant growth, short penis, upward curvature during erection, wide penis, and undescended testes. Exstrophy affects 1/30,000 newborns. The bladder opens against the abdominal wall in bladder exstrophy, a rare genitourinary condition. This study is vital to provide appropriate therapy choices as a basis to improve patient outcomes. This study may explain bladder exstrophy and provide treatment. Epispadias, secretory placenta, cloacal exstrophy, and other embryonic abnormalities comprise the exstrophy-spades complex. The mesenchymal layer does not migrate from the ectoderm and endoderm layers in the first trimester, affecting the cloacal membrane. Embryological problems define the exstrophy-aspidistra complex, which resembles epimedium, classic bladder, cloacal exstrophy, and other diseases. Urogenital ventral body wall anomalies expose the bladder mucosa, causing bladder exstrophy. Genetic mutations in the Hedgehog cascade pathway, Wnt signal, FGF, BMP4, Alx4, Gli3, and ISL1 cause ventral body wall closure and urinary bladder failure. External factors such as high maternal age, smoking moms, and high maternal body mass index have also been associated to bladder exstrophy. Valproic acid increases bladder exstrophy risk; chemicals and pollutants during pregnancy may increase bladder exstrophy risk. Bladder exstrophy has no identified cause despite these risk factors. Exstrophy reconstruction seals the bladder, improves bowel function, reconstructs the vaginal region, and restores urination.

• 대한임상검사과학회지
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• 제37권1호
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• pp.56-60
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• 2005

Human chorionic gonadotrophin (hCG) and unconjugated estriol (uE3) were added to AFP to make what is commonly known as the Triple test. The Triple test combines results from these three tests and has been a standard screening procedure for several years. Recent studies have demonstrated the usefulness of adding inhibin-A to Down's syndrome risk assessment. The Quad test adds dimeric Inhibin-A (DIA) to the three other markers and uses the same computer program to calculate risk factors. Testing was performed between 14 and 21 weeks of gestation. Sample size were 648 samples and period of study was from 1, July, 2004 to 30, September, 2004. Used analytical methods for AFP, hCG and uE3 were radioimmunoassay (RIA) and dimeric inhibin A was enzyme-linked immunosorbent assay (ELISA). Adding dimeric inhibin-A as a fourth marker to the standard triple test increases the detection rate from 62 % to 75 % with a false-positive rate of 5%. The DIA based Quad test has been shown to be the most effective second trimester screening test for Down's syndrome suitable for routine use. Increased DIA values are observed during normal pregnancy where a bimodal pattern response is seen. Values increase during the first trimester, decline after 14 weeks, and re-ascend between 17-25 weeks. Values for DIA may be additionally elevated during a Down's syndrome pregnancy. Dimeric inhibin A is a glycoprotein hormone made by the ovary and placenta. DIA levels are twice as high in Down's syndrome pregnancies. AFP, hCG, and uE3 levels vary with gestational age, and incorrect gestational dating will influence results. DIA levels do not vary substantially with gestational age, resulting in greater screening accuracy. Although the Quad test is an improvement over the Triple test, it is important to underscore the fact that a positive test on both should be done. Most women who initially screen positive will be found to be carrying normal babies when amniocentesis and definitive diagnostic chromosome analysis are done.

• 대한임상검사과학회지
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• 제50권1호
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• pp.1-10
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• 2018

갑상선의 기능적 발달 이전인 임신초기에 갑상선자극호르몬은 갑상선 장애 및 임신 동안 매우 민감한 지표이다. 임신동안 정상수준은 감소 변화를 보이는 것은 모체로부터 태아가 받는 갑상선호르몬의 영향이다. 갑상선자극호르몬과 유리 티록신의 농도는 임신동안 및 검사실간에 다양하게 보고된다. 갑상선자극호르몬의 참고치는 비임신군에 비하면 상한값과 하한값의 참고범위의 감소가 임신동안 보인다. 각 실험실은 임신 중에 다른 결과를 산출하는 호르몬 분석법과 일부 자체 기준에 맞는 혈중 농도를 산출한다. 따라서, 혈청 유리 티록신 분석에 사용되는 자동화 된 면역 분석법은 여전히 널리 사용되고 있지만 고려할 사항이 있다. 집단 기준, 삼분위 기간별 특이적 참고범위 사용은 문제해결의 최상의 방법이다. 임신 7~12주에 발생하는 호르몬의 하향은 7주 이전에는 보이지 않아 참고범위의 개별적 정량적으로 상승 및 하강을 보여준다. 본 연구에서는 집단별과 임신 특이적 갑상선 매개 변수의 참조범위에 대한 산출 중요성을 강조한다. 정밀의학 의 도래에 있어서 많은 개체의 유전적, 생물학적, 심리사회학적, 환경적 변수를 수집하고 분석이 필요하다. 이러한 논쟁을 해결하기 위해서는 다량의 전향적인 무작위 통제 연구가 필요하다.

• 한국간호교육학회지
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• 제5권2호
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• pp.232-249
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• 1999

The purpose of the study was to analyze the experiences of and the unmet needs for sex education of university students during their primary and secondary education. Development and refinement strategies of the sex education curriculum were constructed using the words of university students. The study was conducted during the second trimester of 1998 and the first trimester of 1999. and 356 male and female students were asked to submit weekly descriptive reports on the proposed issues related to sex education. The data were collected and analyzed by the researcher to present and summarize the in-depth meanings . The results were as follows: 1) The problems of the present sex education of primary and secondary education curriculum : it was revealed as too superficial and conventional: it brought about adverse effects because it was not efficient: also it was insufficient and not appropriate to the level of the students. The erroneous stereotypes of our society towards the sexuality act as barriers to effective sex education. 2) The abstract needs for sex education revealed on the analysis of adjectives used by the students were: 'honest, interesting, easy, useful, and correct' 3) The concrete needs for the sex education were: correct understanding of sexuality, establishment of the right sense of values towards sexuality, understanding of male and female sex psychology, knowledge of solutions for sexual problems 4) The developmental strategies for the sex education curriculum were structural, comprehensive, broad, and sufficient education content, concrete and honest explanations about sexuality : provision of early sex education; sex education provided by the parents ; establishment of an open environment for the sex education, graded education reflecting the developmental stages of the youngsters ; up-to-date sex education; preservation of the perspectives of the youngsters; provision of the same sex education opportunities for both girls and boys; practical use of audiovisual aides; open discussion; development of novel education methods like field trips 5) The change of knowledge, attitudes, and values towards sexuality after finishing the sex education course were: establishment of right sense of value towards sexuality ; reconfirmation of the concepts and value for life; belief of the necessity of sex education; change of attitudes towards womanhood; reinforcement of the self-conceit, consolidation of filial piety; and acquisition of the practical knowledge.

• 한국식생활문화학회지
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• 제16권3호
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• pp.203-214
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• 2001

Maternal stress was very common symptom that every pregnant women could have experienced during pregnant period. We found that the causative factors of stress for subjects were physical change(50.8%), family relationship(13.6%), change of body image(7.4%), concern baby(6.8%), economic difficulties(6.4%), depress(4.3%), morning sickness(3%), and miscellaneous(3.5%). According to our study, maternal stress during the first trimester negatively correlated with food and nutrients intake of pregnant women and gave low weight gain during pregnancy and low birth weight of infants. It also significantly correlated with monthly income(p<0.001) and monthly food cost(p<0.001) during pregnant period. Mean intake of Calcium and Iron were $47{\sim}60%$ of RDA and $35{\sim}48$ of RDA, respectively. With the Iron supplement the total intake of Iron exceeded 100% of RDA. We also found majority of food items, except seaweeds, fruits and vegetables, were negatively correlated with maternal stress during three trimesters. Additional support system projected by professionals in health-care field could mediate maternal stress and lead to healthy pregnancy outcome.

• Journal of Nutrition and Health
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• 제9권4호
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• pp.28-35
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• 1976

To know changes of the food preferences and the practice of pica during pregnancy, ninety two women in the latter half of pregnancy were interviewed in April, 1976 at ten medical centers in Seoul. They were average 27.1 years old, and mostly middle class. 83.7% of the total subjects felt the changes of food preferences due to pregnancy within the first trimester. 60.9% had vomiting as well as losing their appetite and 17.3% vomited three or more times daily which might induce difficulties of water and electrolytes balance in body. The preferences about foods, the taste of foods, and various dishes cooked during morning sickness were changed significantly and showed in lower scores of likes and higher scores of dislikes than those before pregnancy. Particularly, cooked rice and kimchi indicated the increase of more than 50% in dislikes. The preferences after the morning sickness were turned back to those before pregnancy. Desire for water through foods like soft drinks, juice, ice cream, and gamju and salty foods seemed to be spontaneous during pregnancy. A majority of the subjects had three meals and no snack had included more snacks instead of meals during losing appetite and thereafter, had more frequent meals and snacks. Superstitions about chicken, squid, and cuttlefish for pregnant women were prevalent. 11.9% tabooed chicken because of harm for fetus. On the contrary, intended higher inclusions of milk, meat and dried small sardines would be helpful to satisfy the increased recommended allowances of calcium and protein for them. The practice of pica was found in 5.4% and rice was the only real item mentioned. Pica such as amylophagia or geophagia often reported in the U.S. was not answered in this study.