• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10263-10266
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• 2015

Background: The risk of febrile neutropaenia (FN) and treatment related death (TRD) with first line palliative chemotherapy for de novo metastatic breast cancer (MBC) remains unknown outside of a clinical trial setting despite its widespread usage. This study aimed to determine rates in a large cohort of patients treated in the University of Malaya Medical Centre (UMMC). Materials and Methods: Patients who were treated with first line palliative chemotherapy for de novo MBC from 2002-2011 in UMMC were identified from the UMMC Breast Cancer Registry. Information collected included patient demographics, histopathological features, treatment received, including the different chemotherapy regimens, and presence of FN and TRD. FN was defined as an oral temperature > $38.5^{\circ}C$ or two consecutive readings of > $38.0^{\circ}C$ for 2 hours and an absolute neutrophil count < $0.5{\times}10^9/L$, or expected to fall below $0.5{\times}10^9/L$ (de Naurois et al, 2010). TRD was defined as death occurring during or within 30 days of the last chemotherapy treatment, as a consequence of the chemotherapy treatment. Statistical analysis was performed using the SPSS version 18.0 software. Survival probabilities were estimated using the Kaplan-Meier method and differences in survival compared using log-rank test. Results: Between $1^{st}$ January 2002 and $31^{st}$ December 2011, 424 patients with MBC were treated in UMMC. A total of 186 out of 221 patients with de novo MBC who received first line palliative chemotherapy were analyzed. The mean age of patients in this study was 49.5 years (range 24 to 74 years). Biologically, ER status was negative in 54.4% of patients and Her-2 status was positive in 31.1%. A 5-flourouracil, epirubicin and cyclophosphamide (FEC) chemotherapy regimen was chosen for 86.6% of the cases. Most patients had multiple metastatic sites (58.6%). The main result of this study showed a FN rate of 5.9% and TRD rate of 3.2%. The median survival (MS) for the entire cohort was 19 months. For those with multiple metastatic sites, liver only, lung only, bone only and brain only metastatic sites, the MS was 18, 24, 19, 24 and 8 months respectively (p-value= 0.319). Conclusions: In conclusion, we surmise that FEC is a safe regimen with acceptable FN and TRD rates for de novo MBC.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5493-5498
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• 2014

Objective: To compare the efficacy of taxane-based regimens in the first line setting retrospectively in Chinese patients with recurrent and/or metastatic esophageal cancer. Methods: We analyzed 102 recurrent and/or metastatic esophageal cancer patients who received taxanes-based regimens in a first-line setting from January 2009 to December 2013. Sixteen (15.7%) patients were administered Nab-PTX based chemotherapy and 86 patients (84.3%) received paclitaxel (PTX) or docetaxel (DTX) based chemotherapy. Patients in the PTX/DTX group could be further divided into TP (71 patients) and TPF (15 patients) groups. Results: The objective response rate (ORR) of all patients was 20.6%, and the disease control rate (DCR) was 67.6%. The median overall survival (OS) was 10.5 months (95% CI 10.1-16.4) and the median progression-free survival (PFS) was 6.04 months (95% CI 5.09-7.91). The DCR was higher in the TPF group than the TP group (93.3% vs. 59.1%; p = 0.015 ). There were no significant differences in ORR, OS, and PFS among Nab-PTX, TPF and TP groups. Conclusions: The three regimens of Nab-PTX based, TP and TPF proved active in a first line setting of Chinese patients with recurrent and/or metastatic esophageal cancer, and should thus be regarded as alternative treatments.

• Mood & Emotion
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• v.16 no.3
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• pp.129-133
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• 2018

Objectives : The fourth revision of Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) was performed in 2018, to provide newer guidelines for clinicians. In this section, we examined expert opinions to facilitate clinical decisions relative to treating bipolar disorder with medical comorbidity. Methods : The survey was completed by the review committee, consisting of 61 experienced psychiatrists. This part of the survey constitutes treatment strategies, under major medical comorbidities. The executive committee analyzed results, and discussed the final production of algorithm. Results : Aripiprazole was the first-line medication for bipolar patients with metabolic syndrome, cardiovascular, hepatic, renal, and cerebrovascular comorbidities. Ziprasidone also was recommended as the first-line medication in case of metabolic syndrome. Lithium also was regarded as the first-line medication, in case of hepatic problems. Valproate also was considered as the first-line medication, in case of cerebrovascular problems. Conclusion : This study provided the most recent consensus among experts, for treatment of bipolar disorder with physical problems.

• Tuberculosis and Respiratory Diseases
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• v.58 no.5
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• pp.465-472
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• 2005

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second-line chemotherapy, for which Docetaxel ($Taxotere^{(R)}$) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first-line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either $75mg/m^2$ or $100mg/m^2$, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression-free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. ${\geq}60years$: 6.6 months, p = 0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment-related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first-line platinum-based chemotherapy.

• Proceedings of the KSR Conference
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• 2011.05a
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• pp.1118-1123
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• 2011

The introduction of high speed railway(KTX) in Korea after the Korean high speed train through the KTX-II of the development is being run is made. Thus the demand for the railway technology advances and high performance, Korean government promoted the development of the next-generation high speed train system(HEMU-400X). In addition to the production of train system essential element of the train through an on-line test is to evaluate the performance. Through the on-line test of the train in order to evaluate the performance test items should be selected first and need to the test procedures are required. In addition, an Overall Measuring System(OMS) to measure the performance of the train system should be established. In this study for the on-line test of the HEMU-400X test items was selected for detailed measurements and performance evaluation of a comprehensive and efficient trains to test an OMS for the development are discussed.

• 제어로봇시스템학회:학술대회논문집
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• 1997.10a
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• pp.832-835
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• 1997

In this paper, we first analyze the structural limitation of the conventional PID controller in controlling unstable processes through mathematical proof. To overcome this structural limitation, we add an internal feedback loop to the PID controller. Secondly, we obtain conditions when unstable processes can be stabilized by a controller through an analytical analysis. Finally, we propose a simple on-line process identification and autotuning method for unstable processes. Many simulation results show that, in spite of its simplicity, the proposed on-line process identification method provides good accuracy in modeling the unstable process and acceptable robustness to measurement noises and disturbances. Also, the proposed autotuner shows good control performances for both servo and regulatory problems.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1994.04a
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• pp.95-102
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• 1994

A path-switching strategy by combining the use of generalized inverse and line search is proposed. A reliable predictor for the tangent vector to bifurcation path is first computed by using the generalized inverse approach. A line search in the direction of maximum gradient of total potential at the point of intersection between the above predictor and a constant loading plane introduced in the vicinity of the detected bifurcation point is then carried out for the purpose of obtaining an improved approximation for a point on bifurcation path. With this approximation obtained, an actual point on bifurcation path is then computed through iteration on the constant loading plane.

• Journal of the korean Society of Automotive Engineers
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• v.7 no.3
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• pp.42-55
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• 1985

The study is concerned with the investigation of curved line folding of developable surface from flat sheets of metal. General geometric relations among folding line, folded surface, folded angle are derived. From the derived geometric relations, the required plastic work and punch force are derived for the first approximation. Five methods of forming are suggested and the experiment is carried out using two chosen methods for the prismatic developable surfaces of which cross-sections have 103.deg.arc, 180.deg.arc, sinusoidal shape. In the die design for the tolding of prismatic developable surfaces, a stack of sheets were used to form shapes of the dies by which acceptable folded surfaces were obtained. The computed plastic work and punch force turned out to be in reasonable agreement with the experimental result.

• Animal Systematics, Evolution and Diversity
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• v.36 no.1
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• pp.78-80
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• 2020

A sphingid species, Macroglossum corythus Walker, 1856 is newly recorded from Korea. Macroglossum corythus can be characterized by grayish or dark greenish fore- and hindwings, blackish basal, ante- and postmedial lines with a blackish discal dot on the forewing and transverse antemedial line, as well as a strongly dentate postmedial line and a thick, dark brownish tinged subterminal line on the hindwing. The male genitalia of Macroglossum corythus can be characterized by the long saccular process of valva and the phallus with one hooked distal process and the large penshaped cornutus and a notched ridge. The female genitalia of Macroglossum corythus can be characterized by the long tubular ductus bursae and the long ovate corpus bursae with multiple stripes and a long triangular patch of minute signa. To date, six species of the genus Macroglossum have been identified in Korea.

• Fashion & Textile Research Journal
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• v.13 no.2
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• pp.155-161
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• 2011

This thesis, concerning Femme Fatale Images Costume Form in paintings viewed from DeLong's Theory, analyzed frequency and traits on the basis of DeLong's Form Observation Theory and drew out the result as followings. First, Costume Form was mostly open, whole, planer integration, rounded, and indeterminate. The styles were similar each other. Second, surface structure was expressed by line & shape, color, texture, and pattern of which color had the highest priority. Next, line & shape and texture had the priority in order. They were expressed through intereaction. Third, the traits of Costume Form were a similar color harmony or large light and darkness contrast+soft quality+interaction by ambiguous line & shape. So, Femme Fatale Image in paintings was expressed by soft and pure images and erotic images.