• Journal of Pharmaceutical Investigation
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• v.40 no.spc
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• pp.113-118
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• 2010

Pharmaceutical technology has primarily focused on the development of the best dosage forms depending on the route of administration. The design of dosage forms is greatly influenced by the route of administration. Due to a variety of advantages such as avoidance of first-pass effect, abundant blood supply and easy access to the absorption site, the oral cavity has frequently been selected as a site for drug delivery. Since the oral cavity is relatively unique from the anatomical and physiological viewpoint, one should always consider these conditions when designing the drug delivery systems for the oral cavity. In this regard, the current review paper was prepared to summarize the essential features of the drug delivery systems utilized in the oral cavity, along with the introduction of various dosage forms developed to date.

• Journal of the Korean Society of Clothing and Textiles
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• v.34 no.8
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• pp.1290-1302
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• 2010

This study examines the effects of competency and service orientation of imported fashion luxury brands salespersons on the organizational commitment and service delivery level. Questionnaire data from 162 salespersons of imported fashion luxury brands were analyzed. The results were summarized as follows. First, self-management ability, professional executive ability, and the friendly attitude of six competency factors had significant effects on organizational commitment. Second, professional executive ability, self-management ability, and friendly attitude of the six competency factors had significant effects on service delivery level. Third, all factors of service orientation had significant influences on organizational commitment. Finally, special treatment/awareness of needs and instant response/communicative skill of three service orientation factors had significant influences on the service delivery level.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.6
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• pp.2180-2200
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• 2015

This paper considers mobility control to improve packet delivery in delay-tolerant networks (DTNs) under group mobility. Based on the group structure in group mobility, we propose two mobility control techniques; group formation enforcement and group purposeful movement. Both techniques can be used to increase the contact opportunities between groups by extending the group's reachability. In addition, they can be easily integrated into some existing DTN routing schemes under group mobility to effectively expedite the packet delivery. This paper is divided into 2 parts. First, we study how our proposed mobility control schemes reduce the packet delivery delay in DTNs by integrating them into one simple routing scheme called group-epidemic routing (G-ER). For each scheme, we analytically derive the cumulative density function of the packet delivery delay to show how it can effectively reduce the packet delivery delay. Then, based on our second proposed technique, the group purposeful movement, we design a new DTN routing scheme, called purposeful movement assisted routing (PMAR), to further reduce the packet delay. Extensive simulations in NS2 have been conducted to show the significant improvement of PMAR over G-ER under different practical network conditions.

• International Journal of Precision Engineering and Manufacturing
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• v.7 no.4
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• pp.40-46
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• 2006

The market of programmable implantable pumps has bound to a monopolistic situation, inducing high device costs, thus making them inaccessible to most patients. Micro-mechanical and medical innovations allow improved performances by reducing the dimensions. This affects the consumption and weight, and, by reducing the number of parts, the cost is also affected. This paper presents the procedure followed to design an innovative implantable drug delivery system. This drug delivery system consists of a low flow pump which shall be implanted in the human body to relieve pain. In comparison to classical known solutions, this pump presents many advantages of high interest in both medical and mechanical terms. The first section of the article describes the specifications which would characterize a perfect delivery system from every points of view. This concerns shape, medication, flow, autonomy, biocompatibility, security and sterilization ability. Afterwards, an overview of existing systems is proposed in a decisional tree. Positive displacement motorized pumps are classified into three main groups: the continuous movement group, the fractioned translation group and the alternative movement group. These systems are described and the different problems which are specific to these mechanisms are presented. Since none of them fully satisfy the specifications, an innovation is justified.. The decisional tree is therefore extended by adding new principles: fractioned refilling and fractioned injection within the fractioned translation movement group, spider guiding system within the alternative translation movement group, rotational bearing guided device and notch hinge guided device in the alternative rotation movement group.

• Archives of Pharmacal Research
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• v.25 no.5
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• pp.572-584
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• 2002

Rapid development in molecular biology and recent advancement in recombinant technology increase identification and commercialization of potential protein drugs. Traditional forms of administrations for the peptide and protein drugs often rely on their parenteral injection, since the bioavailability of these therapeutic agents is poor when administered nonparenterally. Tremendous efforts by numerous investigators in the world have been put to improve protein formulations and as a result, a few successful formulations have been developed including sustained-release human growth hormone. For a promising protein delivery technology, efficacy and safety are the first requirement to meet. However, these systems still require periodic injection and increase the incidence of patient compliance. The development of an oral dosage form that improves the absorption of peptide and especially protein drugs is the most desirable formulation but one of the greatest challenges in the pharmaceutical field. The major barriers to developing oral formulations for peptides and proteins are metabolic enzymes and impermeable mucosal tissues in the intestine. Furthermore, chemical and conformational instability of protein drugs is not a small issue in protein pharmaceuticals. Conventional pharmaceutical approaches to address these barriers, which have been successful with traditional organic drug molecules, have not been effective for peptide and protein formulations. It is likely that effective oral formulations for peptides and proteins will remain highly compound specific. A number of innovative oral drug delivery approaches have been recently developed, including the drug entrapment within small vesicles or their passage through the intestinal paracellular pathway. This review provides a summary of the novel approaches currently in progress in the protein oral delivery followed by factors affecting protein oral absorption.

• Journal of Pharmaceutical Investigation
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• v.29 no.4
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• pp.337-341
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• 1999

We have studied the stability and transdennal flux of prostaglandin $E_1\;(PGE_1)$ from various donor solutions through hairless mouse skin. Stability in HEPES buffer or in propylene glycol (PG) solution where enhancer (oleic acid (OA), propylene glycol monolaurate (PGML), transcutol (TC), ethanol (EtOH))s dissolved was investigated. $$PGE_1 was not stable in HEPES buffer. The concentration of $$PGE_1 decreased continuously for 7 days, and the degradation rate constant was $0.0028\;h^{-1}$, assuming first order reaction. The effect of current or penetration enhancer on the degradation was minimal. Percutaneous transport from HEPES buffer by passive or iontophoretic delivery without enhancer was close to nil. When OA or PGML was used together with PG, both passive and iontophoretic flux increased. PGML showed better enhancing effect than OA. Flux by cathodal delivery was about 2 times larger than that by passive delivery. Flux by anodal delivery was lower than that by passive delivery. TC and EtOH also increased the transdermal flux, but the effect was not as good as that observed when OA or PGML was used. These stability and flux data provide important information on how to formulate the patch, which will be the next step of this work, and on the polarity of current to use during iontophoresis.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.36 no.3
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• pp.71-78
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• 2013

An efficient vehicle routing heuristic for different vehicle moving times for forward and backward between two points is studied in this research. Symmetric distance or moving times are assumed to move back and forth between two points in general, but it is not true in reality. Also, various moving speeds along time zones are considered such as the moving time differences between rush hours or not busy daytimes. To solve this type of extremely complicated combinatorial optimization problems, delivery zones are specified and delivery orders are determined for promising results on the first stage. Then delivery orders in each zone are determined to be connected with other zones for a tentative complete delivery route. Improvement steps are followed to get an effective delivery route for unsymmetric-time-varing vehicle moving speed problems. Performance evaluations are done to show the effectiveness of the suggested heuristic using computer programs specially designed and developed using C++.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.6 no.12
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• pp.3257-3274
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• 2012

Broadcast routing has become an important research field for vehicular ad-hoc networks (VANETs) recently. However, the packet delivery rate is generally low in existing VANET broadcast routing protocols. Therefore, the design of an appropriate broadcast protocol based on the features of VANET has become a crucial part of the development of VANET. This paper analyzes the disadvantage of existing broadcast routing protocols in VANETs, and proposes an improved algorithm (namely ODAM-C) based on the ODAM (Optimized Dissemination of Alarm Messages) protocol. The ODAM-C algorithm improves the packet delivery rate by two mechanisms based on the forwarding features of ODAM. The first distance-based mechanism reduces the possibility of packet loss by considering the angles between source nodes, forwarding nodes and receiving nodes. The second mechanism increases the redundancy of forwarding nodes to guarantee the packet success delivery ratio. We show by analysis and simulations that the proposed algorithm can improve packet delivery rate for vehicular networks compared against two widely-used existing protocols.

• Journal of Arbitration Studies
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• v.31 no.1
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• pp.173-194
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• 2021

This study was conducted to investigate the effect of the factors of delivery app service failure on consumption well conflict emotion and complaining behavior targeting consumers with experience using delivery apps, and the results of the study are summarized as follows. First, when looking at the demographic analysis, the proportion of men was 58.1% and women were 41.9%, and the age group was the highest with 91.9% in their 20s. Second, as a result of testing hypothesis 1 that the factor of delivery app service failure will have a significant influence on consumer conflict emotions, failure to provide app information and failure to deliver/food service showed a significant positive (+) relationship. Third, as a result of the verification of Hypothesis 2, that consumer conflict emotions will have a significant effect on the consumer's continued use intention, it was found to be insignificant and rejected. Lastly, hypothesis 3 that consumer conflict emotions will have a significant effect on consumer complaints behavior is that negative word of mouth behavior, complaint behavior from service providers, and complaint behavior from service managers were adopted, but the complaint behavior was rejected by third parties.

• Research in Community and Public Health Nursing
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• v.33 no.3
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• pp.312-320
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• 2022

Purpose: This study was performed to explore the effect of the delivery format on teaching presence, learning presence, and learning outcomes in distance learning of nursing students. Methods: A descriptive survey was conducted to understand teaching presence, learning presence, and learning outcomes depending on the delivery format of distance learning. Quota sampling methodology was used to recruit 295 nursing students from all over the country, and data collection was done from July 27 to September 10, 2020. The first delivery format for distance learning was synchronous learning in which communication between the instructor and students occurred simultaneously. The second delivery format was asynchronous learning in which prerecorded videos were provided and communication did not occur simultaneously. Results: In synchronous learning, teaching presence (especially direct facilitation) and learning presence (especially emotional expression) had a statistical significance that was higher than in asynchronous learning. However, in learning outcomes, there was no statistically significant difference. There were significant positive correlations between teaching presence, learning presence, and learning outcomes, and there were significant positive correlations. Conclusion: It can be suggested that learning outcomes can be improved if presence is improved in the distance learning environment based on the results of this study. It is necessary to add contact with nursing students and instructors to improve teaching presence in the asynchronous learning, and it is necessary to help students express their emotions to improve learning presence.