• Molecules and Cells
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• 제23권3호
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• pp.316-322
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• 2007

Zinc finger transcription factor genes are a significant fraction of the genes in the vertebrate genome. Here we report the isolation and characterization of a human zinc finger-containing gene, ZNF435, from a fetal brain cDNA library. ZNF435 cDNA is 1290 base pairs in length and contains an open reading frame encoding 349 amino acids with four C2H2-type zinc fingers at its carboxyl terminus and a SCAN motif at its amino terminus. RT-PCR results showed that ZNF435 was expressed in all tested tissues. A ZNF435-GFP fusion protein was located in the nucleus and the four zinc fingers acted as nuclear localization signals (NLSs). ZNF435 was found to be capable of homo-association, and this effect was independent of its zinc fingers. Furthermore, ZNF435 proved to be a transcription repressor as its overexpression in AD293 cells inhibited the transcriptional activities of AP-1.

• 대한인간공학회지
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• 제26권2호
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• pp.149-155
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• 2007

Recently, various devices requiring text input such as mobile phone IPTV, PDA and UMPC are emerging. The frequency of text entry for them is also increasing. This study was focused on the evaluation of Korean text entry interface. Various models to evaluate text entry interfaces have been proposed. Most of models were based on human cognitive process for text input. The cognitive process was divided into two components; visual scanning process and finger movement process. The time spent for visual scanning process was modeled as Hick-Hyman law, while the time for finger movement was determined as Fitts' law. There are three questions on the model-based evaluation of text entry interface. Firstly, are human cognitive processes (visual scanning and finger movement) during the entry of text sequentially occurring as the models. Secondly, is it possible to predict real text input time by previous models. Thirdly, does the human cognitive process for text input vary according to users' text entry speed. There was time gap between the real measured text input time and predicted time. The time gap was larger in the case of participants with high speed to enter text. The reason was found out investigating Eye-Hand Coordination during text input process. Differently from an assumption that visual scan on the keyboard is followed by a finger movement, the experienced group performed both visual scanning and finger movement simultaneously. Arrival Lead Time was investigated to measure the extent of time overlapping between two processes. 'Arrival Lead Time' is the interval between the eye fixation on the target button and the button click. In addition to the arrival lead time, it was revealed that the experienced group uses the less number of fixations during text entry than the novice group. This result will contribute to the improvement of evaluation model for text entry interface.

• Restorative Dentistry and Endodontics
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• 제29권3호
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• pp.226-232
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• 2004

Use of electric pulp testing elicits painful response in vital teeth. In this study, we examined the excessive time from pain feeling to stimulation disconnection in clinical situation. D626D (Parkell Inc., USA.) scan type electric pulp tester was used in total of 23 young healthy individuals. Each of the right central incisors and first premolars were used as testing teeth. Stimulation disconnection was achieved by EMG in anterior belly of digastric muscle, finger span, and voice and the excessive stimulation time over the sensory thresh-old was recorded. As a result, we found that the short responses before the stimulation disconnection appeared following order：EMG, finger span, and voice. The EMG disconnection is suggested to be used to reduce the excessive stimulus time in electric pulp testing.

• 대한의생명과학회지
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• 제28권1호
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• pp.9-24
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• 2022

The aim of this study was to identify the expression of zinc finger E-box binding homeobox 1 (ZEB1), its prognostic significance, and correlation between ZEB1 and infiltrating immune cells in lung cancer. Correlation between ZEB1 and telomerase was also analyzed in different types of cancers. RNA sequencing analysis and survival rates of patients were confirmed by Gene Expression Profiling Interactive Analysis (GEPIA). The Kaplan-Meier plotter and PrognoScan databases were used to analyze the prognostic value of ZEB1 in various cancers. The Tumor IMmune Estimation Resource (TIMER) was used to determine the correlation between ZEB1 and infiltrating immune cells. Lower ZEB1 expression was lower in lung cancer and was related to poor prognosis in lung adenocarcinoma (LUAD). ZEB1 expression exhibited a significantly positive correlation with infiltration levels of immune cells in LUAD and lung squamous cell carcinoma. Furthermore, we found that the ZEB1 expression correlated with subunits of telomerase. Our findings suggest ZEB1 as a potential biomarker to be used for prognostic significance and tumor immunology in lung cancer. The correlation between the expression of ZEB1 and telomere-related gene will help in understand the cancer-promoting mechanisms.

• 핵의학기술
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• 제28권1호
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• pp.49-56
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• 2024

Purpose: When performing nuclear medicine examinations, body wraps or plastic supports are used to support and immobilize the patient's upper extremities to prevent patient safety accidents. However, the existing plastic supports compromised patient and staff safety, including finger entrapment and falls. Moreover, the body wrap provided by manufacturers compromised image quality such as upper extremities cutoff during whole body bone scan. Therefore, a new design of body wrap was developed to improve the issue, and this study aims to evaluate the usability of this medical body wrap. Materials and Methods: To evaluate the usability of the newly designed medical body wrap, a quality assessment of whole body bone scan images and a user satisfaction survey were conducted. Adult patients (male:female=129:152, age: 60.3±12.4 years, BMI: 24.0±4.2) aged 16 years or older who underwent a whole body bone scan during two periods: June to July 2022 (before improvement, n=139) and June to July 2023 (after improvement, n=142) were randomly selected for image quality evaluation. Five radiotechnologists visually evaluated the posterior view of the whole body bone image, including the left and right elbow (2 points), arm (2 points), whether the hand is extended (2 points), whether the hand is included (2 points), and the number of visible fingers (10 points), with a total of 18 points, which were converted to 100 points and analyzed for difference before and after improvement using an independent sample t-test. The user satisfaction questionnaire was evaluated using a 5-point Likert scale among 16 radiotechnologists from three general hospitals who experienced the new body wrap. Results: The image quality assessment was 82.0±13.8 before the improvement and 89.3±10.1 after the improvement, an average of 7.3 points higher, with a statistically significant difference (t=5.02, p<0.01). The user satisfaction survey showed an overall satisfaction rating of 4.1±0.8 for ease of use, 3.8±0.7 for scan preparation time, 3.9±0.7 for patient safety, 3.8±1.2 for scan accuracy, and 4.2±0.7 for recommendation (87.5% questionnaire response rate). Conclusion: The developed body wrap showed higher image quality and user satisfaction compared to the old method. Considering these results, it is deemed that the new body wrap may be more useful than existing methods.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2005년도 춘계종합학술대회
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• pp.824-827
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• 2005

개인의 정보뿐만 아니라 산업체나 국가기관의 정보보안에 있어서 비밀번호는 매우 중요한 수단이 되어왔다. 그러나 비밀번호는 암기에 대한 부담, 정보 누출의 문제뿐만 아니라 여러 가지 해킹기술에 의하여 거의 무용지물이 되고 있는 실정이다. 인터넷 금융 업무를 위해 정부에서 시행하고 있는 공인인증서(PKI, 공개키기반구조)도 비밀번호 방식에 근간을 두고 있는 것이다. 사람은 손 모양, 지문, 손등의 혈관 패턴, 눈동자의 망막, 홍채, 서명, 음성 등 저마다 다른 생리적(Physiological), 행동적(Behavioral) 특징을 가지고 있다. 이것이 한계에 이른 개인의 비밀번호를 대체하거나 보완할 수 있는 생체인식기술이다. 본 논문에서는 생체인식기술에 대한 종류, 시장 분석, 다중생체인식, 표준화, 개인 프라이버시 보호 및 생체인식산업의 향후 전망 등에 대해 살펴보고자 한다.

• 대한한방내과학회지
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• 제22권2호
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• pp.257-262
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• 2001

Cheiro-oral syndrome is characterized by a partial sensory disturbance in one hand and the ipsilateral oral comer. Its lesion is on the sensory track, and it is comparatively small. Most studies are case studies. These studies reported less than 10 cases. We studied two cases. In one, we observed intracranial hemorrhage involving left thalamus, posterior limb of internal capsule about 5cc in brain computed tomographic scan. The case was shown paresthesia of the right hand and ipsilateral comer of the mouth. The patient also complained about disturbing dysstereognosis and disorder of graphaesthesia. In the other case, we observed nodular calcification at the left basal ganglia external capsule in brain computed tomographic scan. The patient also complained about dysesthesia of the right thumb and index finger, fatigue and verbal disturbance. These cases appeared to be typical strokes in the acute phase, but after acute phase, they had dysethesia in the hand and periord for three months.

• Interaction and multiscale mechanics
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• 제3권2호
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• pp.173-191
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• 2010

Damage detection plays a very important role to the maintenance of bridge structures. Traditional damage detection methods are usually based on structural dynamic properties, which are acquired from pre-installed sensors on the bridge. This is not only time-consuming and costly, but also suffers from poor sensitivity to damage if only natural frequencies and mode shapes are concerned in a noisy environment. Recently, the idea of using the dynamic responses of a passing vehicle shows a convenient and economical way for damage detection of bridge structures. Inspired by this new idea and the well-established tap test in the field of non-destructive testing, this paper proposes a new method for obtaining the damage information through the acceleration of a passing vehicle enhanced by a tapping device. Since no finger-print is required of the intact structure, this method can be easily implemented in practice. The logistics of this method is illustrated by a vehicle-bridge interaction model, along with the sensitivity analysis presented in detail. The validity of the method is proved by some numerical examples, and remarks are given concerning the potential implementation of the method as well as the directions for future research.

• 한국콘텐츠학회논문지
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• 제17권9호
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• pp.132-144
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• 2017

대용량 지문 데이터베이스를 사용하는 지문인식 시스템에서 처리 속도와 정확성을 높이기 위해서는 지문을 클래스별로 카테고리화하는 지문분류 기술을 사용해야 한다. 지문분류 방법은 지문 융선으로부터 특징을 추출하고 지문 융선의 흐름과 형상에 따라 정의되어 있는 클래스를 기준으로 학습 및 추론 기법을 이용하여 분류한다. 기존에는 종이에 회전 날인하여 습득된 NIST 데이터베이스를 이용한 연구가 많이 수행되었지만, 지문인식 입력 센서를 이용한 자동화된 시스템이 보편화됨에 따라 FVC에서 공개한 지문 데이터와 같이 센서로부터 입력된 지문 이미지를 이용한 연구가 증가하고 있으며, 최근에는 딥러닝을 이용한 지문분류 방법이 제안되고 있다. 본 논문에서는 지문분류를 위한 특징 추출 및 분류 기술의 동향을 살펴보고 분류성능을 비교한다. 또한 센서 기반 지문 이미지의 다양한 품질을 고려한 지문분류 기술 연구의 필요성에 대하여 정리하고, 딥러닝 기술을 적용한 지문분류 방법을 분석해 봄으로써 지속적으로 사용이 증가되고 있는 대용량 지문 데이터베이스의 분류 기술 연구에 대한 성능향상에 보탬이 되고자 한다.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2016년도 제54차 하계학술대회논문집 24권2호
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• pp.243-244
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• 2016

은행거래를 하려면 Active X를 기반으로 하는 보안 통합설치프로그램, 공인인증 보안프로그램, 개인 PC방화벽 프로그램 등 보안에 필요한 프로그램을 설치해야한다. 그러나 Active X의 보안취약점으로 앞으로 나올 브라우저에서는 Active X대신 웹 표준 모듈을 기반으로 하는 보안 시스템을 제공하고 있다. 본 논문은 Active X를 대체할 수 있는 것으로 웹 표준 모델에 근거한 QR코드 및 지문인식을 통한 인증을 제안한다. 본 논문에서 제안한 시스템을 적용한다면, 보다 안전한 은행거래를 하는데 도움을 줄 수 있다.