• Title/Summary/Keyword: Finger

검색결과 2,171건 처리시간 0.03초

근 기능 훈련 및 장치 치료를 시행한 환자들의 혀, 입술, 볼의 최대 압력 비교 (Evaluation of the Pressure of the Tongue, Lips, and Cheeks in Patients with Myofunctional Therapy and Appliance)

  • 성민아;지명관;이난영
    • 대한소아치과학회지
    • /
    • 제50권1호
    • /
    • pp.13-23
    • /
    • 2023
  • 이 연구의 목적은 평균 혀, 입술, 볼의 압력을 비교하여 구강 내 근육 불균형을 확인하고 근 기능 훈련에 따른 변화를 관찰하는 것이다. 구강 악습관으로 인한 근 기능 이상이 관찰되는 환자들을 대상으로 장치를 동반한 근 기능 훈련을 시행하였다. 압력 측정 장치를 사용하여 구강 근육의 기능 향상 정도를 측정하였다. 연구 대상은 만성 구호흡, 손가락 빨기, 입술 빨기, 혀 내밀기, 잘못된 연하 습관과 같은 구강 악습관이 있는 21명의 환자들로 구성하였다. 치료 전, 두 그룹 간의 측정값을 비교했을 때 혀와 입술의 측정값 사이에 큰 차이가 관찰되었다. 혀의 측정값은 근 기능 훈련을 시작하고 나서 1개월 이후 가장 크게 증가하였고 입술의 측정값은 치료 시작 후 3개월에서 6개월 사이에 가장 큰 폭으로 증가하였다. 대조군에서 측정한 혀, 입술, 우측 볼, 좌측 볼의 값은 실험군이 근 기능 훈련을 시작하고 나서 6개월 이후 측정한 값과 매우 유사했다. 장치를 동반한 근 기능 훈련을 꾸준히 시행할 경우, 혀와 입술의 압력이 눈에 띄게 증가하는 것을 확인할 수 있다. 또한 구강 악습관으로 인한 구강 근육 불균형이 관찰되는 환자의 경우 적어도 6개월 이상의 근 기능 훈련이 추천된다.

N6-Methyladenosine modification (m6A) of circRNA-ZNF638 contributes to the induced activation of SHF stem cells through miR-361-5p/Wnt5a axis in cashmere goats

  • Ronghuan Yin;Ronglan Yin;Man Bai;Yixing Fan;Zeying Wang;Yubo Zhu;Qi Zhang;Taiyu Hui;Jincheng Shen;Siyu Feng;Wenlin Bai
    • Animal Bioscience
    • /
    • 제36권4호
    • /
    • pp.555-569
    • /
    • 2023
  • Objective: The objective of this study was to investigate the effects of N6-Methyladenosine modification-circRNA-zinc finger protein 638 (m6A-circRNA-ZNF638) on the induced activation of secondary hair follicle (SHF) stem cells with its potential mechanisms in cashmere goats. Methods: The m6A modification of ZNF638 was analyzed using methylation immunoprecipitation with real-time quantitative polymerase chain reaction technique in SHF stem cells. The effects of circRNA-ZNF638 on the induced activation of SHF stem cells in m6A dependence were evaluated through the overexpression of circRNA-ZNF638/its m6A-deficient mutants in circRNA-ZNF638 knockdown SHF stem cells. The competitive binding of miR-361-5p to circRNA-ZNF638/Wnt5a 3'- untranslated region was analyzed through Dual-luciferase reporter assay. Results: The m6A-circRNA-ZNF638 had significantly higher transcription at anagen SHF bulge of cashmere goats compared with that at telogen, as well as it positively regulated the induced activation of SHF-stem cells in cashmere goats. Mechanismly, m6A-circRNA-ZNF638 sponged miR-361-5p to heighten the transcriptional expression of Wnt5a gene in SHF-stem cells. We further demonstrated that the internal m6A modification within circRNA-ZNF638 is required for mediating the miR-361-5p/Wnt5a pathway to regulate the induced activation of SHF stem cells through an introducing of m6A-deficient mutant of circRNA-ZNF638. Conclusion: The circRNA-ZNF638 contributes the proper induced activation of SHF-stem cells in cashmere goats in m6A-dependent manner through miR-361-5p/Wnt5a axis.

트래커를 활용한 딥러닝 기반 실시간 전신 동작 복원 (Deep Learning-Based Motion Reconstruction Using Tracker Sensors)

  • 김현석;강경원;박강래;권태수
    • 한국컴퓨터그래픽스학회논문지
    • /
    • 제29권5호
    • /
    • pp.11-20
    • /
    • 2023
  • 본 논문에서는 손 동작을 포함한 전신 동작 생성이 가능하고 동작 생성 딜레이를 조절할 수 있는 새로운 딥러닝 기반 동작 복원 기술을 제안한다. 제안된 방법은 범용적으로 사용되는 센서인 바이브 트래커와 딥러닝 기술의 융합을 통해 더욱 정교한 동작 복원을 가능하게함과 동시에 IK 솔버(Inverse Kinematics solver)를 활용하여 발 미끄러짐 현상을 효과적으로 완화한다. 본 논문은 학습된 오토인코더(AutoEncoder)를 사용하여 트래커 데이터에 적절한 캐릭터 동작의 실시간 복원이 가능하고, 동작 복원 딜레이를 조절할 수 있는 방법을 제안한다. 복원된 전신 동작에 적합한 손 동작을 생성하기 위해 FCN(Fully Connected Network)을 사용하여 손 동작을 생성하고, 오토인코더에서 복원된 전신 동작과 FCN 에서 생성된 손 동작을 합쳐 손 동작이 포함된 캐릭터의 전신 동작을 생성할 수 있다. 앞서 딥러닝 기반의 방법으로 생성된 동작에서 발 미끄러짐 현상을 완화시키기 위해 본 논문에서는 IK 솔버 를 활용한다. 캐릭터의 발에 위치한 트래커를 IK 솔버의 엔드이펙터(end-effector)로 설정하여 캐릭터의 발 움직임을 정확하게 제어하고 보정하는 기술을 제안함으로써, 생성된 동작의 전반적인 정확성을 향상시켜 고품질의 동작을 생성한다. 실험을 통해, 본 논문에서 제안한 딥러닝 기반 동작 복원에서 정확한 동작 생성과 사용자 입력에 따라 프레임 딜레이 조정이 가능함을 검증하였고, 생성된 전신 동작의 발미끄러짐 현상에 대해 IK 솔버가 적용되기 이전 전신 동작과 비교하여 보정에 대한 성능을 확인하였다.

군 수사현장에서 용의자의 비언어적 행동을 이용한 거짓말 탐지 (Detecting lies through suspect's nonverbal behaviors in the investigation scene)

  • 김시업;전우병;전충현
    • 한국심리학회지 : 문화 및 사회문제
    • /
    • 제12권2호
    • /
    • pp.101-114
    • /
    • 2006
  • 본 연구는 실제 사건의 용의자를 대상으로 거짓말 탐지의 비언어적 단서와 Othello의 오류(상대방이 자신의 결백을 믿지 않는 것에 대한 '불신의 두려움'을 거짓말 하는 사람이 나타내는 '발각의 두려움'이라고 잘못 판단하는 오류) 단서를 찾고, 기존의 연구결과와 어떤 차이가 있는지를 알아보고자 하였다. 연구 대상자는 영내 무단 음주사건의 혐의자 18명이었다. 이 중 8명은 실제 음주행위를 했던 용의자들이었고(거짓집단), 나머지 10명은 무혐의자들이었다(진실집단). 거짓집단이 사건 무관련 질문(거짓을 말할 필요가 없음으로 진실반응을 나타냄)과 사건 관련 질문(사건과 관련되기 때문에 거짓반응을 나타냄)에서 나타낸 행동특징들 중 유의미한 차이를 나타낸 행동을 거짓말 탐지의 단서로 삼았다. 또한 진실집단이 사건 무관련 질문(진실반응)과 사건 관련 질문(진실반응)에서 나타낸 행동특징들 중 유의미한 차이를 나타낸 행동을 Othello의 오류 단서로 삼았다. 그 결과, 거짓집단에게서 발견된 거짓말 탐지단서는 잠시멈춤 시간, 잠시멈춤 빈도, 미세표정, 머리움직임이었다. 즉 거짓을 말할 때 잠시멈춤 시간과 빈도가 감소하였고, 미세표정과 머리움직임은 증가하였다. 그러나 진실집단이 사건 관련 질문에서 더 짧은 답변지연시간을 나타낸 것은 Othello의 오류와 관련된 것이 아니었다. 그리고 본 연구와 기존의 국내 연구결과를 비교하였을 때 잠시멈춤 빈도가 일치된 단서로 나타났다. 즉, 진실을 말할 때보다 거짓을 말할 때 잠시멈춤빈도가 감소되는 것으로, 이는 상대방에게 신뢰로운 인상을 주고자 행동통제를 시도한 것으로 해석될 수 있다.

전신 뼈 검사에서 의료용 신체 고정구의 유용성 평가 (Evaluating the Usability of Medical Body Wrap in Whole Body Bone Scan)

  • 심동오;정우영;류재광;박철홍;김윤재
    • 핵의학기술
    • /
    • 제28권1호
    • /
    • pp.49-56
    • /
    • 2024
  • Purpose: When performing nuclear medicine examinations, body wraps or plastic supports are used to support and immobilize the patient's upper extremities to prevent patient safety accidents. However, the existing plastic supports compromised patient and staff safety, including finger entrapment and falls. Moreover, the body wrap provided by manufacturers compromised image quality such as upper extremities cutoff during whole body bone scan. Therefore, a new design of body wrap was developed to improve the issue, and this study aims to evaluate the usability of this medical body wrap. Materials and Methods: To evaluate the usability of the newly designed medical body wrap, a quality assessment of whole body bone scan images and a user satisfaction survey were conducted. Adult patients (male:female=129:152, age: 60.3±12.4 years, BMI: 24.0±4.2) aged 16 years or older who underwent a whole body bone scan during two periods: June to July 2022 (before improvement, n=139) and June to July 2023 (after improvement, n=142) were randomly selected for image quality evaluation. Five radiotechnologists visually evaluated the posterior view of the whole body bone image, including the left and right elbow (2 points), arm (2 points), whether the hand is extended (2 points), whether the hand is included (2 points), and the number of visible fingers (10 points), with a total of 18 points, which were converted to 100 points and analyzed for difference before and after improvement using an independent sample t-test. The user satisfaction questionnaire was evaluated using a 5-point Likert scale among 16 radiotechnologists from three general hospitals who experienced the new body wrap. Results: The image quality assessment was 82.0±13.8 before the improvement and 89.3±10.1 after the improvement, an average of 7.3 points higher, with a statistically significant difference (t=5.02, p<0.01). The user satisfaction survey showed an overall satisfaction rating of 4.1±0.8 for ease of use, 3.8±0.7 for scan preparation time, 3.9±0.7 for patient safety, 3.8±1.2 for scan accuracy, and 4.2±0.7 for recommendation (87.5% questionnaire response rate). Conclusion: The developed body wrap showed higher image quality and user satisfaction compared to the old method. Considering these results, it is deemed that the new body wrap may be more useful than existing methods.

A Mixture of Morus alba and Angelica keiskei Leaf Extracts Improves Muscle Atrophy by Activating the PI3K/Akt/mTOR Signaling Pathway and Inhibiting FoxO3a In Vitro and In Vivo

  • Hyun Hwangbo;Min Yeong Kim;Seon Yeong Ji;Da Hye Kim;Beom Su Park;Seong Un Jeong;Jae Hyun Yoon;Tae Hee Kim;Gi-Young Kim;Yung Hyun Choi
    • Journal of Microbiology and Biotechnology
    • /
    • 제33권12호
    • /
    • pp.1635-1647
    • /
    • 2023
  • Muscle atrophy, which is defined as a decrease in muscle mass and strength, is caused by an imbalance between the anabolism and catabolism of muscle proteins. Thus, modulating the homeostasis between muscle protein synthesis and degradation represents an efficient treatment approach for this condition. In the present study, the protective effects against muscle atrophy of ethanol extracts of Morus alba L. (MA) and Angelica keiskei Koidz. (AK) leaves and their mixtures (MIX) were evaluated in vitro and in vivo. Our results showed that MIX increased 5-aminoimidazole-4-carboxamide ribonucleotide-induced C2C12 myotube thinning, and enhanced soleus and gastrocnemius muscle thickness compared to each extract alone in dexamethasone-induced muscle atrophy Sprague Dawley rats. In addition, although MA and AK substantially improved grip strength and histological changes for dexamethasone-induced muscle atrophy in vivo, the efficacy was superior in the MIX-treated group. Moreover, MIX further increased the expression levels of myogenic factors (MyoD and myogenin) and decreased the expression levels of E3 ubiquitin ligases (atrogin-1 and muscle-specific RING finger protein-1) in vitro and in vivo compared to the MA- and AK-alone treatment groups. Furthermore, MIX increased the levels of phosphorylated phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) that were reduced by dexamethasone, and downregulated the expression of forkhead box O3 (FoxO3a) induced by dexamethasone. These results suggest that MIX has a protective effect against muscle atrophy by enhancing muscle protein anabolism through the activation of the PI3K/Akt/mTOR signaling pathway and attenuating catabolism through the inhibition of FoxO3a.

High-fat diet alters the thermogenic gene expression to β-agonists or 18-carbon fatty acids in adipocytes derived from the white and brown adipose tissue of mice

  • Seonjeong Park;Seung A Ock;Yun Jeong Park;Yoo-Hyun Lee;Chan Yoon Park;Sunhye Shin
    • Journal of Nutrition and Health
    • /
    • 제57권2호
    • /
    • pp.171-184
    • /
    • 2024
  • Purpose: Although activating thermogenic adipocytes is a promising strategy to reduce the risk of obesity and related metabolic disorders, emerging evidence suggests that it is difficult to induce adipocyte thermogenesis in obesity. Therefore, this study aimed to investigate the regulation of adipocyte thermogenesis in diet-induced obesity. Methods: Adipose progenitor cells were isolated from the white and brown adipose tissues of control diet (CD) or high-fat diet (HFD) fed mice, and fully differentiated white and brown adipocytes were treated with β-agonists or 18-carbon fatty acids for β-adrenergic activation or peroxisome proliferator-activated receptor (PPAR) activation. Results: Compared to the CD-fed mice, the expression of uncoupling protein 1 (Ucp1) was lower in the white adipose tissue of the HFD-fed mice; however, this was not observed in the brown adipose tissue. The expression of peroxisome proliferator-activated receptor gamma (Pparg) was lower in the brown adipose progenitor cells isolated from HFD-fed mice than in those isolated from the CD-fed mice. Norepinephrine (NE) treatment exerted lesser effect on peroxisome proliferator-activated receptor-γ coactivator (Pgc1a) upregulation in white adipocytes derived from HFD-fed mice than those derived from CD-fed mice. Regardless which 18-carbon fatty acids were treated, the expression levels of thermogenic genes including Ucp1, Pgc1a, and positive regulatory domain zinc finger region protein 16 (Prdm16) were higher in the white adipocytes derived from HFD-fed mice. Oleic acid (OLA) and γ-linolenic acid (GLA) upregulated Pgc1a expression in white adipocytes derived from HFD-fed mice. Brown adipocytes derived from HFD-fed mice had higher expression levels of Pgc1a and Prdm16 compared to their counterparts. Conclusion: These results indicate that diet-induced obesity may downregulate brown adipogenesis and NE-induced thermogenesis in white adipocytes. Also, HFD feeding may induce thermogenic gene expression in white and brown primary adipocytes, and OLA and GLA could augment the expression levels.

이비인후, 안, 치아 및 피부증상의 민간요법에 관한 고찰 (Study on the Herb Remedies of ENT, Eyes, Teeth and Skin Problems)

  • 조결자;강현숙
    • 동서간호학연구지
    • /
    • 제1권1호
    • /
    • pp.50-71
    • /
    • 1997
  • The intention of this study is to apprehend the con. tents and methods of herb remedies that are commonly conducted when there are health-problem cases of ENT, eyes, teeth and skin. Methods of this study are divided into two stages : 1) For a period of six months from December 1994 to June 1995, some 40 persons who are believed to be well versed with herb remedies have been randomly chosen, and we made a survey on herb remedies by symptoms: and 2) we have endeavored to make their grounds evident through the studies on literatures with the focus on the basic data collected. Their results are as follows: 1) When one feels a pain in ears, such herb remedies are employed as pouring the vapor into ears, which is made by steaming Alaska pollack, or as applying or wiping with the juices of radish or the ginkgo, or' alum. Applying the radish juice is effective for sterilization and fever removal: and applying the ginkgo juice is effective for cleanliness. But, plastering alum, sesame oil or castor oil, or pouring the vapor of Alaska pollack into ears are perhaps effective but do not have any pharmacologic grounds. 2) When one bleeds at the nose, such kinds of herb remedies are applied as stimulating nose or head with cold water, pressing nose or ridge of nose, or filling up nares with mashed mugworts. In addition, they have utilized garlic or leeks. Such methods as stimulating with cold water or just pressing nose and ridge of nose is based on reasonable grounds, i.e. vasoconstriction and vascular compression ; and applying mashed garlic on the sole of foot is good for the circulation of Qui ; and the use of mugworts and leeks is based upon the pharmacological function of hemostasis. 3) When one feels a sore throat such kinds of herb remedies are employed as gargling or rinsing throat with brine, drinking hot gruel or water, or drinking the juice of mugwort, radish, ginger or Chinese quince. Gargling with brine or drinking the juice of mugwort, radish or ginger is based upon the pharmacological function of pain alleviation, fever removal, and detoxication. 4) When a boil is formed in mouth, such herb remedies are applied as spreading honey, brine or alum water, and taking gall nut, Chinese matrimony vine, lotus root, etc, for drugs. Spreading honey, brine or water that is made by infusing gallnut, Chinese matrimony vine, lotus root is based upon such functions as hematosis, astriction, antibacterial, and antiphlogistic, Alum, eggplant and licorice are said to be effective, but their pharmacological effects have no grounds. 5) When one has conjunctivitis such herb remedies are commonly applied as irrigation with brine and dropping breast milk in eyes. Moreover, such other drugs are used as plantain. shepherd's purse, and purslane, etc. The use of brine, breast milk, plantain, shepherd's purse and purslane is based upon such functions as sterilization, antiphlogistic, disinfection and pain relieving. Eriocaulon sieboldianum, bean stem, bean pod and narcissus leaves are said to be effective, but their pharmacological action have no basis. When one has a stye, such herb remedies are applied as extracting eyelashes, stimulating by a massage of middle finger, third finger or big toe, as well as sear ing with a heated bamboo comb that is fine-toothed. Other than these, plantain and nightshade's nuts are used as drugs for it. Extracting eyelashes corresponds with exclusing suppurative node and draining the stye of pus ; and the use of plantain is based upon disinfection: and nightshade's nuts are said to be effective, however, their pharmacological action has no grounds. 6) For a treatment of toothache, such herb remedies are commonly employed as rinsing mouth with brine and holding cold water or gasoline in the mouth ; and as the drugs that are believed to be effective have been Welsh onion, ginger and castor-oil, plant, etc. The use of Welsh onion is based upon pain killing, antiinflammatory actions, and the use of ginger is based upon detoxication and disinfection ; and seeds of castor-oil plants are said to be effective, but they have no pharmacological basis. 7) When one has hives, such herb remedies are commonly applied as rubbing burned straw in affected parts, exposing to its smoke, rubbing with salt, sweeping down with a broom, and spreading and drinking boiled water of trifoliate orange. The use of cassia tora seeds, walnut, aloe and radish is said to be effective. The use of cassia tor a seeds has the functions of intestinal order, anti-paralysis, etc. The use of walnut has resulted in an increase of blood by invigorating spirits ; and the use of aloe is based upon disinfection, antibiotic, anti-salt, antihistamine and detoxication action. But, the effects of radish juice and straw's smoke have no pharmacological grounds. 8) When one gets a boil, such herb remedies are commonly used as applying a plaster, paste of flour mixed with yolk, soy sauce or honey, as well as spreading pounded elm tree. Other remedies that have been said to be effective are ; heating with mugwort, brine, wild rocambole, aloe, onion, squid's bone, etc. The use of mugwort is based upon pain killing, astringent antiinflammatory and tranquility. Wild rocambole is based upon the generation and maintenance functions of cell-joining textures ; elm tree upon antiphlogistic ; aloe upon fever removal and antiphlogistic ; onion on pain killing, fever removal, antiphlogistic and tranquility ; squid's bone on astriction: and brine or vinegar on sterilization. Pine resin and gardenia seed are said to be effective, but they have no pharmacological basis. 9) When one cuts his skin, such herb remedies are commonly employed as spreading mugwort's juice or squid's bone powder, or pressing the wounds. In addition, kalopanax, onion and fine soil are employed. The use of mugwort, kalopanax and squid's bone is based upon such functions as hemostasis, sedation, pain killing, antibacterial ; and fine soil is said to be effective, but it has no pharmacological basis. 10) When one suffers from whitlow, such herb remedies are commonly utilized as heating with boiled soy sauce, spreading soybean paste, or dipping into eggs, etc. Other drugs that have been employed are onion root, brine, eggplant, potato, loach, etc. The use of onion is based upon pain killing and antiphlogistic functions ; and that of brine upon antiphlogistic function. The use of soy sauce or soybean paste, fomentation, eggplant, potato and loach is said to be effective, but it has no pharmacblogic ground. 11) For the treatment of frostbite, such herb remedies are commonly used as dipping the affected part into frozen soybean sack, using boiled water of eggplant stem, garlic caulis, onion, hot pepper, caulis. Onion is based upon antiphlogistic and tranquility actions garlic upon disintection, metabolic exacerbation, tonic and aphrodisiac actions and the use of eggplant and hot pepper is based upon help blood circulation, dissolution and excretion of waste matters in vein. 12) For the treatment of burn, such herb remedies or drugs are commonly used as cleansing with Korean gin, spreading eggs, cleansing with cold water and soap water ; and as brine, cactus, moss, soybean paste, oil, etc. The cleansing with Korean gin, cold water, soap water, brine, vinegar is based upon cleaning and sterilizing functions ; and the use of cucumber is based upon nu. trition provision, and strengthening of resisting power by adjustment of metabolism. The use of potato, cactus, moss, oil and eggs is said to be effective, but their phamacological functions are not clarified. In view of the above results, we can realize that the drugs that have been employed in herb remedies are quite diverse. However, in regard to majority of herb remedies that have been employed by symptoms, the pharmacological functions of their drugs have not been clarified, and they are merely known as effective. Furthermore, they have not been recorded in the literature as yet ; and we confirm that there have been many herb remedies that were executed without the proper knowlege of their effects. It is now our view that the results of this survey may be utilized for consulting data in regard to the use of herb remedies.

  • PDF

A Novel Human BTB-kelch Protein KLHL31, Strongly Expressed in Muscle and Heart, Inhibits Transcriptional Activities of TRE and SRE

  • Yu, Weishi;Li, Yongqing;Zhou, Xijin;Deng, Yun;Wang, Zequn;Yuan, Wuzhou;Li, Dali;Zhu, Chuanbing;Zhao, Xueying;Mo, Xiaoyang;Huang, Wen;Luo, Na;Yan, Yan;Ocorr, Karen;Bodmer, Rolf;Wang, Yuequn;Wu, Xiushan
    • Molecules and Cells
    • /
    • 제26권5호
    • /
    • pp.443-453
    • /
    • 2008
  • The Bric-a-brac, Tramtrack, Broad-complex (BTB) domain is a protein-protein interaction domain that is found in many zinc finger transcription factors. BTB containing proteins play important roles in a variety of cellular functions including regulation of transcription, regulation of the cytoskeleton, protein ubiquitination, angiogenesis, and apoptosis. Here, we report the cloning and characterization of a novel human gene, KLHL31, from a human embryonic heart cDNA library. The cDNA of KLHL31 is 5743 bp long, encoding a protein product of 634 amino acids containing a BTB domain. The protein is highly conserved across different species. Western blot analysis indicates that the KLHL31 protein is abundantly expressed in both embryonic skeletal and heart tissue. In COS-7 cells, KLHL31 proteins are localized to both the nucleus and the cytoplasm. In primary cultures of nascent mouse cardiomyocytes, the majority of endogenous KLHL31 proteins are localized to the cytoplasm. KLHL31 acts as a transcription repressor when fused to GAL4 DNA-binding domain and deletion analysis indicates that the BTB domain is the main region responsible for this repression. Overexpression of KLHL31 in COS-7 cells inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). KLHL31 also significantly reduces JNK activation leading to decreased phosphorylation and protein levels of the JNK target c-Jun in both COS-7 and Hela cells. These results suggest that KLHL31 protein may act as a new transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions.

Evidence of Cortical Reorganization in a Monoparetic Patient with Cerebral Palsy Detected by Combined Functional MRI and TMS

  • ;장성호
    • Journal of Yeungnam Medical Science
    • /
    • 제22권1호
    • /
    • pp.96-103
    • /
    • 2005
  • 뇌성마비로 인해 오른 손에서 단부전마비를 호소하는 환자를 대상으로 기능적 자기공명영상 장치와 경두개 자기 자극기를 사용하여 운동신경의 회복기전을 연구하였다. 대상자는 21세 된 남자 환자로 오른손에 경미한 운동 기능의 손상을 보였고, 자기공명영상의 소견에서 좌반구의 precentral knob에서 병변을 보였다. 기능적 자기공명영상 촬영은 한 명의 대상자와 여덟 명의 정상인을 대상으로 표준화된 헤드코일을 사용하여 1.5 T의 장치에서 BOLD 기술을 적용하여 실시하였다. 대상자들의 운동 수행은 1 Hz 주기로 손가락의 굴곡과 신전을 반복하는 과제가 제시되었다. 경두개 자기 자극은 원형 코일을 사용하여 코일의 앞쪽 부분이 대상자의 두피에서 1 cm 정도 떨어진 정접 부위에 적용되었고 양측의 짧은엄지벌림근에서 발생된 운동 유발 전위가 동시에 측정되었다. 자기공명영상의 결과에서 환자의 비손상측(좌측) 손과 정상군의 좌측 손의 운동 수행 시 오른쪽의 일차운동감각영역(SM1)의 precentral knob에서 활성도가 나타났다, 그러나, 환자의 손상측(우측) 손의 운동 수행 시, 좌측 일차운동감각영역의 손상된 precentral knob 내측 부위에서 활성도를 보였다. 또한, 경두개 자기 자극의 결과에서 손상측 짧은엄지벌림근에서 발생된 운동 유발 전위에 해당하는 뇌 부위가 환자의 정상측과 비교하여 1 cm 내측에서 발견되었다. 그러므로 손상측 손의 운동 기능이 손상된 precentral knob의 내측 부분으로 전위되어 신경재구성이 이루어진 것으로 추정되는 결론을 얻었다.

  • PDF