• BMB Reports
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• v.50 no.10
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• pp.496-503
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• 2017

The human body loses several billions of cells daily. When cells die in vivo, the corpse of each dead cell is immediately cleared. Specifically, dead cells are efficiently recognized and cleared by multiple types of neighboring phagocytes. Early research on cell death focused more on molecular mechanisms of cell death regulation while the cellular corpses were merely considered cellular debris. However, it has come to light that various biological stimuli following cell death are important for immune regulation. Clearance of normal dead cells occurs silently in immune tolerance. Exogenous or mutated antigens of malignant or infected cells can initiate adaptive immunity, thereby inducing immunogenicity by adjuvant signals. Several pathogens and cancer cells have strategies to limit the adjuvant signals and escape immune surveillance. In this review, we present an overview of the mechanisms of dead cell clearance and its immune regulations.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.40 no.5
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• pp.388-396
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• 2003

In this paper, a fast motion search algorithm that performs motion search for variable blocks in integer pixel unit is proposed. The proposed method is based on the successive elimination algorithm (SEA) using sum norms to find the best estimate of motion vector and obtains the best estimate of the motion vectors of blocks, including 16${\times}$8, 8${\times}$16, and 8${\times}$8, by searching eight pixels around the best motion vector of 16${\times}$16 block obtained from all candidates. And the motion vectors of blocks, including 8${\times}$4, 4${\times}$8, and 4${\times}$4, is obtained by searching eight pixels around the best motion vector of 8${\times}$8 block. The proposed motion search is applied to the H.264 encoder that performs variable blocks motion estimation (ME). In terms of computational complexity, the proposed search algorithm for motion estimation (ME) calculates motion vectors in about 23.8 times speed compared with the spiral full search without early termination and 4.6 times speed compared with the motion estimation method using hierarchical sum of absolute difference (SAD) of 4${\times}$4 blocks, while it shows 0.1dB∼0.4dB peak signal-to-noise ratio (PSNR) drop in comparison to the spiral full search.

• Physical Therapy Korea
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• v.15 no.4
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• pp.70-79
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• 2008

The purpose of this study was to find out the effects of electroencephalograph (EEG) power and coherence on cognitive function in normal elderly, non-demented elderly with mild cognitive impairment, and demented elderly during working cognition tasks. Forty elderly women (19 demented elderly, 10 non-demented elderly with mild cognitive impairment, 11 norma1 elderly) participated in this study, All subjects performed working cognition tasks with Raven's CPM while EEG signal was recorded, EEGs were measured continuously at rest and during the working cognition task. EEG power and coherence was computed over 21 channels: right and left frontal, central, parietal, temporal and occipital region. We found that there were more correct answers among normal elderly women than in other groups Owing the working cognition task, ${\Theta}$ wave at Fp1, Fp2 and F8, a wave at Fp2, ${\beta}$ wave at Fp1, Fp2. F4 and F8 of the frontal region was increased significantly in the demented elderly group. On the other hand. ${\Theta}$ wave at Fp1, Fp2 and F7, ${\beta}$ wave at Fp1, Fp2, F3 and F7 of the frontal region was increased significantly in the group of non-demented elderly with mild cognitive impairment. In contrast. in the normal elderly group, all of the ${\Theta}$ wave and ${\beta}$ wave at Fp1, Fp2, F3, F4, F7 and F8 of the frontal region (except ${\beta}$ wave at F3) was increased significantly, These results suggest that the nerves in prefrontal and right hemisphere regions were most active in the demented elderly group during problem solving, and the nerves in the prefrontal and left hemisphere lobe were most active in the group of non-demented elderly with mild cognitive impairment. In contrast, me majority of nerves in the frontal region were active in the normal elderly group.