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Model Validation Methods of Population Pharmacokinetic Models (집단 약동학 모형을 위한 모형 진단과 적합도 검정에 대한 고찰)

  • Lee, Eun-Kyung
    • The Korean Journal of Applied Statistics
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    • v.25 no.1
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    • pp.139-152
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    • 2012
  • The result of the analysis of a population pharmacokinetic model can directly influence the decision of the dose level applied to the targeted patients. Therefore the validation procedure of the final model is very important in this area. This paper reviews the validation methods of population pharmacokinetic models from a statistical viewpoint. In addition, the whole procedure of the analysis of population pharmacokinetics, from the base model to the final model (that includes various validation procedures for the final model) is tested with real clinical data.

Effect of Refining Load on the Drainage Characteristics of Pulp (고해부하가 지층 형성시 탈수특성에 미치는 영향)

  • 김용식;원종명
    • Journal of Korea Technical Association of The Pulp and Paper Industry
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    • v.32 no.4
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    • pp.10-17
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    • 2000
  • The change of fiber length, freeness, initial forming drainage velocity, specific filtration resistance, final drainage time and wet web dryness were measured to investigate the effect of the refining load on the drainage characteristics of pulp. The arithmetic average fiber length after refining with higher refining load was shorter than that obtained with lower refining load. Higher refining load decreased initial forming drainage velocity, final drainage time and wet web dryness. The refining load also affected the relationship between freeness and specific filtration resistance, initial forming drainage velocity, final drainage time. It was found that the specific filtration resistance is better than freeness to predict the drainage characteristics of pulp and the wet dryness.

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The effects of composition on the wear characteristics of Al-Si alloys. (Al-Si 합금(合衾)의 마멸특성(磨滅特性)에 미치는 조성(組成)의 영향(影響))

  • Kwon, Hyuk-Moo;Chang, Choong-Kun;Shin, Se-Kyoon
    • Journal of Korea Foundry Society
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    • v.6 no.1
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    • pp.5-11
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    • 1986
  • The Wear Characteristics of Al-Si alloys were investigated with various Si contents by using the not-dispersed alloys and uncoated-graphite dispersed alloys. Uncoated-graphite dispersions were accomplished by Vortex method carrying 1 hr. heating at $400^{\circ}C$ on uncoated-graphite. Wear loss were increased by increasing Si contents at the elevated final load. Hyper-eutectic alloys showed higher wear resistance values at the small final load of 2.1Kg and 3.2Kg, but at the more increased final load, hypo-eutectic alloys showed higher wear resistance values than hyper-eutectic alloys. The property of wear resistance of uncoated-graphite dispersed Al-Si alloys showed more good values than not-dispersed alloys. This peroperty of increased war resistance were resulted from lubricating action of dispersed graphite.

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Dyeing Behavior of Low Temperature Plasma Treated Wool

  • Kan C.W.
    • Fibers and Polymers
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    • v.7 no.3
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    • pp.262-269
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    • 2006
  • In this paper, the effects of low temperature plasma (LTP) treatment on the dyeing properties of the wool fiber were studied. The wool fibers were treated with oxygen plasma and three types of dye that commonly used for wool dyeing, namely: (i) acid dye, (ii) chrome dye and (iii) reactive dye, were used in the dyeing process. For acid dyeing, the dyeing rate of the LTP-treated wool fiber was greatly increased but the final dyeing exhaustion equilibrium did not show any significant change. For chrome dyeing, the dyeing rate of the LTP-treated wool fiber was also increased but the final dyeing exhaustion equilibrium was only increased to a small extent. In addition, the rate of afterchroming process was similar to the chrome dyeing process. For the reactive dyeing, the dyeing rate of the LTP-treated wool fiber was greatly increased and also the final dyeing exhaustion equilibrium was increased significantly. As a result, it could conclude that the LTP treatment could improve the dyeing behavior of wool fiber in different dyeing systems.

Input- Truncatum Faithfulness in English Hypocoristic Names

  • Hwangbo, Young-Shik
    • Korean Journal of English Language and Linguistics
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    • v.2 no.2
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    • pp.287-304
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    • 2002
  • Truncated forms (truncata) in English hypocoristic words have been argued to be faithful to their bases. This means that “ ... the base of truncation is an output form"”(Benua 1995:6,12). For example, in some non-rhotic dialects where syllable-final [r]s are deleted, the [r]s of truncated names such as Gar [gær] (truncated form of Garry [gæri]) are not deleted although they are syllable-final. This is an example of base-truncatum identity. That is, the syllable-final [r] is retained to make the truncatum more faithful to its base. However, there are many English hypocoristic names which are not faithful to their base forms. For example, Letty [equation omitted] (hypocoristic form of Latitia [equation omitted]) is not faithful to its base; the first vowel and the second consonant of the truncatum are not identical to the corresponding segments of the base. It will be argued, therefore, that some truncated forms are more faithful to the inputs than the bases. It will also be argued that McCarthy and Prince's (1995) Full Model is needed to deal successfully with all the phenomena related to truncation.

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MOTION IN PARABOLIC CYLINDRICAL COORDINATES: APPLICATION TO J2 GRAVITY PERTURBED TRAJECTORIES

  • Sharaf, M.A.;Selim, H.H.;Saad, A.S.
    • Journal of The Korean Astronomical Society
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    • v.39 no.4
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    • pp.147-150
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    • 2006
  • In this paper, initial value problem for dynamical astronomy will be established using parabolic cylindrical coordinates. Computation algorithm is developed for the initial value problem of gravity perturbed trajectories. Applications of the algorithm for the problem of final state predication are illustrated by numerical examples of seven test orbits of different eccentricities. The numerical results are extremely accurate and efficient in predicating final state for gravity perturbed trajectories which is of extreme importance for scientific researches as well as for military purposes. Moreover, an additional efficiency of the algorithm is that, for each of the test orbits, the step size used for solving the differential equations of motion is larger than 70% of the step size used for obtaining its reference final state solution.

Effects of Large Particles and Filter Size in Central Chemical Supplying(CCS) System for STI-CMP on Light Point Defects (LPDs) (STI-CMP용 세리아 슬러리 공급시스템에서 거대입자와 필터 크기가 Light Point Defects (LPDs)에 미치는 영향)

  • 이명윤;강현구;박진형;박재근;백운규
    • Journal of the Semiconductor & Display Technology
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    • v.3 no.4
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    • pp.45-49
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    • 2004
  • We examined large particles and filter size effects of Central Chemical Supplying (CCS) system for STI-CMP on Light Point Defects (LPDs) after polishing. As manufacturing process recently gets thinner below 0.1 um line width, it is very important to keep down post-CMP micro-scratch and LPDs in case of STI-CMP. Therefore, we must control the size distribution of large particles in a slurry. With optimization of final filter size, CCS system is one of the solutions for this issue. The oxide and nitride CMP tests were accomplished using nano-ceria slurries made by ourselves. The number of large particles in a slurry and the number of LPDs on the wafer surface after CMP were reduced with decrease of the final filter size. Oxide removal rates slightly changed according to the final filter size, showing the good performance of self-made nano ceria slurries.

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An Analysis of Hot Closed-Die Forging to Reduce Forging Load (단조하중 감소를 위한 열간 형단조공정 해석)

  • 김헌영;김중재;김낙수
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.17 no.12
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    • pp.2970-2981
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    • 1993
  • In hot closed-die forging the load increases rapidly near the final stage. Preforming operation is important to both the sound final forging and die-service life. In this study, the material flows during preforming and final forging are investigated. The physical modeling with Plasticine as a model material showed clear flow patterns. The forging process were numerically simulated by the finite element method with the isothermal and the non-isothermal models. The flow patten of the isothermal simulation showed good agreements with the experiments. Temperature changes and pressure distributions on the die surfaces during one cycle of the forging process were obtained from the non-isothermal simulation. High pressure and temperature were developed at certain areas of the die surfaces. It was concluded that those areas usually coincide with each other and should be distributed by the preforming operations to enhance the die life.

Boundary Tones of Intonational Phrase-Final Morphemes in Dialogues (대화체 억양구말 형태소의 경계성조 연구)

  • Han, Sun-Hee
    • Speech Sciences
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    • v.7 no.4
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    • pp.219-234
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    • 2000
  • The study of boundary tones in connected speech or dialogues is one of the most underdeveloped areas of Korean prosody. This. paper concerns the boundary tones of intonational phrase-final morphemes which are shown in the speech corpus of dialogues. Results of phonetic analysis show that different kinds of boundary tones are realized, depending on the positions of the intonational phrase-final morphemes in the sentences.. This study has also shown that boundary tone patterning is somewhat related to the sentence structure, and for better speech recognition and speech synthesis, it presents a simple model of boundary tones based on the fundamental frequency contour. The results of this study will contribute to our understanding of the prosodic pattern of Korean connected speech or dialogues.

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Sequencing for Mixed-model Assembly Lines Considering Part Supplier in Just-in-time Production Systems (JIT생산시스템에서 부품공급업자를 고려한 혼합조립순서결정에 관한 연구)

  • 남궁석;이상용
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.20 no.43
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    • pp.1-16
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    • 1997
  • This paper improves the autonomy for supplier's schedule and the flexibility of the final assembly line. The final assembly line is a single work station and each product taking different assembly time is considered. In the assembly schedule, the heuristic method based on the goal chasing method is used. Consequently, suppliers can independently determine their output rates and thus, change their workload pattern according to their needs and priorities. Moreover, this flexibility can help to avoid expensive final-assembly-line stoppages in case of sudden part supply disruptions. The sequencing method can be easily implemented into an existing just-in-time system. In addition, the mathematical model was formulated and the algorithm was explained through the flow chart. The numerical example was given and the efficiency of this method is shown through the analysis of computational results of that example.

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