• Genomics & Informatics
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• 제7권1호
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• pp.13-19
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• 2009

Osteoporosis is characterized by impaired osteogenesis. BMD is a major determinant of bone strength. The role of the VDR gene in predisposition to primary osteoporosis has been recognized. However, population-based case-control studies have been reported controversial results for known candidate genes in an ethnically distinct group. To determine the genetic effects of VDR variants on osteoporosis and BMD, we directly sequenced the VDR gene in 24 unrelated Korean individuals and identified eighteen sequence variants. We investigated the potential involvement of eight SNPs in osteoporosis in postmenopausal women (n = 729). Two SNPs (LD) in intron 2, -5294G>C (rs2238135) and -4817G>A (rs17882443) showed the evidence of association with enhanced BMD of the femoral neck ($p_{additive}$=0.031 for rs2238135; $p_{additive}$=0.017 and $p_{dominant}$= 0.019 for 17882443). Moreover, VDR -4817G>A was significantly associated with protective effect on all fracture risk ($p_{recessive}$=0.035, OR=0.2, 95% CI=$0.05{\sim}0.89$), and tended to be higher BMD values at various proximal femur sites. Therefore, we suggest that the -4817G>A may be useful genetic marker for vitamin D-related metabolism and may have an important role in the increased BMD of the proximal femur in postmenopausal Korean women.

• Journal of Trauma and Injury
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• 제26권3호
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• pp.125-130
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• 2013

Purpose: This study was undertaken in order to identify the characteristics of patients diagnosed with occult an hip fracture after hip trauma. Methods: We retrospectively reviewed the medical records and radiology reports of all patients who underwent hip skeletal computed tomography (CT) for suspected hip fractures but had normal initial X-rays after hip trauma between August 2006 and January 2012. The variables evaluated included age, gender, body mass index (BMI), accident mechanism, previous fracture, independence, late presentation, ability to bear weight, pain on passive rotation, tenderness of the groin area, diagnosis and treatment. Patients were divided into two groups, with hip fracture (occult hip fracture group) and without hip fracture (no fracture group) to evaluate the characteristics associated with an occult hip fracture. Results: The patients, a total of 139, had a mean age of 58.3 years and included 72 male patients(51.8%). The occult hip fracture group included 43 patients(30.9%). Of those 43, 21 patients(48.8%) had intertrochanteric or trochanteric fractures, 8 patients(18.6%) had femur neck fractures and 14 patients(32.6%) had acetabular fractures. Of the 43, 15 patients(34.9%) needed operative treatment. Age was higher in the occult hip fracture group than it was in the no fracture group($64.4{\pm}19.1$ years vs. $55.5{\pm}23.6$ years, p=0.021). A previous fracture was associated with the presence of a new fracture (p=0.014; OR=3.971, 95% CI=1.314-11.997). Conclusion: Further evaluation of patients who are older or have history of fractures is prudent, even though the initial X-rays are normal.

• Journal of Trauma and Injury
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• 제23권1호
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• pp.1-5
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• 2010

Purpose: To investigate the results of treatment of reverse oblique trochanteric fractures with compression hip screw. Methods: We reviewed the results of 12 cases of reverse oblique trochanteric fracture treated with compression hip screw from January 2000 to December 2006 which could be followed up for more than 1 year. The mean follow up period was 26 months (15~40). The mean age was 48 years old. Injury mechanism was composed of 6 cases of traffic accident and 6 cases of fall down. 8 persons were man. We investigated the union time, degree of neck-shaft angle change, amount of sliding of compression hip screw, complications, functional and clinical results. Results: 10 cases were united and the mean union time were 5 months (3~8). The mean neck-shaft angle change was 3.5 degrees (0~12). The amount of sliding of compression hip screw was 8.9 mm (2~24). There were six coxa vara, six leg due to coxa vara shortening, two nonunion, and one superficial infection. Unsatisfactory results of Jensen's social function score and Parker and Palmer's mobility score were studied. Conclusion: The results of treatment of reverse oblique trochanteric fractures with compression hip screw were relatively unsatisfied.

• 대한영상의학회지
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• 제82권1호
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• pp.173-181
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• 2021

목적 대퇴골 경부 골절 환자를 대상으로 골다공증 평가를 위해 다중검출 전산화단층촬영(multidetector computed tomography; 이하 MDCT)에서의 감쇠 계수(Hounsfield unit; 이하 HU)와 이중 에너지 X선 흡수 계측법(dual energy X-ray absorptiometry; 이하 DXA)을 비교하였다. 대상과 방법 2016년 6월부터 12월까지 MDCT와 DXA를 모두 시행한 42명의 대퇴골 경부 골절 환자가 본 연구의 대상으로 포함되었다. MDCT에서는 정상 대퇴골 경부의 해면골에서 HU를 측정하였으며 DXA에서는 동 부위의 골밀도 및 T 값을 얻었다. HU와 골밀도 및 T 값의 상관관계를 Spearman 상관계수를 이용하여 분석하였다. 결과 대퇴골 경부 골절 환자의 골밀도와 T 값의 평균은 각각 0.650 g/cm²과 -2.4이었다. 정상, 골감소증, 골다공증 환자 군의 HU의 평균은 각각 131.9, 98.9, 41.3이었다. HU는 골밀도(r² = 0.670; p < 0.001) 및 T 값(r² = 0.676; p < 0.001) 모두와 양의 상관관계를 보였다. 결론 다중검출 전산화단층촬영에서 감쇠계수의 측정은 골다공증 선별검사를 위한 유용한 진단적 도구가 될 수 있다.

• 비파괴검사학회지
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• 제31권5호
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• pp.459-465
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• 2011

대퇴골 근위부의 기하학적 형상은 대퇴골 경부 골절과 중요한 상관관계를 가지고 있는 것으로 보고되고 있다. 기존의 연구에서는 인장실험법과 유한요소해석법을 이용하여 상관관계를 분석해왔다. 그러나 이 방법들은 인체의 미리 정의된 대퇴골 형상을 변경할 수 없고, 다수의 시험편들을 확보하기 어렵기 때문에 다양한 시험편과 모델을 적용할 수 없다는 한계가 있다. 따라서 본 연구에서는 대퇴골 골절 해석에 폭넓게 사용할 수 있도록 매개변수로 기하학적 형상 변형이 가능한 대퇴골 모델을 이용하여 대퇴골 골절과 형상 매개변수의 관계를 분석하였다. 이 관계를 분석하기 위하여 4가지 주요 매개변수(대퇴골두 직경, 대퇴경부 직경, 대퇴경두간 길이, 대퇴경간각)를 이용하여 다양한 해석 모델을 생성하여 유한요소해석을 수행하였다. 이 후 대퇴골두에서의 반력(reaction force)과 경부에서의 응력 분포(stress distribution)를 분석함으로써 유한요 소해석을 수행하였고, 대퇴경부 직경이 대퇴골 경부 골절에 가장 큰 영향을 미치고 대퇴골두 직경이 가장 작은 영향을 미치는 결과가 나타났다.

• Journal of Yeungnam Medical Science
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• 제7권1호
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• pp.69-80
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• 1990

본 영남의대 정형외과학 교실에서는 1984년 1월 부터 1988년 5월 까지 입원 치료한 대퇴 경부 골절 환자 중 최근까지 2년 이상 추적 조사가 가능 하였던 23명의 24례를 대상으로 하여 고찰한 결과를 요약하면 다음과 같다. 1. 총 23명중 여자가 19명, 65세 이상의 노년층의 환자가 11명으로 노년층의 여자에서 호발하였다. 2. 18례에서 경도의 외력에 의한 것이었고 65세 이상의 12례 중 전례에서 경도의 외력에 의해 골절되었고 8례에서 심각한 골조송증을 보였다. 3. 24례 중 14례에서 전위된 골두하 골절이었고 6례에서 전위된 횡경부 골절이었으며 4례에서 전위되지 않은 횡경부 골절이었다. 4. 치료는 14례에서 도수 정복후 내고정을 10례에서 일차적 관절 치환술을 시행하였고 내고정한 14례중 4례에서 대퇴 골두 괴사로 이차적 관절 치환술을 시행하였다. 5. 내고정을 시행한 14례 중 7례에서 합병증을 관찰할 수 있었고 무혈성 괴사가 6례, 불유합 2례, Pin 이동 3례, 내고정물 부전이 1례였다. 6. 관절 치환술을 시행한 14례에서 수술 직후의 대퇴경의 수술적 접합률이 대퇴경의 해리와 관계가 있었다.(r=-0.68. p<0.01) 대퇴 경부 골절의 치료시에 합병증의 발생은 대개 골절의 양상 및 치료시기, 정복의 정도에 의해 결정되며 치료의 지연, 정복의 불가능, 과내반 교정, 병적 골절일 경우에는 일차적 고관절 치환술이 환자의 조기 거동과 사망률의 감소를 위해 바람직할 것으로 사료된다.

• 대한골관절종양학회지
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• 제3권1호
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• pp.32-38
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• 1997

PURPOSE : For the reconstruction of large bone defect after tumor resection, it is possible to reuse the bone involved by tumor with some treatment to it. Several bone-reusing methods have been reported such as autoclaving, low-heat treatment(pasteurization) and intraoperative radiotherapy. We have used extracorporeally radiated autogenous bone graft for reconstruction after tumor resection, and analyzed the periods for junctional union, functional results and complications to know the indications of this method. METHODS : From Dec. 1993 to Sept. 1995, nine patients had taken autogenous bone graft with extracorporeal irradiation. Eight cases were osteosarcoma and 1 giant cell tumor. The graft sites were 5 in femur, 3 proximal tibia and 1 femur and tibia. Stage 3 was 1 case(GCT), Stage IIB 3 and Stage IIIB 5. After wide resection, surrounding soft tissue and intramedullary and extramedullary portion of the tumor were removed. Radiation was done in 5000cGy to the resected bone. Ender nails and bone cement were inserted and filled into the medulla to prevent fracture. RESULTS : Average follow-up period was 12.3(4 to 21) months. Average junctional union period in simple X-ray was 6.5 months in 4 cases. Average functional score following Enneking's criteria was 19(12-27). Complications were as follows ; condylar fractures and femur neck fracture in 4 cases, subluxation of the knee joint 3 and infection 1. Although local recurrence was detected in 1 case, the site of recurrence was not in the radiated bone but surrounding soft tissue. At final follow-up, no recurrence was found in one case(GCT), CDF 2, AWD 2, DOD 3, and died of chemotherapy related sepsis 1. CONCLUSIONS : Extracorporeally radiated bone autograft is considered to be a method for reconstruction of the large bone defect made by tumor resection, especially in the reconstruction around the joint.

• 핵의학기술
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• 제13권3호
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• pp.137-142
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• 2009

목적: WHO (world health organization)에서는 골밀도뿐만 아니라 대규모 역학연구에서 정리된 골절의 위험인자 분석을 통하여 10년 내 골절위험도(10-year fracture probability)를 실제적으로 임상에 적용시킬 수 있는 소프트웨어 프로그램인 FRAX Tool (fracture risk assessment)이 2008년에 공개되었다. 본 연구는 기존에 사용하고 있는 GE Prodigy사의 골절위험도평가와 $FRAX^{TM}$를 이용한 골절위험도평가를 비교분석하고자 한다. 검사방법: 본원에 골밀도 검사를 시행한 201명($55{\pm}3.5$세)의 여자를 대상으로 GE Prodigy를 이용하여 Femur를 측정하였다. 측정한 Femoral Neck의 BMD (bone mineral density)를 구하여 GE Prodigy의 T-값과 골절위험인자를 고려하지 않은 $FRAX^{TM}$의 T-값를 사용하여 10년 내 대퇴골 골절위험도와 주요한 골다공증성 골절 위험도를 계산하여 SPSS통계프로그램으로 GE Prodigy의 골절위험도 평가와 $FRAX^{TM}$의 골절위험도 평가를 비교분석하였다. 결과: GE Prodigy의 T-값($-0.52{\pm}0.97$)과 $FRAX^{TM}$의 T-값 ($-1.45{\pm}0.81$)은 통계적으로 유의한 차이가 있었으며(p=0.000), GE Prodigy의 주요한 골다공증성 골절위험도($9.15{\pm}3.71$)와 $FRAX^{TM}$의 주요한 골다공증성 골절위험도($4.87{\pm}1.51$)도 또한 통계적으로 유의한 차이가 있었다(p=0.000). 그리고 GE Prodigy의 10년내 대퇴골 골절위험도($1.56{\pm}1.48$)와 $FRAX^{TM}$의 10년 내 대퇴골골절위험도($0.53{\pm}0.61$)도 통계적으로 유의한 차이를 보였다(p=0.000). 결론: GE Prodigy와 $FRAX^{TM}$에서 측정한 골절의 절대위험도는 통계적으로 유의한 차이를 보였다. 특히 GE Prodigy의 T-값, 주요한 골다공증성 골절위험도, 10년 내 대퇴골 골절위험도가 높게 측정되었다. 향후 $FRAX^{TM}$에 대한 평가 및 적용에 관한 연구가 필요할 것으로 생각된다.

• Nutrition Research and Practice
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• 제14권1호
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• pp.55-61
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• 2020

BACKGROUND/OBJECTIVES: Osteoporosis is characterized by low bone mass and results in vulnerability to fracture. Calcium and vitamin D are known to play an important role in bone health. Recently, potassium has been identified as another important factor in skeletal health. We examined the link between potassium intake and bone health among the Korean older adult population. SUBJECTS/METHODS: This retrospective, cross-sectional study included 8,732 men and postmenopausal women over 50 years old who completed the Korean National Health and Nutrition Survey (KNHANES) between 2008 and 2011. Potassium consumption was evaluated using a 24-hour recall method. Bone mineral density (BMD) was measured at three sites (total hip, femur neck, and lumbar spine) by dual-energy X-ray absorptiometry (DEXA). Multinomial logistic regression was used to examine the link between potassium intake and prevalence of osteoporosis and osteopenia, after controlling for potential confounding variables. RESULTS: The BMD of the total femur and Ward's triangle were significantly different according to the potassium intake among men (P = 0.031 and P = 0.010, respectively). Women in the top tertile for potassium intake showed higher BMD than those in the bottom tertile at all measurement sites (all P < 0.05). Daily potassium intake was significantly related to a decreased risk of osteoporosis at the lumbar spine in postmenopausal women (odds ratios: 0.68, 95% confidence interval: 0.48-0.96, P trend = 0.031). However, the dietary potassium level was not related to the risk of osteoporosis in men. CONCLUSION: Current findings indicate that higher dietary potassium levels have a favorable effect on bone health and preventing osteoporosis in older Korean women.

• 대한물리의학회지
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• 제10권2호
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• pp.1-7
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• 2015

PURPOSE: The aims of this study were to assess the intra-tester and inter-tester reliability and validity of hip range of motion using a smart phone in hip operative patients. METHODS: Twenty-five patients (eight total hip arthroplasty and seventeen femur neck fracture) participated in this study. The range of motions in active and passive hip flexion, abduction and external rotation were measured with a goniometer and smart phone over two times by two observers. The intra-tester and inter-tester reliability were evaluated using the intraclass correlation coefficient (ICC2,1). The validity was measured by Pearson's correlation coefficient RESULTS: The intra-observer reliability was good in all measured items (ICC>0.78). The inter-observer reliability was high with ICC (>0.90). All correlation coefficients of smart phone and goniometer was greater than 0.85 and showed a significant positive correlation (p<0.01). CONCLUSION: The range of motion measurement with a smart phone showed acceptable reliability. Therefore, it could be convenient and have economical benefits to measure the range of motion of the hip joint using a smart phone.