• 제목/요약/키워드: Felbinac

검색결과 2건 처리시간 0.016초

4-비페닐아세트산(펠비낙)의 합성 (Facile Synthesis of 4-Biphenylacetic Acid (Felbinac))

  • 최홍대;윤호상;강병원
    • 약학회지
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    • 제36권2호
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    • pp.126-128
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    • 1992
  • A new method for felbinac, which is a potent anti-inflammatory agent, is described. Friedel-Crafts reaction of biphenyl with ethyl ${\alpha}-chloro-{\alpha}-(methylthio)acetate(1)$ afforded ethyl 2-methylthio-2-(4-biphenylyl)acetate(4). Felbinac (7) was synthesized by desulfurization of compound (4) with zinc dust in acetic acid, followed by hydrolysis of the resultant ethyl 2-(4-biphenylyl)acetate (6).

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