• BMB Reports
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• v.54 no.7
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• pp.386-391
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• 2021

Owing to rapid advancements in NGS (next generation sequencing), genomic alteration is now considered an essential predictive biomarkers that impact the treatment decision in many cases of cancer. Among the various predictive biomarkers, tumor mutation burden (TMB) was identified by NGS and was considered to be useful in predicting a clinical response in cancer cases treated by immunotherapy. In this study, we directly compared the lab-developed-test (LDT) results by target sequencing panel, K-MASTER panel v3.0 and whole-exome sequencing (WES) to evaluate the concordance of TMB. As an initial step, the reference materials (n = 3) with known TMB status were used as an exploratory test. To validate and evaluate TMB, we used one hundred samples that were acquired from surgically resected tissues of non-small cell lung cancer (NSCLC) patients. The TMB of each sample was tested by using both LDT and WES methods, which extracted the DNA from samples at the same time. In addition, we evaluated the impact of capture region, which might lead to different values of TMB; the evaluation of capture region was based on the size of NGS and target sequencing panels. In this pilot study, TMB was evaluated by LDT and WES by using duplicated reference samples; the results of TMB showed high concordance rate (R² = 0.887). This was also reflected in clinical samples (n = 100), which showed R² of 0.71. The difference between the coding sequence ratio (3.49%) and the ratio of mutations (4.8%) indicated that the LDT panel identified a relatively higher number of mutations. It was feasible to calculate TMB with LDT panel, which can be useful in clinical practice. Furthermore, a customized approach must be developed for calculating TMB, which differs according to cancer types and specific clinical settings.

• Journal of Korean Society of Transportation
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• v.20 no.7
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• pp.43-50
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• 2002

Competition to attract the increasing container cargoes of North China and the West Japan in North-East Asia region is fairly intensed in recent days between the main ports of Korea, China, and Japan. Inducing a new container cargo make those countries possible to invest enormous fund to mordernize its port facilities, as well as to improve efficiency in Port operation and management. In this situation, Strategy to attract transshipment cargoes is of the immediate necessity, This study, therefore, aims to establish the feasible strategies to attract transshipment container cargoes in the North-East Asian region by empirical analysis, he major output of the research is as follows : First, Busan Port to attract transshipment cargoes is required to adjust port tariff and free storage period with flexibility for liner shipping companies and freight forwarder. Second, Price-Demand function of Busan port between main competitive ports in North-East Asian region that is derived from strategies to attract transshipment cargoes, helps marketing manager to fix scientifically port price as understanding the change of demand quantity.

• Water Engineering Research
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• v.1 no.1
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• pp.63-74
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• 2000

This paper presents a two- phase search scheme for optimal pipe expansion of expansion of existing water distribution systems. In pipe network problems, link flows affect the total cost of the system because the link flows are not uniquely determined for various pipe diameters. The two-phase search scheme based on stochastic optimization scheme is suggested to determine the optimal link flows which make the optimal design of existing pipe network. A sample pipe network is employed to test the proposed method. Once the best tree network is obtained, the link flows are perturbed to find a near global optimum over the whole feasible region. It should be noted that in the perturbation stage the loop flows obtained form the sample existing network are employed as the initial loop flows of the proposed method. It has been also found that the relationship of cost-hydraulic gradient for pipe expansion of existing network affects the total cost of the sample network. The results show that the proposed method can yield a lower cost design than the conventional design method and that the proposed method can be efficiently used to design the pipe expansion of existing water distribution systems.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.1
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• pp.112-123
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• 1997

The optimization techniques have been applied to versatile engineering problems for reducing manufacturing cost and for automatic design. The deterministic approaches or op5imization neglect the effects on uncertainties of design variables. The uncertainties include variation or perturbation such as tolerance band. The optimum may be useless when the constraints considering worst cases of design variables can not be satisfied, which results from constraint variation. The variation of design variables can also give rise to drastic change of performances. The two issues are related to constraint feasibility and insensitive performance. Robust design suggested in the present study is developed to gain an optimum insensitive to variation on design variables within feasible region. The multiobjective function is composed to the mean and the standard deviation of original objective function, while the constraints are supplemented by adding penalty term to original constraints. This method has a advantage that the second derivatives of the constraints are not required. A mathematical problem and several standard problems for structural optimization are solved to check out the usefulness of the suggested method.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.5
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• pp.1236-1251
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• 2013

Sharing geo-tagged photos has been a hot social activity in the daily life because these photos not only contain geo information but also indicate people's hobbies, intention and mobility patterns. However, the present raw geo-tagged photo routes cannot provide information as enough as complete GPS trajectories due to the defects hidden in them. This paper mainly aims at analyzing the large amounts of geo-tagged photos and proposing a novel travel route restoring method. In our approach we first propose an Interest Measure Ratio to rank the hot spots based on density-based spatial clustering arithmetic. Then we apply the Hidden Semi-Markov model and Mean Value method to demonstrate migration discipline in the hot spots and restore the significant region sequence into complete GPS trajectory. At the end of the paper, a novel experiment method is designed to demonstrate that the approach is feasible in restoring route, and there is a good performance.

• Smart Structures and Systems
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• v.20 no.3
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• pp.285-301
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• 2017

This paper presents the design and the application of a new self-powered hybrid electromagnetic damper that can harvest energy while mitigating the vibration of a structure. The damper is able to switch between an energy harvesting passive mode and a semi-active mode depending on the amount of energy harvested and stored in the battery. The energy harvested in the passive mode resulting from the suppression of vibration is employed to power up the monitoring and electronic components necessary for the semi-active control. This provides a hybrid control capability that is autonomous in terms of its power requirement. The proposed hybrid circuit design provides two possible options for the semi-active control: without energy harvesting and with energy harvesting. The device mechanism and the circuitry that can drive this self-powered electromagnetic damper are described in this paper. The parameters that determine the device feasible force-velocity region are identified and discussed. The effectiveness of this hybrid damper is evaluated through a numerical simulation study on vibration mitigation of a bridge stay cable under wind excitation. It is demonstrated that the proposed hybrid design outperforms the passive case without external power supply. It is also shown that a broader force range, facilitated by decoupled passive and semi-active modes, can improve the vibration performance of the cable.

• The KSFM Journal of Fluid Machinery
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• v.12 no.3
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• pp.38-43
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• 2009

The Shiwhaho is an artificial lake located in Yellow sea of Korea where the ocean tidal current is significantly strong, and the tidal power plant is currently being under construction to generate electric power from the ocean tidal current. In addition to the tidal power plant under construction, an ocean current power park was proposed to maximize the power generation by utilizing the ocean current generated by the tidal power plant. To evaluate the feasibility of such combined power plant, the flow characteristics in the ocean current power parks connected with the tidal power plants were investigated numerically in the present study. When two different type of generations are operating together as a system, their interference may occur, which affects their efficiency. Therefore, the minimum distances between the tidal power plants and the ocean current power generators are studied in the present study to minimize such interference. The feasible region to generate power around the Shiwha tide embankment is also predicted by considering predicted ocean current speed distribution. Various arrangements of the ocean current generators are examined and an optimal arrangement is also discussed.

• Journal of Advanced Marine Engineering and Technology
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• v.28 no.6
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• pp.993-999
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• 2004

The estimation of fatigue life at the design stage of membrane type LNG tank is very important in order to arrive at feasible and cost effective solutions considering the total lifetime of the tank. In this study, the practical procedure of fatigue life prediction by use of cumulative damage factors based on Miner-Palmgren hypothesis and probability density function has been shown with the corner region of Gaz Transport Membrane type LNG tank being used as an example. In particular the parameters of Weibull distribution that determine the stress spectrum are discussed. The main results obtained from this study are as follows: 1. The recommended value for the shape parameter of Weibull distribution for the LNG tank is 1.1 in case of using the direct calculation method proposed in this study. 2. The calculated fatigue life is influenced by the shape parameter of Weibull distribution and stress block. The safe fatigue design can be achieved by using higher value of shape parameter and the stress blocks divided into more stress blocks.

• Korean System Dynamics Review
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• v.5 no.2
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• pp.149-174
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• 2004

Since the economic crisis in 1997, the Korean government has implemented a number of reforms in order to eliminate inefficiencies in both private and public sectors. One of the reforms made in the public sector was to lower the retirement age of teachers from the original age of 65 to that age 62. The ultimate aim of this compulsory policy was to improve the quality level of education by hiring many young teachers instead of senior teachers. It was made based on the calculation that by lowering the retirement age by three years, the government can hire three young teachers with the saved wages. However, this policy has brought an unexpected result; the imbalance between the supply and demand for teachers has become a much more serious problem in Korea's elementary education system The purpose of this study is largely twofold; First of all, it aims to identify the scope of imbalances occurred in the supply-demand system of elementary school teachers in a region of the nation, and also to find out why such imbalance occurred. Secondly, the purpose of this study is to experiment with feasible policy alternatives and their effects on the system and to suggest some resolutions on the imbalance.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.31 no.4
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• pp.69-75
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• 2003

The ideal thrust function is used to determine the local thrust of supersonic combustor. Method of thrust determination from measured pressures are applied to the Mach 2.5 model supersonic combustor. In this application, measured pressures from the experiments in the University of Michigan are used to determine the local thrust of supersonic combustor. Marginal results of local thrust are obtained and discussed. Combustion and wedge affect thrust distributions in the upstream region significantly. The thrust determination from pressure measurements can be a simple, feasible and applicable method, especially when thrust stand is not available.