• The Korean Journal of Rehabilitation Nursing
• /
• v.10 no.2
• /
• pp.141-146
• /
• 2007

Purpose: This study was conducted to estimate the prevalence rate, and related factors,of fatty liver in male industrial workers. Method: Fatty liver was diagnosed using ultrasonography. The data for abdominal ultrasonography, BMI, smoking, alcohol drinking, exercise, liver enzymes, and lipid profiles were collected in 4,604 male who were examined with a health screening program in 2005. Prevalence rate and associated factors of fatty liver were analyzed using SPSS v. 12.0. Results: Overall prevalence of fatty liver was 34.1% and higher in the 30-39 year male group. Age, body mass index(BMI), hypertriglyceridemia, hypercholesterolemia, HDL cholesterol, r-GTP level were independently associated factors with presence of fatty liver in logistic regression analysis. Conclusion: The prevalence of fatty liver and tendency of associated factors were similar to those in the western world. To prevent development of this hepatic disorder, which may result in end-stage liver disease, risk factors such as obesity and dyslipidemia must be monitored and controlled within normal levels. The results of this study suggested maintenance of a healthy lifestyle, including diet, exercise, and behavioral change, as fundamental rehabilitation nursing implications.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.43 no.1
• /
• pp.40-46
• /
• 2014

We demonstrated that Acanthopanax senticosus fermentation products (FM-5111 and FM-5131) administered to rats functionally protect against DL-ethionine-induced and ethanol-induced fatty liver models. In DL-ethionine-induced fatty liver models, the serum concentrations of aspartate aminotransferase (AST), as well as liver concentrations of triglyceride and total lipid against the control decreased in FM-5111 and FM-5131 treated rats. In ethanol-induced fatty liver models, FM-5111 and FM-5131 treated rats showed a decrease in the liver concentrations of triglyceride and total lipid in ethanol-induced fatty liver models. There were no significant differences in the serum concentrations of AST and alanine aminotransferase in FM-5111 and FM-5131 treated rats. Additionally, FM-5111-, or FM-5131-treated rats showed no significant differences in the body weight gain between the control. These results indicate that Acanthopanax senticosus fermentation products might have protective effects against DL-ethionine-induced and ethanol-induced fatty liver models.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.23 no.4
• /
• pp.555-560
• /
• 1994

In order to observe the effects of the fees mixed with the lard and two vegetable seed oils on the fatty acid compositions of liver and brain tissue, the oils mixed with 2.5% lard and various levels of perilla oil and evening primrose oil were administered to the male rats of the Sprague-Dawley for 4 weeks . In the fatty acid composition of liver lipid, saturated fatty acid (SFA) contents were rich in the phopholiipide and cholesteryl ester fraction. Monounsaturated fatty acid (MUFA) contents were rich in the triglyceride fraction and polyunsaturated fatty acid (PUFA) contents were rich in the phospholipid fraction. In the fatty acid composition of liver lipid fractions, according as the contents of mixed perilla oil decreased and the contents of mixed evening primrose oil increased , n -3 PUFA contents tended to decrease and n-6 PUFA contents tended to increase. Fatty acid composition of liver lipid fractions were influenced from the fatty acid composition of the test lipids. In the fatty acid composition of brain phospholipd, PUFA contents (40%) were rich and according as the contents of mixed evening primrose oil increased, the ratio on n-3/n-6 PUFA and eicosapentaenoid acid (EPA) /arachidonic acid (AA) tended to slightly decrease.

• Asian-Australasian Journal of Animal Sciences
• /
• v.14 no.9
• /
• pp.1331-1341
• /
• 2001

Dairy cows are prone to fatty liver during the time of periparturient. Despite of the extensive studies, etiology and solutions for fatty liver are still not well known.The liver synthesizes triglycerides (TG) using precursors from bloodstream and secretes TG in form of very low density lipoprotein (VLDL) into bloodstream for the utilization by peripheral tissues. When the amount of TG synthesis exceeds the amount of secretion in VLDL-TG, TG accumulation within the liver occurs. Hepatic VLDL assembly and secretion involve multi-biochemical events.The availabilities of apolipoprotein B (apoB), E (apoE), microsomal triglyceride transfer protein (MTP) and soluble low density lipoprotein (LDL) receptor are now believed to be some of the main regulators for hepatic VLDL assembly and secretion. Studies in transgenic animals show that overexpression of these proteins stimulates VLDL production and secretion, which provides a possibility for alleviating bovine fatty liver by gene therapy. However, many problems remain to be solved to attain this goal. This review focuses on the molecular mechanisms of hepatic VLDL assembly and secretion, and the possibilities and problems of applying the knowledges to solve bovine fatty liver by gene therapy.

• Journal of Nutrition and Health
• /
• v.28 no.7
• /
• pp.629-635
• /
• 1995

Obese children have increaed in Korean in recent years as socieconomic status have got more higher than past years. Obese children have many health problems and some kinds of complications. Obese patients who have fatty liver with abnormal liver function should be managed with weight control. This study was intended to investigate the effect of weight control on hepatic abnormalities of obese children with fatty liver. We managed 6 obese children who had fatty liver with abnormal liver finction for weight control containing behavior modification, diet and exercise during 3 months. After 3 months, we compared body weight, liver function test, dietary intake and exercise. Body mass index(BMI) showed significant decrease from 28.1$\pm$2.3kg/$m^2$ to 26.2$\pm$1.7kg/$m^2$ (p<0.01). Aspartate aminotransferase(AST) showed significant improvement from 56$\pm$15IU/l(p<0.01). Alanine aminotransferase(ALT) also showed significant improvement from 108$\pm$38IU/l to 33$\pm$9IU/l(p<0.01). Therefore if we can rule out the other causes of hepatic abnormalities in obese children with fatty liver, these patients showed benefit by weight control as it can improve both obesity and liver functions.

• The Journal of Korean Medicine
• /
• v.24 no.4
• /
• pp.11-18
• /
• 2003

Purpose : This study examined the effect of Tongbiyeum (TBY) on rats with fatty livers. Methods : After administration of TBY extracts to rats with fatty livers, body weight, liver weight, serum, cholesterol, TG, HDL-cholesterol were measured, and histopathological changes were observed. Results : In proportion to density, TBY decreased liver weight and serum TG levels and suppressed fat accumulation and liver cell death, but increased serum HDL levels in comparison with those of controls. Conclusion : TBY might be considered to be used to control fatty liver by inhibiting absorption and storage of TG.

• Journal of Nutrition and Health
• /
• v.19 no.3
• /
• pp.161-168
• /
• 1986

In order to investigate the effect of riboflavin on cholesterol and MLHP (methyl linoleate hydroperoxide) -induced fatty liver electron microscopically, riboflavin was given to rate receiving high cholestero and MLHP diet for 4 weeks, 8 week old male Sprague-Dawley rats were administrated diets daily, as following group ; usual diet (control ), riboflavin 910 ug/20gm BW), cholesterol (50mg/gm BW), MLHP(0.1ml/20gm BW), cholesterol plus MLHP, cholesterol plus riboflavin, cholesterol plus MLHP plus riboflavin, by means of intubation into the stomach for 4 weeks. Each group consisted of 10 rats, The liver of the animals were examined ultrstructurally by transmission electronmicroscope. The results wee as follows ; 1) The three group including cholesterol, MLHP, cholesterol plus MLHP feeding resulted in fatty liver. 2) The main finding of the fatty liver were swelling and vacuolation of mitochondria, a lot of lipid droplets, disarrangements and loss of rough endoplamic reticulums. 3) the most striking features in the group of cholesterol plus riboflavin, cholesterol plus MLHP plus riboflavin feeding were decrease of size and number of lipid droplets, mitochondrial swelling and vesiculation, with restortion of rough endoplasmic retriculums. It is postulated with above findings that riboflavin was effective in prevention of cholesterol and MLHP -induced fatty liver.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.11 no.6
• /
• pp.2093-2098
• /
• 2010

Insulin resistance plays a central role in fatty liver, a part of the metabolic syndrome. This study examined the relationship between fatty liver, metabolic abnormalities and mitochondrial DNA [mtDNA] copy number in peripheral blood that is correlated with diabetes or metabolic markers. Fatty liver was assessed by questionnaire on alcohol consumption and abdominal ultrasonography. MtDNA copy number in peripheral leukocytes was measured by a real-time quantitative polymerase chain reaction [PCR]. Among 445 subjects, 148 subjects had hepatic steatosis and 297 were controls. mtDNA copy number was significantly lower in fatty liver group in comparison with that of normal finding group. This result is similar in both groups, alcoholic or non-alcoholic fatty liver group. MtDNA copy number was inversely correlated with alanine aminotransferase [ALT], aspartate aminotransferase [AST], gamma-glutamyltransferase [$\gamma$-GTP], body mass index [BMI], waist circumference, diastolic blood pressure, and free fatty acid. MtDNA copy number in peripheral leukocytes was associated with fatty liver and insulin resistance related factors.

• Asian-Australasian Journal of Animal Sciences
• /
• v.27 no.9
• /
• pp.1244-1249
• /
• 2014

Goose fatty liver is one of the most delicious and popular foods in the world, but there is no reliable genetic marker for the early selection and breeding of geese with good liver-producing potential. In our study, one hundred and twenty-four 78-day-old Landes geese bred in Shunda Landes goose breeding farm, Jiutai, Jilin, China were selected randomly. The fatty livers were sampled each week after overfeeding during a three week period. Polymerase chain reaction-single strand conformation polymorphism and DNA sequencing were used to identify single nucleotide polymorphisms (SNPs) of fatty acid synthase (FAS), which is an important enzyme involved in the synthesis of fat under both physiological and pathological conditions. Least-squares correlation was established between these SNPs and fatty liver weight, abdominal fat weight, and intestinal fat weight of the overfed Landes geese, respectively. The results showed that fatty liver weight of geese with EF and FF genotypes (amplified by primer P1) was significantly higher than that of the EE genotype (p<0.05), and liver weight of CD and DD genotypes (amplified by primer P2) was significantly higher than that of the CC genotype (p<0.05). Different genotype combinations showed different liver weights, and from highest to lowest were ABDD, DDEF, DDFF, DDEE, ABEF, ABFF, AADD, and CDEF. Further analysis of DNA sequencing showed that there were two SNPs within the 5' promoter region the FAS gene. The geese of EF and FF genotypes carried a change of T to C, and the geese of CD and DD genotypes carried a change of A to G. The changes of the bases could potentially influence the binding of some transcription factors to this region as to regulate FAS gene. To our knowledge, this is the first report of SNPs found within the 5' promoter region of the Landes goose FAS gene, and our data will provide an insight for early selection of geese for liver production.

• Journal of Life Science
• /
• v.11 no.1
• /
• pp.83-92
• /
• 2001

This study evaluated the effects of Dioscorea batatas and Gastrodia rhizoma on fatty acid composition of serum, liver and brain in rats which were fed control diet adding 5%, 10%, 15% Dioscorea batatas powder and 5%, 10%, 15% Gastrodia rhizoma powder for 3 weeks, respectively. In the other total fatty acid composition of serum lipids, the percentage of SFA was higher in the control group than in the other groups. The percentages 18:2 and 20:4 in serum lipids were significantly higher in the group 5, 6 and 7 than control group. In phospholipid fatty acid composition of serum lipids, the percentage of 18:2 was significantly higher in the group 5, 6 and 7 than in the other groups. 16:0, 18:0, 18:1, 18:2 and 20:4 were the main fatty acid in the total fatty acid and phospholipid fatty acid composition of liver lipids. 16:0, 18:0, 18:1, 18:2, 20:4 and 22:6 were the main fatty acid in the total fatty acid and phospholipid fatty acid composition of brain lipids.