• Nutrition Research and Practice
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• v.12 no.2
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• pp.110-117
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• 2018

BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is closely associated with metabolic syndrome. In the present study, we observed the effect of ethanol extract of Allium fistulosum (EAF) on NAFLD and have suggested the possibility of using EAF as a natural product for application in the development of a treatment for NAFLD. MATERIALS/METHODS: The preventive effect on hepatic lipid accumulation was estimated by using an oleic acid (OA)-induced NAFLD model in vitro and a Western diet (high-fat high-sucrose; WD)-induced obese mouse model. Animals were divided into three groups (n = 7): normal diet group (ND), WD group, and WD plus 1% EAF group. RESULTS: EAF reduced OA-stimulated lipid accumulation in HepG2 cells in the absence of cellular cytotoxicity and significantly blocked transcriptional activation of sterol regulatory element-binding protein 1 and fatty acid synthase genes. Subsequently, we investigated these effects in vivo in mice fed either ND or WD in the presence or absence of EAF supplementation. In comparison to the ND controls, the WD-fed mice exhibited increases in body weight, liver weight, epididymal fat weight, and accumulation of fat in hepatocytes, and these effects were significantly attenuated by EAF supplementation. CONCLUSIONS: Allium fistulosum attenuates the development of NAFLD, and EAF elicits anti-lipogenic activity in liver. Therefore, EAF represents a promising candidate for use in the development of novel therapeutic drugs or drug combinations for the prevention and treatment of NAFLD.

• Journal of the Korean Society of Food Science and Nutrition
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• v.31 no.4
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• pp.629-635
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• 2002

This study was performed to develop low-fat comminuted sausages (LFSs, < 3%) manufactured with 1% single (Konjac flour, KF; kappa-carrageenan, k-CN and Locust bean gum, LBG) or mixed hydrocolloids and to select the best combination which had similar textural characteristics to those with regular-fat (~25% fat) control. In experiment 1, LFSs were formulated with each 1% hydrocolloid, smoked and cooked to an internal temperature of 71.7$^{\circ}C$. The pH range of LFSs was 6.29 to 6.34 and approximately 23~24% of fat was removed in the final products, resulting in the higher moisture and protein contents (%) in LFSs, as compared to regular-fat control. No differences (p>0.05) in cooking loss (CL, %), expressible moisture (EM, %), and hunter color values (L, a, b) were observed with the addition of each 1% hydrocolloid. However, LFSs containing 1% k-CN had textural hardness values similar to those with low-/regular-fat controls, whereas LFSs having either KF or LBG had similar cohesiveness values to those with regular-fat counterpart. Tn experiment 2, two or three mixed hydrocolloids were added to the low-fat sausage formulation. The addition of mixed KF+LBG (KLL) and KF+CN+LBG(KCL) reduced EM and textural hardness values, as compared to low-fat control. Among the treatments, LFSs containing two or three combinations of CN with KF or/and LBG had similar textural characteristics to those with regular-fat control. These results suggested that multiple addition of CN with other hydrocolloids (KF or LBG) for the replacement of fats in LFSs would be recommended for the proper functional and textural properties.

• The Journal of the Korea institute of electronic communication sciences
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• v.7 no.4
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• pp.931-936
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• 2012

In this paper, the module which can measure body fat, heart rate and $SpO_2$ has been developed for being mounted on widespread bidets in the home. This moudule was manufactured by a structure that can be mounted on a bidet, users such as elderly, patients with chronic fatigue, heart disease and overworked workers checking their health status in every life through monitoring their body fat, heart rate and $SpO_2$ and preventing of sudden death.

• The Korean Journal of Zoology
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• v.34 no.1
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• pp.1-7
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• 1991

Lipophorin of Lymuntrn'adispor L. has been purified by KBr density gradient ultracentrifugation. The properties and synthetic site of lipophorin and quantitative change of lipophorin during development have been determined using electrophoresis and immunological analysis. Lipophorin is composed of ho subunits. apo-Lpl (230.000), ago-Lpll (49,000). ann contains carbohydrates and lipids. Anti-lipophorin showed positive reactions with fat body extract and ovary extract but not with gut extract. The concentration of lipophorin in hemolymph showed gradual decrease during larval and pupal stages. Also. fat body released lipophorin into medium. Immunological test showed some partial identity between lipophorin of Lymantpia dispar and hemolymph proteins (probably lipophorin) of Hyphontria cuneo and Galleria metlonefla.

• Journal of the Korean Applied Science and Technology
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• v.36 no.3
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• pp.797-803
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• 2019

Recently, osteosarcopenic obesity (OSO) has been identified and notified world wide. Therefore, this study reviewed OSO related to lifestyle factors such as nutritional intake and exercise. Due to aging, OSO may be initiated by dietary factors and obesity related factors. Reduced muscle mass and increased fat mass may negatively impact bone health causing OSO. The complication of OSO development should be related to dietary imbalance combined with declined exercise and this may contribute to induce OSO by decreasing bone mass, muscle mass, and increasing obesity with aging. To prevent OSO, reaching peak bone mass and building optimal muscle and fat mass through exercise would be recommended. For treating OSO, balanced dietary intake and regular exercise through a whole life would be needed. In addition, sufficient carbohydrate and fat intake for minimizing protein catabolism would be recommended to prevent OSO. The combination of aerobic exercise and resistance training also would be an effective intervention for OSO population.

• The Journal of the Korea Contents Association
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• v.14 no.5
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• pp.235-243
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• 2014

The purposes of this study were to observe the effects of the exercise programs which have different order of walking and resistance exercises on the composition of the abdominal fat and the blood lipid profiles of the obese college women and to provide basic materials for the development of more effective and more efficient exercise program in order to reduce and prevent obesity. Classification of group, "A" group(resistance exercise after aerobic exercise) is a group of 12 people, "B" group(resistance exercise after aerobic exercise) is a group of 12 people. To determine the abdominal fat, intestine fat area, subcutaneous fat area, ratio of intestine fat area/subcutaneous fat area were analyzed, while for the blood lipid profiles, total cholesterol, triglyceride, high density lipid protein, and low density lipid protein were analyzed. First, there was statistically significant difference in the interaction in the abdomen subcutaneous fat. In the post analysis, the Resistance first group showed significantly more reduction to confirm that there was difference according to the order of the exercises. Second, there was statistically significant difference in the interaction effects in the factor of triglyceride. In the post analysis, the Resistance first group only showed significant reduction in the triglyceride to confirm that resistance exercise followed by aerobics would be better for the reduction of the triglyceride.

• Journal of the Korean Society of Radiology
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• v.18 no.2
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• pp.135-144
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• 2024

Ultrasonography examination has limitations in quantifying hepatic fat quantification. Therefore, this study aimed to experimentally demonstrate whether changes in signal attenuation during ultrasound imaging can be quantified using simulated hepatic phantoms to assess hepatic fat content. Additionally, we aimed to evaluate the potential of ultrasound imaging for diagnosing hepatic fatty liver by analyzing the relationship between hepatic fat content and signal intensity in ultrasound images. In this study, we developed a total of five stimulated hepatic phantoms by homogeneously mixing water and oil. We confirmed the fat content of the phantoms using magnetic resonance imaging (MRI) and ultrasound imaging, and measured signal intensity according to distance in ultrasound images to analyze the correlation and mean comparison between fat content and signal intensity. We observed that as the fat content increased, the ultrasound penetration intensity decreased, confirming the potential for quantifying hepatic fat content using ultrasound. Additionally, the analysis of the correlation between the measured fat content using MRI and the signal intensity measured in ultrasound images showed a high correlation. Statistical analysis in our study confirmed that as the fat content increased, the slope representing signal during ultrasound imaging (US-GRE) decreased. In this study, it was statistically confirmed that the US-GRE value of ultrasound images gradually decreases as the fat content increases, and it is believed that US-GRE can serve as a biomarker expressing fatty liver content.

• Korean Journal of Environmental Agriculture
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• v.38 no.4
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• pp.296-306
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• 2019

BACKGROUND: Temperature is known to be the main factor affecting development, growth and reproduction of organisms and also a physical factor directly related to insect survival. Insects as ectothermal species should be responsive to climate changes for their survival and develop various survival strategies under the unfavorable temperature such as low temperature. The purpose of this study is to identify genes contributing to adaptation of low temperature. METHODS AND RESULTS: To identify genes contributing to adaptation of low temperature, the transcriptomic data were obtained from fat body in Plutella xyostella larvae via next generation sequencing. We identified structural proteins, heat shock proteins, antioxidant enzymes, detoxification proteins, and cryoprotectant mobilization and biosynthesis-related proteins. Genes encoding chitinase, cuticular protein, Hsp23, chytochrome protein, Glutathione S transferase, and phospholipase 2 were up-regulated under low temperature. Proteins related to energy metabolism such as UDP-glycosy ltransferase, trehalase and trehalose transporter were down-regulated. CONCLUSION: When insect pests were exposed to low temperature, changes in gene expression of fat body could provide some hints for understanding temperature adaptation strategies.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.2
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• pp.206-210
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• 2001

Six Holstein$\times$indigenous multiparous dairy cows, $60{\pm}8$ days in milk, were used in a double $3{\times}3$ Latin square design to investigate the efficiency of milk production. The dairy cows were randomly allocated to total mixed rations (TMR) containing ground corn, ground corn plus cassava chips 50:50 and cassava chips as main sources of total non-fiber carbohydrates. Ether extract and calculated energy intakes for dairy cows fed TMR containing cassava chips were lower (p<0.05) than those fed TMR containing ground corn and ground corn plus cassava chips 50:50. There were no differences (p>0.05) in daily DM intake (3.51, 3.41 and 3.29% BW), in 4% fat corrected milk (19.66, 20.59 and 20.23%), in milk protein (3.37, 3.27 and 3.33%), and in solids-not-fat (9.03, 8.90 and 8.99%) but there were differences in cost of diets per kg of 4% fat corrected milk (40.75, 34.33 and 28.17%; p<0.01) for dairy cows fed TMR containing ground corn, ground corn plus cassava chips 50:50, and cassava chips. It can be concluded that the efficiency of milk production (4% fat corrected milk per dry matter intake) for dairy cows fed TMR containing cassava was greater than for those fed TMR containing corn.

• Archives of Pharmacal Research
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• v.25 no.2
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• pp.178-183
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• 2002

A high molecular ar weight water-soluble chitosan (WSC) with an average molecular weight of 300 kD and a deacethylation level of over 90% was produced using a simple multi-step-membrane separation process. It is known that WSC prevents obesity induced by a high-fat diet. Consequently, this study investigated whether or not WSC improved the ovarian dysfunction caused by obesity in mice. The mice were fed a high density protein and lipid diet for weeks, followed by the administration of WSC at 480 mg/kg body weight per day for 4 days. Thereafter, the changes in body weight, ovulation rate, in vivo and in vitro fertilization and emboryonic development were measured . WSC markedly reduced the body weight of obese mice fed with a high-fat diet, but not in mice fed with a normal diet. WSC had siginificant effects on the ovulation rate, both the in vivo and in vitro fertilization rates and embryonic development. These results indicate an improvement in the ovarian and oviduct dysfunction caused by obesity, and suggest an adjustment in the internal secretions and metabolic functions.