• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5861-5865
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• 2014

High risk forms of the human papilloma virus (HPV) are generally accepted as necessary causative agents for cervical cancer. Recently, a possible relation between HPV and oral squamous cell carcinoma (OSCC) has also been noticed. The present study was conducted to investigate the prevalence of HPV infection in OSCCs in Wuhan city. DNA samples were collected from fresh tissues in 200 patients with OSCC and 68 normal controls. The polymerase chain reaction and direct sequencing were used to identify the HPV types in the samples. The prevalence of HPV of all types in the OSCC group was higher than in the control group (55/200 vs 2/68, OR=11.5, 95% CI=2.6-50.2). HPV16 and HPV18 were the main types detected, with HPV6 was the only low-risk type identified. High-risk HPV types HPV16 and HPV18 are prevalent in OSCC patients and may participate in the development of OSCC with traditional risk factors, tobacco and alcohol, possibly exerting synergistic effects. The results of multinomial logistic regression showed that those who smoked, consumed alcohol and with HPV infection have the highest risk of developing oral cancer (OR=13.3, 95% CI=3.1-56.8). Adjusted for age, smoking and alcohol use, HPV infection was independently associated with oral squamous cell carcinoma.

• 폴리머
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• 제36권5호
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• pp.617-621
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• 2012

폴리아스팔트아미드[${\alpha}$,${\beta}$-poly(2-hydroxyethyl-DL-aspartamides), PHEAs]는 폴리아미노산의 일종으로서 잠재적인 의학 및 약학분야에 응용가능한 생분해성 생체적합성 재료로 널리 연구되어 왔다. 본 연구에서는 PHEA와 폴리(비닐 피롤리돈)(PNVP)의 블렌드 및 semi-IPN 젤에 관하여 다루었다. 블렌드 필름은 용액 캐스팅법으로 제조되었다. 제조된 블렌드는 전 조성에서 투명하였으며 DSC를 통해 조성에 따라 단조롭게 변화하는 단일한 유리전이 온도가 관찰됨으로써 두 개 고분자가 서로 상용성이 있음을 확인하였다. 고분자간의 가능한 수소결합 상호작용을 FTIR을 이용하여 설명하였다. 한편, 일정 조성의 PHEA/PNVP 블렌드 용액을 핵사메틸렌디이소시아네이트(HMDI)를 가교제로 사용하여 semi-IPN 타입의 하이브리드 젤을 제조하고, 제조된 젤의 팽윤 물성과 모폴로지를 조사하였다.

• 천문학회지
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• 제47권2호
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• pp.43-47
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• 2014

Many advanced ground-based solar telescopes improve the spatial resolution of observation images using an adaptive optics (AO) system. As any AO correction remains only partial, it is necessary to use post-processing image reconstruction techniques such as speckle masking or shift-and-add (SAA) to reconstruct a high-spatial-resolution image from atmospherically degraded solar images. In the New Vacuum Solar Telescope (NVST), the spatial resolution in solar images is improved by frame selection and SAA. In order to overcome the burden of massive speckle data processing, we investigate the possibility of using the speckle reconstruction program in a real-time application at the telescope site. The code has been written in the C programming language and optimized for parallel processing in a multi-processor environment. We analyze the scalability of the code to identify possible bottlenecks, and we conclude that the presented code is capable of being run in real-time reconstruction applications at NVST and future large aperture solar telescopes if care is taken that the multi-processor environment has low latencies between the computation nodes.

• Bulletin of the Korean Chemical Society
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• 제30권3호
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• pp.556-560
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• 2009

Aggregation behavior of three kinds of benzindocarbocyanine dyes in aqueous methanol solution was studied by UV-Vis absorption spectrum. The results indicated that the three dyes all existed monomer-dimer equilibrium in aqueous methanol solution (concentration range $10^{−5}\;to\;10^{−6}$ M) at 25.0$\sim$41.0 ${^{\circ}C}$ for Dye 1, 28.0$\sim$49.0 ${^{\circ}C}$ for Dye 2 and 26.0$\sim$47.0 ${^{\circ}C}$ for Dye 3. The fundamental property of the three dyes as the dimeric association constant KD, the dimeric free energy ${\Delta$}G_D, the dimeric entropy ${\Delta$}S_D, and the dimeric enthalpy ${\Delta$}H_D were determined. The ${\Delta$}H_D of three dyes: Dye 1, Dye 2 and Dye 3 was -42.5, -15.1 and -18.9 kJ/mol, respectively. The experimental observations were the subject of a theoretical study including the ground-state geometries which were fully optimized using DFT at B3LYP/6-31G level. The effect of dye molecule structure on ${\Delta$}H_D was discussed by theoretical calculations.

• 천문학회지
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• 제45권6호
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• pp.167-173
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• 2012

Inter-granular Bright Points (igBPs) are small-scale objects in the Solar photosphere which can be seen within dark inter-granular lanes. We present a new algorithm to automatically detect and extract igBPs. Laplacian and Morphological Dilation (LMD) technique is employed by the algorithm. It involves three basic processing steps: (1) obtaining candidate "seed" regions by Laplacian; (2) determining the boundary and size of igBPs by morphological dilation; (3) discarding brighter granules by a probability criterion. For validating our algorithm, we used the observed samples of the Dutch Open Telescope (DOT), collected on April 12, 2007. They contain 180 high-resolution images, and each has a $85{\times}68\;arcsec^2$ field of view (FOV). Two important results are obtained: first, the identified rate of igBPs reaches 95% and is higher than previous results; second, the diameter distribution is $220{\pm}25km$, which is fully consistent with previously published data. We conclude that the presented algorithm can detect and extract igBPs automatically and effectively.

• Molecules and Cells
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• 제23권3호
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• pp.316-322
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• 2007

Zinc finger transcription factor genes are a significant fraction of the genes in the vertebrate genome. Here we report the isolation and characterization of a human zinc finger-containing gene, ZNF435, from a fetal brain cDNA library. ZNF435 cDNA is 1290 base pairs in length and contains an open reading frame encoding 349 amino acids with four C2H2-type zinc fingers at its carboxyl terminus and a SCAN motif at its amino terminus. RT-PCR results showed that ZNF435 was expressed in all tested tissues. A ZNF435-GFP fusion protein was located in the nucleus and the four zinc fingers acted as nuclear localization signals (NLSs). ZNF435 was found to be capable of homo-association, and this effect was independent of its zinc fingers. Furthermore, ZNF435 proved to be a transcription repressor as its overexpression in AD293 cells inhibited the transcriptional activities of AP-1.

• Journal of Microbiology and Biotechnology
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• 제31권8호
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• pp.1134-1143
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• 2021

In the present study, we investigated the inhibitory effect of heat-killed Enterococcus faecalis (E. faecalis) and live E. faecalis on benign prostatic hyperplasia (BPH). The BPH rat model was established by administering male rats with testosterone propionate (TP, 5 mg/kg, in corn oil) via subcutaneous injections daily for four weeks after castration. The rats were divided into five groups: Con, corn oil-injected (s.c.) + DW administration; BPH, TP (5 mg/kg, s.c.) + DW administration; BPH+K_EF, TP (5 mg/kg, s.c.) + heat-killed E. faecalis (7.5 × 10¹² CFU/g, 2.21 mg/kg) administration; BPH+L_EF, TP (5 mg/kg, s.c.) + live E. faecalis (1 × 10¹¹ CFU/g, 166 mg/kg) administration; BPH+Fi, TP (5 mg/kg, s.c.) + finasteride (1 mg/kg) administration. In both of BPH+K_EF and BPH+L_EF groups, the prostate weight decreased and histological changes due to TP treatment recovered to the level of the Con group. Both of these groups also showed regulation of androgen-signaling factors, growth factors, and apoptosis-related factors in prostate tissue. E. faecalis exhibited an inhibitory effect on benign prostatic hyperplasia, and even heat-killed E. faecalis showed similar efficacy on the live cells in the BPH rat model. As the first investigation into the effect of heat-killed and live E. faecalis on BPH, our study suggests that heat-killed E. faecalis might be a food additive candidate for use in various foods, regardless of heat processing.

• 한국콘텐츠학회논문지
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• 제19권9호
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• pp.280-292
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• 2019

본 연구는 부산의 대표적 상업 공간인 센텀 신세계백화점을 대상으로, 실내 휴게 공간과 가구 디자인 현황을 파악하고, 가구를 중심으로 한 방문객의 이용 행태 특성을 분석하고자 한다. 상업공간에서 공공의 영역이라고 할 수 있는 휴게 공간 디자인이 방문객의 특성과 행태를 지원하고 있는지를 파악하여 추후 상업 휴게 공간 디자인을 위한 기초 자료를 제공하고자 한다. 연구방법은 현장 방문 관찰을 진행해 휴게공간에서 각 층별 휴게공간의 위치, 휴게가구 디자인의 유형과 디자인 특성을 파악한 후, 주요 층별 휴게 가구 이용자의 특성과 행태를 분석하였다. 연구결과는 다음과 같다. 휴게공간과 가구를 분석한 결과 휴게공간의 위치나 크기는 적절하다고 여겨진다. 또한 휴게 가구는 베이지에서 브라운, 밝은 회색에서 블랙에 이르는 저채도의 편안한 색채에 부채형, 호형 벤치, 소파, 의자 형 등 다양한 디자인으로 제공되어 있어, 쉬기, 휴대폰 사용, 대화와 같은 가장 일반적인 이용 행태를 적절히 지원하고 있었다.

• Steel and Composite Structures
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• 제43권2호
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• pp.139-152
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• 2022

Steel-reinforced concrete (SRC) L-shaped column is the vertical load-bearing member with high spatial adaptability. The seismic behavior of SRC L-shaped column is complex because of their irregular cross sections. In this study, the hysteretic performance of six steel truss reinforced concrete L-shaped columns specimens under the combined loading of compression, bending, shear, and torsion was tested. There were two parameters, i.e., the moment ratio of torsion to bending (γ) and the aspect ratio (column length-to-depth ratio (φ)). The failure process, torsion-displacement hysteresis curves, and bending-displacement hysteresis curves of specimens were obtained, and the failure patterns, hysteresis curves, rigidity degradation, ductility, and energy dissipation were analyzed. The experimental research indicates that the failure mode of the specimen changes from bending failure to bending-shear failure and finally bending-torsion failure with the increase of γ. The torsion-displacement hysteresis curves were pinched in the middle, formed a slip platform, and the phenomenon of "load drop" occurred after the peak load. The bending-displacement hysteresis curves were plump, which shows that the bending capacity of the specimen is better than torsion capacity. The results show that the steel truss reinforced concrete L-shaped columns have good collapse resistance, and the ultimate interstory drift ratio more than that of the Chinese Code of Seismic Design of Building (GB50011-2014), which is sufficient. The average value of displacement ductility coefficient is larger than rotation angle ductility coefficient, indicating that the specimen has a better bending deformation resistance. The specimen that has a more regular section with a small φ has better potential to bear bending moment and torsion evenly and consume more energy under a combined action.

• 한국어류학회지
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• 제36권1호
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• pp.101-106
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• 2024

2020년 5월 제주도 남동부 해역에서 봉고네트로 성대과 자어 1개체(전장 5.14 mm)가 채집되었다. 본종은 mtDNA COI 염기서열 분석을 통해 우리나라에서 처음 보고되는 달재속 1 미기록종, Lepidotrigla longifaciata로 확인되었다. 본종의 전기자어의 형태적 특징은 긴 주둥이, 큰 입, 부채 모양의 큰 가슴지느러미를 가지며, 흑색소포는 복강과 목덜미에만 관찰되었다. 우리나라에서 처음 발견된 본종의 신국명으로 '긴머리 달재'를 제안한다.