• Title/Summary/Keyword: Failure of Passive Transfer

Search Result 9, Processing Time 0.009 seconds

Comparison of Immune Status Using Diagnosis of Failure of Passive Transfer in Healthy and Sick Horse Population : A Pilot Study (건강한 말과 아픈 말에서 수동면역부전 진단을 이용한 면역상태 비교 : 파일럿 스터디)

  • Yang, J.
    • Journal of Practical Agriculture & Fisheries Research
    • /
    • v.22 no.1
    • /
    • pp.79-85
    • /
    • 2020
  • The current study is the first paper on FPT(failure of passive transfer) of horse population in Korea. The object of this study was to comparison of immune status normal and patient horses. Failure of passive transfer is the most common immunodeficiency disorder of horses. Twenty-two foals and 18 horses from Jeju of the equine hospital were diagnosed with the SNAP Foal IgG Test Kit. All adult horses had normal immune functions (≥800 mg/dl). Thirteen of the 22 newborn babies (59%; ∠800 mg/dl) had a weak immune function but recovered and survived after treatment. Nine of these 22 are horses with strong immunity (≥800 mg/dl), indicating that high IgG concentrations in the blood can cause infectious diseases. There were a total of six dead, four of which were infectious diseases. In addition, early identification of infectious diseases in newborn foals is expected to help prepare systematic health management measures for the development of the disease.

Finite Element Analysis of the Direct Shear Test (직접 전단시험의 유한 요소 해석)

  • 이장덕
    • Geotechnical Engineering
    • /
    • v.12 no.6
    • /
    • pp.21-36
    • /
    • 1996
  • The stress transfer mechanism between soil and grid reinforcements involves two basic mechanism : frictional soil resistance and passive soil resistance. However the mechanism of the passive soil resistance is very complex to understand. To study the failure mechanism of ribbed reinforcement, the direct shear tests which are dominated by passive soil resistance are analyzed by using the finite element method. The finite element method is used to examine the effects of ribs on this passive soil resistance development and the met hanism of failure. The calculated behavior of the ribbed reinforcement is compared with the measured behavi or. Comparisons between the measured and the simulated strain pat terns, failure modes and load displacement relationship are presented. The behavior of the ribbed reinforcements in a cohesive soil is predicted on the basis of a good agreement between the measured and the Predicted behavior of the Ottawa sand.

  • PDF

Studies on immunotherapy to calves with failure of colostrum passive transfer using bovine immune sera (소 면역혈청을 이용한 초유 이행 부전 송아지의 치료 효과)

  • Lee, Jung-Sun;Kang, Mun-Il;Chung, Yong-Un;Lee, Chai-Yong;Han, Dong-Un;Wee, Sung-Hwan;Yoon, So-Rah;Cho, Jae-Jin;Kang, Ju-Won
    • Korean Journal of Veterinary Service
    • /
    • v.31 no.4
    • /
    • pp.533-546
    • /
    • 2008
  • The efficacy of bovine immune sera to correct the calves with failure of passive transfer(FPT) was evaluated. Immune sera were produced from 14 one-year-old Holstein cattle which were inoculated commercial combined viral vaccine, administered by the challenge of some main enteric or respiratory viruses, aseptically filtered and stored at $4^{\circ}C$ before used. After the treatment of bovine immune sera, Mean transfer factor($mg/d{\ell}$, of IgG administered/kg of body weight) was $5.46{\pm}2.74,\;11.17{\pm}1.27,\;1.40{\pm}0.21$ in K-IP, H-IP and K-IV group, respectively. The corrective effect of bovine immune sera to FPT calf without any clinical signs showed that intravenous route was more effective than intraperitoneal administration(P<0.01). FPT calves with severe signs were not effective response to the immunotherapy used and consequently died within 10 days after the treatment. Ten percentage of controls appeared the clinical signs including diarrhea. On the contrary, there were not any clinical signs in K-IP and H-IV group. There was significant increase of the neutralizing titer against bovine viral diarrhea virus and bovine coronavirus as well as of cell population including CD2, CD4, and monocyte in K-IP and H-IV group after the immunotherapy(P<0.05). Also, K-IP and H-IV group showed the successful correction to FPT within one week after the immunotherapy, but controls had kept the FPT two-four weeks even after the same treatment. Consequently, the results were suggesting that the bovine immune sera could be used the corrective tool to young calves with FPT.

Comparison of diagnostic methods on failure of passive immunoglobulin transfer to Korean-indigenous calves (한우 송아지의 초유 섭취 수준 측정 진단법 비교)

  • Lee, Byoung-Seok;Kang, Mun-Il;Chung, Yong-Un;Lee, Chai-Yong;Han, Dong-Un;Wee, Sung-Hwan;Yoon, So-Rah;Cho, Jae-Jin;Kang, Ju-Won
    • Korean Journal of Veterinary Service
    • /
    • v.31 no.4
    • /
    • pp.505-519
    • /
    • 2008
  • For screening the appropriate field diagnostic techniques to failure of passive immunoglobulin transfer(FPT) in Korean-indigenous calves, 258 sera was examined by spectinophotometry for total protein(TP) and globulin(Glo), sodium sulfate precipitation test(SSPT), zinc sulfate turbidity test(ZSTT), and single radial immunodiffusion test(sRID). All calves aged within 6-week old. Morbidity and mortality to various diseases, mainly including enteric and respiratory disorders, were 18.9%(49) and 4.2%(11), respectively. FPT was 27,9%(72/258) when the cutoff point of TP was $4.5g/d{\ell}$ and among them the morbidity and mortality were 27.9% and 6.9%, respectively. FPT was 29.1%(75/258) when the cutoff point of Glo was $2.0g/d{\ell}$ and among them the morbidity and mortality were 29.0% and 6.9%, respectively. FPT was 13.1%(34/258) when the cutoff point of SSPT was 1+ and among them the morbidity and mortality were 67.6% and 23.5%, respectively. FPT was 19.7%(51/258) when the cutoff point of IgG with sRID was $1,000mg/d{\ell}$ and among them the morbidity and mortality were 41.1% and 11.7%, respectively. In addition, mean concentration of IgG with sRID tested was $2,150mg/d{\ell}$ at 3-day old but $1,100mg/d{\ell}$ at 9-days with $1,100mg/d{\ell}$. The results of the study were suggested that SSPT for FPT was the relatively reliable and convinient method for evaluating the immune status of calves(P<0.05).

A parametric study on the use of passive fire protection in FPSO topside module

  • Friebe, Martin;Jang, Beom-Seon;Jim, Yanlin
    • International Journal of Naval Architecture and Ocean Engineering
    • /
    • v.6 no.4
    • /
    • pp.826-839
    • /
    • 2014
  • Fire is a continuous threat to FPSO topside modules as large amounts of oil and gas are passing through the modules. As a conventional measure to mitigate structural failure under fire, passive fire protection (PFP) coatings are widely used on main structural members. However, an excessive use of PFP coatings can cause considerable cost for material purchase, installation, inspection and maintenance. Long installation time can be a risk since the work should be done nearly at the last fabrication stage. Thus, the minimal use of PFP can be beneficial to the reduction of construction cost and the avoidance of schedule delay. This paper presents a few case studies on how different applications of PFP have influence on collapse time of a FPSO module structure. A series of heat analysis and thermal elasto-plastic FE analysis are performed for different PFP coatings and the resultant collapse time and the amount of PFP coatings are compared with each other.

EVALUATION OF METHODOLOGY FOR AXISYMMETRIC SIMULATION OF RCCS IN VHTR (초고온가스로의 RCCS 해석을 위한 축대칭 모사 방법론 평가)

  • Kim, S.H.;Cho, B.H.;Tak, N.I.;Kim, M.H.
    • Journal of computational fluids engineering
    • /
    • v.15 no.1
    • /
    • pp.1-8
    • /
    • 2010
  • RCCS is a passive safety-related system that removes the decay heat of VHTR when normal decay heat removal systems are in failure. Understanding thermo-hydraulics of RCCS is important to design a safer VHTR. RCCS consists of 292 cooling panels, which are placed in the reactor cavity. The layout of RCCS gives an idea that, for CFD simulations, cooling panels can be assumed to be one annulus tube. This assumption can reduce significantly the computational time, especially for the unsteady simulation. To simulate RCCS in an axisymmetric manner, three models were suggested and compared. Each model has (1) the same outer radius, (2) the same cross-sectional area (3) the same pressure drop, respectively, as the RCCS cooling panels. The steady-state simulation was conducted with these three models and the DO radiation model. It is found that over 90% of the heat from the outer wall of the reactor pressure vessel is transported to the RCCS by radiative heat transfer. The simulation with the third model, which has the same pressure drop as the design, estimates the closest wall temperature profiles to a thermo-hydraulic code, GAMMA+, result.

Transient heat transfer and crust evolution during debris bed melting process in the hypothetical severe accident of HPR1000

  • Chao Lv;Gen Li;Jinchen Gao;Jinshi Wang;Junjie Yan
    • Nuclear Engineering and Technology
    • /
    • v.55 no.8
    • /
    • pp.3017-3029
    • /
    • 2023
  • In the late in-vessel phase of a nuclear reactor severe accident, the internal heat transfer and crust evolution during the debris bed melting process have important effects on the thermal load distribution along the vessel wall, and further affect the reactor pressure vessel (RPV) failure mode and the state of melt during leakage. This study coupled the phase change model and large eddy simulation to investigate the variations of the temperature, melt liquid fraction, crust and heat flux distributions during the debris bed melting process in the hypothetical severe accident of HPR1000. The results indicated that the heat flow towards the vessel wall and upper surface were similar at the beginning stage of debris melting, but the upward heat flow increased significantly as the development of the molten pool. The maximum heat flux towards the vessel wall reached 0.4 MW/m2. The thickness of lower crust decreased as the debris melting. It was much thicker at the bottom region with the azimuthal angle below 20° and decreased rapidly at the azimuthal angle around 20-50°. The maximum and minimum thicknesses were 2 and 90 mm, respectively. By contrast, the distribution of upper crust was uniform and reached stable state much earlier than the lower crust, with the thickness of about 10 mm. Moreover, the sensitivity analysis of initial condition indicated that as the decrease of time interval from reactor scram to debris bed dried-out, the maximum debris temperature and melt fraction became larger, the lower crust thickness became thinner, but the upper crust had no significant change. The sensitivity analysis of in-vessel retention (IVR) strategies indicated that the passive and active external reactor vessel cooling (ERVC) had little effect on the internal heat transfer and crust evolution. In the case not considering the internal reactor vessel cooling (IRVC), the upper crust was not obvious.

Dynamic Response of Drill Floor to Fire Subsequent to Blowout

  • Kim, Teak-Keon;Kim, Seul-Kee;Lee, Jae-Myung
    • Journal of Ocean Engineering and Technology
    • /
    • v.34 no.2
    • /
    • pp.110-119
    • /
    • 2020
  • Explosions and fires on offshore drilling units and process plants, which cause loss of life and environmental damage, have been studied extensively. However, research on drilling units increased only after the 2010 Deepwater Horizon accident in the Gulf of Mexico. A major reason for explosions and fires on a drilling unit is blowout, which is caused by a failure to control the high temperatures and pressures upstream of the offshore underwater well. The area susceptible to explosion and fire due to blowout is the drill floor, which supports the main drilling system. Structural instability and collapse of the drill floor can threaten the structural integrity of the entire unit. This study simulates the behavior of fire subsequent to blowout and assesses the thermal load. A heat transfer structure analysis of the drill floor was carried out using the assessed thermal load, and the risk was noted. In order to maintain the structural integrity of the drill floor, passive fire protection of certain areas was recommended.

Performance of Hanwoo calves fed a commercial colostrum replacer versus natural bovine colostrum

  • Ahmadi, Farhad;Kim, Seongjin;Hwangbo, Deok;Oh, Yongik;Yu, Jisu;Bae, Jisun;Kim, Na Yeon
    • Journal of Animal Science and Technology
    • /
    • v.63 no.5
    • /
    • pp.1114-1125
    • /
    • 2021
  • Supplying a sufficient amount of high-quality colostrum is a prevailing challenge in Hanwoo calf production systems. This study aimed to describe the efficiency of a lacteal-derived colostrum replacer versus natural bovine colostrum (from Holstein) fed to Hanwoo calves. Forty newborn Hanwoo calves (25 males and 15 females; 30.7 ± 3.15 kg body weight [mean ± standard deviation]) were blocked by sex and birth weight and fed either natural colostrum or a commercial colostrum replacer. Calves displayed a narrow difference in the evolution of body weight and structural body dimensions when they received a commercial versus natural colostrum. Minor differences existed in the starter and total dry matter consumption between calves fed natural or commercial colostrum. Although the colostrum source had no significant effects on days to first diarrhea (average of 7.6 days; p = 0.17), the duration of diarrhea was longer in natural colostrum-fed calves (3.2 vs. 4.5 days; p = 0.04). Consumption of natural colostrum resulted in greater mean serum immunoglobulin G (IgG) on day 2 (14.7 vs. 10.8 ± 0.92 mg/mL) and day 7 (8.21 vs. 5.12 ± 0.82 mg/mL) of calf life, resulting in a greater proportion of commercial colostrum-fed calves (50% vs. 15%; day 2) to experience failure of passive transfer of immunity (serum IgG < cutoff point of 10 mg/mL). Overall, growth rate, body frame development, and incidence of diarrheal disease were not different in both groups. These results suggested that the colostrum replacer product tested in this study could be an alternative to natural colostrum derived from Holstein cow in securing calf growth and health in Hanwoo calf-rearing operations.