• Journal of Ginseng Research
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• 제31권3호
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• pp.159-174
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• 2007

Pharmacology of Korean Red ginseng gives us unique possibility to develop new class of antiepileptic drugs today and to improve one's biological activity. The chemical structures of ginsenosides (GS) have some principal differences from well-known antiepileptic new generation drugs. The antiepileptic effect of GS was also demonstrated in all models of epilepsy in rats (young and adult), which have studied, in all models of epilepsy including status epilepticus (SE), induced by lithium - pilocarpine. In our experiments in rats new evidences on protective effects were exerted as a result of premedication by GS. Pre-treatment of several GS could induce decrease of the seizures severity and brain structural damage (by MRI), neuronal degeneration in hippocampus. Wave nature of severity of motor seizures during convulsive SE was observed during lithium-pilocarpine model of SE in rats (the first increase of seizures was 30 min after the beginning of SE and the second - 90 min after. The efficacy of treatment on SE by ginsenoside as expected was observed after no less 3 weeks by daily GS i.p. administration. It is blocked SE or significantly decrease the severity of seizures during SE. The implication of presented data is that combination of ginsenosides from Korean Red ginseng and ginseng cell culture Dan25 that could be applied for prevention of epileptical status development. However, a development of optimal ratio of different ginsenosides $(Rb_1$ Rc, Rg, Rf,) should consummate in the new antiepileptic drug development.

• Animal Systematics, Evolution and Diversity
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• nspc9호
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• pp.73-79
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• 2016

In the present study, to explore the current status of mammals that inhabit Jindo Island, Jeollanam-do, South Korea, a survey was conducted from July 6 to July 9, 2016. Using several survey methods, such as Sherman's live trap, footprint, caves, excretions, and road-kill investigations, the mammals observed on Jindo Island were found to be from 5 orders and 9 families, including 12 species in total. Among them, three species of small mammals were Mogera wogura, Crocidura shantungensis, and Apodemus agrarius. Additionally, two legally protected species were found through excretion observations. Lutra lutra and Prionailurus bengalensis, which were designated to endangered wild animal classes I and II, respectively. The survey results can be used as a valuable resource for identifying the distribution and habitat status of mammals in the Jindo-gun area, as well as for building a database for ecosystem preservation.

• Fisheries and Aquatic Sciences
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• 제27권1호
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• pp.35-47
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• 2024

The aim of this study was to analyze the income and productivity of seaweed farmers based on farmed land ownership status. This research was conducted in three provinces on the Sulawesi Island which are ranked among the 10 largest seaweed producers in Indonesia: Central Sulawesi, South Sulawesi and Southeast Sulawesi. The twelve study sites were determined based on 5 special criteria and 792 respondents fulfilled the criteria for seaweed farmers. Data were collected through field surveys and analyzed using qualitative and quantitative methods. Results showed that the seaweed farming areas are considered as private property with 4 types of marine land tenure or ownership status: own land, inherited land, leasehold land and purchased land. The productivity of seaweed farming land had a positive value greater than 1 in South Sulawesi and Southeast Sulawesi, and a positive value of less than 1 in Central Sulawesi. Seaweed cultivation in Central Sulawesi has not been managed effectively. At all sites, the maximum number of growing season cycles was 5 cycles/year. Optimal growing season conditions gave the highest marginal returns at 2-3 cycles/year with additional costs exceeding additional income for more than 3 cycles/year.

• Fisheries and Aquatic Sciences
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• 제25권2호
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• pp.101-116
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• 2022

The harvesting season of lompa fish, Thryssa baelama, through sasi, indigenous knowledge in resources management, in Haruku Village has become a socio-cultural event that attracts many people. The sasi of lompa fish has been conducted for hundreds of years. Information on the bioecology aspect of lompa fish is limited, while this information is crucial for lompa fish sustainability through the sasi approach. This study aimed to investigate some population parameters of lompa fish, its sustainability status, and proposed a sustainable management strategy for the lompa fishery of Haruku Village. Fish population parameter covers length-weight relationship, growth pattern, size distribution, sex ratio, and the body condition index. The sustainability status was assessed following the Rapfish approach. Fisheries management strategy was performed using a conceptual model framework based on Driver Pressure State Impact Response. The research shows that the total length varies between 9.2-14.3 cm. A high relationship was found between total length and weight, and the growth pattern was an allometric negative. There was a difference in sex ratio between males and females, with females dominant. The body condition index varies over time, probably due to reproductive status. The overall sustainability status was at fair condition (61.60%), with the ecological domain having the highest sustainable status (71.07%) and considered sustain. In comparison, the technological domain had the lowest sustainability status (52.58%) and was considered fair sustain. There were seven management strategies proposed for sustainable management for the lompa fishery.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.997-1001
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• 2013

Background: Lymphangiogenesis, assessed as lymphovascular density (LVD), is the initial step of generalized tumor lymphovascular invasion (LVI). It also involves VEGF-C as the most important protein family. Lymphangiogenesis among breast cancer cases correlations with several clinicopathological factors are important to determine prognosis and treatment strategies, but results have been controversial and require clarification. Aim: To define correlations between VEGF-C expression, LVD and LVI with several clinicopathological parameters from Indonesian breast cancer patients. Materials and Methods: Using a cross-sectional study, a total of 48 paraffin-embedded tissues of breast cancer from Dr. Sardjito General Hospital Indonesia were assessed for VEGF-C expression, LVD and LVI by immunohistochemistry. Correlations of these markers with clinicopathological parameters like patient age, tumor size, lymph node status, grade, ER/PR and Her-2 status, cell proliferation and p-53 expression were investigated by linear analysis. Correlations of VEGF-C expression and LVI with several clinicopathological parameters were analyzed with Coefficient Contingency Chi-Square test. Results: The mean of patients age was 53.0 year, pre and post-menopausal patients accounting for 56.3% and 43.8%, respectively. Some 10.4% were well, 41.7% moderate and 47.9% poorly differentiated. ER positivity was evident in 50% while PR and Her-2 positivity was found in 31.3% and 33.3%, respectively. Breast cancer cells with over-expression of p-53 was 64.6% and with high cell proliferation was 56.3%. Lymph node metastasis was noted in 63.5%, and LVI in 72.9%. Significant correlations were found between LVD and tumor size (p:0.037), grade (p:0.000), lymphnode status (p:0.036), LVI (p:0.003), as well as with p-53 and cell proliferation. There were also significant correlation of VEGF-C (p:0.011) and LVI (p:0.001) with tumor grade. Only ER status was found to have a correlation with tumor size (p:0.027). Conclusions: This study suggested that in Indonesian breast cancer patients, lymphangiogenesis is correlated with tumor size, grade, lymph node status and tumor lymphovascular invasion, the latter also being related with p-53 over expression and high cell proliferation.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10627-10630
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• 2015

Background: Epidermal growth factor receptor (EGFR) mutations play a vital role in the prognosis of patients with lung adenocarcinoma. Such somatic mutations are more common in women who are non-smokers with adenocarcinoma and are of Asian origin. However, to our knowledge, there are few studies that have focused on men. Materials and Methods: One hundred and eighty-four consecutive patients (90 men and 94 women) of resected lung adenocarcinoma were studied retrospectively. Results: EGFR mutations were positive in 48.9% and negative (wild type) in 51.1%. Overall mutation was significant in women (66.0% vs. 32.2%) compared with men (p<0.001). For overall patients, EGFR mutation status was associated with gender, pStage, pT status, lepidic dominant histologic subtype, pure or mixed ground-glass nodule type on computed tomography and smoking status. However, in men, EGFR mutation status was only associated with lepidic dominant histologic subtype and not the other variables. Interestingly, the Brinkman index of men with mutant EGFR also did not differ from that for the wild type ($680.0{\pm}619.3$ vs. $813.1{\pm}552.1$ p=0.1077). Conclusions: The clinical characteristics of men with lung adenocarcinoma related to EGFR mutation are not always similar to that of overall patients. Especially we failed to find the relationship between EGFR mutations and smoking status in men.

• 정보관리연구
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• 제39권1호
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• pp.131-149
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• 2008

이 연구의 목적은 대학도서관에 유능한 인적자원을 확보하기 위한 방안의 하나로 대학도서관 전문사서의 교수지위를 제안하는 데 있으며, 이를 위해 국 내외의 연구들을 문헌조사를 통해 살펴보고, 교수지위 부여에 대한 이론적인 근거를 살펴보았다. 또한 교수임용요건을 갖춘 대학도서관의 전문사서에게 교수지위를 부여하는 문제에 관해 교수집단과 사서집단에게 설문조사를 실시하여 두 집단의 견해를 비교 분석하였다. 모든 분석결과에서 동의수준에는 차이가 있지만, 두 집단이 모두 긍정적인 것으로 나타났다. 대학도서관 전문사서의 교수지위 부여는 대학도서관의 사서들에게 자격요건을 갖추게 하는 동기부여의 수단으로 작용됨에 따라 사서들의 자질이 향상되고, 전문사서의 자질향상은 서비스의 질적 향상으로 이어져 대학교육과 연구에 도움을 주는 결과를 가져옴으로써 결과적으로 대학도서관 발전에 기여할 것이다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제26권4호
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• pp.213-223
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• 2023

Purpose: Pediatric patients in low-income countries are at a high risk of malnutrition. Numerous screening tools have been developed to detect the risk of malnutrition, including the Subjective Global Nutritional Assessment (SGNA), Pediatric Yorkhill Malnutrition Score (PYMS), Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP), and Screening Tool for Risk of Nutritional Status and Growth (STRONGkids). However, anthropometry remains the main tool for assessing malnutrition. We aimed to identify the value of four nutritional screening tools versus anthropometry for evaluating the nutritional status of children. Methods: We conducted a cross-sectional study of 1,000 children aged 1-12 years who visited the outpatient clinic of Cairo University Pediatric Hospital. Each participant was evaluated using anthropometric measurements (weight, length/height, and weight for length/height) as well as the PYMS, STAMP, STRONGkids, and SGNA screening tools. The sensitivities and specificities of these four tools were assessed using anthropometry as the gold standard. Results: Of the patients, 1.7% were underweight, 10.2% were wasted, and 35% were stunted. STRONGkids demonstrated the highest sensitivity (79.4%) and a high specificity (80.2%) for detecting malnutrition compared with weight for height, followed by STAMP, which demonstrated lower sensitivity (73.5%) but higher specificity (81.4%). PYMS demonstrated the lowest sensitivity (66.7%) and the highest specificity (93.5%), whereas SAGA demonstrated higher sensitivity (77.5%) and lower specificity (85.4%) than PYMS. Conclusion: The use of nutritional screening tools to evaluate the nutritional status of children is valuable and recommended as a simple and rapid method for identifying the risk of malnutrition in pediatric patients.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.599-602
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• 2013

Objectives: To evaluate the frequency of cytohistologic discrepancy of high-grade squamous intraepithelial lesions (HSILs) in Pap smears and associated factors. Methods: Medical records of 223 women with HSIL Pap smears who were treated at Thammasat University Hospital were reviewed. Data on age, parity, menopausal status, contraceptive use and colposcopic directed biopsy and loop electrosurgical excision procedure (LEEP) pathology results were recorded. Results: Mean (SD) age of patients was 38.0 (9.4) years. The majority were premenopausal (86.5%) and multiparous (83.9%). Cytohistologic discrepancy between the Pap test and colposcopic-directed biopsy histology was 45.7% and that between the Pap test and LEEP histology was 29.5%. Fifty-four (24.2%) women had no high-grade CIN on both colposcopic directed biopsy and LEEP. Nulliparity, postmenopausal status and having no oral contraceptive pills use were factors associated with cytohistologic discrepancy. Conclusion: The exact cytohistologic discrepancy rate was relatively high (24.2%). Factors associated with cytohistologic discrepancy were nulliparity and postmenopausal status and having no oral contraceptive pill use.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6573-6578
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• 2013

Background: The goal of this retrospective study was to evaluate patient characteristics, treatment modalities and prognostic factors in Turkish patients with pancreatic cancer. Materials and Methods: Between January 1997 and December 2012, 64 patients who presented to the Department of Radiation Oncology, Karadeniz Technical University, Faculty of Medicine with a diagnosis of pancreatic cancer were evaluated. The E/K ratio of the cases was 2.4/1 and the median age was 59.6 (32-80) years, respectively. Some 11 cases (18%) were stage 1, 21 (34.4%) were stage 2, 10 (16.4%) were stage 3, and 19 (31.1%) were metastatic. Results: The mean follow-up time was 15.7 months (0.7-117.5) and loco-regional recurrence was noted in 11 (40.7%) who underwent surgery while metastases were observed in 41 patients (66.1%). The median overall survival (OS) was 11.2 months and the 1, 3 and 5-year OS rates were 41.7%, 9.9% and 7.9% respectively. The median disease-free survival (DFS) was 5.2 month and the1, 2 and 5 year DFS were 22.6%, 7.6% and 3.8% respectively. On univariate analysis, prognostic factors affecting OS included status of the operation (p<0.001), tumor stage (p=0.008), ECOG performance status (p=0.005) and CEA level (p=0.017).On multivariate analysis, prognostic factors affecting survival included status of the operation (p=0.033) and age (p= 0.023). Conclusions: In the current study, age and operation status were independent prognostic factors for overall survival with pancreatic patients. Thus, the patients early diagnosis and treatment ars essential. However, prospective studies with more patients are needed for confirmation.