• Journal of Microbiology and Biotechnology
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• 제34권3호
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• pp.606-621
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• 2024

This study evaluated the hepatoprotective effect of fermented Protaetia brevitarsis larvae (FPB) in ethanol-induced liver injury mice. As a result of amino acids in FPB, 18 types of amino acids including essential amino acids were identified. In the results of in vitro tests, FPB increased alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activities. In addition, FPB treatment increased cell viability on ethanol- and H₂O₂-induced HepG2 cells. FPB ameliorated serum biomarkers related to hepatoxicity including glutamic oxaloacetic transaminase, glutamine pyruvic transaminase, total bilirubin, and lactate dehydrogenase and lipid metabolism including triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Also, FPB controlled ethanol metabolism enzymes by regulating the protein expression levels of ADH, ALDH, and cytochrome P450 2E1 in liver tissue. FPB protected hepatic oxidative stress by improving malondialdehyde content, reduced glutathione, and superoxide dismutase levels. In addition, FPB reversed mitochondrial dysfunction by regulating reactive oxygen species production, mitochondrial membrane potential, and ATP levels. FPB protected ethanol-induced apoptosis, fatty liver, and hepatic inflammation through p-AMP-activated protein kinase and TLR-4/NF-κB signaling pathways. Furthermore, FPB prevented hepatic fibrosis by decreasing TGF-β1/Smad pathway. In summary, these results suggest that FPB might be a potential prophylactic agent for the treatment of alcoholic liver disease via preventing liver injury such as fatty liver, hepatic inflammation due to chronic ethanol-induced oxidative stress.

• 한국식품영양과학회지
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• 제40권2호
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• pp.253-258
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• 2011

본 연구에서는 남부 지방의 특산물인 단감의 이용성 다변화를 위하여 식빵에 응용하였다. 단감은 폴리페놀, 카로테노이드, 식이섬유, 미네랄, 비타민 C 등의 다양한 생리활성물질을 함유하고 있어 전통적으로 혈압을 낮추거나 감기를 예방 하는데 널리 이용되어져 왔고 근래에는 과학적으로 건강에 유익한 여러 기능성들이 밝혀지고 있다. 본 연구에서는 단감을 함유한 식빵을 제조하여 제빵 적성을 조사하였다. 단감의 기능성은 과육보다 껍질, 씨, 꼭지 등에 많이 함유되어 있다고 보고되고 있어 본 실험에서는 단감 과육과 단감 전체를 각각 30% 함유한 식빵을 제조하였다. 제조한 대조식빵(WB), 단감 과육 함유 식빵(FPB), 단감 전체 함유 식빵(WPB)의 여러 특성을 비교하였다. 종자치환법으로 각 식빵의 부피를 측정한 후, 비용적을 구한 결과 WB($3.51\;cm^3$/g), FPB($2.99\;cm^3$/g), WPB($3.21\;cm^3$/g)이었으며, 제빵 손실률은 WB (9.81%), FPB(7.78%), WPB(8.86%)이었다. WB에 비해 FPB, WPB로 갈수록 명도는 감소하였고, 적색도와 황색도는 증가하였으며, 백색도는 감소하였다. WB를 기준으로 전체적인 색도 차이(${\Delta}E$)를 구한 결과 FPB는 6.65이었고 WPB는 11.22이었다. DPPH 라디칼 소거능으로 항산화력을 측정한 결과 식빵 추출물 10 mg/mL 농도에서 WB는 $12.39{\pm}0.135%$이었고, FPB는 $14.57{\pm}0.01%$, WPB는 $19.57{\pm}0.44%$로 단감 과육과 단감 전체가 첨가할수록 증가하였다. 각 식빵의 총 페놀 함량은 WB, FPB, WPB가 각각 $177.05{\pm}5.52$, $185.26{\pm}0.79$, $216.24{\pm}5.47$ mg GAE/g으로 역시 단감 과육, 단감 전체가 첨가될수록 증가하였다. WB의 경도는 175.33 Dyne/$cm^3$이었고 FPB와 WPB에서 감소하였다. 관능검사에서는 FPB가 물성, 향기, 맛, 전체적 선호도에서 높은 점수를 얻었고, WPB는 향과 맛에서 WB보다 높은 점수를 얻었다. 단감과 같이 영양과 기능성이 잘 조화된 과일로 현대인의 건강과 기호성에 부합될 수 있는 새로운 가공기술과 가공식품을 연구, 개발하여 제품의 고급화와 다양화를 이룬다면 국민의 건강에도 기여하며 농업의 활성화에도 기여할 것으로 기대한다.

• Earthquakes and Structures
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• 제26권6호
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• pp.463-475
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• 2024

The study aims to investigate the pounding that occurs between the isolator's ring and slider of isolated structures resulting from excessive seismic excitation, while considering soil-structure interaction. The dynamic responses and poundings of structures subjected a series seismic records were comparatively analyzed for three different soil types and fixed-base structures. A series of parametric studies were conducted to thoroughly discuss the effects of the impact displacement ratio, the FPB friction coefficient ratio, and the radius ratio on the structural dynamic response when considering impact and SSI. It was found that the pounding is extremely brief, with an exceptionally large pounding force generated by impact, resulting in significant acceleration pulse. The acceleration and inter-story shear force of the structure experiencing pounding were greater than those without considering pounding. Sudden changes in the inter-story shear force between the first and second floors of the structure were also observed. The dynamic response of structures in soft ground was significantly lower than that of structures in other ground conditions under the same conditions, regardless of the earthquake wave exciting the structure. When the structure is influenced by pulse-type earthquake records, its dynamic response exhibits a trend of first intensifying and then weakening as the equivalent radius ratio and friction coefficient ratio increase. However, it increases with an increase in the pounding displacement ratio, equivalent radius ratio, friction coefficient ratio, and displacement ratio when the structures are subjected to non-pulse-type seismic record.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 1997년도 봄 학술발표회 논문집
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• pp.113-124
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• 1997

• Nutrition Research and Practice
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• 제6권5호
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• pp.381-388
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• 2012

The objective of this study was to determine protein quality and hematological properties of infant diets formulated from local food materials. The food materials were obtained locally, fermented, and milled into flour. The flours were mixed as 70% popcorn and 30% African locust bean (FPA), 70% popcorn and 30% bambara groundnut (FPB), and 70% popcorn, 20% bambara groundnut, and 10% African locust bean (FPAB). Proximate analysis, protein quality, hematological properties, and anthropometric measurements of the animals fed with the formulations were investigated. The protein contents of the formulated diets were significantly higher than that of Cerelac (a commercial preparation) ($15.75{\pm}0.01g$/100 g) and ogi (traditional complementary food) ($6.52{\pm}0.31g$/100 g). The energy value of FPAB ($464.94{\pm}1.22\;kcal$) was higher than those of FPA ($441.41{\pm}3.05\;kcal$) and FPB ($441.48{\pm}3.05\;kcal$). The biological value (BV) of FPAB (60.20%) was the highest followed by FPB (44.24%) and FPA (41.15%); however, BV of the diets was higher than that of ogi (10.03%) but lower than that of Cerelac (70.43%). Net protein utilization (NPU) of the formulations was 41.16-60.20%, whereas true protein digestibility was 41.05-60.05%. Metabolizable energy (232.98 kcal) and digestible energy (83.69 kcal) of FPAB were the highest, whereas that of FPA had the lowest values. The protein digestibility values corrected for amino acid score of the diets (0.22-0.44) were lower than that of Cerelac (0.52), but higher than that of ogi (0.21). The growth patterns and hematological properties (packed cell volume, red blood cells, hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, and mean corpuscular volume) of the formulated diets were higher than those of ogi, but lower than those of Cerelac. In conclusion, we established that the FPAB food sample was rated best in terms of protein quality over the other formulated diets. Therefore, a FPAB blend may be used as a substitute for ogi.

• 한국재난정보학회 논문집
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• 제7권3호
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• pp.171-180
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• 2011

최근 발생한 일본 대지진으로, 지진에 대한 피해를 최소화 할 수 있는 내진 설계의 필요성과 기존 구조물의 성능 향상에 대한 관심이 더욱 증가하고 있다. 사회기반시설물인 교량 등의 손상 붕괴는 사회적 경제적으로 미치는 파급효과가 커 이러한 구조물에 대한 내진성능의 평가가 상당히 중요하게 부각되고 있다. 내진성능에 대한 검토방법들은 결정론적 방법에 의한 것이 대다수로 각각의 부재에 대한 안전성 수준의 평가에는 실용적이지만 전체의 안전성 평가에는 실용적이지 못해 지진에 대한 구조물의 안전성 평가에는 손상단계에 따른 취약성 또는 손상도를 평가하는 방법이 필요하다. 본 논문에서는 탄성마찰포트받침(RFPB)을 사용한 Steel Box 교량에 대하여 지진의 특성인 PGA, PGV, SA, SV, SI 에 대한 손상도 곡선을 구하고, 이를 마찰포트받침(FPB)을 갖는 교량의 손상도곡선과 비교함으로써 두 지진 격리 장치의 성능을 비교 평가하였다.

• 대한물리의학회지
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• 제17권2호
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• pp.21-28
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• 2022

PURPOSE: This study examined the effect of changes in the knee angle and weight shifting of the sole on the activity of the lower extremity muscles during bridge exercise. METHODS: The subjects of this study included 20 healthy adult women (mean age 29.8 ± 4.32). The subjects performed the bridge exercise under three weight-shifting conditions general bridge (GB), hindfoot press bridge (HPB), and fore-foot bridge (FPB) and at two knee angles (90° and 60°). During the bridge exercise, the activity of the quadriceps femoris (rectus femoris, vastus medialis oblique, and vastus lateralis) and biceps femoris muscles were measured using an electromyography sensor. RESULTS: In the quadriceps femoris, the muscle activity of HPB and FPB was significantly higher than that of the GB at knee angles of 90° and 60° (p < .05). In the biceps femoris, the muscle activity increased significantly in the order of GB < HPB < FPB, and the knee angle increased significantly at 60° rather than at 90° (p < .05). There was no significant difference according to the knee angle in all muscles except for the biceps femoris. CONCLUSION: These findings suggest that the weight-shifting bridge of sole bridge exercise was more effective in increasing the activation of the lower extremity muscles than the GB.

• 한국소음진동공학회논문집
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• 제24권3호
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• pp.227-235
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• 2014

The demand of natural gas is gradually increasing as a clean fuel in the world. Therefore, LNG storage tanks and related facilities of the importance of leading a community-based facility have emerged. The seismic design of LNG storage tank including seismic analysis have been developed steadily. But, the seismic analysis and design techniques for LNG storage tanks are lacking, in Korea. Consequently, it is necessary to develop an analysis model that LNG storage tanks in isolation system can describe the behavior. Further, LNG storage tank capable of ensuring safety and economy, it is necessary to develop design techniques. The studies have suggested seismic design procedures of LNG storage tanks with isolation system including triple-FPB and idealized complex hysteresis model of triple-FPB.

• 디지털콘텐츠학회 논문지
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• 제12권2호
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• pp.177-184
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• 2011

본 연구에서는 영상음악의 물리적 관점에서 영상과 음악의 시간일치를 살펴보고 있다. 시간일치는 클릭트랙을 활용하여 영상의 시간과 음악의 마디 위치를 수학적 계산에 의해 나타내게 되는데, 음악적 강조지점인 Hit의 위치는 박자 당 프레임 수(FPB)를 산출하여 시간대별 음표의 위치를 가늠함으로써 찾아 낼 수 있다. Hit은 여린박에 위치 할 수 있으며, 음악의 특성상 센박에 위치하는 것이 작곡가에게 더욱 편리하기 때문에 본 연구에서는 음악과 영상 싱크를 위한 세 가지 방법을 제안한다. 첫째는 박자변환을 통한 싱크, 둘째는 템포변환을 통한 싱크이며, 마지막으로 오프셋을 통한 싱크 방법이 있다. 이 방법들은 각기 장단점이 있으므로, 이들 싱크의 선택 문제는 음악의 자연스러운 흐름을 기초로 판단해야 한다.

• Structural Engineering and Mechanics
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• 제66권6호
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• pp.749-759
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• 2018

Aiming at widely used high-pier bridges in Sichuan-Tibet Railway, this paper presents an investigation to design and evaluate the seismic vibration reduction effects of several measures, including viscous damper (VD), friction pendulum bearing (FPB), and tuned mass damper (TMD). Primarily, according to the detailed introduction of the concerned bridge structure, dynamic models of high-pier bridges with different seismic vibration reduction (SVR) measures are established. Further, the designs for these SVR measures are performed, and the optimal parameters of these measures are investigated. On this basis, the vibration reduction effects of these measures are analyzed and assessed subject to actual earthquake excitations in Wenchuan Earthquake (M=8.0), and the most appropriate SVR measure for high-pier bridges in Sichuan-Tibet Railway is determined at the end of the work. Results show that the height of pier does not obviously affect the performances of the concerned SVR measures. Comprehensively considering the vibration absorption performance, installation and maintenance of all the employed measures in this paper, TMD is the best one to absorb vibrations induced by earthquakes.