• Title/Summary/Keyword: FAP

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Establishment of Days after Anthesis(DAA) and Fruit After-ripening Period(FAP) for High-Quality Seed Production of Watermelon (우량 수박종자 생산을 위한 적정 성숙일수 및 후숙일수 확립)

  • Park, Eun-Ji;Lee, Gyu-Bin;Park, Young-Gil;Suh, Jeong-Min;Kang, Jum-Soon
    • Journal of Environmental Science International
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    • v.24 no.12
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    • pp.1681-1689
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    • 2015
  • This study was conducted to investigate days after anthesis (DAA) and fruit after-ripening period (FAP) for seed-harvesting of high quality watermelon seeds. Fruit weight and number of seed per fruit increased according to DAA, while those did not significant about FAP. Ratio of cotyledon at whole seed was higher about 2 to 4% compared to seed coat irrespective of DAA and FAP. Germinability of watermelon was not a significant effect by DAA, however, it had differences by FAP. Percent of germination (PB) was below 50%, when 30 days maturated fruits after anthesis was omitted ripening, while PB was increased to 92% by ripening. In addition, seeds at DAA 40 and FAP 20 were higher general seedling vigors (hypocotyl length, diameter etc.) in BP test. Results indicated that considering seed productivity, it had maximized seed viability at DAA 40 and FAP 20.

Short hairpin RNA targeting of fibroblast activation protein inhibits tumor growth and improves the tumor microenvironment in a mouse model

  • Cai, Fan;Li, Zhiyong;Wang, Chunting;Xian, Shuang;Xu, Guangchao;Peng, Feng;Wei, Yuquan;Lu, You
    • BMB Reports
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    • v.46 no.5
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    • pp.252-257
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    • 2013
  • Fibroblast activation protein (FAP) is a specific serine protease expressed in tumor stroma proven to be a stimulatory factor in the progression of some cancers. The purpose of this study was to investigate the effects of FAP knockdown on tumor growth and the tumor microenvironment. Mice bearing 4T1 subcutaneous tumors were treated with liposome-shRNA complexes targeting FAP. Tumor volumes and weights were monitored, and FAP, collagen, microvessel density (MVD), and apoptosis were measured. Our studies showed that shRNA targeting of FAP in murine breast cancer reduces FAP expression, inhibits tumor growth, promotes collagen accumulation (38%), and suppresses angiogenesis (71.7%), as well as promoting apoptosis (by threefold). We suggest that FAP plays a role in tumor growth and in altering the tumor microenvironment. Targeting FAP may therefore represent a supplementary therapy for breast cancer.

Two phase algorithm for frequency assignment in cellular mobile systems with maximal distance of channel interference

  • Kim, Sehun;Kim, Seong-Lyun
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 1994.04a
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    • pp.291-300
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    • 1994
  • In this paper we consider the frequency assignment problem (FAP) in a cellular mobile communication system which has a maximal distance of channel interference. This special structure is observed in most cellular systems. To handle the considered FAP, we use the pattern approach which fits naturally to the problem. Based on this approach, we are able to formulate the considered FAP into a manageable optimization problem and propose a two phase heuristic algorithm for the problem. Computational experiments show that our algorithm performs much better in both solution quality and computational time than the recently developed algorithms for FAP. Since the considered FAP well reflects most cellular systems, our algorithm can be applied to many practical situations.

Evaluation on Tungsten CMP Characteristic using Fixed Abrasive Pad with Alumina (알루미나 고정입자패드를 이용한 텅스텐 CMP 특성 평가)

  • 박범영;김호윤;김형재;서헌덕;정해도
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2002.10a
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    • pp.206-209
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    • 2002
  • The fixed abrasive pad(FAP) has been introduced in chemical mechanical polishing(CMP) field recently. In comparison with the general CMP which uses the slurry including abrasives, FAP takes advantage of planarity. resulting from decreasing pattern selectivity and defects such as dishing due to the reduction of abrasive concentration especially. This paper introduces the manufacturing technique of $Al_2$O$_3$-FAP using hydrophilic polymers with swelling characteristic in water and explains the self.texturing phenomenon. It also focuses on the chemical effects on tungsten film and the FAP is evaluated on the removal rate as a function of chemicals such as oxidizer, catalyst, and acid. The removal rate is achieved up to 1000A1min as about 70 percents of the general one. In the future. the research has a plan of the advanced FAP and chemicals in tungsten CMP considering micro-scratch, life-time, and within wafer non-uniformity.

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Anti-Inflammatory Effect of Fermented Artemisia princeps Pamp in Mice

  • Joh, Eun-Ha;Trinh, Hien-Trung;Han, Myung-Joo;Kim, Dong-Hyun
    • Biomolecules & Therapeutics
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    • v.18 no.3
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    • pp.308-315
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    • 2010
  • Essential oil-excluded Artemisia princeps Pamp var Ssajuarissuk (AP) was fermented with Lactobacillus brevis K-1, which was isolated from cabbage Kimchi, and the anti-inflammatory effects of AP and fermented AP (FAP) on lipopolysaccharide (LPS)-induced inflammatory response in peritoneal macrophages were investigated. AP and FAP inhibited LPS-induced TNF-$\alpha$, IL-$1{\beta}$, COX-2, iNOS and COX-2 expression, as well as NF-${\kappa}B$ activation. AP and FAP also reduced ear thickness, inflammatory cytokine (TNF-$\alpha$, IL-$1{\beta}$ and IL-6) expression and NF-${\kappa}B$ activation with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced dermatitis in mice. Furthermore, AP and FAP also reduced exudate volume, cell number, protein amount, inflammatory cytokines (TNF-$\alpha$, IL-$1{\beta}$ and IL-6) expression and NF-${\kappa}B$ activation in carrageenan-induced air pouch inflammation in mice. The inhibitory effects of FAP were more potent than those of non-fermented AP. Based on these findings, we propose that FAP can improve inflammatory diseases, such as dermatitis, by inhibiting the NF-${\kappa}B$ pathway.

Evaluation of Endoscopic Characteristics of Upper Gastrointestinal Polyps in Patients with Familial Adenomatous Polyposis

  • Fatemi, Seyed Reza;Safaee, Azadeh;Pasha, Sara;Pourhoseingholi, Mohamad Amin;Bahrainei, Rasool;Molaei, Mahsa
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.16
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    • pp.6945-6948
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    • 2014
  • Background: Familial adenomatous polyposis (FAP) is a disease inherited in an autosomal dominant fashion. Most FAP patients develop upper gastrointestinal polyps; especially those in the antrum and duodenum are usually neoplastic. The aim of this study was to evaluate the prevalence of gastroduodenal polyps in Iranian FAP patients. Materials and Methods: 28 patients affected by FAP underwent front-view and side-view endoscopy. Papillary biopsies were performed in all patients. Location of polyps, their number and size, pathology study, patient general information (gender, age, family history of FAP or colorectal cancer and gastroduodenal polyps) were analyzed. Results: Gastric polyps were seen in 39.3 % of patients. Some 72.7% of the affected individuals had fundic gland polyps and 36.36% had hyperplastic polyps. Duodenal adenoma was observed in 25% of patients. While 57% of patients had tubular adenoma with low grade dysplasia, 42.8% showed tubulovillous adenoma with low grade dysplasia. Conclusions: Findings of this study indicated that the prevalence of gastroduodenal polyps in FAP patients is high and dysplasia may be evident in duodenal polyps. Therefore, it appears that routine gastroduodenal endoscopy in FAP patients is necessary.

Effects of First Aid Training Program on Child Care Teachers' Coping Intentions and Knowledge in the Case of Emergency Situations (응급처치교육 프로그램이 보육교사들의 응급상황 대처 의지 및 지식에 미치는 효과)

  • Yi, Seung-Hoon
    • The Journal of the Korea Contents Association
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    • v.19 no.5
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    • pp.464-471
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    • 2019
  • The purpose of this study was to analyze the effects of first aid programs(FAP) on the knowledge and will to cope with emergency situations, and to suggest the effective FAP for child care teachers by analyzing the needs of FAP. The subjects of this study were 159 child care teachers who received upgrading education. The results of the study are as follows. First, child care teachers have a willingness to cope with emergency situations. and child care teachers who were not able to do were caused by the burden of legal liability and lack of confidence in first aid techniques. Second, teachers who received FAP showed higher knowledge about first aid knowledge. Third, the type of FAP desired by the child care teachers showed the most favored type of whole practice. Fourth, the contents of FAP desired by child care teachers were CPR, airway obstruction, burn treatment and temperature related symptoms. In this study, FAP is needed in the process of child care teacher training. FAP should be practice-oriented education, and the contents of FAP should be structured based on the needs of child care teachers.

Familial Adenomatous Polyposis Improved by COX-2 Inhibitor in a Child (COX-2 억제제 투여 후 호전을 보인 가족성 선종성 용종증 1례)

  • Oh, Ki Won;Kim, Se Young;Lee, Hwan Suk;Lee, Myung Hoon;Choe, Byung Ho
    • Clinical and Experimental Pediatrics
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    • v.45 no.12
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    • pp.1591-1595
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    • 2002
  • Familial adenomatous polyposis(FAP) is an autosomal dominant disease characterized by numerous adenomas in the colorectum. Patients with FAP are always at risk of malignant transformation, so that colectomy is unavoidable. NSAID, such as sulindac, and selective COX-2 inhibitor, such as celecoxib, have shown a positive effect on FAP by causing polyp regression in some patients. We report a case of FAP in a 9-year-old female whose polyposis regressed markedly after six months-treatment with celecoxib.

Subdivided Facial Muscle Modeling based on MPEG-4 EAP (MPEG-4 FAP 기반 세분화된 얼굴 근육 모델 구현)

  • 이인서;박운기;전병우
    • Proceedings of the IEEK Conference
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    • 2000.09a
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    • pp.631-634
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    • 2000
  • In this paper, we propose a method for implementing a system for decoding the parameter data based on Facial Animation Parameter (FAP) developed by MPEG-4 Synthetic/Natural Hybrid Coding (SNHC) subcommittee. The data is displayed according to FAP with human mucle model animation engine. Proposed model has the basic properties of the human skin specified by be energy funtional for realistic facial animation.

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Fixed Abrasive Pad with Self-conditioning in CMP Process (Self-conditioning 고정입자패드를 이용한 CMP)

  • Park, Boumyoung;Lee, Hyunseop;Park, Kihyun;Seo, Heondeok;Jeong, Haedo;Kim, Hoyoun;Kim, Hyoungjae
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.18 no.4
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    • pp.321-326
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    • 2005
  • Chemical mechanical polishing(CMP) process is essential technology to be applied to manufacturing the dielectric layer and metal line in semiconductor devices. It has been known that overpolishing in CMP depends on pattern selectivity as a function of density and pitch, and use of fixed abrasive pad(FAP) is one method which can improve the pattern selectivity. Thus, dishing & erosion defects can be reduced. This paper introduces the manufacturing technique of FAP using hydrophilic polymers with swelling characteristic in water and explains the self-conditioning phenomenon. When applied to tungsten blanket wafers, the FAP resulted in appropriate performance in point of uniformity, material selectivity and roughness. Especially, reduced dishing and erosion was observed in CMP of tungsten pattern wafer with the proposed FAP.