• Archives of Plastic Surgery
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• v.38 no.4
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• pp.369-375
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• 2011

Purpose: Many hemostatic agents and dressings have been tested with variable degree of success. Chitosan has a positive charge, it attracts red blood cells, which have a negative charge. Our goal is to test the efficacy of new developed chitosan-based hemostatic materials in providing durable hemostasis in a high-flow arterial wound model. Methods: We compared each group with SD rats motality tests and in vitro blood compatibility test by blood clotting index (BCI). We devided the SD rats into 6 groups (N =15) by type of hemostatic agents. A: 100% nonwoven chitosan (degree of the deacetylation: 90%). B: 50% N-acetylation on nonwoven of chitosan gel (degree of the deacetylation: 50%). C: 60% N-acetylation on nonwoven of chitosan ge (degree of the deacetylation: 40%)l. D: Cutanplast$^{(R)}$. E: HemCon$^{(R)}$ F: Gauze. In vivo test, a proximal arterial injury was created in unilateral femoral arteries of 90 anesthetized SD rats. Each materials was made same size and thickness then applied to the injury site for 3 minutes. In vitro test, we compared each group with BCI in human blood. Results: In vivo test, group A showed lower motality rate of 46% than any other groups, Group B and C showed lower motality rate of 60% than group D and E's motality rate of 66%. In vitro test, BCI of group A ($30.6{\pm}1.2$) and B ($29.3{\pm}1.0$) were showed nearly about group D ($29.1{\pm}1.8$) and E ($27.4{\pm}1.6$). Group C ($37.1{\pm}2.0$) showed higher BCI than group A and B, it means group C decreased blood clotting. Conclusion: In conclusion, this study suggests a newly developed chitosan-based hemostatic materials induced durable hemostasis and increased blood clotting, and are considered as effective biologic hemostatic agents.

• The korean journal of orthodontics
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• v.27 no.6 s.65
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• pp.979-995
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• 1997

The purpose of this study was to identify the preventive and the progressive inhibitory effects of enamel demineralization with fluoride releasing light-and self-cured orthodontic sealants(FluoroBond), in vitro, under the polarizing light microscope and the scanning electon microscope. The polarizing light microscopic group was subdivided into seven groups(Group A-Group G). The scanning electron microscopic group was also subdivided into seven groups(Group A'-Goup G'). For polarizing light microscopic evaluation, longitudinal sections were made longitudinally by Maruto cutter(Maruto Co., Japan) and Maruto grinding machine(Maruto Co., Japan). Sections were examined and photographed by the polarizing light microscope(Olympus Optical Co., Japan) using crossed polars and with the enamel rod longitudinal axis oriented at $45^{\circ}$ to the extinction position. For scanning electron microscopic evaluation, the specimens were coated with a highly conducting layer of gold palladium in a model Hus-4 high-vacuum evaporator and examined in an ISI-100B scanning electron microcope operated at 20kV. The results of this study were as follows : 1. The mean depths of artificial carious lesions under a polarized light microscope were $Group\;A(5.08{\mu}m),\;Group\;B(47.82{\mu}m,\;Group\;C(8.42{\mu}m),\;Group\;D(7.20{\mu}m),\;Group\;E(85.41{\mu}m),\;Group\;F(60.38{\mu}m),\;Group\;G(60.13{\mu}m)$. 2. There were statistically significant differences in Group B compared with Group A, C, and D(p<0.05), and also, in Group I compared with Group F and Group G(p<0.05). 3. Light-and self-cured orthodontic sealants had the preventive effects of enamel demineralization. 4. Light-and self-cured orthodontic sealants had the progressive inhibitory effects of enamel demineralization. 5. The time progress of demineralizing agent had no influence on the samples of light-and self-cured orthodontic sealants under the scanning electron microscope. 6. There was no difference between the specimens of light-and self-cured orthodontic sealants both in the polarized light microscopic group and in the scanning electron microscopic group.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.22 no.1
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• pp.7-22
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• 1992

The stress distributions on a human mandible for 18 load cases under two different boundary conditions (mouth open and closed), using the three dimensional finite element modeling were studied. Also, the expected fracture loads for each load cases were calculated by using the Von-Mises yield criterion. The model of a mandible with all teeth was composed of 2402 hexahedron elements and 3698 nodes. CAD techniques were used to analyze the 3-dimensional results. The conclusions of this study were as follows: 1. In the mouth open state, the maximum stress occured at the condyle neck; when the lateral load was exerted, the maximum stress occured at the load side condyle. 2. In the mouth closed state, when the loads were exerted on the mandibular body and chin, the maximum stress occured at the loaded area, and when the loads were exerted on the angle and ramus, the maximum stress occured at the condyle neck. 3. The expected fracture loads in each load case were calculated using the Von-Mises yield criterion, and it was confirmed that the mandible in the mouth open state was more easily fractured than that in the mouth closed state, and the expected fracture loads are lesser in the cases that load direction is parallel at mandibular plane than 45°. 4. The magnitudes of the expected fracture loads increased in the order of angle, ramus, body and chin in case of the mouth closed state, while chin, body, angle and ramus in case of the mouth open state. 5. The Von-Mises stress concentration regions analyzed by F.E.M. corresponded well with the results of clinical studies.

• Asian-Australasian Journal of Animal Sciences
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• v.29 no.10
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• pp.1483-1489
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• 2016

Most of amino acid (AA) digestibility values for feed ingredients are obtained using pigs cannulated in the distal ileum. The ileal-cannulated pig model uses pigs older than six weeks due to difficulties related to implanting the T-cannula in distal ileum of younger pigs and complications during the post-surgical recovery. However, to properly formulate the diet of weaned pigs, the nutritive value of feed ingredients should be determined with younger pigs. Thus, 25 weaned pigs were used to determine the apparent total tract digestibility (ATTD) of nutrients, energy, and apparent ileal digestibility (AID) and standardized ileal digestibility (SID) ileal AA digestibility of broken rice (BR), with or without multicarbohydrase (MC) and phytase (Phy) supplementation. Piglets were weaned at 23 d of age and individually housed in digestibility cages until 45 d of age. The trial consisted of 7 d of adaptation to the experimental diets and 3 d of excreta (feces and urine) collection. Ileal digesta was collected at slaughter (about 6 weeks of age). A completely randomized experimental design was used to determine the effects of MC and Phy. Reference diets (RD, 5% casein) was replaced by 30% of BR with or without MC, Phy, or MC+Phy. The RD was used to quantify endogenous AA losses. BR with Phy supplied had increased the ATTD of dry matter (p<0.05) and SID of histidine (p = 0.05), arginine, leucine, lysine, valine, alanine, and proline (p<0.05). BR with MC had been increased digestible energy and protein and SID for histidine (p<0.05). There was no interaction between Phy and MC on the BR nutrient digestibilities. Standardized amino acid digestibilities of BR, without enzymes, were lower than those values reported in the literature. The MC and Phy improved the digestibility of some nutrients and energy of BR in post-weaned piglet diets.

• Journal of the Korea Concrete Institute
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• v.27 no.5
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• pp.471-480
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• 2015

The building structure is planned to maximize the use of space in recent. It was developed of a hybrid OCB (Optimized Composite Beam) for trying to take advantage of the maximize space. The OCB is composed of the steel h-beam section reinforced by open strands in negative moment zone and the psc concrete section in positive zone. Flexural behaviors of typical architectural bybrid OCB section was investigated. The 15 m OCB specimen was tested under three point static loading system. Following results are obtained from the tests; 1) The OCB with 15 m span develop initial flexural crackings under the 171% of full service loading. 2) Overall deflections of OCB under the service loads are less than those of the allowable limit in KCI Code provision. 3) The crack patterns, failure mode and ultimate load capacity of test specimen and F.E. model in this paper and they are compared to each other. The OCB is verified of structural reliability from the experimental results.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.5
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• pp.1741-1751
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• 2013

The main purpose of this study is to investigate the static behavior of a prestressed concrete (PSC) girder using pre-tension method. A 30m long full-scale pretension PSC girder is fabricated by the portable fabrication system and tested. All results have been compared to those obtained from F.E.A results. Deflections at the middle of girders have been measured for evaluation. Also, strains of concrete at the middle of span have been measured. From the results of experimental, the load when initial crack was developed was obtained to be 1.75 time the unfactered design load in the full-scale girder specimen. Also, the data of specimen are satisfied the desgin requirements of ductility on the Korea Bridge Design Specification(2010). In service state, the vertical deflection at center of test specimen when a initial crack was developed is satisfied the vertical deflection requirement under live load of the Korea Bridge Design Specification(2010). To verify the experimental results, we numerical analyze the test and confirmed that the data were similar with results from the test above. The pretension girder fabricated in site were found to have enough strength for safety under and after construction.

• Communications for Statistical Applications and Methods
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• v.24 no.3
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• pp.241-254
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• 2017

Drawing a sample can be costly or time consuming in some studies. However, it may be possible to rank the sampling units according to some baseline auxiliary covariates, which are easily obtainable, and/or cost efficient. Ranked set sampling (RSS) is a method to achieve this goal. In this paper, we propose a modified approach of the RSS method to allocate units into an experimental study that compares L groups. Computer simulation estimates the empirical nominal values and the empirical power values for the test procedure of comparing L different groups using modified RSS based on the regression approach in analysis of covariance (ANCOVA) models. A comparison to simple random sampling (SRS) is made to demonstrate efficiency. The results indicate that the required sample sizes for a given precision are smaller under RSS than under SRS. The modified RSS protocol was applied to an experimental study. The experimental study was designed to obtain a better understanding of the pathways by which positive experiences (i.e., goal completion) contribute to higher levels of happiness, well-being, and life satisfaction. The use of the RSS method resulted in a cost reduction associated with smaller sample size without losing the precision of the analysis.

• Journal of the Korean Society for Precision Engineering
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• v.29 no.4
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• pp.461-468
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• 2012

Silo is a warehouse for storing granular materials such as grain, cement, petroleum compound and coal. When compared to other warehouses, the silo can use space efficiently. The coal silo are consists of silo, tunnel and extractor. Of these, there are not sufficient study and design data on tunnel. It depends heavily upon trial and error method by field engineers with several years of experience. Recently, silos are constructed with a large size, and tunnel becomes to be in danger of severe cracking and collapse by a huge load of coal. So it is necessary to analyze structural safety for tunnel. In this study, the problems of the tunnel are analyzed by field data, and reinforcement of structural weak area using FE analysis has been carried out to design the tunnel satisfying structural safety. From FE Analysis, the reinforced model which does not exceed the yield strength of the material has been proposed.

• Toxicological Research
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• v.26 no.3
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• pp.171-175
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• 2010

The human genome contains approximately 13 orphan cytochrome P450 (P450, CYP) genes, of which the apparent function or substrate has not been identified. However, they seem to possess their own biological relevance in some tissues or developmental stages. Here, we characterized the heterologously expressed CYP2W1, an orphan P450 enzyme. The recombinant CYP2W1 protein containing a $6{\times}$(His)-tag at Nterminus has been expressed in Escherichia coli and purified. Expression level of CYP2W1 holoenzyme was around 500 nmol P450 holoenzyme per liter culture medium. The reduced CO difference spectrum of CYP2W1 showed a maximum absorption at 449 nm. CYP2W1 indicated the significant induction to bioactivate Trp-P-1, MeIQ, and IQ in E. coli DJ701 tester strain. However, the bioactivation of B[$\alpha$]P, and NNK by CYP2W1 was relatively low. The model structure of CYP2W1 suggested the characteristic P450 folds with the lengths and orientations of the individual secondary elements. The F-G loop is situated on the distal side of heme to accommodate the flexibility of active site of CYP2W1. These studies can provide useful information for the finding of its biological roles and structure-function relationships of an orphan CYP2W1 enzyme.

• Structural Engineering and Mechanics
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• v.53 no.5
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• pp.939-956
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• 2015

In this study, in order to propose an efficient model to predict the torque capacity of steel fiber reinforced concrete (SFRC) beams, the existing experimental data related to torsional response of beams is reviewed. It is observed that existing data neglects the effects of some parameters on the variation of torque capacity. Thus, an experimental research was also conducted to obtain the effects of neglected parameters. In the experimental study, a total of seventeen SFRC beams are tested against torsion. The parameters considered in the experiments are concrete compressive strength, steel fiber aspect ratio, volumetric ratio of steel fibers and longitudinal reinforcement ratio. The effect of each parameter is discussed in terms of torque versus unit angle of twist graphs. The data obtained from this experimental research is also combined with the data got from previous studies and employed in artificial neural network (ANN) analysis to estimate the ultimate torque capacity of SFRC beams. In addition to parameters considered in the experiments, aspect ratio of beam cross-section, yield strengths of both transverse and longitudinal reinforcements, and transverse reinforcement ratio are also defined as parameters in ANN analysis due to their significant effects observed in previous studies. Assessment of the accuracy of ANN analysis in estimating the ultimate torque capacity of SFRC beams is performed by comparing the analytical and experimental results. Comparisons are conducted in terms of root mean square error (RMSE), mean absolute error (MAE) and coefficient of efficiency ($E_f$). The results of this study revealed that addition of steel fibers increases the ultimate torque capacity of reinforced concrete beams. It is also found that ANN is a powerful method and a feasible tool to estimate ultimate torque capacity of both normal and high strength concrete beams within the range of input parameters considered.