• 한국전산유체공학회:학술대회논문집
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• 2008.03b
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• pp.121-125
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• 2008

In this study, the characteristics of internal flow and the heat transfer performance of dimpled plate heat exchanger were numerically investigated. For the numerical analysis, conjugate heat transfer method between cold fluid - plate - hot fluid was studied with appropriate boundary conditions. Velocity magnitude, temperature and pressure distribution were obtained from the simulation. Correlations for fanning f-factor and Colburn j-factor were obtained from numerical results and compared to the experimented data.

• Proceedings of the KIEE Conference
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• 2000.11b
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• pp.250-252
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• 2000

A simple analysis method for inverter-fed induction motor using F.E.M and equivalent circuit is proposed. And an optimum shape of rotor slot for 2Hp inverter-fed induction motor is determined by combining the proposed analysis method and an optimization algorithm. Conjugate gradient method is used for the optimization algorithm. The optimization is performed for higher efficiency and reduction of harmonic loss in the inverter-fed induction motor. The optimization results are verified by comparing with those of the time-step F.E.A and the experiment.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.110-111
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• 2013

FcBP consisting of 13 amino acids specifically binds to Immunoglobulin G Fc domain. Initially, we utilized this peptide for preparation of antibody chip as a PEG composite for enhanced solubility. After then, the peptide conjugate was immobilized on agarose resin, resulting in highly efficient affinity column for antibody purification. The efficiency was comparable to commercial Protein A column. Recently, this peptide was conjugated with cell penetrating peptide (CPP) on a backbone of GFP, affording antibody transducer, which carries antibody into live cells by simple mixing of antibody and the transducer in cell culture media. Antibody transduction into cells was monitored by live cell imaging. More recently, the FcBP was fused to ferritin cage, which consists of 24 ferritin protein molecules. The FcBP-ferritin cage showed greatly increased binding affinity to human IgG. Its binding was analyzed by QCM and SPR analysis. Finally, it was selectively delivered by Herceptin to SKBR3, a breast cancer cell, over MCF10A, non-tumorigenic cells (Fig. 1). Fig. 1. Fluorescent microscopic images of SKBR3 breast cancer cells (A~C) and MCF10A breast cells (D~F) treated with Cy3-trastuzumab/fFcBP-Pf_Fn complexes. Trastuzumab and FcBP-Pf_Fn, which were labeled with Cy3 (Cy3-trastuzumab) and fluorescein (fFcBP-Pf_Fn), respectively, selectively targeted SKBR3 over MCF10A.

• Smart Media Journal
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• v.3 no.2
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• pp.9-13
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• 2014

The Levenberg-Marquardt (LM) algorithm is the most widely used fitting algorithm. It outperforms simple gradient descent and other conjugate gradient methods in a wide variety of problems. Based on the work of paper[1], we propose a modified Levenberg-Marquardt algorithm for better performance of mobile system. The LM parameter at the $k_{th}$ iteration is chosen ${\mu}=A{\bullet}{\parallel}f(x){\parallel}{\bullet}I$ where f is the residual function, and J is the Jacobi of f. In this paper, we show this method is more efficient than traditional method under the situation that the system iteration is limited.

• Pediatric Infection and Vaccine
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• v.10 no.2
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• pp.159-166
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• 2003

Purpose : Streptococcus pneumoniae is part of the normal flora but is also responsible for causing many invasive diseases such as pneumonia, meningitis, and sepsis in addition to noninvasive diseases such as otitis in children. Multi-drug resistant strains has raised a lot of concern worldwide and thus the importance of prevention has been emphasized. We have analyzed the current serotypes and antibiotic sensitivity of each serotype as a baseline study to estimate the efficacy of the pneumococcal vaccine in Korean children. Methods : One hundred sixteen cases of pneumococcus cultured at Yonsei Medical Center from September 2001 to January 2003 were analyzed. The serotyping was done with the Quellung reaction and penicillin resistance was tested using the oxacillin disc diffusion method. Results : Pneumococcus were cultured from the sputum in 76 cases(65.5%), from the blood in 13 cases(11.2%), from the ear discharge in 12 cases(10.3%), from the throat in 7 cases(6.0%), from the nasal cavity in 2 cases(1.7%), and one case(0.9%) each from the cerebrospinal fluid, eye discharge, peritoneal fluid, post-operational wound, brain abscess, and catheter tip. Serotyping was possible with 98 cases and the following serotypes were found; 15 cases of type 19F(15.3%), 11 cases of 19A(11.2%), 8 cases of 11A(8.2%), 7 cases each of 6A, 14 and 3(7.1%), 6 cases each of 35, 6B and 23F(6.1%). Eighty two cases(70.7%) out of 116 cases were penicillin resistant and serotypes 19F, 19A, 11A, 23F, 6A, 9V constituted the majority, 48 cases(59.8%). These serotypes showed resistance to cotrimoxazole (74.4%), tetracycline(69.5%), and erythromycin(90.3%) as well. In the 22 cases cultured from children, 19A and 19F were found in 25.0%, 6A, 6B, and 23F in 10.0%, 11A, 14, 19, and 29 in 5.0%. Fifty percent(10/20) of the clinical isolates were represented in the current 7-valent pneumococcal protein conjugate vaccine, and 85%(17/20) when the cross-reacting serotypes were included. Penicillin resistance was found in 86.4%(19/22). Conclusion : The percentage of serotypes included in the 7 valent pneumococcal protein conjugate vaccine found in our study was 40.8% which was less than other prior studies. In anticipation of a change of pneumococcal serotypes, a nationwide multicenter study is needed before the initiation of pneumococcal vaccines in Korea.

• Pediatric Infection and Vaccine
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• v.26 no.3
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• pp.188-193
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• 2019

Since the implementation of conjugate Haemophilus influenzae serotype b (Hib) vaccine, the rate of infections caused by Hib has dramatically decreased, and the proportion of infections caused by non-type b H. influenzae has increased. Cerebral venous sinus thrombosis (CVST) is rare; however, it should be considered as a potential complication of bacterial meningitis. Herein, we report about a child who developed CVST after being diagnosed with H. influenzae serotype f meningitis.

• Computers and Concrete
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• v.2 no.5
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• pp.345-366
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• 2005

This work presents an assessment of the computational performance of a vector-parallel implementation of probabilistic model for concrete cracking in 3D. This paper shows the continuing efforts towards code optimization as reported in earlier works Paz, et al. (2002a,b and 2003). The probabilistic crack approach is based on the direct Monte Carlo method. Cracking is accounted by means of 3D interface elements. This approach considers that all nonlinearities are restricted to interface elements modeling cracks. The heterogeneity governs the overall cracking behavior and related size effects on concrete fracture. Computational kernels in the implementation are the inexact Newton iterative driver to solve the non-linear problem and a preconditioned conjugate gradient (PCG) driver to solve linearized equations, using an element by element (EBE) strategy to compute matrix-vector products. In particular the paper analyzes code behavior using OpenMP directives in parallel vector processors (PVP), such as the CRAY SV1 and CRAY T94. The impact of the memory architecture on code performance, and also some strategies devised to circumvent this issue are addressed by numerical experiment.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.05a
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• pp.765-767
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• 2014

본 논문에서는 단거리 레이더용 차량 추돌 방지 24-GHz CMOS 고주파 전력 증폭기 (RF Power Amplifier)를 제안한다. 이러한 회로는 class-A 모드 증폭기로서 단간 (inter-stages) 공액 정합 (conjugate matching) 회로를 가진 공통-소스 단으로 구성되어 있다. 칩 면적을 줄이기 위해 실제 인덕터 대신 전송선(Transmission Line)을 이용하였다. 제안한 회로는 TSMC $0.13{\mu}m$ 혼성 신호/고주파 CMOS 공정 ($f_T/f_{MAX}=120/140GHz$)으로 설계하였다. 설계한 CMOS 고주파 전력 증폭기는 최근 발표된 연구결과에 비해 약 22dB의 높은 전력이득 및 7.1%의 높은 PAE 특성을 보였다.

• Economic and Environmental Geology
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• v.55 no.3
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• pp.231-239
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• 2022

The irregular shape of the disturbances is a fundamental issue for mining engineers at the Sidi Chennane phosphate deposit in Morocco. A precise classification of disturbed areas is therefore necessary to understand their part in the overall volume of phosphate. In this paper, we investigate the theoretical and practical aspects of studying and measuring multifractal spectrums as a defining and representative parameter for distinguishing between the phosphate deposit of a low rate of disturbances and the deposit of a high rate. An empirical multifractal approach was used by analyzing the disturbed areas through the geoelectric images of an area located in the Sidi Chennane phosphate deposit. The Generalized fractal dimension, D(q), the Singularities of strength, α(q), the local dimension, f(α) and their conjugate parameter the mass exponent, τ(q) as well as f(α)-α spectrum were the common multifractal parameters used. The results reported show wide variations of the analyzed images, indicating that the multifractal analysis is an indicator for evaluate and characterize the disturbed areas within the phosphates deposits through the studied geoelectric images. This could be the starting point for future work aimed at improving phosphate exploration planning.

• Proceedings of the KIEE Conference
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• 2004.04a
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• pp.86-88
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• 2004

In this paper, optimal stator slot shape of 3-phase inverter-fed induction motor is designed to reduce stator core and winding losses. For the analysis, the F.E.M on 1 phase band periodic condition in stator is coupled with harmonic equivalent circuit. For the optimal design, the conjugate gradient method is used as an optimizing algorithm. The stator core and winding losses are reduced by the design method. The results are verified by those of the time-step finite element analysis.