• Journal of Veterinary Clinics
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• v.30 no.4
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• pp.324-328
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• 2013

A 5-year-old intact male Yorkshire terrier dog was referred with a 1-week history of blindness. In both eyes, menace responses and pupillary light reflexes were absent. The indirect ophthalmoloscopy revealed multiple small gray-white and discoloration lesion in mid-nontapetum area in both eyes. Electroretinograms showed diminished amplitude of a- and b-waves. Multifocal serous retinal detachments were detected with optical coherence tomography (OCT) over the small gray-white and discoloration lesion in the fundus. After one week of treatments, the indirect ophthalmoloscopy showed that irregular patches and hyperpigmentation in the center of hyperreflectivity area. Reattachment and retinal thinning were observed by the OCT. The results indicate that OCT scanning is considered to be a useful method for retinal evaluation in dogs with chorioretinitis.

• Journal of Veterinary Clinics
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• v.40 no.3
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• pp.221-224
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• 2023

A two-year-old spayed female Maltipoo dog was presented with a two-month duration of glaucoma in the right eye. On the first presentation, menace response and dazzle reflex were absent in the right eye, but it was present in the left eye. Slit-lamp biomicroscopy showed buphthalmia, mild corneal edema, and conjunctival and episcleral hyperemia in the right eye. The intraocular pressures were 70 mmHg and 30 mmHg in the right and left eyes, respectively. On the gonioscopic and high-resolution ultrasound examinations, both the iridocorneal angle and ciliary cleft were completely closed in the right eye. However, gonioscopy revealed an opened iridocorneal angle even with some broader base of pectinate ligament fiber, but high-resolution ultrasound showed a narrowed ciliary cleft and increased contact of the iris base with the limbal cornea in the left eye. Based on these results, a diagnosis of primary angle-closure glaucoma was made in both eyes. This case report highlighted the importance of evaluating the ciliary cleft with high-resolution ultrasound as a critical diagnostic and prognostic role in canine glaucoma.

• BMB Reports
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• v.45 no.12
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• pp.693-699
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• 2012

Together with protein tyrosine kinases (PTKs), protein tyrosine phosphatases (PTPs) serve as hallmarks in cellular signal transduction by controlling the reversible phosphorylation of their substrates. The human genome is estimated to encode more than 100 PTPs, which can be divided into eleven sub-groups according to their structural and functional characteristics. All the crystal structures of catalytic domains of sub-groups have been elucidated, enabling us to understand their precise catalytic mechanism and to compare their structures across all sub-groups. In this review, I describe the structure and mechanism of catalytic domains of PTPs in the structural context.

• Animal Systematics, Evolution and Diversity
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• v.25 no.2
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• pp.183-187
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• 2009

A new species, Burmoniscus phuketensis, is described from Ko Phuket, Thailand. The new species belongs to the group characterized by male pereopods 1 and 2 with enlarged and flattened carpi, including B. coecus (Budde-Lund, 1895), B. ferrarai (Schumalfuss, 1983), B. mossambicus (Ferrara and Taiti, 1985), B. rowei Taiti and Manicastri, 1988, and B. rakataensis Green, Ferrara and Taiti, 1990. Among them, this new species resembles B. coecus and B. rakataensis in the pigmentless body and the shape of pereonite 7 epimeron with acute postero-lateral corner, but is easily distinguished from both specie by the shape of telson. While the eyes are absent in B. coecus, they are present in this new species.

• Korean Journal of Veterinary Research
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• v.53 no.2
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• pp.133-136
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• 2013

To report multiple congenital ocular defects in a Bedlington terrier dog aged 2.5 months with blindness. Routine ophthalmic examinations were performed for the clinical signs. Menace responses and cotton ball test were absent in both eyes (OU), but pupillary light reflexes were normal in OU. Slit lamp biomicroscopy reveled corneal dystrophy, posterior subcapsular cataract, microphthalmia in OU and lenticular coloboma in the right eye. In indirect ophthalmoscopy and ultrasonography, retinal detachment and posterior lenticonus were shown in OU. It is the first report of lenticular coloboma and posterior lenticonus in a Bedlington terrier dog.

• Korean Journal of Veterinary Research
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• v.59 no.2
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• pp.113-117
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• 2019

A 6-year-old intact male Maltese dog presented with a history of blindness and ataxia. Neuro-ophthalmic examination revealed dilated pupils with absent pupillary light reflexes and menace response in both eyes. Mild peripapillary edema was noted in the fundus of the right eye. After magnetic resonance imaging, the dog was provisionally diagnosed with meningoencephalitis of unknown etiology. Follow-up funduscopy was performed to monitor the condition of the optic discs for three years. Despite of the treatment with prednisolone, the optic nerve progressed to atrophy and the dog couldn't restore vision.

• Journal of Veterinary Clinics
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• v.26 no.5
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• pp.480-482
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• 2009

A 2-year-old, castrated male, Scottish fold cat was referred to Veterinary Medical Teaching Hospital of Seoul National University (VMTH-SNU) for evaluation of acute bilateral blindness after general anesthesia. For dental prophylaxis in local animal hospital, general anesthesia had been induced with intravenous acepromazine and ketamine, and maintained with isoflurane after intubation. At VMTH-SNU on next day, complete blood count, electrolytes and serum chemistry values were within normal ranges. On neurologic examination, visual placing and postural reactions like as hopping, hemiwalking and wheelborrowing were reduced on right hindlimb. On ophthalmic examination, menace responses were absent on both eyes and pupillary light reflex (PLR) reduced on right eye, but other reflex and fundus were normal. Prednisolone (2 mg/kg sid for 3 days) was administrated orally and tapered. Visual placing was possible on 2nd day, and postural reactions were recovered on 4th day after dental prophylaxis. Based on the process and recovery, this case was considered as postoperative visual loss (POVL) after general anesthesia.

• Korean Journal of Ichthyology
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• v.21 no.3
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• pp.208-213
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• 2009

Histological examination of an individual of the Korean slender gudgeon Squalidus gracilis majimae having cutaneous albinism produced rarely in the wild was made and compared with a normal individual. The external body of the albino was colorless, differing from the normal individual, which has dense brownish black spots over its body surface. To make it clear through histological study, we observed eight skin regions: dorsal, lateral, ventral, upper caudal peduncle, lower caudal peduncle, dorsal fin, anal fin, and the eyes. These regional skins were the same in fundamental structure between albinic and normal gudgeon, but there were significant differences in distribution and development of pigment cells (melanins). In the normal gudgeon, the pigment cells were well developed over the regional skins except on the skin from the ventral region. However, it was confirmed in the albino that the pigment cells were vestigial over the upper regions of the eye and body but absent in the ventral region, lower caudal peduncle, and anal fin.

• Korean Journal of Head & Neck Oncology
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• v.27 no.1
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• pp.84-87
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• 2011

Branchio-otic syndrome(BOS) is a relatively uncommon genetic malformation associated with dysmorphogenesis of the first and second branchial arches and is characterized by branchial fistulae, congenital preauricular fistulae, and anomalies of the pinnae, external, middle, and inner ears, accompanied by hearing loss. Recently, we experienced a case of BOS in a 10 years old female patient and report this case with a review of literature. 10-year-old girl presented with hearing impairment, bilateral preauricular fistula and cervical fistula. The pure tone audiometry revealed that she had 60dB sensorineural hearing loss on right side and 90dB mixed hearing loss on left. Bilateral branchial fistula was found on the neck CT scan and bilateral ossicular and cochlear abnormality combined with enlarged internal auditory canal was noted on the temporal bone CT scan. To investigate the association with EYA1 gene, we performed DNA sequncing with peripheral white blood cell and found the point mutations on Exon 7, 12 and 16 of EYA1 gene. The preauricular fistula and branchial fistula was excised surgically and hearing aid was applied on her left side. There was no sign of fistula recurrence for seven years after the surgery.

• Journal of Veterinary Clinics
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• v.32 no.2
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• pp.209-211
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• 2015

A 5-year-old Siamese cat was presented at the Veterinary Medical Teaching Hospital in Seoul National University with visual impairment. The cat was blind and its pupillary light reflexes were sluggish OU. While there were no remarkable findings in the anterior segment, generalized tapetal hyperreflectivity and retinal vascular attenuation were observed in the posterior segment of both eyes. Any historical significance and clinical symptoms suggestive of infection or inflammation were absent. All of the above findings strongly indicated a diagnosis of hereditary retinal degeneration in the cat. This clinical case report demonstrates the possibility of the presence of feline hereditary retinal degeneration in Korea. Awareness of the condition should be raised to prevent the spread of hereditary retinopathy in the Korean cat population.