• 한국임상수의학회지
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• 제25권5호
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• pp.411-414
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• 2008

This report described a severe bilateral microphthalmia in a young Holstein calf. The anomalous calf with wry tail showed normal vigor, appetite and normal body weight except for eye defect. The orbits were shallower and smaller than normal. The orbit bilaterally contained a white small mass suspected as eyeball. A spot-like remnant of eyeball (REB) was buried in the mixture of vestigial extraocular muscles and adipose tissue of the bilateral orbit. Histologically, the REB was composed of irregularly arranged elements of ocular wall such as sclera, retina and ciliary body. But any destructive changes in the central nervous systems were not detected. This case of eye defect was defined as severe bilateral microphthalmia. The cause of this ocular defect is unknown.

• 대한두개안면성형외과학회지
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• 제20권2호
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• pp.121-125
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• 2019

Merkel cell carcinoma is a rare cutaneous carcinoma, featured by an aggressive clinical course and a mortality rate of 28% at 2 years. A 71-year-old female was affected by a 4.1-cm-wide locally advanced Merkel cell carcinoma of the upper eyelid, previously misdiagnosed as chalazion, with involvement of the extraocular muscles. Although the tumor showed a macroscopic spontaneous regression in size after the incisional biopsy, the mass was treated with neoadjuvant chemotherapy and surgical excision. Good functional and aesthetic result with preservation of the eyeball and absence of tumor recurrence were achieved at 3-year follow-up. In our experience, the combination of the inflammatory cascade due to the incisional biopsy and neoadjuvant chemotherapy led to the regression of a locally advanced large Merkel cell carcinoma of the eyelid.

• 한국안광학회지
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• 제15권2호
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• pp.155-160
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• 2010

목적: 머리 위치에 따른 사위도 변화를 평가하고, 외안근의 불균형과 관련하여 좌 우안의 프리즘 량을 달리할 필요성을 확인하고자 하였다. 방법: 20~30세 남자 44명(88안), 여자 16명(32안)을 대상으로 차폐검사, 자각적 굴절검사, 사위검사 및 융합여력검사를 실시하였다. 머리기울임 검사, 얼굴돌림 검사에 따른 사위 변화량을 비교분석하기 위해 본 그래페를 이용하여 측정하였다. 결과: 머리기울임과 얼굴돌림에 따른 사위도 변화는 Morgan 표준의 수평사위 비정상군에서 유의한 차이를 보였고(p<0.05), 특히 근거리 Sheard 기준으로 수평사위 처방이 필요한 그룹에서 근거리 수평사위 변화량이 크게 나타났다(p<0.05). 수평사위 비정상군의 원거리 Sheard 기준으로 처방이 필요한 그룹과 필요하지 않은 그룹 모두 머리 위치에 따라 사위도 변화는 근거리일 경우 보다는 적었다. 결론: 수평사위 비정상군의 Sheard 기준 처방이 필요한 그룹에서 근거리 머리기울임, 얼굴돌림의 수평사위 변화량이 크게 나타났다. 따라서 근거리 사위에서 프리즘 처방을 해야 할 때 좌 우 외안근의 불균형의 존재를 확인하여 좌 우안에 프리즘량을 달리 처방할 필요성이 있는 것으로 본다.

• 대한후두음성언어의학회지
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• 제23권2호
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• pp.111-118
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• 2012

Botulinum toxin is a potent neurotoxin that is produced by the bacterium Clostridium botulinum. The agent causes muscle paralysis by preventing the release of acetylcholine at the neuromuscular junction of striated muscle. Botulinum toxin A (Botox, AllerganInc., Irvine, California) is the most potent of seven distinct toxin subtypes that are produced by the bacterium. The toxin was initially used clinically in the treatment of strabismus caused by hypertonicity of the extraocular muscles and was sub-sequently described in the treatment of multiple disorders of muscular spasticity and dystonia. In treating patients with Botox for blepharospasm, Carruthers and Carruthers [5] noticed an improvement in glabellar rhytids. This ultimately led to the introduction and development of Botox as a mainstay in the treatment of hyperfunctional facial lines in the upper face. Since its approval by the U.S. Food and Drug Administration for the treatment of facial rhytids (2002), botulinum toxin A has expanded into wide-spread clinical use. Forehead, glabellar, and periocular rhytids are the most frequently treated facial regions. Indications for alternative uses for Botox in facial plastic and reconstructive surgery are expanding. These include a variety of well-established procedures that use Botox as an adjunctive agent to enhance results. In addition, Botox injection is finding increased usefulness as an independent modality for facial rejuvenation and rehabilitation. The agent is used beyond its role in facial rhytids as an effective agent in the management of dynamic disorders of the face and neck. Botox injection allows the physician to precisely manipulate the balance between complex and conflicting muscular interactions, thus resetting their equilibrium state and exerting a clinical effect. This article will address some of the new and unique indications on Botox injection in the face (the lower face and neck, combination with fillers). Important points in terms of its clinical relevance will be stressed, such as an understanding of functional facial anatomy, the importance of precise injections, and correct dosing all are critical to obtaining natural outcomes.

• Archives of Plastic Surgery
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• 제35권5호
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• pp.553-559
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• 2008

Purpose: The lateral orbital wall fractures have been previously classified by some authors. As there are some limitations in applying in their own classifications, we hope to present a refined classification system of the lateral orbital wall fracture and to identify the correlation between the specific type of the fracture and clinical diagnosis. Methods: The facial bone CT scans and medical records of 78 patients with the lateral orbital wall fractures were reviewed in a retrospective manner. The classification is based on the CT scan. In type I, the fracture and its segments are away from the lateral rectus muscle and in type II, they are next to or slightly pushing the muscle in axial CT scan. In type III, the fracture segments compress and displace the longitudinal axis of the muscle or the optic nerve in axial view of CT scan. Type IV fracture includes multiple fractures found around the orbital apex or optic canal in coronal view of CT scans of the type I and type II fractures. Results: The most common fracture pattern was type I(43.6%), followed by type IV(29.5%), type II(20.5%), and type III(6.4%). As diplopia and restriction of extraocular muscles were found in type I and II fractures, severe ophthalmic complications such as superior orbital fissure syndrome, orbital apex syndrome, and traumatic optic neuropathy were found in type III and IV fractures almost exclusively. Conclusion: We propose an easy classification system of the lateral orbital wall fracture which correlates closely with ophthalmic complications and may help to make further treatment plan. In Type III and IV fractures, severe ophthalmic complications may ensue in higher rates, so early diagnosis and treatment should be performed.

• 감성과학
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• 제18권1호
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• pp.27-38
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• 2015

전정안구반사(VOR; vestibulo-ocular reflex)는 머리가 움직이는 동안 안정된 망막상을 얻기 위해 일어나는 안구의 보상적 움직임이다. 망막정보와 전정신호가 감각갈등(sensory conflict)을 일으키면 멀미가 일어나며, VOR 이득(gain)이 변한다는 것이 알려져 있다. 본 보고에서는 VOR을 측정할 수 있는 실용적이고 저렴한 시스템을 LabVIEW와 Arduino를 이용하여 구현하였다. 그리고 이 시스템을 사용하여 VOR의 특징적 변화를 두 가지 실험을 통해서 측정하였다. 실험 1에서는 자기회전검사법을 이용하여 실험참가자(n = 4)의 수평 및 수직 전정안구반사의 특성을 살펴보았다. 실험 2에서는 가상환경 하에서 실험참가자(n = 8)가 정지된 화면을 볼 때와 사이버멀미(cybersickness)를 경험하는 3D 가상주행 영상에 노출되었을 때의 머리 움직임과 안구 운동을 측정하였다. 그 결과, 가상주행을 경험할 때 특징적인 머리 움직임과 안구 운동이 측정되었다. 본 보고에서 소개한 전정안구반사 측정 시스템은 가상환경에서의 사이버멀미 경감을 위한 심리생리학적 연구에 기여할 수 있을 것이다.

• 대한두개안면성형외과학회지
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• 제20권2호
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• pp.101-108
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• 2019

Background: To date, a variety of surgical approaches have been used to reconstruct the medial orbital wall fracture. Still however, there is still a controversy as to their applicability because of postoperative scars, injury of anatomical structures and limited visual fields. The purpose of this study was to introduce a useful additional medial subbrow approach for better reduction and securement more accurate implant pocket of medial orbital wall fracture with the subciliary technique. Methods: We had performed our technique for a total of 14 patients with medial orbital wall fracture at our medical institution between January 2016 and July 2017. All fractures were operated through subciliary technique combined with the additional medial subbrow approach. They underwent subciliary approach accompanied by medial wall dissection using a Louisville elevator through the slit incision of the medial subbrow procedure. This facilitated visualization of the medial wall fracture site and helped to ensure a more accurate pocket for implant insertion. Results: Postoperative outcomes showed sufficient coverage without displacement. Twelve cases of preoperative diplopia improved to two cases of postoperative diplopia. More than 2 mm enophthalmos was 14 cases preoperatively, improving to 0 case postoperatively. Without damage such as major vessels or extraocular muscles, enophthalmos was corrected and there was no restriction of eyeball motion. Conclusion: Our ancillary procedure was useful in dissecting the medial wall, and it was a safe method as to cause no significant complications in our clinical series. Also, there is an only nonvisible postoperative scar. Therefore, it is a recommendable surgical modality for medial orbital wall fracture.

• Korean Journal of Radiology
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• 제23권6호
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• pp.664-673
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• 2022

Objective: To evaluate the performance of baseline clinical characteristics and pretherapeutic histogram parameters derived from T2 mapping of the extraocular muscles (EOMs) in the prediction of treatment response to intravenous glucocorticoid (IVGC) therapy for active and moderate-to-severe thyroid-associated ophthalmopathy (TAO) and to investigate the effect of fat-suppression (FS) in T2 mapping in this prediction. Materials and Methods: A total of 79 patients clinically diagnosed with active, moderate-to-severe TAO (47 female, 32 male; mean age ± standard deviation, 46.1 ± 10 years), including 43 patients with a total of 86 orbits in the responsive group and 36 patients with a total of 72 orbits in the unresponsive group, were enrolled. Baseline clinical characteristics and pretherapeutic histogram parameters derived from T2 mapping with FS (i.e., FS T2 mapping) or without FS (i.e., conventional T2 mapping) of EOMs were compared between the two groups. Independent predictors of treatment response to IVGC were identified using multivariable analysis. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive performance of the prediction models. Differences between the models were examined using the DeLong test. Results: Compared to the unresponsive group, the responsive group had a shorter disease duration, lower kurtosis (FS-kurtosis), lower standard deviation, larger 75th, 90th, and 95th (FS-95th) T2 relaxation times in FS mapping and lower kurtosis in conventional T2 mapping. Multivariable analysis revealed that disease duration, FS-95th percentile, and FS-kurtosis were independent predictors of treatment response. The combined model, integrating all identified predictors, had an optimized area under the ROC curve of 0.797, 88.4% sensitivity, and 62.5% specificity, which were significantly superior to those of the imaging model (p = 0.013). Conclusion: An integrated combination of disease duration, FS-95th percentile, and FS-kurtosis was a potential predictor of treatment response to IVGC in patients with active and moderate-to-severe TAO. FS T2 mapping was superior to conventional T2 mapping in terms of prediction.