• Tuberculosis and Respiratory Diseases
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• 제73권1호
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• pp.61-66
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• 2012

Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type (extranodal MZL) is a distinct subgroup of non-Hodgkin's lymphoma. Pulmonary extranodal MZL is a rare entity and accounts for less than 0.5% of primary pulmonary malignancies. Only a few cases of simultaneous occurrence of lung cancer and pulmonary extranodal MZL have been reported. A 60-year-old woman was referred to our hospital with a pulmonary nodule. She was diagnosed with lung adenocarcinoma by percutaneous needle biopsy. The protrusions into the left main bronchus were found by accident while performing bronchoscopy during lung cancer evaluation. The bronchial lesions were diagnosed as extranodal MZL. Although the patient underwent surgical resection for the lung adenocarcinoma, the pulmonary extranodal MZL was left untreated; it was monitored during follow-up visits. To our knowledge, this is the first report of synchronous lung adenocarcinoma and primary extranodal MZL of the main bronchus.

• 대한두경부종양학회지
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• 제33권1호
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• pp.35-38
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• 2017

The extranodal nasal NK/T-cell lymphoma was formerly known as lethal midline granuloma due to its most common clinical pattern like a destructive midline facial tumor. It often spread to other extranodal sites, such as skin, soft tissue, testis, upper respiratory tract, and gastrointestinal tract etc. For this reason, the term of extranodal NK/T-cell lymphoma, nasal type is preferred. Its disease entity may have a prominent admixture of inflammatory cells and necrotic tissues, further causing difficulty in diagnosis. A 44-year-old man was visited to our clinic with complaints of dysphagia and odynophagia during six months. He underwent three times punch biopsies and then, two times incisional biopsies. Finally, He was diagnosed as extranodal NK/T-cell lymphoma, nasal type involving oropharynx and supraglottis. We report an extremely rare case of extranodal NK/T-cell lymphoma, nasal type occurred in oropharynx and supraglottis with a brief review of literature.

• 대한두경부종양학회지
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• 제36권2호
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• pp.45-50
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• 2020

Extranodal Natural Killer (NK)/T-cell lymphoma, nasal type, is a subtype of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus. Extranodal NK/T-cell lymphoma mostly affects the nasal cavity and there has been no report of the disease's occurrence at the base of tongue. Here we report a case of 43-year-old man who presented with a diffuse ulcerative lesion at the base of tongue. Because the patient had oral bleeding, tracheostomy and lingual artery ligation was performed via a transcervical approach to control bleeding and protect the upper airway. We performed a deep biopsy through the lateral pharyngotomy approach, and finally, the patient was diagnosed with extranodal NK/T-cell lymphoma, nasal type. We report this rare case of extranodal NK/T cell lymphoma at the base of tongue with a literature review.

• Journal of Chest Surgery
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• 제35권10호
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• pp.768-772
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• 2002

Sinus histiocytosis with massive lymphadenopathy는 Rosai-Dorfman 질환(이후 RDD)으로 불리는 조직구증 증후군의 드문 형태의 질환으로, 주로 소아나 청소년기에 발생하며 대부분 경부 림프절을 침범하여 무통성의 심한 림프절 종대를 특징적으로 보이는 질환이다. 림프절외 부위 침범은 약 25∼43%의 환자에서 보고되며, 일부에서는 림프절의 병변없이 림프절외 부위 침범만을 보이기도 한다. 림프절외 질환에서 침범되는 기관은 안구와 부속기관 두경부, 상기도, 유방, 위장관, 중추신경계 등의 다양한 장기에서 보고되고 있다. 최근 저자들은 35세 남자환자에서 수술전 방사선학적 검사상 전종격동 종괴가 발견되어 임상적으로 침윤성 흉선 종의 의진 하에 수술을 시행하였으며, 수술 후 조직검사에서 RDD 질환으로 확진된 1예를 경험하여 보고하고자 한다.

• 대한한방내과학회지
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• 제29권3호
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• pp.810-818
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• 2008

Objective : The aim of this case report is to drive further studies evaluating the effectiveness of Korean oriental medicine on extranodal marginal zone B cells of MALT (mucosa-associated lymphoid tissue) type lymphoma. Methods : This case report is about a patient who was diagnosed with extranodal marginal zone B cell of MALT type lymphoma, who refused chemotherapy and preferred to be treated with Korean oriental medicine. Neck, chest abdomen & pelvis with enhanced computed tomography (CT) and positron emission tomography computed tomography (PET-CT) were performed to evaluate the anticancer effect of Hangam-dan (HAD). Results : The patient diagnosed with MALT showed partial response after receiving 17 months of Korean oriental medical treatment. Neck, chest, abdomen & pelvic CT and PET-CT show decrease in size. Conclusion : This case report shows a possibility that Korean oriental treatment could offer potential benefits for patients with extranodal marginal zone B cell of MALT type lymphoma.

• 한국임상수의학회지
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• 제21권2호
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• pp.214-218
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• 2004

A 16-month old female Golden retriever dog was presented with a 2-week history of left-sided exophthalmos, third eyelid prominence, some scale of the trunk, mild anorexia, mild diarrhea and depression. In radiographic findings, a mass with increased opacity in the left retrobulbar area was observed. Cytologic and histopathologic examinations after enucleation and mass excision showed diffuse round cell accumulation and adjacent small area of elongated cell proliferation were shown. They also illustrated the neoplastic cells with large nucleoli, multiple nucleoli that differ in size and scant cytoplasm with several clear vacuoles. Extent of local invasiveness and central necrosis of the retrobulbar mass was identified by magnetic resonance imaging. Based on the physical and laboratory examination, radiographic, cytologic and histopathologic findings this case was diagnosed as extranodal malignant lymphoma of the retrobulbar area.

• Tuberculosis and Respiratory Diseases
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• 제76권4호
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• pp.184-187
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• 2014

A nasal-type extranodal natural killer/T-cell lymphoma is considered an aggressive form of non-Hodgkin's lymphoma, with approximately half of all patients relapsing during the follow-up period, and most relapses occurring within the first 2 years of remission. Here we report an unusual case of a 42-year-old man who experienced recurrence in single pleura after 8 years of remission.

• Investigative Magnetic Resonance Imaging
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• 제24권3호
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• pp.168-173
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• 2020

Extranodal lymphoma presents in almost one-third of all non-Hodgkin lymphoma cases. The gastrointestinal tract, skin, and central nervous system are common sites of involvement, whereas the urethra and cervix are very rare. To the best of our knowledge, this is the first report on concurrent extranodal involvement of the uterine cervix and urethra. We report imaging findings of malignant lymphoma involving urethra and cervix concurrently in a 79-year-old female patient with literature review. The magnetic resonance imaging showed huge intermediate to high signal intensity mass on T2 weighted images and strong homogeneous enhancement in uterine cervix and periurethral area, but no surrounding architectural disruption.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제37권4호
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• pp.329-332
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• 2011

Extranodal NK/T-cell lymphoma (NTCL), nasal type is rare and highly fatal malignant neoplasm. Early diagnosis and establishing treatment plan are very difficult. Furthermore, NTCL in the mandible is an extremely rare condition. The clinical significance of presented case is the very rare location of NTCL. To the best of author's knowledge, this is the first reported case of NTCL of the mandible in the literature.

• Journal of Yeungnam Medical Science
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• 제38권3호
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• pp.231-234
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• 2021

We report a rare case of metachronous lymphoma with two distinct cell lineages in a 75-year-old man. The patient complained about having nasal obstruction for 2 years and extranodal natural killer (NK)/T-cell lymphoma of the nasal type was diagnosed from a biopsy. The immunohistochemical staining for CD56 and in situ hybridization for Epstein-Barr virus (EBV)-encoded small RNA (EBER-ISH) were positive and the tumor cells were negative for CD20. After 13 months of concurrent chemoradiotherapy, the patient presented with swelling of the left testis. Positron emission tomography scan detected an abnormal uptake in the testis. A diffuse large B-cell lymphoma, not otherwise specified, was diagnosed from subsequent radical orchiectomy. The immunohistochemical staining revealed to be positive for CD20, BCL2, BCL6, and MYC and negative for CD10 and EBER-ISH.