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Utilizing Various Natural Language Processing Techniques for Biomedical Interaction Extraction

  • Park, Kyung-Mi;Cho, Han-Cheol;Rim, Hae-Chang
    • Journal of Information Processing Systems
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    • v.7 no.3
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    • pp.459-472
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    • 2011
  • The vast number of biomedical literature is an important source of biomedical interaction information discovery. However, it is complicated to obtain interaction information from them because most of them are not easily readable by machine. In this paper, we present a method for extracting biomedical interaction information assuming that the biomedical Named Entities (NEs) are already identified. The proposed method labels all possible pairs of given biomedical NEs as INTERACTION or NO-INTERACTION by using a Maximum Entropy (ME) classifier. The features used for the classifier are obtained by applying various NLP techniques such as POS tagging, base phrase recognition, parsing and predicate-argument recognition. Especially, specific verb predicates (activate, inhibit, diminish and etc.) and their biomedical NE arguments are very useful features for identifying interactive NE pairs. Based on this, we devised a twostep method: 1) an interaction verb extraction step to find biomedically salient verbs, and 2) an argument relation identification step to generate partial predicate-argument structures between extracted interaction verbs and their NE arguments. In the experiments, we analyzed how much each applied NLP technique improves the performance. The proposed method can be completely improved by more than 2% compared to the baseline method. The use of external contextual features, which are obtained from outside of NEs, is crucial for the performance improvement. We also compare the performance of the proposed method against the co-occurrence-based and the rule-based methods. The result demonstrates that the proposed method considerably improves the performance.

A Compression Study on a Synthetic Talc (합성 활석에 대한 압축 연구)

  • Kim, Young-Ho;Kim, Soon-Oh
    • Journal of the Mineralogical Society of Korea
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    • v.27 no.4
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    • pp.283-291
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    • 2014
  • Talc ($Mg_3Si_4O_{10}(OH)_2$), one of sheet silicates, is soft and has been widely used in industry. Powdered talc specimen was synthesized at the pressure of 200 MPa and temperature of $600^{\circ}C$ using external heated hydrothermal high pressure apparatus. High pressure angular dispersive X-ray diffraction (ADXRD) mode experiments were performed at the Pohang Light Source (PLS) using the symmetrical diamond anvil cell (SDAC). Compression pressure was loaded up to 11.06 GPa at room temperature. This synthetic talc shows no phase transition(s) within the present pressure limit. Based on ADXRD data, bulk modulus of talc was calculated to be 72.4 GPa using Birch-Muranghan equation of state (EOS). This value is lower than that of natural talc determined previously.

Comparison of the effect of peat moss and zeolite on ammonia volatilization as a source of fine particulate matter (PM 2.5) from upland soil

  • Park, Seong Min;Hong, Chang Oh
    • Korean Journal of Agricultural Science
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    • v.46 no.4
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    • pp.907-914
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    • 2019
  • Ammonia (NH3) that reacts with nitric or sulfuric acid in the air is the major culprit contributing to the formation of fine particulate matter (PM2.5). NH3 volatilization mainly originates from nitrogen fertilizer and livestock manure applied to arable soil. Cation exchange capacity (CEC) of peat moss (PM) and zeolite (ZL) is high enough to adsorb ammonium (NH4+) in soil. Therefore, they might inhibit volatilization of NH3. The objective of this study was to compare the effect of PM and ZL on NH3 volatilization from upland soil. For this, a laboratory experiment was carried out, and NH3 volatilization from the soil was monitored for 12 days. PM and ZL were added at the rate of 0, 1, 2, and 4% (wt wt-1) with 354 N g m-2 of urea. Cumulative NH3-N volatilization decreased with increasing addition rate of both materials. Mean value of cumulative NH3-N volatilization across application rate with PM was lower than that with ZL. CEC increased with increasing addition rate of both materials. While the soil pH increased with ZL, it decreased with PM. Increase in CEC resulted in NH4+ adsorption on the negative charge of the external surface of both materials. In addition, decrease in soil pH hinders the conversion of NH4+ to NH3. Based on the above results, the addition of PM or ZL could be an optimum management to reduce NH3 volatilization from the soil. However, PM was more effective in decreasing NH3 volatilization than ZL due to the combined effect of CEC and pH.

Design and Self-sustainable Operation of 1 kW SOFC System (1kW 고체산화물 연료전지(SOFC) 시스템 설계 및 자열운전)

  • Lee, Tae-Hee;Choi, Jin-Hyeok;Park, Tae-Sung;Yoo, Young-Sung;Nam, Suk-Woo
    • Journal of Hydrogen and New Energy
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    • v.20 no.5
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    • pp.384-389
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    • 2009
  • KEPRI (Korea Electric Power Research Institute) has studied planar type solid oxide fuel cell (SOFC) stacks using anode-supported cells and kW class co-generation systems for residential power generation. In this work, a 1 kW SOFC system consisted of a hot box part, a cold BOP (balance of plant) part, and a hot water reservoir. The hot box part contained a SOFC stack made up of 48 cells, a fuel reformer, a catalytic combustor, and heat exchangers. Thermal management and insulation system were especially designed for self-sustainable operation in that system. A cold BOP part was composed of blowers, pumps, a water trap, and system control units. When the 1 kW SOFC stack was tested using hydrogen at $750^{\circ}C$, the stack power was about $1.2\;kW_e$ at 30 A and $1.6\;kW_e$ at 50 A. Turning off an electric furnace, the SOFC system was operated using hydrogen and city gas without any external heat source. Under self-sustainable operation conditions, the stack power was about $1.3\;kW_e$ with hydrogen and $1.2\;kW_e$ with city gas respectively. The system also recuperated heat of about $1.1\;kW_{th}$ by making hot water.

SD and EEG Evaluation of the Visual Cognition to the Natural and Urban Landscape (SD 및 EEG 기법을 통한 자연 및 도시경관의 시지각적 인지분석)

  • Hwang, Jee-Wook;Hong, Chul-Un;Chong, Woo-Suk
    • Journal of Environmental Science International
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    • v.15 no.4
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    • pp.305-310
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    • 2006
  • The color and structure of urban constructions is a factor of urban landscape and shows their characteristics. Hence the modern buildings deal with their materials and external appearance as an important factor, making up the urban image. But it was nearby impossible to evaluate the value of visual landscape with objective measuring method. Most of all, it depends on the subjective estimation of a few talented or high educated experts with a sense of beauty. Such kinds of estimation can in some cases include arbitrary interpretations. In relation to this kind of problems, it is tried here in this study to analyse the human response of brain wave pattern (EEG) with use of SD method, while the tested persons watch the urban landscape scenery constructed in a visual reality. The tested persons were 20 adult male and female with no color blindness and intact cognitive function. Light source with color filter was used for color environment in a dark soundproof chamber. The signal of EEG is analysed digitally and grouped into the ${\alpha}$ and ${\beta}$ waves. The result showed that relative power of ${\alpha}$ wave ratio increased in the natural landscape scenery with blue and green color. From these results it was possible to evaluate the human response, which is affected by urban and natural color and structure stimulation and it might be useful as an indicator of visual cognition amenity toward the design of urban construction environment.

Preliminary Research of CZT Based PET System Development in KAERI

  • Jo, Woo Jin;Jeong, Manhee;Kim, Han Soo;Kim, Sang Yeol;Ha, Jang Ho
    • Journal of Radiation Protection and Research
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    • v.41 no.2
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    • pp.81-86
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    • 2016
  • Background: For positron emission tomography (PET) application, cadmium zinc telluride (CZT) has been investigated by several institutes to replace detectors from a conventional system using photomultipliers or Silicon-photomultipliers (SiPMs). The spatial and energy resolution in using CZT can be superior to current scintillator-based state-of-the-art PET detectors. CZT has been under development for several years at the Korea Atomic Energy Research Institute (KAERI) to provide a high performance gamma ray detection, which needs a single crystallinity, a good uniformity, a high stopping power, and a wide band gap. Materials and Methods: Before applying our own grown CZT detectors in the prototype PET system, we investigated preliminary research with a developed discrete type data acquisition (DAQ) system for coincident events at 128 anode pixels and two common cathodes of two CZT detectors from Redlen. Each detector has a $19.4{\times}19.4{\times}6mm^3$ volume size with a 2.2 mm anode pixel pitch. Discrete amplifiers consist of a preamplifier with a gain of $8mV{\cdot}fC^{-1}$ and noise of 55 equivalent noise charge (ENC), a $CR-RC^4$ shaping amplifier with a $5{\mu}s$ peak time, and an analog-to-digital converter (ADC) driver. The DAQ system has 65 mega-sample per second flash ADC, a self and external trigger, and a USB 3.0 interface. Results and Discussion: Characteristics such as the current-to-voltage curve, energy resolution, and electron mobility life-time products for CZT detectors are investigated. In addition, preliminary results of gamma ray imaging using 511 keV of a $^{22}Na$ gamma ray source were obtained. Conclusion: In this study, the DAQ system with a CZT radiation sensor was successfully developed and a PET image was acquired by two sets of the developed DAQ system.

A Review of SERS for Biomaterials Analysis Using Metal Nanoparticles (바이오 물질 분석을 위한 금속 나노입자를 이용한 SERS 분석 연구동향)

  • Jang, Eue-Soon
    • Ceramist
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    • v.22 no.3
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    • pp.281-300
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    • 2019
  • Surface enhanced Raman scattering (SERS) was first discovered in 1974 by an unexpected Raman signal increase from Pyridine adsorbed on rough Ag electrode surfaces by the M. Fleishmann group. M. Moskovits group suggested that this phenomenon could be caused by surface plasmon resonance (SPR), which is a collective oscillation of free electrons at the surface of metal nanostructures by an external light source. After about 40 years, the SERS study has attracted great attention as a biomolecule analysis technology, and more than 2500 new papers and 500 review papers related to SERS topic have been published each year in recently. The advantages of biomaterials analysis using SERS are as follows; ① Molecular level analysis is possible based on unique fingerprint information of biomolecule, ② There is no photo-bleaching effect of the Raman reporters, allowing long-term monitoring of biomaterials compared to fluorescence microscopy, ③ SERS peak bandwidth is approximately 10 to 100 times narrower than fluorescence emission from organic phosphor or quantum dot, resulting in higher analysis accuracy, ④ Single excitation wavelength allows analysis of various biomaterials, ⑤ By utilizing near-infrared (NIR) SERS-activated nanostructures and NIR excitation lasers, auto-fluorescence noise in the visible wavelength range can be avoided from in vivo experiment and light damage in living cells can be minimized compared to visible lasers, ⑥ The weak Raman signal of the water molecule makes it easy to analyze biomaterials in aqueous solutions. For this reason, SERS is attracting attention as a next-generation non-invasive medical diagnostic device as well as substance analysis. In this review, the principles of SERS and various biomaterial analysis principles using SERS analysis will be introduced through recent research papers.

A Case Study on the Role of LED Lighting at the Residential Space

  • Kim, Hye Young
    • International Journal of Advanced Culture Technology
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    • v.4 no.4
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    • pp.6-12
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    • 2016
  • Due to the development of technology, the modern people became to require not only more convenient life but also more comfortable and emotional environment, and individually suitable living environment is applied to residents in a residential space. Recently, while the LED lighting was variously attempted in every sector in society, it is needed to express differentiated lighting according to the resident's individual lifestyle in a residential space. In this paper, we analyze the role of LED lighting suitable for the digitalized lifestyle of the modern people through the relevant literature survey and case studies. The following results are obtained in summary of the rapidly changed recent trends of LED lighting. First, LED light replace existing light sources due to the advanced new technology in LED industry, and take the spotlight as a new lighting solution with the development of variable color LED bulb and the control technology by the wired and wireless communications. Second, LED lighting can be structurally applicable to every lighting device because of its compact and lightweight units, can produce abundant light environment by expression of variable colors and moods with the easy coloring and dimming control, can be reborn as emotional lighting design. Third, as recently practices are constantly appeared that integrate LED lights in the interior elements, such as object and furniture, and combine advanced LED lighting technology to new materials, the portion of illumination on the indoor environment is further increased after integrating the LED lighting and interior elements make boundaries of lighting and product architecture become blurred. LED lighting is confirmed that is being changed from the external functionality including material, shape, color, and etc. into the contextual emotion design including the lights expression, variable color, brightness control, making image, and etc. as the light source in current smart lighting era.

GPS-X Based Modeling on the Process of Gang-byeon Sewage Treatment Plant and Design of Recycle Water Treatment Process (GPS-X 기반 모델링에 의한 강변사업소 처리효율 분석 및 반류수 처리 공정 설계)

  • Shin, Choon Hwan
    • Journal of Environmental Science International
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    • v.25 no.11
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    • pp.1493-1498
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    • 2016
  • The efficiencies of Gang-Byeon sewage treatment facilities, which are based on GPS-X modelling, were analysed and used to design recycle water treatment processes. The effluent of an aeration tank contained total kjeldahl nitrogen (TKN) of 1.8 mg/L with both C-1 and C-2 conditions, confirming that most ammonia nitrogen ($NH_3{^+}-N$) was converted to nitrate nitrogen ($NO_3{^-}-N$). The concentrations of $NH_3{^+}-N$ and $NO_3{^-}-N$ were found to be 222.5 and 227.2 mg/L, respectively, with C-1 conditions and 212.2 and 80.4 mg/L with C-2 conditions. Although C-2 conditions with higher organic matter yielded a slightly higher nitrogen removal efficiency, sufficient denitrification was not observed to meet the discharge standards. For the total nitrogen (T-N) removal efficiency, the final effluent concentrations of T-N were 293.8 mg/L with biochemical oxygen demand (BOD) of 2,500 mg/L, being about 1.5 times lower than that (445.3 mg/L) with BOD of 2,000 mg/L. Therefore, an external carbon source to increase the C/N ratio was required to get sufficient denitrification. During the winter period with temperature less than $10^{\circ}C$, the denitrification efficiency was dropped rapidly even with a high TKN concentration (1,500 mg/L). This indicates that unit reactors (anoxic/aerobic tanks) for winter need to be installed to increase the hydraulic retention time. Thus, to enhance nitrification and denitrification efficiencies, flexible operations with seasons are recommended for nitrification/anoxic/denitrification tanks.

Novel Defog Algorithm via Evaluation of Local Color Saturation (국부영역 색포화 평가 방법을 통한 안개제거 알고리즘)

  • Park, Hyungjo;Park, Dubok;Ko, Hanseok
    • Journal of the Institute of Electronics and Information Engineers
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    • v.51 no.3
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    • pp.119-128
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    • 2014
  • This paper presents a new method for improving the quality of images corrupted by an external source that generates an attenuation and scattering of light like dust, water droplets and fog. Conventional defog methods typically encounter a distortion such that the restored image has low contrast and oversaturation of color in some regions because of the mis-estimated airlight and wrong media transmission. Therefore, in order to mitigate these problems, we propose a robust airlight selection method and local saturation evaluation method for estimating media transmission. The proposed method addresses the wrong media transmission and over-saturation problems caused by the mis-estimated airlight and thereby improves the restored image quality. The results of relevant experiments of the proposed method against conventional ones confirm the improved accuracy of atmospheric light estimation and the quality of restored images with regard to objective and subjective performance measures.