• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.1
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• pp.1-16
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• 2014

Objectives : The aim of this study is to examine the effect of external application containing herbal extracts (Betula platyphyllae Cortex, Viticis Fructus, Agrimoniae herba) to patients with atopic dermatitis. Methods : Twenty patients (experiment group) were treated with the external application containing herbal extracts (Betula platyphyllae Cortex, Viticis Fructus, Agrimoniae herba) and other twenty patients (control group) were treated with normal external application that doesn't contain herbal extracts for 2weeks. We observed comparisons between experiment and control group after 1week, 2weeks. Degrees of severity of atopic dermatitis were measured by SCORAD index (Scoring of Atopic Dermatitis Index). Statistical significance was achieved if the probability was less than 5% (p<0.05). Results : 1. After 1week of external application treatment, SCORAD Index in experiment group was significantly decreased comparing with control group, which is a marginally significant result between two groups. But after 2weeks the experiment group showed no statistically significant result. 2. After 1week of external application treatment, Intensity Criteria (Erythema, Edema/papulation, Total) in experiment group was significantly decreased comparing with control group, which is a statistically significant result between two groups. But after 2weeks the experiment group showed no statistically significant result. 3. After 1week and 2weeks of external application treatment, comparison of changes in Subjective Symptoms (Pruritus, Insomnia) indicated that the experiment group showed no statistically significant result. 4. After 1week of external application treatment, Total Quality of life through Skindex-29 in experiment group was significantly decreased comparing with control group, which is a marginally significant result between two groups. But after 2weeks the experiment group showed no statistically significant result. Conclusions : As a result of applying the external application containing herbal extracts to patients with atopic dermatitis and watching the progress, we can speculate that the external application containing herbal extracts has especially short-term therapeutical effects in mitigating the symptoms of Atopic Dermatitis. Thus, it is concluded and considered that the external application containing herbal extracts can be used by atopic patients effectively with almost no side-effect.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.30 no.3
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• pp.155-165
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• 2017

Objectives : The purpose of this study is to analyze the trends of domestic experimental research of external treatment in Korean medicine and use it as a basic data to expand the therapeutic field of Korean medicine. Methods : In December 2016, two authors searched for experimental studies of external treatment in Korean medicine researches in 6 Korean databases. Results : Among the 379 researches that were initially searched, two authors reviewed 190 researches, excluding duplicate researches, and finally 11 researches were selected for the study. The target disease was confined to the skin and mucosa, and the most of selected Korean medicine was based on the literature. Conclusions : Considering the range of application of the external treatment described in the literature and the domestic market for external medicine, it is expected that the development of various external medicine using herbal medicine will be expected in the future.

• The Journal of Korean Medical History
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• v.30 no.2
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• pp.73-81
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• 2017

This literature review focuses on external treatments for the throat, as found in the classic Korean text, Hyang-Yak-Jib-Sung-Bang Throat. Sections of the text related to external treatment of throat disorders were reviewed. Examples of frequently used external methods include gargling, application of powder, and brushing of the throat. These methods are still used in modern Korean Medicine treatments for Ear-Nose-Throat (ENT) disorders. This discussion is provided with intention to invigorate the ancient practices of throat treatments, by highlighting benefits and results of the therapeutic protocols described in Hyang-Yak-Jib-Sung-Bang Throat. Discovering new effective herbal medicines and developing more precise external treatments will advance ENT treatment in Korean medicine.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.3
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• pp.40-55
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• 2014

Objectives : The purpose of this study is to confirm the effects of external applications(CLANCHE SM A Clinic) containing herbal extracts on patient with atopic dermatitis. Methods : A total of 24 patients who visited Semyung Oriental Medical Center from January 15th, 2014 to February 20th, 2014 were included in the study. In this study, the patients were treated with external applications(CLANCHE SM A Clinic) containing herbal extracts. For 4 weeks of gross examination and instrumental assesment were made before and after the study. Results : 1. In the primary endpoint, SCORAD index showed a statistically significant decline. 2. In the secondary endpoint, index of skin hydration and index of TEWL showed statistical significance. 3. In the secondary endpoint, index of skin pH showed no statistically significant result. 4. To evaluate the safety of the products for the human body, vital sign check were conducted and showed no statistically significant result. And There were no severe adverse events during this study. Therefore, it is suggested that the safety of the products, if used for certain period, should be safe for the human body. 5. In global assesment of efficacy, both experimenter and subjects evaluated external applications were effective. Conclusions : According to the above experiments, it is suggested that external applications(CLANCHE SM A Clinic) containing herbal extracts should be effective for the atopic dermatitis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.3
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• pp.153-158
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• 2017

As social interest in acne treatment has grown, various external preparations have been developed and studied. So, we investigated the external prescription which can treat acne in medical classics, then reviewed and divided it by dynasty. The data for analysis of Herbal formula was taken from 'medicine Dictionary of traditional Chinese medicine prescriptions(中醫方劑大辭典)'. 31 external medicines were searched, 3 were before song(宋) dynasty, 11 were Song(宋) dynasty, 11 were Yuan(元) dynasty, 7 were Ming(明) dynasty and 7 were Qing(淸) dynasty. The recipe and usage were only making them pill(丸) and paste(膏) using grinded medicinal herbs, then rubbing to face. As the age developed, unique manufacturing process(i.e fermentation method), and usage(i.e time-based usage, herbal medicine extracts for wash) were proposed. The external application with oriental medicine for acne used with Angelicae Gahuricae Radix(n=12), Bletillae Rhizoma(n=8), Syzygii Flos, Saposhnikoviae Radix(n=7) and so on. In particular, Bletillae Rhizoma was searched with high frequency in this study, but it was not included or studied in patent composition. The results of this study will provide basic data for future experiments and clinical studies.

• Journal of Pharmacopuncture
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• v.23 no.1
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• pp.8-17
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• 2020

Aim of the study: The objective of this systematic review is to critically evaluate the evidence of the effectiveness and safety of external application of herbal medicines (EAHM) for acne vurgalis (AV). Methods: English, Chinese and Korean language databases were searched up to May 2018. Randomized clinical trials (RCTs) that reported the effects of EAHM for AV were included and analysed. Results: A total of 10 randomized trials with 656 AV patients were identified. A meta-analysis of two RCTs indicated that EAHM had a significant effect on improving primary outcome 'global assessment' compared with placebo (mean difference (MD) = -2.62, confidence interval (CI) = -4.84 to -0.40, p = 0.02). Furthermore, data extracted from two RCTs showed that EAHM significantly reduce primary outcome 'inflammatory lesion count of acne' (MD = -1.25, CI = -1.68 to -0.83, p < 0.00001) and 'non-inflammatory lesion count of acne' (MD = -1.32, CI = -1.75 to -0.90, p < 0.00001). No significant difference was observed between groups in secondary outcome 'sebum of skin' (MD = -0.21, CI = -0.53 to 0.11, p = 0.20) and 'patient-reported changes in symptom' (relative risk (RR) = 2.56, CI = 0.43 to 15.22, p = 0.30). No severe adverse events (AEs) were found and no treatment was stopped due to AEs of EAHM. Conclusions: EAHM seems to have affirmative effects, but quality of evidence, and non-standardized use of EAHM make our conclusion weak. Our suggestion is rigorously designed RCTs and standardization of EAHM are required in the future.

• The Journal of Internal Korean Medicine
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• v.41 no.6
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• pp.1282-1288
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• 2020

Objective: The case study assessed the possibility of improving symptoms by external treatment in a patient complaining of night sweats who could not take oral herbal medicine. Methods: Chinensis galla, Ostreae concha, and Cinnabaris were mixed in a 2:1:1 ratio and applied to CV8 before the patient went to bed. The treatment was removed upon waking and repeated every night. If itchiness and skin redness occurred, the position was changed to 2-3 cm up or down from the navel or application was changed to once every two days. Results: The external treatment eliminated the symptoms of sweating in the arms, legs, chest, and abdomen and reduced sweating in the occipital and neck areas. The sweating was improved to the extent that it no longer interfered with daily life. Conclusions: This case study shows the possibility of using external treatments rather than herbal medicine to treat night sweats.

• The Journal of Pediatrics of Korean Medicine
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• v.27 no.1
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• pp.36-49
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• 2013

Objectives The goal of this review is to investigate clinical and experimental studies on external application treatment for atopic dermatitis in Korean literature and to propose for the better method of clinical studies in order to seek more effective treatment. Methods Electronic researches were performed with KTKP, OASIS, National Assembly Library, Korean Medicine Database, KISS, DBpia, and KISTI. Results and Conclusions In Twenty six studies, the numbers of clinical and experimental studies are respectively 10 (38.46%) and 16 (61.54%). The numbers of studies that used herbal complex were 20 (76.92%), and out of that, 6 studies had used a single herbal medicine (23.08%). The external application with oriental medicine for the atopic dermatitis used with Phellodendri Cortex (7), Sophorae Radix (6), Scutellariae Radix (6), Lonicerae Flos (5), Coptidis Rhizoma (5) and so on. Among the clinical studies, the 5 studies were double-blind and randomized-controlled study (50%). The numbers of studies that used Hanifin and Rajka Diagnostic Criteria (1980) were 6 (60%), and that used the Diagnostic Criteria in Korean Atopic Dermatitis (2005) were 4 (40%). Among the clinical studies, categories to evaluate of atopic dermatitis are respectively SCORAD Index (80%), Total IgE (80%), Eosinophil count (70%) and so on. All of the clinical studies (100%) showed a statistically significant decline in atopic dermatitis according to the SCORAD Index, Modified SCORAD Index, the Clinic index score. Among the experimental studies, the numbers of studies that used NC/Nga mice were 9 (56.25%), and out of that 5 studies used BALB/c mice (31.25%). Most of the studies (68.75%) used DNCB as allergy inducing materials. The scales for evaluation of atopic dermatitis were Clinical skin severity score, Histopathologic examination, Immunohematologic examination, safety test and so on. In 12 cases (75%) of experimental studies, the IgE level of experimental group showed a statistically significant decline after using external application. In 8 study cases (50%), Clinical skin severity score of experimental group showed a statistically significant decline after using external application.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.13 no.1
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• pp.63-86
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• 2007

External treatments have various curative effects. So it had been used to cure various patients. But, it has a limited sphere of application in the present South Korea. Therefore we would like to bring out its sphere of application and detailed method in the oriental medicine classics. Especially, we would like to bring out external use of medecal herbs at base of External treatments. And then we have arrived at following conclusions. 238 species herbs have been used externalpreparation. comparatively often used a herbal medicines are Argyi Wormwood Leaf(艾), Realgar(雄黃), Croton Seed(巴豆), Musk(麝香), Cochinchina Momordica Seed(木鱉仁), Glycyrrhiza uralensis(甘草) and Chuanxiong Rhizome(川芎).

• Journal of Sasang Constitutional Medicine
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• v.27 no.4
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• pp.429-435
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• 2015

Objectives The purpose of this study was to report the effects of treatments to traumatic subcutaneous hematoma on the shin using herbal medication and external application without venesection, which had no change in spite of previous 3 weeks medical conservative treatment so it had a risk of sepsis.Methods The patient diagnosed as Soyangin was prescribed with Yangkyuksanhwa-tang. The subcutaneous hematoma lesion was treated by external application of Daehwangchija-san(大黃梔子散). We evaluated the size of hematoma, pain and gait disturbance.Results and Conclusions Subcutaneous hematoma and relevant symptoms disappeared within 11 days of admission. Any kind of sequela did not show up and skin color was recovered after 4 month later follow-up.