• Korean Journal of Computational Design and Engineering
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• v.6 no.4
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• pp.215-221
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• 2001

In the zigzag milling of a pocket having islands, tool retraction is one of the primary factors that decrease productivity. Therefore, tool path with minimum number of tool retraction has been needed. Most researches about this topic have been concentrated on obtaining the optimum solution formulated through the geometric reasoning off pocket. Recently, several attempts were made to simplify this problem into region partitioning in order to get the numerically expressed minimum solution. In this research, a method reducing the number of tool retractions extended from existing region partitioning is provided. Applying the segment that is normal to the reference direction of zigzag milling, region partitioning is carried out and structural elements of the region are searched via graphs of islands and characteristic points. Through the processes presented, the number of region partitioned is less than that of existing processes.

• Bulletin of the Korean Chemical Society
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• v.11 no.2
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• pp.95-99
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• 1990

The dioxygen transfer reaction from $N^5$-ethyl-4a-hydroperoxy-3-methyllumiflavin anion (4a-FlEtOO-) has been extended to isomeric aminophenol systems (1a-4a). O-aminophenol (o-AP, 1a & 2a) and p-aminophenol(p-AP, 3a & 4a) were turned out to be good substrates, whereas m-aminophenol(m-AP, 5a) was not. This is due to the charge location which is not on the carbon bearing the amino group. o-AO's react with 4a-FlEtOO- to give isophenoxazine derivatives (6 & 7) and with p-AP's to produce p-benzoquinone derivatives (8 & 9). The partition coefficients $(k_2/k_3)$ of 1a & 2a were $4.84{\times}10^{-4}\;&\;1.66{\times}10^{-5}M$, respectively and those of methylated aminophenolates, 2a & 4a were 4-10 times greater than nonmethylated substrates, 1a & 3a.

• Annals of Hepato-Biliary-Pancreatic Surgery
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• v.27 no.3
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• pp.227-240
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• 2023

Hilar cholangiocarcinomas are highly aggressive malignancies. They are usually at an advanced stage at initial presentation. Surgical resection with negative margins is the standard of management. It provides the only chance of cure. Liver transplantation has increased the number of 'curative' procedures for cases previously considered to be unresectable. Meticulous and thorough preoperative planning is required to prevent fatal post-operative complications. Extended resection procedures, including hepatic trisectionectomy for Bismuth type IV tumors, hepatopancreaticoduodenectomy for tumors with extensive longitudinal spread, and combined vascular resection with reconstruction for tumors involving hepatic vascular structures, are challenging procedures with surgical indications expanded. Liver transplantation after the standardization of a neoadjuvant protocol described by the Mayo Clinic has increased the number of patients who can undergo operation.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.5
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• pp.942-948
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• 2016

WSN based on wireless sensor nodes, Sensor nodes can not be reassigned and recharged if they once placed. Each sensor node comes into being involved to a communication network with its limited energy. But the existing proposed clustering techniques, being applied to WSN environment with irregular dispersion of sensor nodes, have the network reliability issues which bring about a communication interruption with the local node feature of unbalanced distribution in WSN. Therefore, the communications participation of the sensor nodes in the suggested algorithm is extended by 25% as the sensor field divided in the light of the non-uniformed distribution of sensor nodes and a static or a dynamic clustering algorithm adopted according to its partition of sensor node density in WSN. And the entire network life cycle was extended by 14% to ensure the reliability of the network.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.3
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• pp.639-647
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• 2011

In this paper, we introduce a design methodology of data-centroid Radial Basis Function neural networks with extended polynomial function. The two underlying design mechanisms of such networks involve K-means clustering method and Particle Swarm Optimization(PSO). The proposed algorithm is based on K-means clustering method for efficient processing of data and the optimization of model was carried out using PSO. In this paper, as the connection weight of RBF neural networks, we are able to use four types of polynomials such as simplified, linear, quadratic, and modified quadratic. Using K-means clustering, the center values of Gaussian function as activation function are selected. And the PSO-based RBF neural networks results in a structurally optimized structure and comes with a higher level of flexibility than the one encountered in the conventional RBF neural networks. The PSO-based design procedure being applied at each node of RBF neural networks leads to the selection of preferred parameters with specific local characteristics (such as the number of input variables, a specific set of input variables, and the distribution constant value in activation function) available within the RBF neural networks. To evaluate the performance of the proposed data-centroid RBF neural network with extended polynomial function, the model is experimented with using the nonlinear process data(2-Dimensional synthetic data and Mackey-Glass time series process data) and the Machine Learning dataset(NOx emission process data in gas turbine plant, Automobile Miles per Gallon(MPG) data, and Boston housing data). For the characteristic analysis of the given entire dataset with non-linearity as well as the efficient construction and evaluation of the dynamic network model, the partition of the given entire dataset distinguishes between two cases of Division I(training dataset and testing dataset) and Division II(training dataset, validation dataset, and testing dataset). A comparative analysis shows that the proposed RBF neural networks produces model with higher accuracy as well as more superb predictive capability than other intelligent models presented previously.

• Interaction and multiscale mechanics
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• v.3 no.3
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• pp.235-255
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• 2010

This paper investigates the heat equation for domains subjected to an internal source with a sharp spatial gradient. The solution is first approximated using linear finite elements, and sufficiently small time-step sizes to yield stable simulations. The main area of interest is then in the ability to approximate the solution using Generalized Finite Elements, and again explore the time-step limitations required for stable simulations. Both high order elements, as well as elements with special enrichments are used to generate solutions. When compared to linear finite elements, the high order elements deliver better accuracy at a given level of mesh refinement, but do not offer an increase in critical time-step size. When special enrichment functions are used, the solution can be approximated accurately on very coarse meshes, while yielding solutions which are both accurate and computationally efficient. The major conclusion of interest is that the significantly larger element size yields larger allowable time-step sizes while still maintaining stability of the time-stepping algorithm.

• Journal of Electrical Engineering and information Science
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• v.2 no.3
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• pp.105-112
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• 1997

The performance of a shared memory multiprocessor system is very sensitive to process scheduling. w can enhance the performance of a whole system as well as of an individual process by taking the multiprocessor characteristics into account in the design of the process scheduler. In this paper, we proposed a general purpose scheduler for a shared memory multiprocessor, called the Two-Level Multi-Scan (TLMS) process scheduler, that considers the processor affinity loosely and decreases the interference among multiple processors greatly. The TLMS scheduler is composed of a local scheduler at each processor and a semi-global scheduler that balances the load among processors. In particular, the semi-global scheduler tries to minimize priority inversion, which is an important factor of the system performance. The TLMS scheduler also tries to reduce the number of resources to be shared and improves the processor utilization. to meet these requirements, th semi-global scheduler interacts with the operation of the local scheduler when a need arises, thus the name is loose processor-affinity. We also show that the proposed scheduling technique can be extended for other types of resources making it a general purpose resource management queue.

• Proceedings of the Botanical Society of Korea Conference
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• 1998.07a
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• pp.61-70
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• 1998

Genome and chromosome analyses in plants using fluorescence in situ hybridization (FISH) and immuno-staining (IMS) methods are reviewed by presenting the recent results obtained by the Chromosome Link, a group of chromosome and genome researchers. FISH is now effective to detect unique nucleotide sequences with 153 bp on the extended DNA fibers. Genomic in situ hybridization (GISH) also allows painting plant chromosomes of different genomes. GISH is quite effective to detect the genomic differentiation in the individual chromosomes within a nucleus. Three dimensional (3D) analyses are now available by confocal microscopy and a deconvolution system. These techniques are invaluable to visualize both the structural and functional dynamics within a nucleus. 3D-FISH revealed the spatial differentiation of different genomees within a nucleus. 3D-FISH also proved structural partition of centromeric and telomeric domains within a barely nucleus. The dynamic acetylation of histone H4 at the specific regions of a genome during a cell cycle is also analyzed using 3D-IMS. It is anticipated that these methods will provide us powerful tools to understand the structural and functional significance of plant chromosomes and genomes.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.5
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• pp.2031-2037
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• 2011

The French doors have the advantage that they can use inner space more efficiently due to without of partition between two rooms. However, when they are used for refrigerators, the door gaskets for sealing may cause interference of themselves during opening and closing, which causes fatal effect on sealing by worn out of the gaskets as well as increases door opening force. This research proposes a new mechanism for the French doors using the parallelogram motion of 4-bar linkage mechanism, which does not make any interference between gaskets. We manufactured the French doors of proposed mechanism to verify that they do not cause any interference during opening and closing, as well as opening force is decreased. The use of our developed mechanism is not limited to refrigerators, but can be extended to other industrial products with the French doors.

• Archives of Pharmacal Research
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• v.26 no.4
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• pp.258-263
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• 2003

Colon-specific delivery of glucocorticoids is highly desirable for the efficient treatment of inflammatory bowel disease. We synthesized prednisolone 21-sulfate sodium (PDS) as a colon-specific prodrug of prednisolone (PD) and investigated its properties using rats as test animals. We expected that introduction of sulfate ester as a sodium salt might increase the hydrophilicity and restrict the absorption in the GI tract. If PDS is stable and nonabsorbable in the upper intestine, it will be delivered to the colon as an intact form, where it hydrolyze by the sulfatase to release PD. Compared with PD, the solubility of PDS increased and the apparent partition coefficient decreased greatly. PDS was stable on incubation with pH 1.2 and 6.8 buffer solutions and with the contents of the stomach and small intestine. On incubation with the cecal contents, PDS decreased to 9.6％ of the dose in 10 h producing PD. The amount of PD increased to give a maximum 54％ of the dose and decreased. As a control, when PD was incubated with the cecal contents, it decreased to 29％ of the dose in 8 h, which implied that reduction of PD proceeded under such conditions. These results suggested that hydrolysis of PDS took place to produce and accumulate PD, which decreased by reduction as the incubation period extended. Our results suggested that PDS can be a promising colon-specific prodrug of PD, and sulfate ester group might serve as a potential colon-specific promoiety, especially for the drugs which are resistant to reduction in the colon.