• BMB Reports
• /
• v.42 no.4
• /
• pp.212-216
• /
• 2009

The short in vivo half-life of GLP-1 prevents it from being used clinically. This short half-life occurs because GLP-1 is rapidly degraded by dipeptidyl peptidases such as DPP-IV. To overcome this obstacle, a GLP-1/Fc was constructed and evaluated to determine if it was degraded by DPP-IV and in serum. When the degradation of GLP-1/Fc by human DPP-IV and rabbit serum was compared with that of GLP-1 it was found to be reduced by approximately 5- and 4-fold, respectively. Furthermore, GLP-1/Fc showed a potent activity for human GLP-1 receptor activation ($EC_{50}$ approximately 6 nM). Taken together, these results indicate that GLP-1/Fc may have an extended half-life in vivo that occurs as a result of inhibition of degradation by human DPP-IV. Due to the extended half life, GLP-1/Fc may be useful for clinical treatments.

• Journal of the Korean Data and Information Science Society
• /
• v.28 no.3
• /
• pp.547-557
• /
• 2017

The health-related quality of life data are commonly skewed and bounded with spike at the perfect health status, and the variance tended to be heteroscedastic. In this study, we have developed a prediction model for EQ-5D using linear regression model, beta regression model, and extended beta regression model with mean and precision submodel, and also compared the predictive accuracy. The extended beta regression model allows to model skewness and differences in dispersion related to covariates. Although the extended beta regression model has higher prediction accuracy than the linear regression model, the overlapped confidence intervals suggested that the extended beta regression model was superior to the linear regression model. However, the expended beta regression model could explain the heteroscedasticity and predict within the bounded range. Therefore, the expended beta regression model are appropriate for fitting the health-related quality of life data such as EQ-5D.

• Proceedings of the KSME Conference
• /
• 2003.04a
• /
• pp.255-260
• /
• 2003

Most of the fatigue test were achieved in fully reversed condition that mean stress is zero. But, generally, mean stress can not be zero. This research was achieved the bending fatigue test that changes mean stress to spring steel and was studied relation with the mean stress and the fatigue life. The method to search effect about mean stress was extended S-N graph in two cases. One method was extended S-N graph using modified Miner's rule with considering damage. Another was extended using tendency of S-N graph. The exponential value(${\alpha}$) of mean stress-alternating stress equation is converged between the Goodman's and the Gerber's value even if fatigue life increases.

• BMB Reports
• /
• v.42 no.2
• /
• pp.65-71
• /
• 2009

Autophagy, which is a process of self eating, has gained interest in the past decade due to its both beneficial and controversial roles in various biological phenomena. The discovery of autophagy genes (ATG) in yeast has led to focused research designed to elucidate the mechanism and regulation of this process. The role of autophagy in a variety of biological phenomena, including human disease, is still the subject of debate. However, recent findings suggest that autophagy is a highly regulated process with both beneficial and negative effects. Indeed, studies conducted using various model organisms have demonstrated that increased autophagy leads to an extended lifespan. Despite these findings, it is still unknown if all pathways leading to extended lifespan converge at the process of autophagy or not. Here, an overview of modern developments related to the process of autophagy, its regulation and the molecular machinery involved is presented. In addition, this review focuses on one of the beneficial aspects of autophagy, its role in lifespan regulation.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
• /
• 2004.04a
• /
• pp.317-322
• /
• 2004

This paper deals with a prediction method of tool life in view of the reliability assessment. In this study, the flank wear was studied among multi-factors deciding the tool wear state. Firstly, tool lift was predicted by correlation between flank wear and cutting time, based on the extended Taylor tool life equation of turning data, including parameters of cutting speed, feed rate, and cutting depth. Secondly, each of cutting conditions of endmilling was equivalently converted to apply ball endmill data to the extended Taylor equation. The web-based reliability prediction program for tool lift is being developed as one of reliability assessment programs to for the machine tools.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
• /
• 2003.11a
• /
• pp.152-157
• /
• 2003

This study represents the newly advanced formulation of hydraulic fluids for extended drain interval and introduces the performance results of used oil samples from various excavators. The used oil samples, in this paper show that there is a sharp change in viscosity drop and moderate additive depletion when viscosity index of hydraulic oil is very high. For the extension of hydraulic fluid life, it is necessary to improve the stability of viscosity and oxidation. New target properties from the used oil analysis were proposed for extended life. Performance of newly developed hydraulic oil based on used oil analysis is compared with previously used one. The properties of new formulation are the viscosity index of 140 and improved thermal stability consists of VHVI base oil. Field test results showed the possibility of extension of fluid life. Additionally, for development of high performance product, new required properties and performances were discussed.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.22 no.1
• /
• pp.32-39
• /
• 2018

Repairing timing and the extended service life with repairing are very important for cost estimation during operation. Conventionally used model for repair cost shows a step-shaped cost elevation without consideration of variability of extended service life due to repairing. In the work, RC(Reinforced Concrete) Column is considered for probabilistic evaluation of repairing number and cost. Two mix proportions are prepared and chloride behavior is evaluated with quantitative exterior conditions. The repairing frequency and cost are investigated with varying service life and the extended service life with repairing which were derived from the chloride behavior analysis. The effect of COV(Coefficient of Variation) on repairing frequency is small but the 1st repairing timing is shown to be major parameter. The probabilistic model for repairing cost is capable of reducing the number of repairing with changing the intended service life unlike deterministic model of repairing cost since it can provide continuous repair cost with time.

• Journal of Applied Reliability
• /
• v.14 no.2
• /
• pp.122-128
• /
• 2014

In this paper, we consider the periodic preventive maintenance model for a repairable system following the expiration of extended warranty under replacement-repair warranty. Under the replacement-repair warranty, the failed system is replaced or minimally repaired by the manufacturer at no cost to the user. Also, under extended warranty, the failed system is minimally repaired by the manufacturer at no cost to the user during the original extended warranty period. As a criterion of the optimality, we utilize the expected cost rate per unit time during the life cycle from the user's perspective. And then we determine the optimal preventive maintenance period and the optimal preventive maintenance number by minimizing the expected cost rate per unit time. Finally, the optimal periodic preventive maintenance policy is given for Weibull distribution case.

• Journal of Welding and Joining
• /
• v.16 no.4
• /
• pp.92-97
• /
• 1998

Because of the low melting temperature of solder, each temperature cycle initiates an irrecoverable creep deformation at the solder interconnection which connects the package body with the PCB. The crack starts and propagates from the position where the creep deformation is maximized. This work has tried to compare and analyze the thermal fatigue life of solder interconnection which is affected by the lead material, the size of die pad, chip thickness, and interface delamination of 48-Pin TSOP under the temperature cycle ($0^{\circ}C$~1$25^{\circ}C$). The crack initiation position and thermal fatigue life which are calculated by using FEA method are well matched with the results of experiments. The thermal Fatigue life of copper lead frame is extended around 3.6 times longer than that of alloy 42 lead frame. It is maximized when the chip size is matched with the length of the lead. It tends to be extended as the thickness of chip got thinner. As the interfacial delamination between die pad and EMC is increased, the thermal fatigue life tends to decrease in the beginning of delamination, and increase after the delamination grew after 45% of the length of die pad.

• Structural Engineering and Mechanics
• /
• v.57 no.1
• /
• pp.65-89
• /
• 2016

This paper presents the development of methodologies using Extended Finite Element Method (XFEM) for cracked unstiffened and concentric stiffened panels subjected to constant amplitude tensile fatigue loading. XFEM formulations such as level set representation of crack, element stiffness matrix formulation and numerical integration are presented and implemented in MATLAB software. Stiffeners of the stiffened panels are modelled using truss elements such that nodes of the panel and nodes of the stiffener coincide. Stress Intensity Factor (SIF) is computed from the solutions of XFEM using domain form of interaction integral. Paris's crack growth law is used to compute the number of fatigue cycles up to failure. Numerical investigations are carried out to model the crack growth, estimate the remaining life and generate damage tolerant curves. From the studies, it is observed that (i) there is a considerable increase in fatigue life of stiffened panels compared to unstiffened panels and (ii) as the external applied stress is decreasing number of fatigue life cycles taken by the component is increasing.