• 제어로봇시스템학회논문지
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• 제7권4호
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• pp.326-333
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• 2001

This paper focuses on a method to connect mobile devices such as mobile robot. Automated Guided Vehicle (AGV) and Unmanned Container Transporter(UCT) to a fieldbus. In this paper, the IEEE 802.11 wireless LAN is used to extend a Profibus network for the mobile devices. In order to integrate these two networks, a gateway is developed using two threads and an internal buffer. Furthermore, a polling algorithm is applied at the gateway in order to satisfy real-time requirements on data communication, Finally, the performance measures such as data latency and throughput are experimentally evaluated on a wirelessly-extended Profibus network. The results shows the feasibility of the wireless extension of Profilbus for various mobile device.

• KIEAE Journal
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• 제7권5호
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• pp.87-92
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• 2007

As expansion of balconies at apartments has been legalized, the major function of the balconies as a thermal buffer zone is disappearing. This weakens the ability of window to insulate heat and multiplies surface condensation. Thus more and more residents require solutions to increasing surface condensation and aggravation in thermal comfort. This study intends to provide basic data by evaluating performance of triple layered Low-E windows, triple layered clear windows, double layered Low-E windows and double layered clear window used for expanded balconies and marketed within the country in terms of surface condensation and thermal environment through simulation. Results revealed that no surface condensation occurred at double layered Low-E windows and triple layered Low-E windows. Surface condensation took place at double layered clear windows and triple layered clear windows at a relative humidity of 60%. Thermal environment analysis suggested that double layered clear windows showed the most time falling into the range of comfort at $23^{\circ}C$. The figure were $22^{\circ}C$ for triple layered clear windows, $22^{\circ}C$ for double layered Low-E windows and $21^{\circ}C$ for triple layered Low-E windows.

• 한국조경학회지
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• 제40권4호
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• pp.1-17
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• 2012

본 연구는 서울시 아파트단지의 시기별 녹지배치구조와 식재구조의 변화과정을 분석하여 보다 친환경적인 아파트단지 내 녹지조성 개선방안을 제시하고자 하였다. 연구대상지는 서울시에 조성된 아파트단지 중 조성시기, 용적률, 지하주차장에 의한 지반현황, 녹지율의 차이가 뚜렷한 아파트단지 12개소를 선정하였다. 연구대상지 유형화는 시기별로 녹지율과 지반현황을 기준으로 녹지율이 높은(40% 이상) 자연지반 아파트, 녹지율이 낮은(40% 미만) 자연지반 아파트, 녹지율이 낮은(40% 미만) 인공지반 아파트, 녹지율이 높은(40% 이상) 인공지반 아파트 네 가지로 구분하였다. 아파트단지 녹지배치 구조의 가장 근원적 변화요인은 녹지율과 인공지반 여부로 용적률이 상승하면서 주차장 면적비율도 높아져 상대적으로 녹지율은 낮아졌다. 녹지배치구조가 가장 많이 변한 녹지유형은 전면녹지와 완충녹지로 전면녹지는 녹지율이 높은 자연지반 아파트의 평균 녹지 폭 10.0m에서 3.5m, 2.7m, 4.5m로 시기별로 축소 변화하였다. 완충녹지는 녹지율이 높은 자연지반 아파트에서 평균 녹지 폭 15.0m로 단지외곽 경계부를 연결하였으나, 녹지율이 낮은 인공지반 아파트에서 주차장 확대로 평균 녹지 폭이 7.7m, 2.7m로 점차 축소되고 일부 구간은 단절되었으나, 2001년 이후 녹지에 대한 인식변화로 다시 평균 녹지 폭이 3.8m로 넓어지면서 연결되었다. 녹량 변화를 살펴보면, 녹지율이 높은 자연지반 아파트 녹지용적계수가 $1.27m^3/m^2$이었고, 식재밀도가 높아지면서 녹지율이 낮은 자연지반 아파트의 녹지용적계수가 $3.47m^3/m^2$로 가장 높았다. 반면에 녹지율이 높은 인공지반 아파트의 녹지용적계수는 $0.72m^3/m^2$로 매우 낮은 상태이었다. 식재밀도는 교목 아교목층의 경우 5.0주/$100m^2$에서 14.5주/$100m^2$로 증가하였다. 아파트단지 녹지를 보다 친환경적이고 기능적으로 조성하기 위한 방안으로 녹지율 40% 이상의 아파트단지 내 전면녹지는 녹지 폭 4.5m 이상으로 확대하여 정원개념의 경관 식재지로 조성하고, 후면녹지는 녹지 폭 5.0m이상으로 확대하고 복층구조로 식재하여 녹지량을 증진하는 것을 제시하였다. 측면녹지는 수고가 높은 수종을 식재하여 벽면 차폐와 녹음기능을 증진하고, 완충녹지는 자생수종을 자연림에 가까운 다층구조로 조성하는 생태적 배식기법을 적용하면서 단지내부녹지와 연결해야 할 것으로 판단되었다.

• Journal of Pharmaceutical Investigation
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• 제33권4호
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• pp.311-317
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• 2003

Felodipine is a calcium antagonist that lowers blood pressure by reducing peripheral resistance by meas of a direct, selective action on smooth muscle in arterial resistance vessels. Futhermore, it have been approved for the effective in angina pectoris and cardiac failure. The purpose of the present study was to evaluate the bioequivalence of two felodipine extended release (ER) tablets, Splendil (YuHan Corporation) and Stapin (Hana Pharmaceutial Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The felodipine release from the two felodipine formulations in vitro was tested using KP VIII Apparatus II method at pH 6.5 buffer solution. Twenty six healthy male subjects, $22.73{\pm}1.78$ years in age and $66.66{\pm}7.28\;kg$ in body weight, were divided into two groups and a radomized $2{\times}2$ cross-over study was employed. After two tablets containing 5 mg as felodipine were orally administered, blood sample was taken at predetermined time intervals and the concentrations of felodipine in serum were determined using column-switching HPLC method with UV detector. The dissolution profiles of two formulations were similar at pH 6.5 buffer solution. Besides, the pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t\;and\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the Splendil were 2.53%, 1.32% and 18.32% for $AUC_t,\;C_{max}\;and\;T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance rage of log(0.86) to log(1.25) $(e.g.,\;log(0.86){\sim}log(1.20)\;and\;log(0.89){\sim}log(1.23)\;for\;AUC_t,\;C_{max},\;respectively)$. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Stapin ER tablet and Splendil ER tablet are bioequivalent.

• Restorative Dentistry and Endodontics
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• 제24권2호
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• pp.372-380
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• 1999

The purpose of this study was to investigate the distribution of calcitonin gene-related peptide(CGRP) containing nerve fivers after pulp exposure in rats. The Spague-Dawley rats weighing about 250 - 300g were used. The animals were devided into normal control group and experimental groups. Experimental animals were sacrified on 2, 4, 7, 10 days after pulp exposure. The maxillary teeth and alveolar bone were removed and immersed in the 4% paraformaldehyde plus 0.1M phosphate buffer (pH 7.4). Serial frozen $50{\mu}m$ thick sections were cut with a cryostat. In the immunohistochemical staining procedure, the rabbit CGRP antibody was used as a primary antibody. The sections were incubated for 48 hours at $4^{\circ}C$, and placed into biotinylated anti-rabbit IgG as a secondary antibody and incubated in ABC (avidin-biotin complex), The sections were visualized by 0.05% 3.3 diaminobenzidine tetrahydrochloride. The results of this study were as follows: 1. In control group, CGRP containing nerve fibers ran parallel to the long axis of root and reached the coronal pulp. They were distributed on Raschkow plexus under the odontoblastic layer. 2. In 2 day group after pulp exposure, tissue necrosis and acute inflammation occurred and CGRP containing nerve fibers increased. In 4 day group, the necrotic tissue extended to the pulp and CGRP containing nerve fibers were distributed around the inflammation zone. 3. In 7 day group after pulp exposure, pulp necrosis occurred, and in 10 day group, the abscess under the necrotic pulp extended to the root apex area and CGRP containing nerve fibers were not observed in root canals. 4.The sprouting of CGRP nerve fibers was most remarkable at the pulp chamber under injury in 4 day group, and it was found at inflammation zone under the necrotic tissue in 7 day group and the remaining root pulp tissue in 10 day group. As mentioned above, CGRP nerve fibers had a tendency to increase around the inflammatory zone, especially around the acute inflammation tissue, when compared with control group. It is suggested that CGRP nerve fibers maybe related to the control of inflammatory response of pulp tissue.

• 한국통신학회논문지
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• 제41권8호
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• pp.942-949
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• 2016

사물 인터넷 환경 중에서 통신기기들이 필드 안에 무작위의 패턴으로 배치되는 무선 센서네트워크는 효율적인 라우팅 프로토콜을 통한 에너지소모의 최적화가 중요하다. 노드간에 주고받는 데이터의 크기가 다양한 사물 인터넷 환경에서는 클러스터 헤드노드의 버퍼의 크기가 데이터손실율과 네트워크의 수명에 큰 영향을 준다. 유한한 버퍼 상황에서 데이터의 손싱율을 최소화 하기 위하여서는 각 클러스터에 균일한 숫자의 멤버가 할당되는 부하 균등화가 중요하다. 본 논문은 네트워크 구성 직후 싱크 노드와 센서 노드가 몇 차례의 메시지를 교환하고 이를 바탕으로 싱크 노드가 삼변 측량으로 센서 노드의 근사적 위치를 파악하고 클러스터를 구성함으로써, 클러스터 헤드의 수와 멤버수를 결정적(deterministic)으로 구현하였다. 컴퓨터 시뮬레이션을 통하여 데이터의 손실율과 네트워크의 평균 수명에 있어서 성능향상을 확인하였다.

• 한국정보과학회논문지:정보통신
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• 제31권6호
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• pp.620-632
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• 2004

IP는 네트워크 주소를 기반으로 한 라우팅으로 인해 접속 네트워크가 동적으로 변경되는 이동 노드에는 그대로 사용할 수 없다. 이동노드에게 지속적인 인터넷 접속서비스를 제공하기 위해서 IETF는 모바일 IP를 정의하였다. 하지만 모바일 W는 삼각 라우팅 문제와 계층3 핸드오프에 의한 패킷손실로 인해 전송성능이 저하되는 문제를 안고 있다. 특히, 실시간 멀티미디어 서비스를 모바일 IP에서 제공하기 위한 IETF의 두 가지 멀티캐스트 지원방안은 긴 전송경로와 패킷 중복(양방향 터널링 방안), 핸드오프 시 대량의 패킷손실(원격지 가입 방안)로 인해 실시간 멀티미디어 서비스의 품질을 보장하기가 어렵다. 본 논문은 모바일 IP에서의 실시간 멀티미디어 서비스 품질 보장을 위해 IETF의 원격지 가입 방안을 개선한 무손실 원격지 방안을 제안한다. 시뮬레이션 결과 본 논문에서 제안된 무손실 원격지 가입 방안은 IETF의 저 지연 핸드오프(low latency handoff)를 멀티캐스트 그룹관리에 적용함으로써 그룹 재가입에 따른지연을 줄였으며, 무손실을 위해 서비스망 전체에서 요구되는 저장공간의 평균 크기가 기존에 제안되었던 무손실 방안의 약 0.58% 만을 사용해도 되는 수준으로 줄었다.

• Journal of Pharmaceutical Investigation
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• 제37권3호
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• pp.193-196
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• 2007

This study aimed to evaluate and develop $Eudragit^{(R)}$-coated pellets based on the dissolution using the paddle method. As coating materials, two types of $Eudragit^{(R)}$ were applied to obtain either sustained release form or fast released form. The dissolution test was carried out in phosphate buffer solution (pH 6.5) at $37^{\circ}C$, 100 rpm. In order to develop a sustained release preparation containing felodipine, a comparative dissolution study was done using commercial product as a control. The dissolution at 30 min of felodipine from $Eudragit^{(R)}$ RS or RL-coated pellets were 0.96% and 99.65, respectively. The weight ratio of $Eudragit^{(R)}$ RL pellets to RS pellets altered the dissolution rate, but did not optimize the dissolution rate. However, the sustained dissolution of felodipine from pellets was optimized by varying the coating ratios of $Eudragit^{(R)}$ RS. It is suggested that the coating ratio of pellets is the main factor which controls dissolution rate. Taken together, $Eudragit^{(R)}$ RS 30D-coated pellets showed the most comparable dissolution rate pattern to commercial product, $Splendil^{(R)}$. This sustained release pellets for oral delivery system of felodipine was simply manufactured, and drug release behavior was highly reproducible.

• Archives of Pharmacal Research
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• 제26권4호
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• pp.258-263
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• 2003

Colon-specific delivery of glucocorticoids is highly desirable for the efficient treatment of inflammatory bowel disease. We synthesized prednisolone 21-sulfate sodium (PDS) as a colon-specific prodrug of prednisolone (PD) and investigated its properties using rats as test animals. We expected that introduction of sulfate ester as a sodium salt might increase the hydrophilicity and restrict the absorption in the GI tract. If PDS is stable and nonabsorbable in the upper intestine, it will be delivered to the colon as an intact form, where it hydrolyze by the sulfatase to release PD. Compared with PD, the solubility of PDS increased and the apparent partition coefficient decreased greatly. PDS was stable on incubation with pH 1.2 and 6.8 buffer solutions and with the contents of the stomach and small intestine. On incubation with the cecal contents, PDS decreased to 9.6％ of the dose in 10 h producing PD. The amount of PD increased to give a maximum 54％ of the dose and decreased. As a control, when PD was incubated with the cecal contents, it decreased to 29％ of the dose in 8 h, which implied that reduction of PD proceeded under such conditions. These results suggested that hydrolysis of PDS took place to produce and accumulate PD, which decreased by reduction as the incubation period extended. Our results suggested that PDS can be a promising colon-specific prodrug of PD, and sulfate ester group might serve as a potential colon-specific promoiety, especially for the drugs which are resistant to reduction in the colon.

• 한국수정란이식학회지
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• 제16권2호
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• pp.133-138
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• 2001

개의 인공수정에 사용할 정자의 보존방법을 확립하기 위하여, 동결속도와 응해 온도를 설정하여 적절한 동결방법을 정립하고자 본 실험을 실시하여 다음과 같은 결과를 얻었다. 동결의 방법에 있어서는 액체질소의 표면으로부터 17 cm 높이에서 동결하는 -3$^{\circ}C$/min의 동결속도로 실시하여 37$^{\circ}C$에서 2분간 응해하는 방법이 가장 좋은 결과를 보였다. 생존성과 운동성에 있어서의 차이는 없지만 첨체의 intact한 비율은 약간 낮은 결과를 보였으며, 이의 보완을 위해, 액체질소 표면으로부터 10cm와 17cm의 높이를 세분화하여 동결속도를 설정한 후보다 나은 정액동결방범을 찾는다면 동결정액을 이용한 인공수정의 수태율은 더욱 향상될 수 있을 것으로 사료된다.