• Toxicological Research
• /
• 제29권1호
• /
• pp.1-6
• /
• 2013

The process of drug discovery and development requires substantial resources and time. The drug industry has tried to reduce costs by conducting appropriate animal studies together with molecular biological and genetic analyses. Basic science research has been limited to in vitro studies of cellular processes and ex vivo tissue examination using suitable animal models of disease. However, in the past two decades new technologies have been developed that permit the imaging of live animals using radiotracer emission, X-rays, magnetic resonance signals, fluorescence, and bioluminescence. The main objective of this review is to provide an overview of small animal molecular imaging, with a focus on nuclear imaging (single photon emission computed tomography and positron emission tomography). These technologies permit visualization of toxicodynamics as well as toxicity to specific organs by directly monitoring drug accumulation and assessing physiological and/or molecular alterations. Nuclear imaging technology has great potential for improving the efficiency of the drug development process.

• 한국정보통신학회논문지
• /
• 제11권5호
• /
• pp.1037-1045
• /
• 2007

도시에서 교통 및 주차 관리의 효율성은 삶의 질과도 직접적으로 관련이 있는 중요한 문제이다. 거주자우선주차장은 도시의 주차공간 확보에 큰 비중을 차지하면서도 개별 주차 구역이 작고 별도의 출입구가 없어 효율적인 운영을 위한 적절한 인증시스템이 부재하였다. 본 논문에서는 무선 센서 네트워크를 이용하여 추가적인 관리인 없이 적은 비용으로 거주자우선주차장을 효율적으로 관리할 수 있는 인증시스템을 설계하고 구현하였다. 구현된 시스템의 실험을 통하여 저전력 소모를 위한 슬립 주기별 센서 노드의 수명을 측정하였고, 간단히 측정된 조도값의 변화만으로 주차 여부를 판단하기 위하여 시간대별로 주차 유무에 따른 조도값의 변화를 실험하여 그 오차범위가 최소 45 이상이면 주차 여부를 확인할 수 있음을 보였다.

• 한국안전학회지
• /
• 제8권4호
• /
• pp.139-148
• /
• 1993

Thermosyphons are simple devices that can passively transport thermal energy over relatively long distance with little temperature degradation. These attributes permit the use of low grade thermal energy for thermal control of structures including the snow melting and deicing to the pavement surface. The thermosyphon system requires no costly energy input and Is completely maintenance free. This paper presents the experimental results of the snow melting system in which thermosyphon was utilized to transfer the geothermal energy to the pavement to obviate slipping traffic accidents due to freezing of pavement in winter.

• 한국화재소방학회논문지
• /
• 제10권2호
• /
• pp.13-19
• /
• 1996

An estimation methodology, based on statistics and numerical method, has been developed for estimating the upper explosive limits(UEL) of paraffinic and olefinic hydrocarbon compounds. With proposed method, the UEL has been calculated for 24 paraffinic and 10 olefinic hydrocarbon compounds. The estimated the UEL agree with the experimental values within a few percent. A comparisond with four other methods avaiable in the literature are also presented. It is hoped eventually that this method will permit estimation of the UEL with improved accuracy and broader application for other compounds.

• Journal of Advanced Marine Engineering and Technology
• /
• 제13권1호
• /
• pp.57-68
• /
• 1989

This paper treats the analytical and experimental studies on the improvement of commutating circuit for the speed control of DC motor. A simple circuit composed of R, L and C elements is proposed here for switching off power SCR carrying the load current. The real important in this chopper circuit is to determine the reasonable values of commutating circuit constants. In this paper, the reasonable values of the commutating circuit constants are basically determined on a view point of commutating performances in the given circuit model and must satisfy the following conditions. The first, the peak commutating current should be larger than the anticipated maximum load current. The second, the circuit turn-off time (tc) must be longer than the SCR turn-off time (tq). The third, the resistor should be enough large to permit the current to be neglected in the analysis of the commutation circuit, as well as be enough small to permit to charge the capacity voltage (Ec) to the half the value of source voltage (E) before the next communication cycle is initiated. The last, the period of chopping signal must be the least possible multiple of the damping vibration period of commutating circuit. The improved chopper circuit used in the experiment under unloaded condition was composed to meet the reasonable conditions mentioned above, and a successful commuting performance was achieved without failure. Several types of microprocessor having a different value of CPU speed individually have been applied to the experiment under the loaded conditions. Also it shows that the faster the speed of CPU is, the more stable the commutation turns out.

• Computers and Concrete
• /
• 제12권2호
• /
• pp.109-129
• /
• 2013

This work presents an approach to model concrete shrinkage. The goal is to permit the concrete industry's experts to develop independent prediction models based on a reduced number of experimental data. The proposed approach combines fuzzy logic and genetic algorithm to optimize the fuzzy decision-making, thereby reducing data collection time. Such an approach was implemented for an experimental data set related to self-compacting concrete. The obtained prediction model was compared against published experimental data (not used in model development) and well-known shrinkage prediction models. The predicted results were verified by statistical analysis, which confirmed the reliability of the developed model. Although the range of application of the developed model is limited, the genetic-fuzzy approach introduced in this work proved suitable for adjusting the prediction model once additional training data are provided. This can be highly inviting for the concrete industry's experts, since they would be able to fine-tune their models depending on the boundary conditions of their production processes.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2000년도 춘계학술대회논문집
• /
• pp.888-893
• /
• 2000

This experimental study is the improvement of running stability for freight car. KNR (Korean National Railroad)'s conventional wagons, light bodies running on Barber style bogies with 5-1/$2{\times}10$ journals, would be considered fundamentally to be a most difficult car to control above 100km/h. From the results of experiment, to permit high speed operation safely, was realized with the resilient side bearing. Also, equipped with resilient side bearing, and elastowedge friction elements to eliminate bolster wedge pocket wear, KNR's wagons can be secure the running stability with lower maintenance requirements than current experience.

• 산업경영시스템학회지
• /
• 제30권3호
• /
• pp.54-61
• /
• 2007

Machining processes produce high accurate metallic parts in metal working industries. Lubrication for machining enhances quality of machined surface and it prolongs the life of cutting tools. Since lubricant is poisonous to human body and environment, it causes occupational diseases for workers and air pollution in environment. Because of these problems generated, developed countries do not permit the excessive usage of lubricant in machining shops. This research focuses on the development of MQL machining technique that consumes minimal amount of lubricant, which reduces possible outbreak of occupational diseases and air pollution. This research sets experimental equipments for MQL machining. Experiments for this study are designed with major machining parameters in MQL. Through the analysis of experiments, this paper presents the optimal machining parameters.

• 생물정신의학
• /
• 제6권2호
• /
• pp.161-169
• /
• 1999

There are a number of approaches in developing experimental models for depression, but there is no such thing as a best model for depressive syndrome. Animal models are subject to the obvious limitations inherent in the assumption that human psychopathology can be represented accurately in lower animals. Recently, the concern increasingly is to develop a variety of experimental paradigms in animals to study selected aspects of human psychopathology, and animal models should be understood as basically experimental preparations that are developed to carry out these objects. Therefore, a battery of a variety of animal models should be applied to permit detailed pathophysiological studies and to develop new antidepressant treatments. Animal models of depression basically consider behavioral isomorphism with the human depression a plus, but not a req-uirement, and the model behavior should be defined operationally in order to be reproduced reliably by other researchers and be responsive to those agents possessing demonstrated clinical efficacy in human depression. In conclusion, animal models of depression have played a significant role in elucidating pathophysiology of depression and developing current treatments for depression, but there is no single comprehensive model for depression until now. Each of the proposed animal model has its advantages and limitations. In other words, certain paradigms are suitable for studying certain phenomena, whereas others are more suitable for studying other aspects. The best model for depression depends upon what the question is.

• 한국콘크리트학회:학술대회논문집
• /
• 한국콘크리트학회 2008년도 춘계 학술발표회 제20권1호
• /
• pp.833-836
• /
• 2008

본 연구는 기존 벤토나이트 방수재가 염수환경의 지하구조물 적용에 있어서 초기 수화에 의한 팽창이 안 됨으로써 염수의 침입을 허용하여 구조물이 누수로 이어지는 문제점을 보완하기 위하여 최근 개발된 사전수화 시킨 형태의 벤토나이트 쉬트에 관하여 염수환경 적용 특성을 중심으로 연구하고자 하였다. 이를 위해 본 연구에서는 사전수화형 벤토나이트 시트를 대상으로 염수환경을 기본 전제조건으로 한 상태에서 점결성, 팽윤성, 투수성 등의 시험을 통하여 그 성능특성의 변화를 중점 고찰하였다. 본 연구결과 염수환경에서 초기 투수를 허용하지 않았으며, 최대 $3kgf/cm^2$ 수압으로 72시간까지 투수가 발생하지 않았다. 점결성과 팽윤성 확인결과 담수환경에서는 겔화의 충분한 진행이 확인 되었고, 염수환경에서는 판상구조의 갈라짐 현상이 보였으나 이는 벤토나이트가 수화하면서 결정층간이 팽윤된 것으로 판단된다. 따라서 방수재 상부에 누름층과 같은 압밀조건이 형성된다면 염수환경의 지하구 조물 적용에 있어서 기대가된다.