• Title/Summary/Keyword: Experimental Design Technique

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Effects of Manual Therapy on Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  • Eunsang Lee;Hyunjoong Kim
    • Physical Therapy Rehabilitation Science
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    • v.12 no.1
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    • pp.12-18
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    • 2023
  • Objective: Chemotherapy is usually given to inhibit cancer progression. It is the most common side effect of chemotherapyinduced peripheral neuropathy (CIPN) after chemotherapy, and its symptoms include pain such as paresthesia, dysesthesia, allodynia, hyperalgesia, and electrical stimulation. Therefore, in this review, randomized controlled trials (RCTs) were combined to analyze the effect qualitatively and quantitatively in order to find out the effect of manual therapy on patients with CIPN through a meta-analysis. Design: A systematic review and meta-analysis Methods: This review conducted a literature search through international databases (CINAHL, Embase, MEDLINE, Web of Science) in December 2022 to synthesize the effect of manual therapy on the symptomatic improvement of CIPN. Qualitative evaluation (risk of bias) and quantitative evaluation using ReVMan provided by the Cochrane Group were expressed as a random effect model and standardized mean difference (SMD). Results: In four RCTs 165 patients with CIPN were evaluated for symptoms of neuropathy. The experimental group consisting of manual therapy and its subcategories showed significant improvement compared to the control group. The results analyzed through the random effects model were SMD=-1.11; 95% confidence interval, -1.97 to -0.24. Conclusions: We came to the conclusion that manual therapy could significantly contribute to improving the symptoms of CIPN, and since it may vary depending on the technique of manual therapy, further studies on manual therapy suitable for neuropathy are needed.

Stochastic buckling quantification of porous functionally graded cylindrical shells

  • Trinh, Minh-Chien;Kim, Seung-Eock
    • Steel and Composite Structures
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    • v.44 no.5
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    • pp.651-676
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    • 2022
  • Most of the experimental, theoretical, and numerical studies on the stability of functionally graded composites are deterministic, while there are full of complex interactions of variables with an inherently probabilistic nature, this paper presents a non-intrusive framework to investigate the stochastic nonlinear buckling behaviors of porous functionally graded cylindrical shells exposed to inevitable source-uncertainties. Euler-Lagrange equations are theoretically derived based on the three variable refined shear deformation theory. Closed-form solutions for the shell buckling loads are achieved by solving the deterministic eigenvalue problems. The analytical results are verified with numerical results obtained from finite element analyses that are conducted in the commercial software ABAQUS. The non-intrusive framework is completed by integrating the Monte Carlo simulation with the verified closed-form solutions. The convergence studies are performed to determine the effective pseudorandom draws of the simulation. The accuracy and efficiency of the framework are verified with statistical results that are obtained from the first and second-order perturbation techniques. Eleven cases of individual and compound uncertainties are investigated. Sensitivity analyses are conducted to figure out the five cases that have profound perturbative effects on the shell buckling loads. Complete probability distributions of the first three critical buckling loads are completely presented for each profound uncertainty case. The effects of the shell thickness, volume fraction index, and stochasticity degree on the shell buckling load under compound uncertainties are studied. There is a high probability that the shell has non-unique buckling modes in stochastic environments, which should be known for reliable analysis and design of engineering structures.

CFD Analytical Analysis of Jetting Characteristics in Aerosol Jet Printing Process Using Particle Tracking Technique (입자 추적 기법을 활용한 에어로졸 제트 프린팅 공정의 분사 특성에 대한 CFD 해석적 분석)

  • Sang-Min Chung;Seungwoon Park;Euikeun Choi;Soobin Oh;Chul-Hee Lee
    • Journal of Drive and Control
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    • v.21 no.1
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    • pp.8-15
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    • 2024
  • This thesis investigates the jetting characteristics of an aerosol jet printing (AJP) process as a function of design and operating conditions. The governing equations of the AJP system are derived for experimentation and analysis. To understand the characteristics of the AJP system, it analyzes the jetting characteristics as a function of the flow rate of the carrier gas and the sheath gas, and the variation of the linewidth with the nozzle exit size based on particle tracking. The thesis focuses on computational fluid dynamics (CFD), which is a computer simulation. The particle tracking results obtained by CFD were analyzed using MATLAB. CFD analytical models can be analyzed in environments with different conditions and consider more specific situations than mathematical computational models. The validity of the CFD analysis is shown by comparing the experimental results with the CFD analysis.

CFD Analytical Analysis of Jetting Characteristics in Aerosol Jet Printing Process Using Particle Tracking Technique (입자 추적 기법을 활용한 에어로졸 제트 프린팅 공정의 분사 특성에 대한 CFD 해석적 분석)

  • Sang-Min Chung;Seungwoon Park;Euikeun Choi;Soobin Oh;Chul-Hee Lee
    • Journal of Drive and Control
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    • v.21 no.2
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    • pp.8-14
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    • 2024
  • This paper investigates the jetting characteristics of an aerosol jet printing (AJP) process as a function of design and operating conditions. The governing equations of the AJP system are derived for experimentation and analysis. To understand the characteristics of the AJP system, this thesis analyzes the jetting characteristics as a function of the flow rate of the carrier gas and the sheath gas, and the variation of the linewidth with the nozzle exit size based on particle tracking. This thesis focuses on computational fluid dynamics (CFD), which is a computer simulation. The particle tracking results obtained by CFD were analyzed using MATLAB. CFD analytical models can be analyzed in environments with different conditions and consider more specific situations than mathematical computational models. The validity of the CFD analysis is shown by comparing the experimental results with the CFD analysis.

A Prototype Design for a Real-time VR Game with Hand Tracking Using Affordance Elements

  • Yu-Won Jeong
    • Journal of the Korea Society of Computer and Information
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    • v.29 no.5
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    • pp.47-53
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    • 2024
  • In this paper, we propose applying interactive technology in virtual environments to enhance interaction and immersion by inducing more natural movements in the gesture recognition process through the concept of affordance. A technique is proposed to recognize gestures most similar to actual hand movements by applying a line segment recognition algorithm, incorporating sampling and normalization processes in the gesture recognition process. This line segment recognition was applied to the drawing of magic circles in the <VR Spell> game implemented in this paper. The experimental method verified the recognition rates for four line segment recognition actions. This paper aims to propose a VR game that pursues greater immersion and fun for the user through real-time hand tracking technology using affordance Elements, applied to immersive content in virtual environments such as VR games.

The Study of Bone Formation around Titanium Implants Placed in Adrenalectomized Rat's Tibia (부신 제거 백서에 티타늄 임플랜트 매식후 주위 골형성에 관한 연구)

  • Choi, Kab-Lim;Kim, Jong-Ryoul;Park, Bong-Soo;Sung, Iel-Yong
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.22 no.3
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    • pp.274-287
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    • 2000
  • The use of dental implants has increased tremendously in recent years and is expected to increase even more in the future. The successful outcome of any implant procedure is surely dependent on interrelationship of the various components of an equation that includes biocompatibility of implant material, macroscopic and microscopic nature of the implant surface, the status of implant bed, surgical technique, undisturbed healing phase and subsequent prosthetic design and long-term loading phase. The purpose of this study was to clarify the effects of adrenalectomy on the osseointegration of pure titanium implants. Seventy rats, 11 weeks of age, were divided into two groups : an adrenalectomized group and a control group. Titanium screw implant(diameter, 2.0mm; length, 3.5mm) was placed into left tibia of 70 rats, 35 in control group and 35 in the experimental group. The rats were sacrificed at different time interval (1, 2, 3, 4, 6, 8, and 12 weeks after implantation) for histopathologic observation, histomorphometric analysis and immunohistochemistry with fibronectin and CD44 antibody. The results obtained from this study were as follows: 1. Histopathogically, findings, newly formed bone was seen at 3 weeks control group and became lamellar bone at 12 weeks. At 6 weeks, lipocytes were observed in bone marrow space. Thickness of regenerated trabecular bone increased till 6 weeks after then, that decreased gradually. 2. By histomorphometric analysis, marrow bone density and contact ratio of marrow bone to implant decreased significantly from 8 to 12 weeks in experimental group compared to control group and also total bone to implant contact ratio decreased significantly from 4 to 12 weeks in experimental group compared to control group. 3. Fibronectin immunoreactivity was very strong at 3 and 4 weeks control group. And after that reduced gradually. But it was continuously strong from 1 to 12 weeks experimental group. 4. CD44 immunoreactivity was very strong in the newly formed osteoblasts at 3 and 4 weeks control group. But it reacted minimally later. However, it reacted continuously strong from 3 to 12 weeks experimental group. From these results, bone to implant contact ratio decreased gradually from 4 weeks in adrenalectomized group compared to control group. CD44 and fibronectin immunoreactivities were strong at all times in adrenalectomized rats. Therefore, it could be stated that immature bone remained continuously for a long time and not readily proceeded into mature status.

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Collision Analysis of STF Impregnated Kevlar Fabric Using the 3D-Shell Element (쉘요소를 활용한 STF 함침된 Kevlar Fabric의 방탄해석)

  • Lee, Duk-Gyu;Park, Jong-Kyu;Jung, Wui-Kyung;Lee, Man-Young;Kim, See-Jo;Moon, Sang-Ho;Son, Kwon-Joong;Cho, Hee-Keun
    • Composites Research
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    • v.29 no.1
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    • pp.24-32
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    • 2016
  • Ballistic impact analyses have been performed with the Kevlar fabric impregnated with STF(shear thickening fluid). Multi-layer laminates modeled with 3D isoparametric shell elements were used for the performance analysis and their results are compared with experimental results. Both experiments and numerical analyses have been done to verify the usefulness of STF to enhance the impact resistance performance. The results showed that STF increases friction within a bundle of fiber, and this phenomena is more apparent in the velocity range of under near 450 m/s. In this research, it is emphasized that FEA analyses of STF impregnated Kevlar fabric laminate were successfully conducted using shell elements. Moreover, the effectiveness of the technique and accuracy were verified through the comparison with reliable experimental data.

Experimental Study on Behavior of Green Water for Rectangular Structure (사각형 해양구조물의 청수현상 발생과정에 대한 실험적 연구)

  • Chae, Young Jun;Lee, Kang Nam;Jung, Kwang Hyo;Suh, Sung Bu;Lee, Jae Yong
    • Journal of Ocean Engineering and Technology
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    • v.30 no.1
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    • pp.44-50
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    • 2016
  • An experimental study was performed to investigate the behavior of green water on a structure with a rectangular cross section under wave conditions, along with the flow characteristics in bubbly water flow. An experiment was conducted in a two-dimensional wave flume using an acrylic model (1/125) of FPSO BW Pioneer operating in the Gulf of Mexico under its design wave condition. The occurrence of green water, including its development, in front of the model was captured using a high-speed Charge Coupled Device (CCD) camera with the shadowgraph technique. Using consecutive images, the generation procedure for green water on the model was divided into five phases: flip through, air entrapment, wave run-up, wave overturning, and water shipping. In addition, the distinct water elevations of the green water were defined as the height of flip through, height of splashing jet, and height of freeboard exceedance, and showed a linear relationship with the incoming wave height.

Experimental Verification of Characteristics of Magnetic Abrasive Polishing Combined with Ultrasonic Vibration (실험계획법에 의한 초음파가 부가된 자기연마가공의 특성평가)

  • Jin, Dong-Hyun;Kwak, Jae-Seob
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.39 no.9
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    • pp.923-928
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    • 2015
  • In this paper, we propose an ultrasonic magnetic abrasive polishing (US-MAP) technique to effectively machine a high-strength material, and we prove the efficiency of hybrid finishing. We use Taguchi's experimental method to determine the influence of each parameter. Based on the results, US-MAP exhibited a higher polishing efficiency than traditional MAP, and a suitable frequency for hybrid finishing was 28 kHz. When investigating the effect of the parameters on the surface roughness, the ultrasonic amplitude had the greatest effect. However, when machining with $55-{\mu}m$ amplitude, the machining efficiency decreased as the magnetic flux density varied.

Experimental Study on the Deck Wetting of a Container Ship in Irregular Head Waves (콘테이너선의 불규칙파중 갑판침수에 관한 실험적 고찰)

  • Sa-Young,Hong;Pan-Mook,Lee;Do-Sig,Gong
    • Bulletin of the Society of Naval Architects of Korea
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    • v.27 no.2
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    • pp.31-39
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    • 1990
  • Deck wetness phonomena has long been considered as one of the factors that degrade the performance of a ship in waves. In rough weather, the frequent shipping of water may give rise to the capsizing of the ship. Therefore an appropriate above water bow design is an improtant assert to a ship of which successful performance in rough weather is a prerequisite such as a warship. In this paper the experimental technique for estimation of deck wetness frequency is presented. The results of the model tests are compared with those of calculation using Ochi's formula. Finally the applicability of Ochi's formula is discussed.

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