• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.19 no.3
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• pp.186-192
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• 2016

Purpose: To evaluate the correlation between colon transit time (CTT) test value and initial maintenance dose of polyethylene glycol (PEG) 4000 or lactulose. Methods: Of 415 children with chronic functional constipation, 190 were enrolled based on exclusion criteria using the CTT test, defecation diary, and clinical chart. The CTT test was performed with prior disimpaction. The laxative dose for maintenance was determined on the basis of the defecation diary and clinical chart. The Shapiro-Wilk test and Pearson's and Spearman's correlations were used for statistical analysis. Results: The overall group median value and interquartile range of the CTT test was 43.8 (31.8) hours. The average PEG 4000 dose for maintenance in the overall group was $0.68{\pm}0.18g/kg/d$; according to age, the dose was $0.73{\pm}0.16g/kg/d$ (<8 years), $0.53{\pm}0.12g/kg/d$ (8 to <12 years), and $0.36{\pm}0.05g/kg/d$ (12 to 15 years). The dose of lactulose was $1.99{\pm}0.43mL/kg/d$ (<8 years) or $1.26{\pm}0.25mL/kg/d$ (8 to <12 years). There was no significant correlation between CTT test value and initial dose of laxative, irrespective of the subgroup (encopresis, abnormal CTT test subtype) for either laxative. Even in the largest group (overall, n=109, younger than 8 years and on PEG 4000), the correlation was weak (Pearson's correlation coefficient [R]=0.268, p=0.005). Within the abnormal transit group, subgroup (n=73, younger than 8 years and on PEG 4000) correlation was weak (R=0.267, p=0.022). Conclusion: CTT test value cannot predict the initial maintenance dose of PEG 4000 or lactulose with linear correlation.

• Physical Therapy Rehabilitation Science
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• v.7 no.1
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• pp.35-40
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• 2018

Objective: The purpose of this study was to investigate the immediate effect of applying self-myofascial release (SMR) to the plantar fascia using a foam roller on hamstring and lumbar spine superficial back line (SBL). Design: Randomized controlled trial. Methods: Thirty-one healthy adults agreed to the method and purpose of the study. Selection and exclusion criteria were screened, and baseline measurements for the Toe Touch test and passive straight leg raise (PSLR) test were obtained. The participants were then randomly assigned to the SMR group or the sham group. After group assignment, the SMR group rolled the surface of the foot from the heel to the metatarsal head using a foam roller for 5 minutes. The sham group received passive mobilization of the ankle joint in the supine position. Afterwards, the Toe Touch test and the passive straight leg-raise test were re-assessed. Results: In the SMR group, the Toe Touch test results showed significant improvement (p<0.05). Left and right PSLR test results showed a significant increase (p<0.05). In the sham group, there was no significant difference between pre and post-test results. The SMR group showed a significant difference in the PSLR test and Toe Touch test compared to the sham group (p<0.05). Conclusions: The results of this study showed that SMR on the plantar fascia was immediately effective for improving the flexibility of the SBL of the lumbar spine and hamstring.

• Journal of the Korea Society of Computer and Information
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• v.27 no.5
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• pp.101-107
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• 2022

Modeling and simulation is a technique used for operational verification, performance analysis, operational optimization, and prediction of target systems. Discrete Event System Specification (DEVS) of this representative technology defines models with a strict formalism and stratifies the structures between the models. When the atomic DEVS models operate with an intention different the target system, the simulation may lead to erroneous decision-making. However, most DEVS systems have the exclusion of the model test or provision of the manual test, so developers spend a lot of time verifying the atomic models. In this paper, we propose a script-based automated test system for accurate and fast validation of atomic models in Python-based DEVS. The proposed system uses both the existing method of manual testing and the new method of the script-based testing. As Experimental results in our system, the script-based test method was executed within 24 millisecond when the script was executed 10 times consecutively. Thus, the proposed system guarantees a fast verification time of the atomic models in our script-based test and improves the reusability of the test script.

• Journal of Korean society of Dental Hygiene
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• v.20 no.5
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• pp.763-771
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• 2020

Objectives: Erigeron bonariensis is a type of Erigeron found throughout the tropical and subtropical areas as one of the perennial plants or pioneer plants. It is known to show detoxifying, antipyretic, and anticancer effects for various cancers. However, there are no reports on the anticancer effect of E. bonariensis on oral cancer cells. In the present study, we investigated the effects of the methanol extract of Erigeron bonariensis (MEEB) on the inhibition of cell growth and induction of apoptosis in mucoepidermoid carcinoma (MEC) cell lines, including the MC3 and YD15 oral cancer cells. Methods: MC3 Cells were treated by dimethyl sulfoxide (DMSO) or methanol extracts of 20 various natural products 20 ㎍/mL for 48 hours and cell viability were analyzed as Trypan blue exclusion assay. The effects of MEEB treatment on the cell viability of MC3 and YD15 cells, for 48 h, were analyzed by Trypan blue exclusion assay. The anticancer efficacy and apoptosis of oral cancer cell lines were analyzed by western blot analysis. The statistical significance of differences between groups was analyzed by Student's two-tailed t-test. A value of P<0.05 compared to the vehicle control was considered statistically significant. Results: Among 20 different naturally derived products, MEEB significantly inhibited cell viability and increased cleaved poly [ADP-ribose] polymerase 1 (PARP) protein in the MC3 and YD15 cells in a concentration-dependent manner. Conclusions: These results suggest that MEEB can be used as a natural anticancer drug for the treatment of human oral cancer.

• Korean Journal of Microbiology
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• v.33 no.2
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• pp.105-110
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• 1997

Ustilago maydis strains (A-series and SH-series) containg virus or viral dsRNAs were artificially mated in corn seedling to generate 6 progeny strains, designated A23, A45, A21l, A31O, SH24 and SH61O. The dsRNA patterns of progeny strains were identical to those of the parental strains and there was no molecular exclusion mechanism among dsRNAs of parental strains. Virus particles were purified from 6 progeny strains and viral dsRNAs were analyzed on 5% PAGE. There was no mixed encapsidation between virus or dsRNAs of parental strains. Progeny strain SH6l4 produced toxin which inhibits the growth of SH9, SHIO and SH11. Likewise, toxins from A310 and SH24 inhibited growth of the SH11 strains. These results indicate that the presence of different types of dsRNA does not interfere the expression of toxin gene.

• Progress in Medical Physics
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• v.20 no.4
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• pp.208-215
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• 2009

This study is to compare the accuracy of evaluation regarding the volume of the prostate, which three-dimensional volume rendering was produced the shape of protrusion, by measuring two kinds of craniocaudal length from the top of the protrusion and from the exclusion of the protrusion as the starting points. For the imaginary protrusion prostate models, total of 10 models were roughly made by using devils-tongue jelly and changing each of the 10 ml of capacity from 10 ml to 100 ml. For the protrusion prostate models aimed at estimating the real volume, through 64 cannel computed tomography (CT) and 3.0 tesla magnetic resonance image (MRI) were conducted by planimetry technique from three-dimensional volume rendering. And then we performed to evaluate on significance of these volumes by wilcoxon signed rank test. Also the obtained volumes data by ellipsoid volume formula were measured the volume of protrusion prostate models two times with each method using the two kinds of craniocaudal length from top of the protrusion and from exclusion of the protrusion as the starting points. Finally, the significance of differences using wilcoxon signed rank test was evaluated between the real volume by planimetry technique and the measured volume by ellipsoid volume formula from three-dimensional volume rendering. The average of the protrusion length on the models was $0.90{\pm}0.18\;mm$ in CT and was $0.75{\pm}0.11\;mm$ in MRI. There were not statistically significant difference between MRI and CT from the volume of protrusion prostate models (p=0.414). In MRI (p=0.139) and CT (p=0.057), there were not statistically significant difference between the real volume by planimetry technique and the measured volume by ellipsoid volume from exclusion of the protrusion as the starting points. While, there were statistically significant difference between the real volume by planimetry technique and the measured volume by ellipsoid volume from top of the protrusion as the starting points in MRI (p=0.005) and CT (p=0.005). For the accurate measurement of the protrusion prostate models, the craniocaudal length of the prostate should be measured from the exclusion of the protrusion as the starting points.

• Clinics in Shoulder and Elbow
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• v.26 no.2
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• pp.182-190
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• 2023

Elbow traumas represent a relatively common condition in clinical practice. However, there is a lack of evidence regarding the most accurate tests for screening these potentially serious conditions and excluding elbow fractures. The purpose of this investigation was to analyze the literature concerning the diagnostic accuracy of clinical tests for the detection or exclusion of suspected elbow fractures. A systematic review was performed using the Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies (PRISMA-DTA) guidelines. Literature databases including PubMed, Cumulative Index to Nursing and Allied Health Literature, Diagnostic Test Accuracy, Cochrane Library, the Web of Science, and ScienceDirect were searched for diagnostic accuracy studies of subjects with suspected traumatic elbow fracture investigating clinical tests compared to imaging reference tests. The risk of bias in each study was assessed independently by two reviewers using the Quality Assessment of Diagnostic Accuracy Studies 2 checklist. Twelve studies (4,485 patients) were included. Three different types of index tests were extracted. In adults, these tests were very sensitive, with values up to 98.6% (95% confidence interval [CI], 95.0%-99.8%). The specificity was very variable, ranging from 24.0% (95% CI, 19.0%-30.0%) to 69.4% (95% CI, 57.3%-79.5%). The applicability of these tests was very high, while overall studies showed a medium risk of bias. Elbow full range of motion test, elbow extension test, and elbow extension and point tenderness test appear to be useful in the presence of a negative test to exclude fracture in a majority of cases. The specificity of all tests, however, does not allow us to draw useful conclusions because there was a great variability of results obtained.

• 한국생물공학회:학술대회논문집
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• 2005.04a
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• pp.158-162
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• 2005

Enterobacteria, named ${\lambda}-bacteria$ isolated from fusiform fish, have strong anti-angiogenesis effect. ${\lambda}-28$ species bore higher anti-angiogenesis effect. Cultured liquid was performed salting out, dialysed and freezed dried. This sample was executed size exclusion chromatography with fraction collector. Anti-angiogenesis, cytotoxicity, and SDS-PAGE were carried out with fraction number. ${\lambda}-28$ species was lower toxicity against HUVECs and effective band was conformed with SDS-PAGE.

• Korean Journal of Pharmacognosy
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• v.27 no.2
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• pp.155-158
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• 1996

The methanol extract of Albizzia julibrissin Durazz. (Leguminosae) was successively partitioned into dichloromethane, ethylacetate, butanol (BuOH) and water fractions, and the effects of the each solvent extract on catecholamine biosynthesis in PC12 cells were investigated. Among them, the BuOH fraction $(5{\mu}g/ml\;medium)$ showed 68.8% and 63.6% inhibition on dopamine and norepinephrine content in PC12 cells, respectively. Tyrosine hydroxylase (TH) activity was also reduced markedly by treatment of the BuOH fraction (41.8% inhibition at $5{\mu}g/ml$ in the medium). Each solvent fraction did not show cytotoxicity towards PC12 cells by trypan blue exclusion test. This result suggests that the BuOH fraction has an inhibitory effect on catecholamine biosynthesis by reducing TH activity in PC12 cells.

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.773-775
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• 2003

From the view point of data fusion, we integrate LIDAR data and digital aerial images to perform 3D building modeling in this study. The proposed scheme comprises two major parts: (1) building block extraction and (2) building model reconstruction. In the first step, height differences are analyzed to detect the above ground areas. Color analysis is then performed for the exclusion of tree areas. Potential building blocks are selected first followed by the refinement of building areas. In the second step, through edge detection and extracting the height information from LIDAR data, accurate 3D edges in object space is calculated. The accurate 3D edges are combined with the already developed SMS method for building modeling. LIDAR data acquired by Leica ALS 40 in Hsin-Chu Science-based Industrial Park of north Taiwan will be used in the test.