• 한국산학기술학회논문지
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• 제18권3호
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• pp.694-702
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• 2017

선하역사의 경우 차량-궤도에서 발생하는 하중 및 진동이 직접적으로 전달되는 구조적 한계로 인하여 발생하는 구조체 전달 형태의 진동과 소음레벨이 다른 역사형식 대비 월등히 높음으로 인하여 역사 내 상업 및 업무시설 이용객과 종사자들의 불편과 민원이 증가하고 있다. 선하역사에 발생하는 소음 진동을 저감하기 위한 대책중 하나로 알려진 플로팅 궤도의 경우 궤도 하부에 고무 마운트나 패드 요소를 적용한 장치가 주로 설치되어 댐퍼 역할을 한다. 이러한 장치의 경우, 열차 운행 시 발생하는 비선형 하중에 대하여 정확한 강성 및 감쇠비를 설계하기 어렵다는 단점이 있다. 본 연구에서는 플로팅 궤도에 적용 가능하며 정확한 강성 설계가 가능한 마찰 쐐기형 방진장치를 소개한다. 또한, 방진장치 강성 설계값과 시험값을 비교 분석하고 마찰 쐐기형 블록 배치에 따른 감쇠비를 열차 하중조건에 따라 도출하였다. 방진장치의 성능시험은 DIN45673-7 규정에 의거하여 진행하였으며 시험항목인 정적 및 동적하중 시험을 모두 포함한다. 성능시험 하중조건은 DIN 규정에 따라 열차 및 궤도 중량을 고려하여 적용하였으며 수직 하중 및 수평 하중에 대한 시험을 진행하여 방진장치 적용에 따른 궤도의 구조안전성을 확보한다. 더불어, 하중재하속도에 따른 마찰재의 마찰계수 변화 양상을 확인함으로서 다양한 하중재하속도 조건에 대한 마찰쐐기형 방진장치의 진동저감 성능을 확인한다.

• 한국강구조학회 논문집
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• 제27권1호
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• pp.31-42
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• 2015

소성응력분포법과 변형률적합법은 콘크리트충전 각형강관(RCFT, rectangular concrete filled tube) 기둥의 P-M조합강도 산정을 위한 대표적인 두 방법으로, 일반적으로 소성응력분포법은 근사적인 강도치를 제공하는 반면 변형률적합법은 단면에 사용되는 각 물성치의 구성방정식이 정확하다는 전제 하에서 정해에 가까운 해를 제공한다. 최근 변형률적합법에 따른 RCFT기둥의 P-M조합강도 산정에 관한 필자의 연구에 따르면, 현재 연구된 외부 강관으로 구속된 콘크리트 구성방정식이 부정확하기 때문에, 변형률적합법을 통해 산정된 다양한 물성치를 가지는 콘크리트와 강재의 조합으로 이루어진 단면의 P-M조합 강도가 부정확하게 산정되는 것으로 나타났다. 이에 따라 본 연구에서는 기존에 수행된 실험결과를 분석하여 콘크리트충전 각형 강관기둥의 P-M 조합강도 예측을 위한 변형률적합법에 활용될 수 있는 충전콘크리트의 구성방정식을 제시하고 그 타당성을 입증하였다. 본 연구에서 추구하는 모형은 실무적용을 위한 우회적이고 현상학적 모형으로, 외부 강재와 내부 콘크리트 간 상대강도비와 강재의 판폭두께비의 P-M조합강도에 대한 영향을 압괴변형률의 크기에 반영하여 단면내의 힘의 재분배 정도를 조절함으로써 실험결과와 합치하는 결과를 얻어내는 모형이다. 이를 위해 현 규준에서 제시하고 있는 압괴변형률 0.003의 일괄적 제한의 한계를 지적하였으며, 상대강도비와 판폭두께비의 P-M조합강도에 대한 영향을 압괴변형률의 크기에 반영하여 단면내의 힘의 재분배 정도를 조절함으로써 실험결과와 합치하는 결과를 얻어내는 모형을 제시하였다.

• 한국태양에너지학회:학술대회논문집
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• 한국태양에너지학회 2008년도 추계학술발표대회 논문집
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• pp.202-207
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• 2008

Measures for coping with energy shortage are being sought all over the world. Following such a phenomenon, effort to use less energy in the design of buildings and equipment are being conducted. In particular, a program to evaluate the performance of a building comes into the spotlight. However. indispensable standard wether data to estimate the exact energy consumption of a building is currently unprepared. Thus, after appling standard weather data for four weather factors which were used in previous researches to Visual DOE 4.0, we compared it with the result of the existing data and evaluated them. For the monthly cooling and heating load of our target building, we used revised data for June, July, August, and September during which cooling load is applied. When not the existing data but the revised data was used, the research shows that an average of 14.9% increased in June, August, and September except for July. Also, in a case of heating load, the result by the revised data shows a reduction of an average of 11.9% from October to April during which heating load is applied. In particular, the heating loads of all months for which the revised data was used were more low than those of the existing data. In the maximum cooling and heating load according to load factors, the loads by residents and illumination for which the revised data was used were the same as those of the existing data, but the maximum cooling loads used by the two data have a difference in structures such as walls and roofs. Through the above results, the research cannot clearly grasp which weather data influences the cooling and heating load of a building. However, in the maximum loads by the change of weather data in four factors (dry-bulb temperature, web-bulb temperature, cloud amount, and wind speed) among 14 weather factors, the research shows that 5.95% in cooling load and 27.56% in heating load increased, and these results cannot be ignored. In order to make weather data for Performing energy performance evaluation for future buildings, the flow of weather data for the Present and past should be obviously grasped.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.4049-4057
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• 2016

Background: High-risk human papillomaviruses (HR-HPV), particularly types 16 and 18, have been found to play an important role in head and neck cancer, including oropharyngeal squamous cell carcinoma (OPSCC) and oral squamous cell carcinoma (OSCC). p16, a cell cycle inhibitor, has been postulated as a surrogate marker for HR-HPV, since p16 is aberrantly overexpressed in such lesions, especially in HR-HPV-positive OPSCC. However, p16 as a surrogate marker for HR-HPV infection in cancers of the oral cavity remains controversial. Objective: The objectives of the study were to investigate the expression of p16 and the presence of HR-HPV in OSCC and oral verrucous carcinoma (VC) and to determine if p16 could be used as a surrogate marker for HR-HPV. Materials and Methods: Forty one formalin-fixed, paraffin-embedded tissues of OSCC (n=37) or VC (n=4) with clinical and histopathologic data of each case were collected. Expression of p16 was determined by immunohistochemistry, focusing on both staining intensity and numbers of positive cells. The presence of HPV types 16 and 18 was detected by polymerase chain reaction (PCR). Descriptive statistics were employed to describe the demographic, clinical, and histopathologic parameters. Associations between p16 overexpression, HR-HPV and all variables were determined by Fisher's exact test, odds ratios (ORs) and corresponding 95% confidence intervals (CIs). In addition, the use of p16 as a surrogate marker for HR-HPV was analyzed by sensitivity and specificity tests. Results: p16 was overexpressed in 8/37 cases (21.6%) of OSCC and 2/4 cases (50%) of VC. HPV-16 was detected in 4/34 OSCC cases (11.8%) and HPV-18 was detected in 1/34 OSCC cases (2.9%). Co-infection of HPV-16/18 was detected in 1/4 VC cases (25%). Both p16 overexpression and HR-HPV were significantly associated with young patients with both OSCC and VC (p<0.05, OR 20, 95% CI 1.9-211.8; p<0.05, OR 23.3, 95% CI 2.4-229.7, respectively). p16 was able to predict the presence of HPV-16/18 in OSCC with 40% sensitivity and 79.3% specificity and in VC with 100% sensitivity and 66.7% specificity, respectively. Conclusions: p16 overexpression was found in 24.4% of both OSCC and VC. HR-HPV, regardless of type, was detected in 15.8% in cases of OSCC and VC combined. The results of sensitivity and specificity tests suggest that p16 can be used as a surrogate marker for HR-HPV in OSCC and VC.

• 전산구조공학
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• 제8권4호
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• pp.87-97
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• 1995

2차원 유한요소 모델의 동일한 형상과 하중 조건에 있어서 6절점 요소의 굽힘 강성은 8절점 요소의 굽힘 강성보다 더 크게 나타난다. 이와 같은 현상은 3차원 16절점 요소와 20절점 요소에서도 나타나며, 완전 요소의 중간 절점들을 제거하므로 인하여 나타난다. 따라서 이 현상을 상대적 강성강화 현상이라 할 수 있다. 강성강화 현상을 보정하기 위한 매우 효과적인 방법으로 가우스 적분점 수정법을 도출하였으며, 이 방법은 확장적인 강성과 같이 다른 종류의 강성을 변화시키지 않으며, 또한 패취시험을 통과하였다. 적분점 수정량은 재료의 포아송비의 함수로 나타나며, 2차원 평면응력 상태와 평면변형율 상태에 대한 두개의 수정식을 구하였고, 또한 3차원 고체요소에 대하여 확장하였다. 가우스 적분점 수정법의 효과를 검증하기 위하여 보와 판의 자유 및 강제운동 문제를 해석하였으며, 등방성 적층 보와 판에 대해서도 단층보와 단층판과 같은 방법으로 적용하여 그 효율성을 입증하였다.

• 한국응급구조학회지
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• 제15권2호
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• pp.101-108
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• 2011

Purpose: Cardiopulmonary resuscitation (CPR) prevents tissue necrosis of the brain and cardiac muscle in the cardiac arrest patient and requires exact skills in order to increase survival rate. Through comparison of the training effects of feedback manikin and non-feedback manikin, this study present the effective CPR device to CPR instructors. Method: This CPR course for 80 students by using Resusci Anne $SkillReporter^{TM}$ (RASR; Laerdal Medical, Stavanger, Norway) and Actar 911 $Squadron^{TM}$ (A911; Vital Signs, New Jersey, USA) held on December 22, 2009. Thirty seven students and two assistants were placed in one laboratory, there were five RASR manikins which provide the LED performance indicator, not the metronome. Forty two students and two assistants were placed in the other laboratory, there were 20 A911 manikins which don't provide any feedback indicator. Chest compression scores and ventilation compression scores obtaining from two groups were analysed statistically by using independent t-test. Results: Chest compression scores, average depth (mm) was 37.5 in RASR and 41.80 A911 (p=.004), too depth (#) was 2.8 in RASR and 19.4 A911 (p=.005), average number per min (#/min) was 64.4 in RASR and 68.2 A911 (p=.038), wrong hand position (#/min) was 10.9 in RASR and 30.8 A911 (p=.040). Four items that showed better scores in group RASR had statistically significant difference. Ventilation compression scores, percent correct (%) was 40.6 in RASR and 20.6 A911 (p<.001), number correct (#) was 4.7 in RASR and 2.1 A911 (p=.002), too fast (#) was 0.9 in RASR and 2.9 A911 (p=.003), average volume (ml) was 536.5 in RASR and 707.1 A911 (p=.011). Also, three items that showed better scores in group RASR had statistically significant difference. Conclusions: Regarding the positive effect of CPR training feedback, comparison between the real-time visual feedback manikin (RASR) and the non-feedback manikin (A911) showed that RASR had better results than A911 in chest compression except average number per min (it means that we need harder chest manikin) and ventilation. Verification of the training effect in the real world such as CPR outcomes is also necessary. A proper application of manikin in training circumstances and research on retention of CPR skills will be needed.

• Tuberculosis and Respiratory Diseases
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• 제67권1호
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• pp.8-13
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• 2009

Background: The insulin receptor substrate-1 (IRS-1) is the primary docking molecule for the insulin-like growth factor I receptor (IGF-IR), and is required for activation of the phosphatidylinositol 3'-kinase (PI3K) pathway. IRS-1 activation of the (PI3K) pathway regulates IGF-mediated survival, enhancement of cellular motility and apoptosis. Therefore, we attempted to ascertain whether IRS-1 genetic variations affect an individual's risk for non-small cell lung cancer (NSCLC). Methods: Two-hundred and eighteen subjects, either diagnosed with NSCLC or control subjects, were matched by age, gender and smoking status. Genomic DNA from each subject was amplified by PCR and analyzed according to the restriction fragment length polymorphism (RFLP) profile to detect the IRS-1 G972R polymorphism. Results: The frequencies of each polymorphic variation, in the control population, were as follows: GG=103 (94.5%) and GR=6 (5.5%); for the NSCLC subjects, the genotypic frequencies were as follows: GG=106 (97.2%) and GR=3 (2.8%). We could not demonstrate statistically significant differences in the genotypic distribution between the NSCLC and the control subjects (p=0.499, Fisher's Exact test). The relative risk of NSCLC, associated with the IRS-1 G972R polymorphic variation, was 1.028 (95% CI; 0.63~9.90). In addition, we found no differences between polymorphic variants with regard to the histological subtype of NSCLC. Conclusion: We did not observe any noteworthy differences in the frequency of the IRS-1 G972R polymorphism in NSCLC patients, compared to control subjects. These results suggest suggesting that, in our study population, the IRS-1 G972R polymorphism does may not appear to be associated with an increased risk of NSCLC.

• Journal of Gastric Cancer
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• 제1권1호
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• pp.4-9
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• 2001

Purpose: The trefoil factor family 1 (TFF1) has a protective effect against gastric mucosal damage induced by nonsteroidal anti-inflammatory drugs or ethanol. In addition, a TFF1 knockout mouse model has exhibited circumferential adenomas with high-grade dysplasia, of which $30\%$ progressed into frankly invasive carcinomas. We tried to determine whether the expression pattern of the TFF1 could be involved in the development of sporadic gastric carcinomas. Materials and Methods: We examined TFF1 expression in a series of 43 sporadic gastric carcinomas and 18 gastric adenomas by immunohistochemistry. Results: Strong positive TFF1 staining was identified primarily in the normal gastric mucosa, mainly in the cytoplasm of the superficial and foveolar epithelium. We found TFF1 expression in $55.8\%$ (24 out of 43) of the gastric carcinomas and in $16.7\%$ (3 out of 18) of the gastric adenomas. Statistically, TFF1 immunoreactivity was significantly higher in diffuse-type ($82.4\%$) than in intestinal-type ($38.5\%$) carcinomas(p=0.0058, Fisher's exact test). Conclusion: Our findings provide sufficient evidence that the expression of TFF1 in gastric cancer may simply disclose gastric-type differentiation of neoplastic cells and provide further support for the existence of at least two pathways of malignant transformation of the gastric mucosa: one via intestinal metaplasia and adenomatous dysplasia, leading to glandular carcinomas with intestinal-type differentiation, and the other via hyperplastic changes or de novo changes, leading to diffuse carcinomas and to a subset of glandular carcinomas displaying gastric-type differentiation.

• 가정간호학회지
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• 제8권2호
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• pp.148-158
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• 2001

Purpose: This study is to investigate the attitudes on the Home Health Care among the physicians and nurses in P University. Method: Data were gathered from 71 physicians and 264 nurses. working at P University Hospital. from May 1 to May 15, 2001 and analyzed using descriptive statistics and Fisher exact test. Results: 1) As to the previous information about home health care program, those who have been familiar to it were 100% of physicians, and 99.6% of nurses, and 39% of the physicians and 66.1% of the nurses. were found to have responded with right answers, 2) As to the acceptance of the home health care program, 87% of physicians and 98.5% of nurses were found to be positive and there showed a significant difference(p= .019), 3) The main reasons for accepting the system were: the alleviation of the family burden of time, the maintenance of continuity of care, and the reasons for opposing the system were incomplete legal assurance. the possibility of providing illegal medical services. 4) The physician's intention rate of patient referrals to home care program reveled 49.2%. 5) According to the services related to Home Health Care. the orders of acceptance rates were medical tests related services (77.8%, 92%); therapeutic nursing interventions(69.0%, 88.2%): and services for medication(68.3%, 82.5%) among physicians and nurses. respectively. Conclusion: For the stabilization and successful implementation of home health care system. it should be accompanied with education for physicians about home care. setting specific laws and regulations for home care. legal assurance of home care business. outcome research for home care recipients. and support systems of hospital administration.

• 대한치과보철학회지
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• 제50권3호
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• pp.176-183
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• 2012

연구 목적: 부분 무치악 환자에서 Mg titanate implant (M Implant system, Shinhung, Korea)의보철 후 1년간의 방사선사진을 이용한 변연골 흡수량과 Osstell$^{(R)}$을 이용한 임플란트 안정성 평가 결과를 분석하여 임상적인 성공률에 대해 알아보고자 한다. 연구 재료 및 방법: 38명의 환자에 79개의 임플란트를 식립하여 보철 후 1년 동안 변연골 흡수량, 임플란트의 동요도, 임플란트 식립 위치에 따른 분포 및 성공률, 보철 전후에 따른 성공률을 분석했다. 결과: 변연골의 흡수량은 보철물 장착 후 1년간의 평가에서 상악에서는 평균 1.537 mm, 하악에서는 평균 1.172 mm의 변연골 흡수가 관찰되었으며, 전체적인 상하악의 평균 변연골 흡수량은 1.255 mm로 관찰되었다. 수술 후 시간이 경과함에 따라 ISQ값은 미약하게 감소하였다가 증가하는 경향을 보였으나, 상악과 하악 모두에서 식립 당일 이후 예비 인상일, 최종 보철물의 장착일과 주기적인 평가 기간 동안 ISQ값의 큰 증가나 감소를 나타내지는 않았다. 성공률은 상악에서의 94.12%였고, 하악에서의 98.39%였다. 결론: 본 실험의 결과로 미루어 Mg titanate implant는 임상적으로 양호한 결과를 보여주었다.